Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8B6_LEIBR

TriTrypDb:

LbrM.15.1480 , LBRM2903_150022000

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8B6

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	925	929	PF00656	0.579
CLV_MEL_PAP_1	177	183	PF00089	0.320
CLV_NRD_NRD_1	36	38	PF00675	0.688
CLV_NRD_NRD_1	672	674	PF00675	0.447
CLV_NRD_NRD_1	675	677	PF00675	0.481
CLV_NRD_NRD_1	822	824	PF00675	0.517
CLV_NRD_NRD_1	930	932	PF00675	0.729
CLV_PCSK_FUR_1	34	38	PF00082	0.604
CLV_PCSK_FUR_1	673	677	PF00082	0.581
CLV_PCSK_KEX2_1	36	38	PF00082	0.617
CLV_PCSK_KEX2_1	671	673	PF00082	0.541
CLV_PCSK_KEX2_1	675	677	PF00082	0.567
CLV_PCSK_KEX2_1	822	824	PF00082	0.517
CLV_PCSK_KEX2_1	930	932	PF00082	0.729
CLV_PCSK_PC7_1	671	677	PF00082	0.548
CLV_PCSK_SKI1_1	209	213	PF00082	0.474
CLV_PCSK_SKI1_1	260	264	PF00082	0.374
CLV_PCSK_SKI1_1	332	336	PF00082	0.374
CLV_PCSK_SKI1_1	427	431	PF00082	0.374
CLV_PCSK_SKI1_1	434	438	PF00082	0.374
CLV_PCSK_SKI1_1	54	58	PF00082	0.523
CLV_PCSK_SKI1_1	589	593	PF00082	0.648
CLV_PCSK_SKI1_1	823	827	PF00082	0.326
DEG_APCC_DBOX_1	822	830	PF00400	0.223
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DOC_CYCLIN_RxL_1	819	828	PF00134	0.223
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	511	517	PF00134	0.374
DOC_MAPK_gen_1	401	410	PF00069	0.506
DOC_MAPK_gen_1	589	599	PF00069	0.638
DOC_MAPK_gen_1	930	937	PF00069	0.497
DOC_MAPK_HePTP_8	927	939	PF00069	0.478
DOC_MAPK_MEF2A_6	216	223	PF00069	0.554
DOC_MAPK_MEF2A_6	332	341	PF00069	0.486
DOC_MAPK_MEF2A_6	573	580	PF00069	0.725
DOC_MAPK_MEF2A_6	604	612	PF00069	0.575
DOC_MAPK_MEF2A_6	930	939	PF00069	0.502
DOC_MAPK_NFAT4_5	332	340	PF00069	0.486
DOC_MAPK_NFAT4_5	573	581	PF00069	0.728
DOC_MAPK_RevD_3	211	225	PF00069	0.472
DOC_PP2B_LxvP_1	175	178	PF13499	0.388
DOC_PP2B_LxvP_1	335	338	PF13499	0.374
DOC_PP4_FxxP_1	5	8	PF00568	0.512
DOC_PP4_FxxP_1	618	621	PF00568	0.537
DOC_USP7_MATH_1	11	15	PF00917	0.708
DOC_USP7_MATH_1	275	279	PF00917	0.482
DOC_USP7_MATH_1	384	388	PF00917	0.368
DOC_USP7_MATH_1	439	443	PF00917	0.374
DOC_USP7_MATH_1	606	610	PF00917	0.580
DOC_USP7_MATH_1	61	65	PF00917	0.622
DOC_USP7_MATH_1	66	70	PF00917	0.638
DOC_USP7_MATH_1	783	787	PF00917	0.338
DOC_WW_Pin1_4	4	9	PF00397	0.711
DOC_WW_Pin1_4	597	602	PF00397	0.600
DOC_WW_Pin1_4	617	622	PF00397	0.410
DOC_WW_Pin1_4	734	739	PF00397	0.374
LIG_14-3-3_CanoR_1	128	134	PF00244	0.488
LIG_14-3-3_CanoR_1	180	189	PF00244	0.597
LIG_14-3-3_CanoR_1	318	324	PF00244	0.517
LIG_14-3-3_CanoR_1	37	43	PF00244	0.616
LIG_14-3-3_CanoR_1	441	445	PF00244	0.417
LIG_14-3-3_CanoR_1	494	503	PF00244	0.516
LIG_14-3-3_CanoR_1	582	591	PF00244	0.634
LIG_14-3-3_CanoR_1	631	635	PF00244	0.372
LIG_14-3-3_CanoR_1	930	939	PF00244	0.719
LIG_Actin_WH2_2	164	182	PF00022	0.324
LIG_APCC_ABBA_1	803	808	PF00400	0.235
LIG_BRCT_BRCA1_1	441	445	PF00533	0.374
LIG_BRCT_BRCA1_1	608	612	PF00533	0.589
LIG_BRCT_BRCA1_1	619	623	PF00533	0.444
LIG_Clathr_ClatBox_1	705	709	PF01394	0.268
LIG_eIF4E_1	782	788	PF01652	0.517
LIG_FHA_1	172	178	PF00498	0.479
LIG_FHA_1	202	208	PF00498	0.484
LIG_FHA_1	210	216	PF00498	0.498
LIG_FHA_1	22	28	PF00498	0.541
LIG_FHA_1	329	335	PF00498	0.374
LIG_FHA_1	42	48	PF00498	0.395
LIG_FHA_1	505	511	PF00498	0.374
LIG_FHA_1	545	551	PF00498	0.387
LIG_FHA_1	714	720	PF00498	0.374
LIG_FHA_1	766	772	PF00498	0.505
LIG_FHA_1	83	89	PF00498	0.556
LIG_FHA_2	243	249	PF00498	0.622
LIG_FHA_2	259	265	PF00498	0.315
LIG_FHA_2	474	480	PF00498	0.517
LIG_FHA_2	539	545	PF00498	0.389
LIG_FHA_2	598	604	PF00498	0.499
LIG_LIR_Apic_2	617	621	PF02991	0.547
LIG_LIR_Gen_1	111	121	PF02991	0.533
LIG_LIR_Gen_1	374	385	PF02991	0.374
LIG_LIR_Gen_1	453	462	PF02991	0.417
LIG_LIR_Gen_1	538	548	PF02991	0.409
LIG_LIR_Gen_1	620	628	PF02991	0.428
LIG_LIR_Gen_1	694	701	PF02991	0.344
LIG_LIR_Gen_1	709	719	PF02991	0.423
LIG_LIR_Nem_3	111	117	PF02991	0.534
LIG_LIR_Nem_3	119	124	PF02991	0.584
LIG_LIR_Nem_3	174	179	PF02991	0.471
LIG_LIR_Nem_3	374	380	PF02991	0.374
LIG_LIR_Nem_3	538	543	PF02991	0.378
LIG_LIR_Nem_3	546	551	PF02991	0.372
LIG_LIR_Nem_3	552	557	PF02991	0.371
LIG_LIR_Nem_3	620	626	PF02991	0.434
LIG_LIR_Nem_3	694	698	PF02991	0.344
LIG_LIR_Nem_3	709	714	PF02991	0.423
LIG_LIR_Nem_3	770	775	PF02991	0.398
LIG_PCNA_yPIPBox_3	420	430	PF02747	0.268
LIG_PCNA_yPIPBox_3	518	530	PF02747	0.417
LIG_PDZ_Class_2	934	939	PF00595	0.514
LIG_PTB_Apo_2	170	177	PF02174	0.540
LIG_PTB_Apo_2	726	733	PF02174	0.374
LIG_PTB_Phospho_1	170	176	PF10480	0.547
LIG_PTB_Phospho_1	726	732	PF10480	0.374
LIG_Rb_pABgroove_1	868	876	PF01858	0.394
LIG_REV1ctd_RIR_1	895	903	PF16727	0.394
LIG_RPA_C_Fungi	577	589	PF08784	0.557
LIG_SH2_CRK	674	678	PF00017	0.437
LIG_SH2_CRK	784	788	PF00017	0.517
LIG_SH2_GRB2like	679	682	PF00017	0.374
LIG_SH2_PTP2	176	179	PF00017	0.423
LIG_SH2_PTP2	711	714	PF00017	0.486
LIG_SH2_SRC	490	493	PF00017	0.374
LIG_SH2_SRC	695	698	PF00017	0.268
LIG_SH2_STAP1	455	459	PF00017	0.417
LIG_SH2_STAT3	505	508	PF00017	0.394
LIG_SH2_STAT5	176	179	PF00017	0.439
LIG_SH2_STAT5	300	303	PF00017	0.311
LIG_SH2_STAT5	695	698	PF00017	0.403
LIG_SH2_STAT5	711	714	PF00017	0.417
LIG_SH2_STAT5	732	735	PF00017	0.374
LIG_SH3_3	186	192	PF00018	0.385
LIG_SH3_3	286	292	PF00018	0.393
LIG_SH3_3	305	311	PF00018	0.256
LIG_SH3_3	5	11	PF00018	0.632
LIG_SH3_3	835	841	PF00018	0.394
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.523
LIG_SUMO_SIM_anti_2	520	526	PF11976	0.374
LIG_SUMO_SIM_anti_2	94	102	PF11976	0.492
LIG_SUMO_SIM_par_1	405	412	PF11976	0.491
LIG_SUMO_SIM_par_1	595	600	PF11976	0.588
LIG_SUMO_SIM_par_1	711	716	PF11976	0.374
LIG_SUMO_SIM_par_1	94	102	PF11976	0.366
LIG_TRAF2_1	245	248	PF00917	0.672
LIG_TRAF2_1	600	603	PF00917	0.593
LIG_TYR_ITIM	642	647	PF00017	0.420
LIG_UBA3_1	444	449	PF00899	0.486
LIG_WRC_WIRS_1	377	382	PF05994	0.374
LIG_WRC_WIRS_1	902	907	PF05994	0.268
MOD_CDK_SPxxK_3	597	604	PF00069	0.586
MOD_CK1_1	122	128	PF00069	0.487
MOD_CK1_1	41	47	PF00069	0.606
MOD_CK1_1	538	544	PF00069	0.400
MOD_CK1_1	743	749	PF00069	0.374
MOD_CK1_1	765	771	PF00069	0.268
MOD_CK1_1	82	88	PF00069	0.532
MOD_CK1_1	836	842	PF00069	0.394
MOD_CK1_1	877	883	PF00069	0.331
MOD_CK1_1	933	939	PF00069	0.691
MOD_CK2_1	242	248	PF00069	0.624
MOD_CK2_1	258	264	PF00069	0.308
MOD_CK2_1	40	46	PF00069	0.620
MOD_CK2_1	458	464	PF00069	0.517
MOD_CK2_1	473	479	PF00069	0.239
MOD_CK2_1	597	603	PF00069	0.495
MOD_CK2_1	747	753	PF00069	0.374
MOD_Cter_Amidation	928	931	PF01082	0.691
MOD_GlcNHglycan	13	16	PF01048	0.649
MOD_GlcNHglycan	17	20	PF01048	0.563
MOD_GlcNHglycan	192	195	PF01048	0.566
MOD_GlcNHglycan	303	306	PF01048	0.493
MOD_GlcNHglycan	360	363	PF01048	0.417
MOD_GlcNHglycan	460	463	PF01048	0.508
MOD_GlcNHglycan	479	482	PF01048	0.406
MOD_GlcNHglycan	496	499	PF01048	0.417
MOD_GlcNHglycan	585	588	PF01048	0.517
MOD_GlcNHglycan	613	616	PF01048	0.393
MOD_GlcNHglycan	63	66	PF01048	0.733
MOD_GlcNHglycan	68	71	PF01048	0.673
MOD_GlcNHglycan	743	746	PF01048	0.374
MOD_GlcNHglycan	932	935	PF01048	0.580
MOD_GSK3_1	104	111	PF00069	0.574
MOD_GSK3_1	11	18	PF00069	0.702
MOD_GSK3_1	120	127	PF00069	0.473
MOD_GSK3_1	167	174	PF00069	0.566
MOD_GSK3_1	242	249	PF00069	0.562
MOD_GSK3_1	251	258	PF00069	0.353
MOD_GSK3_1	262	269	PF00069	0.190
MOD_GSK3_1	324	331	PF00069	0.374
MOD_GSK3_1	37	44	PF00069	0.606
MOD_GSK3_1	473	480	PF00069	0.394
MOD_GSK3_1	490	497	PF00069	0.394
MOD_GSK3_1	529	536	PF00069	0.308
MOD_GSK3_1	555	562	PF00069	0.366
MOD_GSK3_1	57	64	PF00069	0.584
MOD_GSK3_1	743	750	PF00069	0.374
MOD_GSK3_1	79	86	PF00069	0.603
MOD_N-GLC_1	154	159	PF02516	0.478
MOD_N-GLC_1	319	324	PF02516	0.505
MOD_N-GLC_1	393	398	PF02516	0.579
MOD_N-GLC_1	559	564	PF02516	0.473
MOD_N-GLC_1	66	71	PF02516	0.676
MOD_N-GLC_1	727	732	PF02516	0.374
MOD_N-GLC_1	747	752	PF02516	0.190
MOD_N-GLC_1	836	841	PF02516	0.409
MOD_N-GLC_2	118	120	PF02516	0.321
MOD_N-GLC_2	220	222	PF02516	0.348
MOD_NEK2_1	21	26	PF00069	0.633
MOD_NEK2_1	246	251	PF00069	0.509
MOD_NEK2_1	27	32	PF00069	0.602
MOD_NEK2_1	341	346	PF00069	0.517
MOD_NEK2_1	376	381	PF00069	0.374
MOD_NEK2_1	458	463	PF00069	0.394
MOD_NEK2_1	647	652	PF00069	0.462
MOD_NEK2_1	713	718	PF00069	0.392
MOD_NEK2_1	842	847	PF00069	0.394
MOD_NEK2_1	874	879	PF00069	0.394
MOD_NEK2_2	275	280	PF00069	0.382
MOD_NEK2_2	384	389	PF00069	0.368
MOD_NEK2_2	535	540	PF00069	0.394
MOD_PIKK_1	201	207	PF00454	0.409
MOD_PIKK_1	504	510	PF00454	0.394
MOD_PIKK_1	68	74	PF00454	0.666
MOD_PK_1	506	512	PF00069	0.486
MOD_PKA_1	930	936	PF00069	0.744
MOD_PKA_2	179	185	PF00069	0.518
MOD_PKA_2	215	221	PF00069	0.604
MOD_PKA_2	242	248	PF00069	0.606
MOD_PKA_2	266	272	PF00069	0.374
MOD_PKA_2	35	41	PF00069	0.669
MOD_PKA_2	440	446	PF00069	0.417
MOD_PKA_2	581	587	PF00069	0.639
MOD_PKA_2	630	636	PF00069	0.409
MOD_PKA_2	930	936	PF00069	0.671
MOD_Plk_1	154	160	PF00069	0.444
MOD_Plk_1	198	204	PF00069	0.551
MOD_Plk_1	246	252	PF00069	0.518
MOD_Plk_1	319	325	PF00069	0.427
MOD_Plk_1	393	399	PF00069	0.580
MOD_Plk_1	439	445	PF00069	0.374
MOD_Plk_1	559	565	PF00069	0.477
MOD_Plk_1	659	665	PF00069	0.494
MOD_Plk_1	727	733	PF00069	0.374
MOD_Plk_1	747	753	PF00069	0.190
MOD_Plk_1	842	848	PF00069	0.448
MOD_Plk_4	171	177	PF00069	0.508
MOD_Plk_4	246	252	PF00069	0.500
MOD_Plk_4	266	272	PF00069	0.190
MOD_Plk_4	27	33	PF00069	0.601
MOD_Plk_4	341	347	PF00069	0.423
MOD_Plk_4	393	399	PF00069	0.561
MOD_Plk_4	409	415	PF00069	0.406
MOD_Plk_4	421	427	PF00069	0.436
MOD_Plk_4	440	446	PF00069	0.219
MOD_Plk_4	506	512	PF00069	0.374
MOD_Plk_4	659	665	PF00069	0.464
MOD_Plk_4	691	697	PF00069	0.383
MOD_Plk_4	727	733	PF00069	0.374
MOD_Plk_4	747	753	PF00069	0.190
MOD_Plk_4	825	831	PF00069	0.517
MOD_Plk_4	901	907	PF00069	0.268
MOD_ProDKin_1	4	10	PF00069	0.710
MOD_ProDKin_1	597	603	PF00069	0.593
MOD_ProDKin_1	617	623	PF00069	0.404
MOD_ProDKin_1	734	740	PF00069	0.374
MOD_SUMO_rev_2	41	50	PF00179	0.672
TRG_DiLeu_BaEn_1	247	252	PF01217	0.606
TRG_ENDOCYTIC_2	176	179	PF00928	0.431
TRG_ENDOCYTIC_2	2	5	PF00928	0.708
TRG_ENDOCYTIC_2	455	458	PF00928	0.417
TRG_ENDOCYTIC_2	644	647	PF00928	0.424
TRG_ENDOCYTIC_2	674	677	PF00928	0.441
TRG_ENDOCYTIC_2	679	682	PF00928	0.374
TRG_ENDOCYTIC_2	683	686	PF00928	0.374
TRG_ENDOCYTIC_2	695	698	PF00928	0.374
TRG_ENDOCYTIC_2	711	714	PF00928	0.438
TRG_ENDOCYTIC_2	784	787	PF00928	0.448
TRG_ER_diArg_1	35	37	PF00400	0.670
TRG_ER_diArg_1	671	673	PF00400	0.548
TRG_ER_diArg_1	674	676	PF00400	0.556
TRG_ER_diArg_1	822	824	PF00400	0.517
TRG_ER_diArg_1	930	932	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	785	789	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	69%	100%
A0A1X0NUP8	Trypanosomatidae	61%	100%
A0A3Q8I987	Leishmania donovani	85%	100%
A0A3R7RI37	Trypanosoma rangeli	69%	100%
A0A3S7WTN0	Leishmania donovani	76%	100%
A4H893	Leishmania braziliensis	82%	100%
A4HWN6	Leishmania infantum	76%	100%
A4HWN7	Leishmania infantum	85%	100%
B3P3K2	Drosophila erecta	29%	83%
B4JXX2	Drosophila grimshawi	27%	87%
B4K9L4	Drosophila mojavensis	28%	84%
B4LVU6	Drosophila virilis	28%	100%
B4NAL6	Drosophila willistoni	28%	83%
B4PSS5	Drosophila yakuba	28%	82%
B4QZU1	Drosophila simulans	29%	82%
C9ZXQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
C9ZXQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AQE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AQE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O00408	Homo sapiens	30%	100%
O54735	Rattus norvegicus	28%	100%
O76074	Homo sapiens	28%	100%
O77746	Canis lupus familiaris	28%	100%
P0C1Q2	Mus musculus	32%	100%
P11541	Bos taurus	24%	100%
P14099	Bos taurus	30%	100%
P16499	Homo sapiens	25%	100%
P16586	Bos taurus	26%	100%
P23439	Bos taurus	25%	100%
P23440	Mus musculus	24%	100%
P27664	Mus musculus	25%	100%
P33726	Canis lupus familiaris	25%	100%
P35913	Homo sapiens	24%	100%
P51160	Homo sapiens	25%	100%
P52731	Gallus gallus	24%	100%
Q01062	Rattus norvegicus	31%	100%
Q1KKS3	Takifugu rubripes	31%	100%
Q28156	Bos taurus	28%	100%
Q28263	Canis lupus familiaris	25%	100%
Q298P4	Drosophila pseudoobscura pseudoobscura	28%	85%
Q4QF31	Leishmania major	86%	100%
Q8CA95	Mus musculus	29%	100%
Q8CG03	Mus musculus	28%	100%
Q8VID6	Rattus norvegicus	31%	100%
Q91ZQ1	Mus musculus	26%	100%
Q922S4	Mus musculus	30%	100%
Q9HCR9	Homo sapiens	31%	100%
Q9QYJ6	Rattus norvegicus	29%	100%
Q9VFI9	Drosophila melanogaster	29%	84%
Q9Y233	Homo sapiens	28%	100%