NTP_transf_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8B7_LEIBR

TriTrypDb:

LbrM.15.1490 , LBRM2903_150022100

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.698
CLV_NRD_NRD_1	242	244	PF00675	0.615
CLV_NRD_NRD_1	481	483	PF00675	0.785
CLV_NRD_NRD_1	490	492	PF00675	0.712
CLV_NRD_NRD_1	598	600	PF00675	0.731
CLV_NRD_NRD_1	617	619	PF00675	0.473
CLV_NRD_NRD_1	64	66	PF00675	0.435
CLV_PCSK_KEX2_1	156	158	PF00082	0.609
CLV_PCSK_KEX2_1	244	246	PF00082	0.583
CLV_PCSK_KEX2_1	310	312	PF00082	0.487
CLV_PCSK_KEX2_1	450	452	PF00082	0.593
CLV_PCSK_KEX2_1	458	460	PF00082	0.729
CLV_PCSK_KEX2_1	464	466	PF00082	0.710
CLV_PCSK_KEX2_1	475	477	PF00082	0.712
CLV_PCSK_KEX2_1	481	483	PF00082	0.702
CLV_PCSK_KEX2_1	566	568	PF00082	0.714
CLV_PCSK_KEX2_1	617	619	PF00082	0.787
CLV_PCSK_KEX2_1	64	66	PF00082	0.439
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.682
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.583
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.700
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.593
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.706
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.752
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.631
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.769
CLV_PCSK_PC7_1	471	477	PF00082	0.580
CLV_PCSK_SKI1_1	101	105	PF00082	0.576
CLV_PCSK_SKI1_1	174	178	PF00082	0.702
CLV_PCSK_SKI1_1	181	185	PF00082	0.623
CLV_PCSK_SKI1_1	216	220	PF00082	0.499
CLV_PCSK_SKI1_1	256	260	PF00082	0.571
CLV_PCSK_SKI1_1	310	314	PF00082	0.488
CLV_PCSK_SKI1_1	35	39	PF00082	0.637
CLV_PCSK_SKI1_1	392	396	PF00082	0.561
CLV_PCSK_SKI1_1	404	408	PF00082	0.635
CLV_PCSK_SKI1_1	41	45	PF00082	0.600
CLV_PCSK_SKI1_1	499	503	PF00082	0.771
CLV_PCSK_SKI1_1	504	508	PF00082	0.696
CLV_PCSK_SKI1_1	589	593	PF00082	0.579
CLV_PCSK_SKI1_1	75	79	PF00082	0.624
CLV_Separin_Metazoa	297	301	PF03568	0.472
DEG_SCF_FBW7_1	394	401	PF00400	0.549
DEG_SCF_FBW7_1	505	512	PF00400	0.569
DEG_SPOP_SBC_1	593	597	PF00917	0.567
DEG_SPOP_SBC_1	604	608	PF00917	0.528
DOC_CKS1_1	612	617	PF01111	0.717
DOC_CYCLIN_RxL_1	307	315	PF00134	0.488
DOC_CYCLIN_yClb5_NLxxxL_5	89	96	PF00134	0.390
DOC_MAPK_gen_1	243	251	PF00069	0.555
DOC_MAPK_gen_1	280	287	PF00069	0.689
DOC_MAPK_gen_1	387	396	PF00069	0.564
DOC_MAPK_gen_1	481	487	PF00069	0.569
DOC_MAPK_gen_1	561	570	PF00069	0.578
DOC_MAPK_gen_1	85	96	PF00069	0.539
DOC_PP1_RVXF_1	616	623	PF00149	0.551
DOC_PP2B_LxvP_1	218	221	PF13499	0.557
DOC_PP2B_LxvP_1	574	577	PF13499	0.778
DOC_PP4_FxxP_1	158	161	PF00568	0.574
DOC_SPAK_OSR1_1	245	249	PF12202	0.539
DOC_USP7_MATH_1	467	471	PF00917	0.740
DOC_USP7_MATH_1	495	499	PF00917	0.623
DOC_USP7_MATH_1	569	573	PF00917	0.814
DOC_USP7_MATH_1	584	588	PF00917	0.519
DOC_USP7_MATH_1	593	597	PF00917	0.540
DOC_USP7_UBL2_3	101	105	PF12436	0.577
DOC_USP7_UBL2_3	134	138	PF12436	0.594
DOC_USP7_UBL2_3	35	39	PF12436	0.459
DOC_USP7_UBL2_3	404	408	PF12436	0.660
DOC_USP7_UBL2_3	419	423	PF12436	0.664
DOC_USP7_UBL2_3	499	503	PF12436	0.714
DOC_USP7_UBL2_3	559	563	PF12436	0.843
DOC_USP7_UBL2_3	85	89	PF12436	0.477
DOC_WW_Pin1_4	157	162	PF00397	0.689
DOC_WW_Pin1_4	174	179	PF00397	0.426
DOC_WW_Pin1_4	394	399	PF00397	0.550
DOC_WW_Pin1_4	445	450	PF00397	0.742
DOC_WW_Pin1_4	505	510	PF00397	0.569
DOC_WW_Pin1_4	611	616	PF00397	0.634
LIG_14-3-3_CanoR_1	180	187	PF00244	0.548
LIG_14-3-3_CanoR_1	207	212	PF00244	0.606
LIG_14-3-3_CanoR_1	250	256	PF00244	0.465
LIG_14-3-3_CanoR_1	288	294	PF00244	0.649
LIG_14-3-3_CanoR_1	300	308	PF00244	0.560
LIG_14-3-3_CanoR_1	320	326	PF00244	0.451
LIG_14-3-3_CanoR_1	342	348	PF00244	0.569
LIG_14-3-3_CanoR_1	465	470	PF00244	0.598
LIG_14-3-3_CanoR_1	51	57	PF00244	0.413
LIG_14-3-3_CanoR_1	6	13	PF00244	0.694
LIG_14-3-3_CanoR_1	603	613	PF00244	0.826
LIG_Actin_WH2_2	286	302	PF00022	0.467
LIG_Actin_WH2_2	89	107	PF00022	0.616
LIG_AP2alpha_1	539	543	PF02296	0.553
LIG_BRCT_BRCA1_1	609	613	PF00533	0.825
LIG_CaM_IQ_9	28	43	PF13499	0.593
LIG_CtBP_PxDLS_1	212	216	PF00389	0.401
LIG_EH1_1	369	377	PF00400	0.731
LIG_FHA_1	126	132	PF00498	0.584
LIG_FHA_1	376	382	PF00498	0.703
LIG_FHA_1	395	401	PF00498	0.490
LIG_FHA_1	429	435	PF00498	0.804
LIG_FHA_1	464	470	PF00498	0.726
LIG_FHA_1	472	478	PF00498	0.719
LIG_FHA_1	563	569	PF00498	0.704
LIG_FHA_2	140	146	PF00498	0.767
LIG_FHA_2	384	390	PF00498	0.506
LIG_FHA_2	513	519	PF00498	0.780
LIG_FHA_2	526	532	PF00498	0.643
LIG_LIR_Gen_1	108	116	PF02991	0.657
LIG_LIR_Gen_1	168	176	PF02991	0.580
LIG_LIR_Gen_1	182	190	PF02991	0.541
LIG_LIR_Gen_1	192	198	PF02991	0.609
LIG_LIR_Gen_1	22	31	PF02991	0.525
LIG_LIR_Gen_1	346	356	PF02991	0.702
LIG_LIR_Nem_3	108	114	PF02991	0.669
LIG_LIR_Nem_3	153	158	PF02991	0.618
LIG_LIR_Nem_3	182	187	PF02991	0.535
LIG_LIR_Nem_3	192	196	PF02991	0.606
LIG_LIR_Nem_3	22	27	PF02991	0.524
LIG_LIR_Nem_3	226	232	PF02991	0.409
LIG_LIR_Nem_3	254	258	PF02991	0.516
LIG_LIR_Nem_3	269	275	PF02991	0.520
LIG_LIR_Nem_3	283	289	PF02991	0.477
LIG_LIR_Nem_3	346	351	PF02991	0.708
LIG_LIR_Nem_3	55	60	PF02991	0.409
LIG_MYND_1	398	402	PF01753	0.538
LIG_PCNA_PIPBox_1	50	59	PF02747	0.636
LIG_PDZ_Class_1	629	634	PF00595	0.595
LIG_Pex14_2	229	233	PF04695	0.630
LIG_Pex14_2	539	543	PF04695	0.553
LIG_PTAP_UEV_1	553	558	PF05743	0.840
LIG_REV1ctd_RIR_1	304	315	PF16727	0.489
LIG_SH2_CRK	208	212	PF00017	0.634
LIG_SH2_NCK_1	370	374	PF00017	0.481
LIG_SH2_SRC	348	351	PF00017	0.605
LIG_SH2_STAP1	348	352	PF00017	0.600
LIG_SH2_STAT3	68	71	PF00017	0.392
LIG_SH2_STAT5	286	289	PF00017	0.488
LIG_SH3_2	554	559	PF14604	0.841
LIG_SH3_2	612	617	PF14604	0.767
LIG_SH3_3	399	405	PF00018	0.542
LIG_SH3_3	548	554	PF00018	0.825
LIG_SH3_3	609	615	PF00018	0.692
LIG_SH3_4	404	411	PF00018	0.688
LIG_UBA3_1	312	317	PF00899	0.485
LIG_UBA3_1	52	59	PF00899	0.493
LIG_UBA3_1	92	101	PF00899	0.542
LIG_WRC_WIRS_1	166	171	PF05994	0.592
LIG_WRC_WIRS_1	190	195	PF05994	0.448
LIG_WRC_WIRS_1	252	257	PF05994	0.473
MOD_CDC14_SPxK_1	401	404	PF00782	0.541
MOD_CDC14_SPxK_1	448	451	PF00782	0.843
MOD_CDK_SPK_2	445	450	PF00069	0.583
MOD_CDK_SPxK_1	174	180	PF00069	0.452
MOD_CDK_SPxK_1	398	404	PF00069	0.543
MOD_CDK_SPxK_1	445	451	PF00069	0.838
MOD_CDK_SPxK_1	611	617	PF00069	0.769
MOD_CDK_SPxxK_3	174	181	PF00069	0.450
MOD_CDK_SPxxK_3	611	618	PF00069	0.566
MOD_CK1_1	141	147	PF00069	0.666
MOD_CK1_1	182	188	PF00069	0.500
MOD_CK1_1	194	200	PF00069	0.605
MOD_CK1_1	324	330	PF00069	0.570
MOD_CK1_1	333	339	PF00069	0.588
MOD_CK1_1	343	349	PF00069	0.640
MOD_CK1_1	8	14	PF00069	0.758
MOD_CK2_1	139	145	PF00069	0.761
MOD_CK2_1	165	171	PF00069	0.597
MOD_CK2_1	220	226	PF00069	0.586
MOD_CK2_1	383	389	PF00069	0.502
MOD_CK2_1	525	531	PF00069	0.560
MOD_DYRK1A_RPxSP_1	174	178	PF00069	0.453
MOD_GlcNHglycan	181	184	PF01048	0.556
MOD_GlcNHglycan	198	201	PF01048	0.588
MOD_GlcNHglycan	326	329	PF01048	0.474
MOD_GlcNHglycan	342	345	PF01048	0.622
MOD_GlcNHglycan	7	10	PF01048	0.688
MOD_GSK3_1	121	128	PF00069	0.450
MOD_GSK3_1	172	179	PF00069	0.591
MOD_GSK3_1	271	278	PF00069	0.577
MOD_GSK3_1	394	401	PF00069	0.736
MOD_GSK3_1	463	470	PF00069	0.776
MOD_GSK3_1	505	512	PF00069	0.747
MOD_GSK3_1	589	596	PF00069	0.775
MOD_GSK3_1	603	610	PF00069	0.790
MOD_N-GLC_1	194	199	PF02516	0.614
MOD_NEK2_1	115	120	PF00069	0.581
MOD_NEK2_1	165	170	PF00069	0.594
MOD_NEK2_1	172	177	PF00069	0.580
MOD_NEK2_1	233	238	PF00069	0.435
MOD_NEK2_1	251	256	PF00069	0.578
MOD_NEK2_1	27	32	PF00069	0.465
MOD_NEK2_1	271	276	PF00069	0.458
MOD_NEK2_1	312	317	PF00069	0.597
MOD_NEK2_1	338	343	PF00069	0.615
MOD_NEK2_1	428	433	PF00069	0.551
MOD_NEK2_1	5	10	PF00069	0.685
MOD_NEK2_1	67	72	PF00069	0.641
MOD_NEK2_1	96	101	PF00069	0.411
MOD_NEK2_2	116	121	PF00069	0.669
MOD_PIKK_1	25	31	PF00454	0.406
MOD_PIKK_1	549	555	PF00454	0.577
MOD_PIKK_1	584	590	PF00454	0.753
MOD_PIKK_1	67	73	PF00454	0.397
MOD_PIKK_1	8	14	PF00454	0.788
MOD_PK_1	365	371	PF00069	0.464
MOD_PK_1	465	471	PF00069	0.577
MOD_PKA_1	138	144	PF00069	0.711
MOD_PKA_2	179	185	PF00069	0.563
MOD_PKA_2	206	212	PF00069	0.613
MOD_PKA_2	299	305	PF00069	0.594
MOD_PKA_2	5	11	PF00069	0.687
MOD_Plk_1	107	113	PF00069	0.477
MOD_Plk_1	194	200	PF00069	0.707
MOD_Plk_1	330	336	PF00069	0.649
MOD_Plk_2-3	525	531	PF00069	0.560
MOD_Plk_4	333	339	PF00069	0.627
MOD_Plk_4	343	349	PF00069	0.561
MOD_Plk_4	365	371	PF00069	0.464
MOD_Plk_4	52	58	PF00069	0.371
MOD_Plk_4	576	582	PF00069	0.654
MOD_ProDKin_1	157	163	PF00069	0.690
MOD_ProDKin_1	174	180	PF00069	0.423
MOD_ProDKin_1	394	400	PF00069	0.551
MOD_ProDKin_1	445	451	PF00069	0.744
MOD_ProDKin_1	505	511	PF00069	0.569
MOD_ProDKin_1	611	617	PF00069	0.632
MOD_SUMO_for_1	443	446	PF00179	0.581
MOD_SUMO_rev_2	30	38	PF00179	0.582
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.491
TRG_ENDOCYTIC_2	208	211	PF00928	0.634
TRG_ENDOCYTIC_2	286	289	PF00928	0.437
TRG_ENDOCYTIC_2	348	351	PF00928	0.605
TRG_ENDOCYTIC_2	47	50	PF00928	0.405
TRG_ER_diArg_1	243	246	PF00400	0.598
TRG_ER_diArg_1	481	483	PF00400	0.704
TRG_ER_diArg_1	63	65	PF00400	0.438
TRG_NLS_MonoExtN_4	390	396	PF00514	0.540
TRG_NLS_MonoExtN_4	415	421	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB6	Leptomonas seymouri	42%	98%
A0A3Q8ICE3	Leishmania donovani	69%	95%
A4HWN8	Leishmania infantum	70%	95%
E9AQE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4QF30	Leishmania major	69%	100%