| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 6 |
| Silverman et al. | no | yes: 3 |
| Pissara et al. | yes | yes: 12 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 12 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005634 | nucleus | 5 | 11 |
| GO:0043226 | organelle | 2 | 11 |
| GO:0043227 | membrane-bounded organelle | 3 | 11 |
| GO:0043229 | intracellular organelle | 3 | 11 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 11 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
| GO:0005654 | nucleoplasm | 2 | 1 |
| GO:0032991 | protein-containing complex | 1 | 1 |
| GO:0043626 | PCNA complex | 3 | 1 |
| GO:0044796 | DNA polymerase processivity factor complex | 3 | 1 |
| GO:0140513 | nuclear protein-containing complex | 2 | 1 |
| GO:0150005 | enzyme activator complex | 2 | 1 |
Related structures:
AlphaFold database: A4H8B2
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 12 |
| GO:0006259 | DNA metabolic process | 4 | 12 |
| GO:0006260 | DNA replication | 5 | 11 |
| GO:0006275 | regulation of DNA replication | 6 | 12 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 5 | 12 |
| GO:0019222 | regulation of metabolic process | 3 | 12 |
| GO:0031323 | regulation of cellular metabolic process | 4 | 12 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 12 |
| GO:0043170 | macromolecule metabolic process | 3 | 12 |
| GO:0044237 | cellular metabolic process | 2 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 12 |
| GO:0046483 | heterocycle metabolic process | 3 | 12 |
| GO:0050789 | regulation of biological process | 2 | 12 |
| GO:0050794 | regulation of cellular process | 3 | 12 |
| GO:0051052 | regulation of DNA metabolic process | 5 | 12 |
| GO:0051171 | regulation of nitrogen compound metabolic process | 4 | 12 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 12 |
| GO:0065007 | biological regulation | 1 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:0080090 | regulation of primary metabolic process | 4 | 12 |
| GO:0090304 | nucleic acid metabolic process | 4 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 12 |
| GO:0000731 | DNA synthesis involved in DNA repair | 6 | 1 |
| GO:0006271 | DNA strand elongation involved in DNA replication | 6 | 1 |
| GO:0006272 | leading strand elongation | 7 | 1 |
| GO:0006281 | DNA repair | 5 | 1 |
| GO:0006298 | mismatch repair | 6 | 1 |
| GO:0006301 | postreplication repair | 6 | 1 |
| GO:0006950 | response to stress | 2 | 1 |
| GO:0006974 | DNA damage response | 4 | 1 |
| GO:0009058 | biosynthetic process | 2 | 1 |
| GO:0009059 | macromolecule biosynthetic process | 4 | 1 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 1 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 1 |
| GO:0019985 | translesion synthesis | 7 | 1 |
| GO:0022616 | DNA strand elongation | 5 | 1 |
| GO:0033554 | cellular response to stress | 3 | 1 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 1 |
| GO:0044249 | cellular biosynthetic process | 3 | 1 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 1 |
| GO:0050896 | response to stimulus | 1 | 1 |
| GO:0051716 | cellular response to stimulus | 2 | 1 |
| GO:0071897 | DNA biosynthetic process | 5 | 1 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 1 |
| GO:1901576 | organic substance biosynthetic process | 3 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 12 |
| GO:0003677 | DNA binding | 4 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0008047 | enzyme activator activity | 3 | 12 |
| GO:0030234 | enzyme regulator activity | 2 | 12 |
| GO:0030337 | DNA polymerase processivity factor activity | 4 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:0098772 | molecular function regulator activity | 1 | 12 |
| GO:0140677 | molecular function activator activity | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 132 | 136 | PF00656 | 0.311 |
| CLV_NRD_NRD_1 | 158 | 160 | PF00675 | 0.311 |
| CLV_NRD_NRD_1 | 263 | 265 | PF00675 | 0.771 |
| CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.495 |
| CLV_PCSK_KEX2_1 | 62 | 64 | PF00082 | 0.296 |
| CLV_PCSK_PC1ET2_1 | 62 | 64 | PF00082 | 0.302 |
| CLV_PCSK_SKI1_1 | 126 | 130 | PF00082 | 0.296 |
| CLV_PCSK_SKI1_1 | 239 | 243 | PF00082 | 0.405 |
| CLV_PCSK_SKI1_1 | 311 | 315 | PF00082 | 0.395 |
| DOC_CYCLIN_yCln2_LP_2 | 282 | 288 | PF00134 | 0.325 |
| DOC_MAPK_gen_1 | 157 | 167 | PF00069 | 0.311 |
| DOC_MAPK_MEF2A_6 | 113 | 121 | PF00069 | 0.325 |
| DOC_USP7_MATH_1 | 234 | 238 | PF00917 | 0.400 |
| DOC_USP7_MATH_1 | 299 | 303 | PF00917 | 0.355 |
| DOC_USP7_MATH_1 | 88 | 92 | PF00917 | 0.441 |
| DOC_USP7_UBL2_3 | 213 | 217 | PF12436 | 0.330 |
| DOC_USP7_UBL2_3 | 242 | 246 | PF12436 | 0.663 |
| DOC_WW_Pin1_4 | 11 | 16 | PF00397 | 0.460 |
| DOC_WW_Pin1_4 | 313 | 318 | PF00397 | 0.296 |
| DOC_WW_Pin1_4 | 4 | 9 | PF00397 | 0.481 |
| DOC_WW_Pin1_4 | 40 | 45 | PF00397 | 0.423 |
| LIG_14-3-3_CanoR_1 | 10 | 17 | PF00244 | 0.469 |
| LIG_14-3-3_CanoR_1 | 183 | 189 | PF00244 | 0.460 |
| LIG_14-3-3_CanoR_1 | 239 | 249 | PF00244 | 0.615 |
| LIG_14-3-3_CanoR_1 | 307 | 311 | PF00244 | 0.296 |
| LIG_Actin_WH2_2 | 114 | 131 | PF00022 | 0.296 |
| LIG_APCC_ABBA_1 | 200 | 205 | PF00400 | 0.296 |
| LIG_BRCT_BRCA1_1 | 189 | 193 | PF00533 | 0.296 |
| LIG_BRCT_BRCA1_2 | 189 | 195 | PF00533 | 0.296 |
| LIG_Clathr_ClatBox_1 | 167 | 171 | PF01394 | 0.296 |
| LIG_FHA_1 | 18 | 24 | PF00498 | 0.468 |
| LIG_FHA_1 | 183 | 189 | PF00498 | 0.379 |
| LIG_FHA_1 | 204 | 210 | PF00498 | 0.296 |
| LIG_FHA_1 | 41 | 47 | PF00498 | 0.518 |
| LIG_FHA_2 | 251 | 257 | PF00498 | 0.610 |
| LIG_FHA_2 | 279 | 285 | PF00498 | 0.427 |
| LIG_FHA_2 | 301 | 307 | PF00498 | 0.311 |
| LIG_FHA_2 | 47 | 53 | PF00498 | 0.293 |
| LIG_LIR_Gen_1 | 190 | 200 | PF02991 | 0.296 |
| LIG_LIR_Nem_3 | 103 | 109 | PF02991 | 0.297 |
| LIG_LIR_Nem_3 | 190 | 196 | PF02991 | 0.306 |
| LIG_LIR_Nem_3 | 59 | 64 | PF02991 | 0.404 |
| LIG_Pex14_2 | 290 | 294 | PF04695 | 0.296 |
| LIG_PTB_Apo_2 | 323 | 330 | PF02174 | 0.441 |
| LIG_PTB_Phospho_1 | 323 | 329 | PF10480 | 0.441 |
| LIG_SH2_CRK | 228 | 232 | PF00017 | 0.311 |
| LIG_SH2_NCK_1 | 266 | 270 | PF00017 | 0.630 |
| LIG_SH2_STAP1 | 57 | 61 | PF00017 | 0.361 |
| LIG_SH2_STAT5 | 228 | 231 | PF00017 | 0.441 |
| LIG_SH2_STAT5 | 329 | 332 | PF00017 | 0.344 |
| LIG_SH2_STAT5 | 333 | 336 | PF00017 | 0.344 |
| LIG_SH3_5 | 178 | 182 | PF00018 | 0.355 |
| LIG_SUMO_SIM_anti_2 | 90 | 98 | PF11976 | 0.296 |
| LIG_SUMO_SIM_par_1 | 142 | 153 | PF11976 | 0.308 |
| LIG_SUMO_SIM_par_1 | 166 | 171 | PF11976 | 0.352 |
| LIG_SUMO_SIM_par_1 | 184 | 192 | PF11976 | 0.239 |
| LIG_SUMO_SIM_par_1 | 205 | 212 | PF11976 | 0.311 |
| LIG_SUMO_SIM_par_1 | 283 | 289 | PF11976 | 0.298 |
| LIG_SxIP_EBH_1 | 10 | 22 | PF03271 | 0.458 |
| LIG_TRAF2_1 | 281 | 284 | PF00917 | 0.441 |
| LIG_TRFH_1 | 332 | 336 | PF08558 | 0.296 |
| LIG_TYR_ITIM | 55 | 60 | PF00017 | 0.361 |
| MOD_CDK_SPxK_1 | 4 | 10 | PF00069 | 0.482 |
| MOD_CK1_1 | 133 | 139 | PF00069 | 0.270 |
| MOD_CK1_1 | 184 | 190 | PF00069 | 0.330 |
| MOD_CK1_1 | 191 | 197 | PF00069 | 0.330 |
| MOD_CK1_1 | 237 | 243 | PF00069 | 0.405 |
| MOD_CK1_1 | 302 | 308 | PF00069 | 0.355 |
| MOD_CK2_1 | 250 | 256 | PF00069 | 0.693 |
| MOD_CK2_1 | 278 | 284 | PF00069 | 0.427 |
| MOD_CK2_1 | 300 | 306 | PF00069 | 0.441 |
| MOD_CK2_1 | 46 | 52 | PF00069 | 0.423 |
| MOD_GlcNHglycan | 220 | 223 | PF01048 | 0.364 |
| MOD_GlcNHglycan | 238 | 242 | PF01048 | 0.330 |
| MOD_GSK3_1 | 142 | 149 | PF00069 | 0.336 |
| MOD_GSK3_1 | 184 | 191 | PF00069 | 0.303 |
| MOD_GSK3_1 | 205 | 212 | PF00069 | 0.413 |
| MOD_GSK3_1 | 240 | 247 | PF00069 | 0.715 |
| MOD_GSK3_1 | 25 | 32 | PF00069 | 0.542 |
| MOD_GSK3_1 | 302 | 309 | PF00069 | 0.318 |
| MOD_N-GLC_1 | 133 | 138 | PF02516 | 0.441 |
| MOD_N-GLC_1 | 188 | 193 | PF02516 | 0.223 |
| MOD_N-GLC_1 | 40 | 45 | PF02516 | 0.423 |
| MOD_NEK2_1 | 203 | 208 | PF00069 | 0.315 |
| MOD_NEK2_1 | 46 | 51 | PF00069 | 0.472 |
| MOD_NEK2_1 | 89 | 94 | PF00069 | 0.296 |
| MOD_PKA_2 | 182 | 188 | PF00069 | 0.441 |
| MOD_PKA_2 | 306 | 312 | PF00069 | 0.296 |
| MOD_PKA_2 | 9 | 15 | PF00069 | 0.477 |
| MOD_Plk_1 | 133 | 139 | PF00069 | 0.472 |
| MOD_Plk_1 | 278 | 284 | PF00069 | 0.368 |
| MOD_Plk_1 | 89 | 95 | PF00069 | 0.296 |
| MOD_Plk_4 | 226 | 232 | PF00069 | 0.441 |
| MOD_Plk_4 | 46 | 52 | PF00069 | 0.582 |
| MOD_Plk_4 | 56 | 62 | PF00069 | 0.400 |
| MOD_ProDKin_1 | 11 | 17 | PF00069 | 0.455 |
| MOD_ProDKin_1 | 313 | 319 | PF00069 | 0.296 |
| MOD_ProDKin_1 | 4 | 10 | PF00069 | 0.482 |
| MOD_ProDKin_1 | 40 | 46 | PF00069 | 0.425 |
| MOD_SUMO_for_1 | 241 | 244 | PF00179 | 0.668 |
| MOD_SUMO_for_1 | 245 | 248 | PF00179 | 0.564 |
| MOD_SUMO_for_1 | 249 | 252 | PF00179 | 0.535 |
| MOD_SUMO_rev_2 | 238 | 247 | PF00179 | 0.674 |
| TRG_DiLeu_BaEn_4 | 283 | 289 | PF01217 | 0.390 |
| TRG_DiLeu_BaLyEn_6 | 60 | 65 | PF01217 | 0.245 |
| TRG_ENDOCYTIC_2 | 228 | 231 | PF00928 | 0.311 |
| TRG_ENDOCYTIC_2 | 57 | 60 | PF00928 | 0.425 |
| TRG_Pf-PMV_PEXEL_1 | 62 | 66 | PF00026 | 0.311 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I656 | Leptomonas seymouri | 93% | 100% |
| A0A0S4JJ69 | Bodo saltans | 60% | 100% |
| A0A1X0NVI3 | Trypanosomatidae | 73% | 100% |
| A0A3R7LTI5 | Trypanosoma rangeli | 74% | 100% |
| A0B7Y8 | Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) | 24% | 100% |
| A0RXH7 | Cenarchaeum symbiosum (strain A) | 30% | 100% |
| A1RXU8 | Thermofilum pendens (strain DSM 2475 / Hrk 5) | 23% | 100% |
| A2SSW6 | Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) | 20% | 100% |
| A4G0K8 | Methanococcus maripaludis (strain C5 / ATCC BAA-1333) | 22% | 100% |
| A4HWN2 | Leishmania infantum | 95% | 100% |
| A6UQZ4 | Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) | 22% | 100% |
| A6UUW0 | Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) | 24% | 100% |
| A6VHX7 | Methanococcus maripaludis (strain C7 / ATCC BAA-1331) | 23% | 100% |
| A9A2X4 | Nitrosopumilus maritimus (strain SCM1) | 27% | 100% |
| A9A8V2 | Methanococcus maripaludis (strain C6 / ATCC BAA-1332) | 22% | 100% |
| B6YVZ1 | Thermococcus onnurineus (strain NA1) | 25% | 100% |
| B9LU30 | Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) | 20% | 100% |
| C5A5N6 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 24% | 100% |
| C6A1Y5 | Thermococcus sibiricus (strain DSM 12597 / MM 739) | 26% | 100% |
| C9D8Q5 | Leishmania donovani | 95% | 100% |
| C9ZXQ4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 74% | 100% |
| E9AQE0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| G0SF70 | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | 40% | 100% |
| O01377 | Bombyx mori | 36% | 100% |
| O02115 | Caenorhabditis elegans | 35% | 100% |
| O10308 | Orgyia pseudotsugata multicapsid polyhedrosis virus | 23% | 100% |
| O16852 | Sarcophaga crassipalpis | 37% | 100% |
| O41056 | Paramecium bursaria Chlorella virus 1 | 27% | 100% |
| O58398 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 24% | 100% |
| O73947 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 23% | 100% |
| O82134 | Pisum sativum | 39% | 100% |
| O82797 | Nicotiana tabacum | 40% | 100% |
| P04961 | Rattus norvegicus | 38% | 100% |
| P11038 | Autographa californica nuclear polyhedrosis virus | 33% | 100% |
| P12004 | Homo sapiens | 38% | 100% |
| P15873 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 33% | 100% |
| P17070 | Oryza sativa subsp. japonica | 41% | 100% |
| P17917 | Drosophila melanogaster | 37% | 100% |
| P17918 | Mus musculus | 38% | 100% |
| P18248 | Xenopus laevis | 37% | 100% |
| P22177 | Glycine max | 38% | 100% |
| P24314 | Catharanthus roseus | 40% | 100% |
| P31008 | Plasmodium falciparum (isolate K1 / Thailand) | 33% | 100% |
| P53358 | Styela clava | 36% | 100% |
| P57761 | Cricetulus griseus | 38% | 100% |
| P57762 | Sulfurisphaera ohwakuensis | 23% | 100% |
| P57765 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 20% | 100% |
| P61074 | Plasmodium falciparum (isolate 3D7) | 33% | 100% |
| P61258 | Macaca fascicularis | 38% | 100% |
| Q00265 | Daucus carota | 40% | 94% |
| Q00268 | Daucus carota | 39% | 100% |
| Q03392 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 40% | 100% |
| Q12U18 | Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) | 25% | 100% |
| Q2FNX1 | Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) | 20% | 100% |
| Q3ZBW4 | Bos taurus | 38% | 100% |
| Q43124 | Brassica napus | 40% | 100% |
| Q43266 | Zea mays | 40% | 100% |
| Q46E39 | Methanosarcina barkeri (strain Fusaro / DSM 804) | 23% | 100% |
| Q4JAI6 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 21% | 100% |
| Q4QF35 | Leishmania major | 96% | 100% |
| Q54K47 | Dictyostelium discoideum | 38% | 100% |
| Q57697 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 23% | 100% |
| Q5JF32 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 26% | 100% |
| Q5JFD3 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 22% | 100% |
| Q6B6N4 | Haplochromis burtoni | 37% | 100% |
| Q6LWJ8 | Methanococcus maripaludis (strain S2 / LL) | 23% | 100% |
| Q74MV1 | Nanoarchaeum equitans (strain Kin4-M) | 22% | 100% |
| Q7KQJ9 | Plasmodium falciparum (isolate 3D7) | 23% | 100% |
| Q84513 | Paramecium bursaria Chlorella virus 1 | 24% | 100% |
| Q8PX25 | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) | 23% | 100% |
| Q8TUF7 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 23% | 100% |
| Q8TWK3 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 21% | 100% |
| Q8ZTY0 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 23% | 100% |
| Q973F5 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 22% | 100% |
| Q975N2 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 21% | 100% |
| Q9DDF1 | Coturnix japonica | 38% | 100% |
| Q9DEA3 | Gallus gallus | 38% | 100% |
| Q9M7Q7 | Arabidopsis thaliana | 40% | 100% |
| Q9MAY3 | Populus nigra | 38% | 100% |
| Q9PTP1 | Danio rerio | 37% | 100% |
| Q9UWR9 | Thermococcus fumicolans | 26% | 100% |
| Q9UYX8 | Pyrococcus abyssi (strain GE5 / Orsay) | 25% | 100% |
| Q9VIT0 | Drosophila melanogaster | 36% | 100% |
| Q9W644 | Anguilla japonica | 37% | 100% |
| Q9YFT8 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 21% | 100% |
| Q9ZW35 | Arabidopsis thaliana | 41% | 100% |
| V5DL99 | Trypanosoma cruzi | 75% | 100% |