TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TMEM164 family, putative

Species:

Leishmania braziliensis

UniProt:

A4H8A7_LEIBR

TriTrypDb:

LbrM.15.1390 , LBRM2903_150020900

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H8A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	300	302	PF00675	0.337
CLV_NRD_NRD_1	90	92	PF00675	0.217
CLV_PCSK_KEX2_1	90	92	PF00082	0.242
CLV_PCSK_SKI1_1	270	274	PF00082	0.576
CLV_PCSK_SKI1_1	275	279	PF00082	0.524
CLV_PCSK_SKI1_1	301	305	PF00082	0.317
CLV_PCSK_SKI1_1	99	103	PF00082	0.365
DEG_APCC_DBOX_1	274	282	PF00400	0.363
DEG_MDM2_SWIB_1	144	152	PF02201	0.360
DEG_ODPH_VHL_1	241	252	PF01847	0.409
DOC_CYCLIN_RxL_1	298	306	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.340
DOC_MAPK_DCC_7	275	283	PF00069	0.328
DOC_MAPK_gen_1	124	134	PF00069	0.251
DOC_MAPK_MEF2A_6	127	134	PF00069	0.237
DOC_MAPK_MEF2A_6	275	283	PF00069	0.293
DOC_MAPK_MEF2A_6	61	68	PF00069	0.173
DOC_PP2B_LxvP_1	137	140	PF13499	0.360
DOC_PP2B_LxvP_1	206	209	PF13499	0.332
DOC_PP2B_LxvP_1	256	259	PF13499	0.247
DOC_PP4_FxxP_1	240	243	PF00568	0.350
DOC_PP4_FxxP_1	57	60	PF00568	0.284
DOC_WW_Pin1_4	173	178	PF00397	0.366
DOC_WW_Pin1_4	4	9	PF00397	0.294
DOC_WW_Pin1_4	56	61	PF00397	0.277
LIG_14-3-3_CanoR_1	260	268	PF00244	0.416
LIG_14-3-3_CanoR_1	301	310	PF00244	0.546
LIG_14-3-3_CanoR_1	82	92	PF00244	0.516
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_BRCT_BRCA1_1	232	236	PF00533	0.192
LIG_BRCT_BRCA1_1	80	84	PF00533	0.566
LIG_CSL_BTD_1	174	177	PF09270	0.325
LIG_deltaCOP1_diTrp_1	172	175	PF00928	0.388
LIG_deltaCOP1_diTrp_1	185	193	PF00928	0.253
LIG_DLG_GKlike_1	90	97	PF00625	0.421
LIG_EH1_1	201	209	PF00400	0.369
LIG_eIF4E_1	165	171	PF01652	0.409
LIG_FHA_1	216	222	PF00498	0.500
LIG_FHA_1	5	11	PF00498	0.288
LIG_GBD_Chelix_1	109	117	PF00786	0.399
LIG_HCF-1_HBM_1	188	191	PF13415	0.269
LIG_LIR_Apic_2	25	29	PF02991	0.383
LIG_LIR_Gen_1	145	153	PF02991	0.299
LIG_LIR_Gen_1	194	204	PF02991	0.372
LIG_LIR_Gen_1	222	229	PF02991	0.544
LIG_LIR_Gen_1	305	314	PF02991	0.475
LIG_LIR_Nem_3	145	151	PF02991	0.282
LIG_LIR_Nem_3	172	178	PF02991	0.406
LIG_LIR_Nem_3	194	199	PF02991	0.293
LIG_LIR_Nem_3	222	226	PF02991	0.493
LIG_LIR_Nem_3	305	310	PF02991	0.459
LIG_MYND_1	276	280	PF01753	0.409
LIG_NRBOX	133	139	PF00104	0.290
LIG_NRBOX	165	171	PF00104	0.409
LIG_Pex14_2	144	148	PF04695	0.360
LIG_Pex14_2	236	240	PF04695	0.315
LIG_PTB_Apo_2	234	241	PF02174	0.350
LIG_SH2_CRK	216	220	PF00017	0.469
LIG_SH2_CRK	24	28	PF00017	0.223
LIG_SH2_PTP2	196	199	PF00017	0.192
LIG_SH2_PTP2	26	29	PF00017	0.380
LIG_SH2_SRC	24	27	PF00017	0.232
LIG_SH2_STAP1	24	28	PF00017	0.223
LIG_SH2_STAT3	55	58	PF00017	0.351
LIG_SH2_STAT5	150	153	PF00017	0.376
LIG_SH2_STAT5	165	168	PF00017	0.170
LIG_SH2_STAT5	191	194	PF00017	0.286
LIG_SH2_STAT5	196	199	PF00017	0.294
LIG_SH2_STAT5	211	214	PF00017	0.125
LIG_SH2_STAT5	26	29	PF00017	0.380
LIG_SH2_STAT5	67	70	PF00017	0.391
LIG_SH3_3	171	177	PF00018	0.325
LIG_SH3_4	129	136	PF00018	0.326
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.290
LIG_TRFH_1	254	258	PF08558	0.282
LIG_UBA3_1	295	302	PF00899	0.413
LIG_WRC_WIRS_1	304	309	PF05994	0.307
LIG_WW_3	257	261	PF00397	0.499
MOD_CDK_SPK_2	56	61	PF00069	0.338
MOD_CK2_1	11	17	PF00069	0.301
MOD_GlcNHglycan	161	164	PF01048	0.378
MOD_GlcNHglycan	85	88	PF01048	0.384
MOD_GSK3_1	227	234	PF00069	0.328
MOD_GSK3_1	260	267	PF00069	0.318
MOD_GSK3_1	36	43	PF00069	0.500
MOD_NEK2_1	303	308	PF00069	0.575
MOD_NEK2_1	9	14	PF00069	0.520
MOD_NEK2_1	97	102	PF00069	0.507
MOD_NEK2_2	231	236	PF00069	0.192
MOD_PKA_1	90	96	PF00069	0.255
MOD_PKA_2	259	265	PF00069	0.532
MOD_PKA_2	78	84	PF00069	0.380
MOD_PKA_2	90	96	PF00069	0.378
MOD_Plk_4	165	171	PF00069	0.325
MOD_Plk_4	227	233	PF00069	0.301
MOD_Plk_4	264	270	PF00069	0.315
MOD_Plk_4	283	289	PF00069	0.337
MOD_ProDKin_1	173	179	PF00069	0.366
MOD_ProDKin_1	4	10	PF00069	0.356
MOD_ProDKin_1	56	62	PF00069	0.334
TRG_DiLeu_BaEn_2	193	199	PF01217	0.193
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.432
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.354
TRG_ENDOCYTIC_2	111	114	PF00928	0.409
TRG_ENDOCYTIC_2	150	153	PF00928	0.406
TRG_ENDOCYTIC_2	196	199	PF00928	0.350
TRG_ENDOCYTIC_2	216	219	PF00928	0.125
TRG_ENDOCYTIC_2	24	27	PF00928	0.275
TRG_ER_diArg_1	89	91	PF00400	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P785	Leptomonas seymouri	53%	100%
A0A0S4JGE0	Bodo saltans	36%	100%
A0A1X0NUN8	Trypanosomatidae	37%	100%
A0A3Q8IIU5	Leishmania donovani	82%	100%
A0A422NBZ1	Trypanosoma rangeli	41%	100%
A4HWM7	Leishmania infantum	82%	100%
E9AQD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QF41	Leishmania major	78%	100%
Q54KD4	Dictyostelium discoideum	24%	100%
V5DL97	Trypanosoma cruzi	43%	100%