Phosphomevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomevalonate kinase protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8B3_LEIBR

TriTrypDb:

LbrM.15.1450 , LBRM2903_150021700

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8B3

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006629	lipid metabolic process	3	10
GO:0006637	acyl-CoA metabolic process	4	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009240	isopentenyl diphosphate biosynthetic process	6	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0033865	nucleoside bisphosphate metabolic process	5	10
GO:0033875	ribonucleoside bisphosphate metabolic process	6	10
GO:0034032	purine nucleoside bisphosphate metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0035383	thioester metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046490	isopentenyl diphosphate metabolic process	5	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006720	isoprenoid metabolic process	4	1
GO:0006721	terpenoid metabolic process	5	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	1
GO:0016114	terpenoid biosynthetic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045337	farnesyl diphosphate biosynthetic process	6	1
GO:0045338	farnesyl diphosphate metabolic process	5	1
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004631	phosphomevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.459
CLV_C14_Caspase3-7	298	302	PF00656	0.405
CLV_NRD_NRD_1	221	223	PF00675	0.323
CLV_NRD_NRD_1	319	321	PF00675	0.463
CLV_PCSK_KEX2_1	221	223	PF00082	0.287
CLV_PCSK_KEX2_1	319	321	PF00082	0.450
CLV_PCSK_SKI1_1	269	273	PF00082	0.342
CLV_PCSK_SKI1_1	369	373	PF00082	0.263
CLV_PCSK_SKI1_1	39	43	PF00082	0.352
DEG_APCC_DBOX_1	368	376	PF00400	0.407
DEG_Nend_UBRbox_2	1	3	PF02207	0.423
DEG_SPOP_SBC_1	166	170	PF00917	0.421
DOC_CDC14_PxL_1	339	347	PF14671	0.386
DOC_CYCLIN_RxL_1	363	374	PF00134	0.334
DOC_MAPK_DCC_7	144	152	PF00069	0.470
DOC_MAPK_MEF2A_6	144	152	PF00069	0.470
DOC_MAPK_MEF2A_6	263	272	PF00069	0.350
DOC_PP4_FxxP_1	262	265	PF00568	0.312
DOC_USP7_MATH_1	102	106	PF00917	0.393
DOC_USP7_MATH_1	258	262	PF00917	0.275
DOC_USP7_MATH_1	365	369	PF00917	0.459
DOC_USP7_MATH_1	48	52	PF00917	0.402
DOC_USP7_MATH_1	87	91	PF00917	0.437
DOC_WW_Pin1_4	19	24	PF00397	0.441
DOC_WW_Pin1_4	2	7	PF00397	0.249
DOC_WW_Pin1_4	279	284	PF00397	0.434
DOC_WW_Pin1_4	296	301	PF00397	0.368
DOC_WW_Pin1_4	453	458	PF00397	0.327
DOC_WW_Pin1_4	57	62	PF00397	0.366
DOC_WW_Pin1_4	72	77	PF00397	0.347
LIG_14-3-3_CanoR_1	227	231	PF00244	0.422
LIG_14-3-3_CanoR_1	293	297	PF00244	0.365
LIG_14-3-3_CanoR_1	35	41	PF00244	0.386
LIG_BRCT_BRCA1_1	65	69	PF00533	0.303
LIG_BRCT_BRCA1_1	89	93	PF00533	0.246
LIG_CSL_BTD_1	255	258	PF09270	0.465
LIG_deltaCOP1_diTrp_1	254	262	PF00928	0.365
LIG_FHA_1	166	172	PF00498	0.421
LIG_FHA_1	245	251	PF00498	0.446
LIG_FHA_1	35	41	PF00498	0.317
LIG_FHA_1	393	399	PF00498	0.400
LIG_FHA_1	53	59	PF00498	0.387
LIG_FHA_1	76	82	PF00498	0.317
LIG_FHA_2	108	114	PF00498	0.379
LIG_FHA_2	442	448	PF00498	0.309
LIG_LIR_Apic_2	260	265	PF02991	0.390
LIG_LIR_Gen_1	113	120	PF02991	0.426
LIG_LIR_Gen_1	209	219	PF02991	0.468
LIG_LIR_Gen_1	413	420	PF02991	0.407
LIG_LIR_Gen_1	66	74	PF02991	0.340
LIG_LIR_Nem_3	113	118	PF02991	0.401
LIG_LIR_Nem_3	206	211	PF02991	0.407
LIG_LIR_Nem_3	217	223	PF02991	0.274
LIG_LIR_Nem_3	301	307	PF02991	0.320
LIG_LIR_Nem_3	413	419	PF02991	0.407
LIG_LIR_Nem_3	429	435	PF02991	0.407
LIG_LIR_Nem_3	66	70	PF02991	0.341
LIG_LIR_Nem_3	89	94	PF02991	0.194
LIG_MYND_3	345	349	PF01753	0.263
LIG_NRBOX	387	393	PF00104	0.421
LIG_PDZ_Class_1	453	458	PF00595	0.327
LIG_RPA_C_Fungi	358	370	PF08784	0.352
LIG_SH2_CRK	211	215	PF00017	0.375
LIG_SH2_CRK	412	416	PF00017	0.280
LIG_SH2_CRK	435	439	PF00017	0.361
LIG_SH2_CRK	94	98	PF00017	0.168
LIG_SH2_NCK_1	211	215	PF00017	0.375
LIG_SH2_NCK_1	412	416	PF00017	0.280
LIG_SH2_NCK_1	98	102	PF00017	0.270
LIG_SH2_SRC	130	133	PF00017	0.379
LIG_SH2_SRC	15	18	PF00017	0.318
LIG_SH2_STAP1	211	215	PF00017	0.261
LIG_SH2_STAP1	412	416	PF00017	0.261
LIG_SH2_STAP1	94	98	PF00017	0.287
LIG_SH2_STAT5	130	133	PF00017	0.336
LIG_SH2_STAT5	15	18	PF00017	0.294
LIG_SH2_STAT5	188	191	PF00017	0.307
LIG_SH2_STAT5	211	214	PF00017	0.261
LIG_SH2_STAT5	314	317	PF00017	0.288
LIG_SH2_STAT5	332	335	PF00017	0.312
LIG_SH3_3	145	151	PF00018	0.413
LIG_SH3_3	252	258	PF00018	0.436
LIG_SH3_3	340	346	PF00018	0.385
LIG_SH3_3	401	407	PF00018	0.242
LIG_SH3_3	451	457	PF00018	0.480
LIG_SH3_3	55	61	PF00018	0.277
LIG_SUMO_SIM_par_1	441	448	PF11976	0.315
LIG_TRFH_1	262	266	PF08558	0.433
LIG_TYR_ITIM	92	97	PF00017	0.182
MOD_CDC14_SPxK_1	5	8	PF00782	0.224
MOD_CDK_SPxK_1	2	8	PF00069	0.232
MOD_CK1_1	105	111	PF00069	0.487
MOD_CK1_1	165	171	PF00069	0.260
MOD_CK1_1	386	392	PF00069	0.165
MOD_CK1_1	51	57	PF00069	0.514
MOD_CK1_1	72	78	PF00069	0.318
MOD_CK2_1	107	113	PF00069	0.391
MOD_CK2_1	441	447	PF00069	0.270
MOD_GlcNHglycan	164	167	PF01048	0.243
MOD_GlcNHglycan	205	208	PF01048	0.242
MOD_GlcNHglycan	233	236	PF01048	0.611
MOD_GlcNHglycan	353	356	PF01048	0.362
MOD_GlcNHglycan	387	391	PF01048	0.207
MOD_GlcNHglycan	447	452	PF01048	0.445
MOD_GlcNHglycan	49	53	PF01048	0.601
MOD_GSK3_1	156	163	PF00069	0.242
MOD_GSK3_1	292	299	PF00069	0.411
MOD_GSK3_1	347	354	PF00069	0.305
MOD_GSK3_1	47	54	PF00069	0.511
MOD_N-GLC_1	351	356	PF02516	0.352
MOD_NEK2_1	1	6	PF00069	0.409
MOD_NEK2_1	161	166	PF00069	0.278
MOD_NEK2_1	167	172	PF00069	0.305
MOD_NEK2_1	231	236	PF00069	0.460
MOD_NEK2_1	392	397	PF00069	0.242
MOD_NEK2_1	63	68	PF00069	0.374
MOD_NEK2_1	69	74	PF00069	0.301
MOD_NEK2_2	258	263	PF00069	0.274
MOD_NEK2_2	52	57	PF00069	0.453
MOD_PIKK_1	123	129	PF00454	0.307
MOD_PIKK_1	130	136	PF00454	0.348
MOD_PIKK_1	197	203	PF00454	0.359
MOD_PK_1	136	142	PF00069	0.272
MOD_PKA_2	226	232	PF00069	0.457
MOD_PKA_2	292	298	PF00069	0.366
MOD_PKA_2	34	40	PF00069	0.372
MOD_Plk_1	136	142	PF00069	0.363
MOD_Plk_4	167	173	PF00069	0.261
MOD_Plk_4	226	232	PF00069	0.483
MOD_Plk_4	87	93	PF00069	0.278
MOD_ProDKin_1	19	25	PF00069	0.431
MOD_ProDKin_1	2	8	PF00069	0.251
MOD_ProDKin_1	279	285	PF00069	0.417
MOD_ProDKin_1	296	302	PF00069	0.361
MOD_ProDKin_1	57	63	PF00069	0.369
MOD_ProDKin_1	72	78	PF00069	0.343
MOD_SUMO_for_1	381	384	PF00179	0.375
MOD_SUMO_rev_2	374	383	PF00179	0.375
TRG_DiLeu_BaEn_1	387	392	PF01217	0.320
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.256
TRG_ENDOCYTIC_2	15	18	PF00928	0.294
TRG_ENDOCYTIC_2	211	214	PF00928	0.320
TRG_ENDOCYTIC_2	220	223	PF00928	0.207
TRG_ENDOCYTIC_2	412	415	PF00928	0.261
TRG_ENDOCYTIC_2	435	438	PF00928	0.324
TRG_ENDOCYTIC_2	94	97	PF00928	0.179
TRG_ER_diArg_1	220	222	PF00400	0.282
TRG_ER_diArg_1	318	320	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.245

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P784	Leptomonas seymouri	76%	100%
A0A0S4JMH3	Bodo saltans	54%	100%
A0A1D8PLH0	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
A0A1X0NVR4	Trypanosomatidae	55%	100%
A0A3S5IQX7	Trypanosoma rangeli	54%	98%
A0A3S7WTM8	Leishmania donovani	84%	100%
A4HWN3	Leishmania infantum	84%	100%
C9ZXQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AQE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
I1RZD0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
P24521	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4QF34	Leishmania major	84%	100%
Q4WV38	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	95%
Q9C6T1	Arabidopsis thaliana	35%	91%
Q9UT88	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%