Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8B8_LEIBR

TriTrypDb:

LbrM.15.1500 , LBRM2903_150022200

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	114	120	PF00089	0.433
CLV_NRD_NRD_1	149	151	PF00675	0.564
CLV_NRD_NRD_1	218	220	PF00675	0.655
CLV_NRD_NRD_1	371	373	PF00675	0.521
CLV_PCSK_FUR_1	147	151	PF00082	0.582
CLV_PCSK_KEX2_1	149	151	PF00082	0.564
CLV_PCSK_KEX2_1	218	220	PF00082	0.655
CLV_PCSK_KEX2_1	371	373	PF00082	0.500
CLV_PCSK_SKI1_1	136	140	PF00082	0.438
CLV_PCSK_SKI1_1	149	153	PF00082	0.421
CLV_PCSK_SKI1_1	196	200	PF00082	0.573
CLV_PCSK_SKI1_1	218	222	PF00082	0.550
CLV_Separin_Metazoa	94	98	PF03568	0.438
DEG_APCC_DBOX_1	98	106	PF00400	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DOC_CKS1_1	246	251	PF01111	0.620
DOC_CYCLIN_RxL_1	191	200	PF00134	0.665
DOC_CYCLIN_RxL_1	395	405	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.450
DOC_MAPK_gen_1	147	156	PF00069	0.584
DOC_MAPK_gen_1	317	326	PF00069	0.671
DOC_MAPK_HePTP_8	144	156	PF00069	0.577
DOC_MAPK_MEF2A_6	147	156	PF00069	0.589
DOC_PP2B_LxvP_1	152	155	PF13499	0.587
DOC_PP2B_LxvP_1	48	51	PF13499	0.423
DOC_PP2B_LxvP_1	71	74	PF13499	0.442
DOC_USP7_MATH_1	312	316	PF00917	0.523
DOC_USP7_MATH_1	366	370	PF00917	0.530
DOC_USP7_MATH_1	51	55	PF00917	0.430
DOC_WW_Pin1_4	116	121	PF00397	0.703
DOC_WW_Pin1_4	245	250	PF00397	0.583
DOC_WW_Pin1_4	275	280	PF00397	0.756
DOC_WW_Pin1_4	28	33	PF00397	0.526
LIG_14-3-3_CanoR_1	149	155	PF00244	0.499
LIG_14-3-3_CanoR_1	162	168	PF00244	0.569
LIG_14-3-3_CanoR_1	193	199	PF00244	0.551
LIG_14-3-3_CanoR_1	201	211	PF00244	0.509
LIG_14-3-3_CanoR_1	271	281	PF00244	0.747
LIG_14-3-3_CanoR_1	292	301	PF00244	0.679
LIG_14-3-3_CanoR_1	371	375	PF00244	0.462
LIG_14-3-3_CanoR_1	383	387	PF00244	0.434
LIG_14-3-3_CanoR_1	393	399	PF00244	0.473
LIG_14-3-3_CanoR_1	83	91	PF00244	0.465
LIG_14-3-3_CanoR_1	99	109	PF00244	0.419
LIG_Actin_WH2_2	204	220	PF00022	0.537
LIG_APCC_ABBA_1	14	19	PF00400	0.447
LIG_BRCT_BRCA1_1	103	107	PF00533	0.415
LIG_BRCT_BRCA1_1	258	262	PF00533	0.740
LIG_BRCT_BRCA1_1	307	311	PF00533	0.622
LIG_BRCT_BRCA1_1	59	63	PF00533	0.431
LIG_FHA_1	11	17	PF00498	0.608
LIG_FHA_1	176	182	PF00498	0.632
LIG_FHA_1	276	282	PF00498	0.603
LIG_FHA_1	325	331	PF00498	0.482
LIG_FHA_2	155	161	PF00498	0.319
LIG_FHA_2	87	93	PF00498	0.450
LIG_LIR_Gen_1	106	116	PF02991	0.569
LIG_LIR_Gen_1	227	235	PF02991	0.491
LIG_LIR_Gen_1	394	404	PF02991	0.587
LIG_LIR_Nem_3	104	110	PF02991	0.544
LIG_LIR_Nem_3	135	141	PF02991	0.418
LIG_LIR_Nem_3	205	210	PF02991	0.632
LIG_LIR_Nem_3	227	232	PF02991	0.490
LIG_LIR_Nem_3	259	265	PF02991	0.679
LIG_LIR_Nem_3	288	293	PF02991	0.579
LIG_LIR_Nem_3	394	399	PF02991	0.574
LIG_NRBOX	43	49	PF00104	0.414
LIG_PCNA_yPIPBox_3	317	330	PF02747	0.614
LIG_Pex14_1	203	207	PF04695	0.655
LIG_Pex14_1	289	293	PF04695	0.696
LIG_Pex14_1	360	364	PF04695	0.645
LIG_Pex14_2	180	184	PF04695	0.521
LIG_PTB_Apo_2	329	336	PF02174	0.483
LIG_REV1ctd_RIR_1	136	144	PF16727	0.512
LIG_REV1ctd_RIR_1	333	343	PF16727	0.517
LIG_SH2_CRK	38	42	PF00017	0.404
LIG_SH2_GRB2like	228	231	PF00017	0.509
LIG_SH2_NCK_1	253	257	PF00017	0.733
LIG_SH2_STAP1	213	217	PF00017	0.538
LIG_SH2_STAT5	143	146	PF00017	0.449
LIG_SH2_STAT5	188	191	PF00017	0.629
LIG_SH2_STAT5	207	210	PF00017	0.357
LIG_SH2_STAT5	309	312	PF00017	0.569
LIG_SH2_STAT5	38	41	PF00017	0.401
LIG_SH2_STAT5	70	73	PF00017	0.442
LIG_SH3_3	262	268	PF00018	0.736
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.531
LIG_SUMO_SIM_par_1	73	80	PF11976	0.459
LIG_WRC_WIRS_1	361	366	PF05994	0.578
MOD_CDK_SPxK_1	245	251	PF00069	0.616
MOD_CK1_1	101	107	PF00069	0.681
MOD_CK1_1	119	125	PF00069	0.611
MOD_CK1_1	231	237	PF00069	0.530
MOD_CK1_1	270	276	PF00069	0.712
MOD_CK1_1	277	283	PF00069	0.697
MOD_CK1_1	28	34	PF00069	0.419
MOD_CK1_1	86	92	PF00069	0.455
MOD_CK2_1	125	131	PF00069	0.510
MOD_CK2_1	76	82	PF00069	0.467
MOD_CK2_1	86	92	PF00069	0.423
MOD_GlcNHglycan	262	265	PF01048	0.751
MOD_GlcNHglycan	8	11	PF01048	0.579
MOD_GSK3_1	119	126	PF00069	0.642
MOD_GSK3_1	150	157	PF00069	0.473
MOD_GSK3_1	2	9	PF00069	0.454
MOD_GSK3_1	256	263	PF00069	0.674
MOD_GSK3_1	267	274	PF00069	0.622
MOD_GSK3_1	277	284	PF00069	0.666
MOD_GSK3_1	288	295	PF00069	0.475
MOD_GSK3_1	360	367	PF00069	0.600
MOD_GSK3_1	57	64	PF00069	0.430
MOD_GSK3_1	83	90	PF00069	0.466
MOD_N-GLC_1	348	353	PF02516	0.613
MOD_N-GLC_1	354	359	PF02516	0.590
MOD_NEK2_1	123	128	PF00069	0.676
MOD_NEK2_1	182	187	PF00069	0.546
MOD_NEK2_1	2	7	PF00069	0.559
MOD_NEK2_1	202	207	PF00069	0.326
MOD_NEK2_1	281	286	PF00069	0.558
MOD_NEK2_1	302	307	PF00069	0.547
MOD_NEK2_1	311	316	PF00069	0.485
MOD_NEK2_1	370	375	PF00069	0.475
MOD_NEK2_1	381	386	PF00069	0.423
MOD_NEK2_1	43	48	PF00069	0.411
MOD_NEK2_2	282	287	PF00069	0.465
MOD_NEK2_2	354	359	PF00069	0.600
MOD_NEK2_2	366	371	PF00069	0.533
MOD_PIKK_1	25	31	PF00454	0.427
MOD_PK_1	150	156	PF00069	0.600
MOD_PKA_1	218	224	PF00069	0.623
MOD_PKA_2	161	167	PF00069	0.566
MOD_PKA_2	218	224	PF00069	0.510
MOD_PKA_2	270	276	PF00069	0.775
MOD_PKA_2	370	376	PF00069	0.408
MOD_PKA_2	382	388	PF00069	0.410
MOD_PKA_2	84	90	PF00069	0.464
MOD_PKA_2	98	104	PF00069	0.545
MOD_Plk_1	324	330	PF00069	0.544
MOD_Plk_1	354	360	PF00069	0.580
MOD_Plk_1	381	387	PF00069	0.553
MOD_Plk_4	203	209	PF00069	0.551
MOD_Plk_4	277	283	PF00069	0.515
MOD_Plk_4	297	303	PF00069	0.622
MOD_Plk_4	305	311	PF00069	0.528
MOD_Plk_4	43	49	PF00069	0.414
MOD_Plk_4	66	72	PF00069	0.429
MOD_ProDKin_1	116	122	PF00069	0.702
MOD_ProDKin_1	245	251	PF00069	0.595
MOD_ProDKin_1	275	281	PF00069	0.751
MOD_ProDKin_1	28	34	PF00069	0.520
TRG_DiLeu_BaEn_1	325	330	PF01217	0.585
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.475
TRG_ENDOCYTIC_2	207	210	PF00928	0.487
TRG_ENDOCYTIC_2	38	41	PF00928	0.401
TRG_ER_diArg_1	147	150	PF00400	0.456
TRG_ER_diArg_1	190	193	PF00400	0.570
TRG_ER_diArg_1	217	219	PF00400	0.649
TRG_ER_diArg_1	316	319	PF00400	0.681
TRG_ER_diArg_1	370	372	PF00400	0.441
TRG_ER_diArg_1	96	99	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	400	405	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM1	Leptomonas seymouri	64%	100%
A0A3S7WTP0	Leishmania donovani	90%	100%
A0A422N5B2	Trypanosoma rangeli	38%	100%
A4HWN9	Leishmania infantum	90%	100%
C9ZXP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QF29	Leishmania major	90%	100%
V5BFJ3	Trypanosoma cruzi	36%	100%