Putative nucleolar RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8A6_LEIBR

TriTrypDb:

LbrM.15.1380 , LBRM2903_150020800

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	12
GO:0030684	preribosome	3	12
GO:0031428	box C/D RNP complex	4	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.437
CLV_C14_Caspase3-7	403	407	PF00656	0.805
CLV_C14_Caspase3-7	437	441	PF00656	0.542
CLV_NRD_NRD_1	21	23	PF00675	0.505
CLV_NRD_NRD_1	401	403	PF00675	0.563
CLV_NRD_NRD_1	53	55	PF00675	0.460
CLV_PCSK_KEX2_1	21	23	PF00082	0.517
CLV_PCSK_KEX2_1	401	403	PF00082	0.640
CLV_PCSK_KEX2_1	413	415	PF00082	0.710
CLV_PCSK_KEX2_1	53	55	PF00082	0.343
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.723
CLV_PCSK_SKI1_1	188	192	PF00082	0.287
CLV_PCSK_SKI1_1	22	26	PF00082	0.439
CLV_PCSK_SKI1_1	305	309	PF00082	0.285
CLV_PCSK_SKI1_1	314	318	PF00082	0.276
CLV_PCSK_SKI1_1	53	57	PF00082	0.443
CLV_PCSK_SKI1_1	75	79	PF00082	0.472
CLV_PCSK_SKI1_1	99	103	PF00082	0.528
DEG_APCC_DBOX_1	20	28	PF00400	0.566
DOC_CKS1_1	315	320	PF01111	0.487
DOC_CYCLIN_RxL_1	21	32	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.374
DOC_MAPK_gen_1	21	30	PF00069	0.437
DOC_MAPK_gen_1	78	86	PF00069	0.433
DOC_PP1_RVXF_1	130	136	PF00149	0.493
DOC_PP2B_LxvP_1	6	9	PF13499	0.382
DOC_PP2B_LxvP_1	84	87	PF13499	0.458
DOC_PP4_FxxP_1	412	415	PF00568	0.745
DOC_USP7_MATH_1	220	224	PF00917	0.498
DOC_USP7_MATH_1	346	350	PF00917	0.487
DOC_USP7_MATH_1	439	443	PF00917	0.530
DOC_USP7_MATH_1	87	91	PF00917	0.552
DOC_USP7_UBL2_3	156	160	PF12436	0.487
DOC_WW_Pin1_4	133	138	PF00397	0.509
DOC_WW_Pin1_4	314	319	PF00397	0.487
DOC_WW_Pin1_4	360	365	PF00397	0.592
LIG_14-3-3_CanoR_1	401	405	PF00244	0.560
LIG_Actin_WH2_2	121	136	PF00022	0.461
LIG_Clathr_ClatBox_1	14	18	PF01394	0.405
LIG_deltaCOP1_diTrp_1	167	173	PF00928	0.487
LIG_FHA_1	267	273	PF00498	0.487
LIG_FHA_1	295	301	PF00498	0.487
LIG_FHA_1	361	367	PF00498	0.592
LIG_FHA_1	38	44	PF00498	0.431
LIG_FHA_1	81	87	PF00498	0.426
LIG_GBD_Chelix_1	76	84	PF00786	0.434
LIG_LIR_Gen_1	201	212	PF02991	0.487
LIG_LIR_LC3C_4	66	71	PF02991	0.470
LIG_LIR_Nem_3	201	207	PF02991	0.487
LIG_LIR_Nem_3	317	323	PF02991	0.487
LIG_LIR_Nem_3	97	101	PF02991	0.424
LIG_NRBOX	23	29	PF00104	0.519
LIG_SH2_CRK	186	190	PF00017	0.487
LIG_SH2_CRK	320	324	PF00017	0.477
LIG_SH2_STAT3	249	252	PF00017	0.548
LIG_SH2_STAT5	186	189	PF00017	0.573
LIG_SH2_STAT5	256	259	PF00017	0.487
LIG_SH2_STAT5	60	63	PF00017	0.598
LIG_TRAF2_1	378	381	PF00917	0.591
LIG_TYR_ITIM	184	189	PF00017	0.498
LIG_UBA3_1	150	156	PF00899	0.487
LIG_UBA3_1	287	292	PF00899	0.487
LIG_UBA3_1	307	312	PF00899	0.356
LIG_WRC_WIRS_1	354	359	PF05994	0.487
LIG_WRC_WIRS_1	95	100	PF05994	0.455
MOD_CDC14_SPxK_1	136	139	PF00782	0.503
MOD_CDK_SPK_2	314	319	PF00069	0.487
MOD_CDK_SPxK_1	133	139	PF00069	0.508
MOD_CK1_1	223	229	PF00069	0.487
MOD_CK1_1	286	292	PF00069	0.487
MOD_CK2_1	104	110	PF00069	0.492
MOD_CK2_1	146	152	PF00069	0.492
MOD_CK2_1	353	359	PF00069	0.495
MOD_CK2_1	367	373	PF00069	0.467
MOD_CMANNOS	168	171	PF00535	0.287
MOD_GlcNHglycan	110	115	PF01048	0.525
MOD_GlcNHglycan	350	353	PF01048	0.287
MOD_GlcNHglycan	387	390	PF01048	0.643
MOD_GlcNHglycan	419	422	PF01048	0.772
MOD_GlcNHglycan	440	444	PF01048	0.670
MOD_GlcNHglycan	89	92	PF01048	0.566
MOD_GSK3_1	234	241	PF00069	0.556
MOD_GSK3_1	251	258	PF00069	0.478
MOD_GSK3_1	381	388	PF00069	0.540
MOD_GSK3_1	87	94	PF00069	0.595
MOD_N-GLC_1	117	122	PF02516	0.451
MOD_N-GLC_1	234	239	PF02516	0.373
MOD_N-GLC_1	266	271	PF02516	0.287
MOD_N-GLC_1	324	329	PF02516	0.373
MOD_N-GLC_1	417	422	PF02516	0.808
MOD_NEK2_1	117	122	PF00069	0.451
MOD_NEK2_1	37	42	PF00069	0.426
MOD_NEK2_1	417	422	PF00069	0.782
MOD_NEK2_1	434	439	PF00069	0.466
MOD_PKA_2	199	205	PF00069	0.498
MOD_PKA_2	400	406	PF00069	0.806
MOD_PKB_1	414	422	PF00069	0.808
MOD_Plk_1	117	123	PF00069	0.449
MOD_Plk_1	234	240	PF00069	0.573
MOD_Plk_1	266	272	PF00069	0.487
MOD_Plk_1	324	330	PF00069	0.573
MOD_Plk_1	91	97	PF00069	0.444
MOD_Plk_4	104	110	PF00069	0.556
MOD_Plk_4	146	152	PF00069	0.524
MOD_Plk_4	252	258	PF00069	0.543
MOD_Plk_4	267	273	PF00069	0.416
MOD_Plk_4	283	289	PF00069	0.487
MOD_Plk_4	324	330	PF00069	0.573
MOD_ProDKin_1	133	139	PF00069	0.508
MOD_ProDKin_1	314	320	PF00069	0.487
MOD_ProDKin_1	360	366	PF00069	0.592
MOD_SUMO_rev_2	209	216	PF00179	0.439
MOD_SUMO_rev_2	67	77	PF00179	0.423
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.487
TRG_ENDOCYTIC_2	186	189	PF00928	0.487
TRG_ENDOCYTIC_2	3	6	PF00928	0.387
TRG_ENDOCYTIC_2	320	323	PF00928	0.477
TRG_ER_diArg_1	163	166	PF00400	0.498
TRG_ER_diArg_1	414	417	PF00400	0.782
TRG_ER_diArg_1	52	54	PF00400	0.339
TRG_NES_CRM1_1	141	153	PF08389	0.409
TRG_NES_CRM1_1	7	20	PF08389	0.410
TRG_NLS_Bipartite_1	401	417	PF00514	0.705
TRG_NLS_MonoCore_2	412	417	PF00514	0.748
TRG_NLS_MonoExtN_4	21	26	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD49	Leptomonas seymouri	93%	100%
A0A0N1PE54	Leptomonas seymouri	38%	94%
A0A0S4IXK2	Bodo saltans	42%	98%
A0A0S4JJS5	Bodo saltans	81%	100%
A0A1X0NRL9	Trypanosomatidae	38%	91%
A0A1X0NUB3	Trypanosomatidae	81%	100%
A0A3Q8IDJ5	Leishmania donovani	23%	100%
A0A3R7NI91	Trypanosoma rangeli	80%	100%
A0A3R7NLD9	Trypanosoma rangeli	41%	92%
A0A3S5H6F4	Leishmania donovani	37%	94%
A0A3S5H6V9	Leishmania donovani	95%	100%
A1CL70	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	50%	75%
A1D688	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	49%	75%
A2QE38	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	50%	77%
A3LUT0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	49%	86%
A4H602	Leishmania braziliensis	37%	100%
A4HL50	Leishmania braziliensis	24%	100%
A4HUC9	Leishmania infantum	37%	94%
A4HWM6	Leishmania infantum	95%	100%
A4I8M9	Leishmania infantum	23%	100%
A5DHW0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	49%	88%
A5E4V9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	49%	86%
A6QYH8	Ajellomyces capsulatus (strain NAm1 / WU24)	49%	70%
A6RMY5	Botryotinia fuckeliana (strain B05.10)	48%	78%
A6ZPE5	Saccharomyces cerevisiae (strain YJM789)	50%	87%
A7F2R6	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	47%	78%
A7TIF5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	50%	86%
C9ZVG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
C9ZXR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	88%
E9AN29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	94%
E9AQD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	99%
E9B3J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
O00567	Homo sapiens	41%	75%
O04656	Arabidopsis thaliana	44%	99%
O04658	Arabidopsis thaliana	51%	83%
O94514	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	89%
P0CP26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	78%
P0CP27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	79%
Q0CQH1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	51%	77%
Q12460	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	88%
Q12499	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	87%
Q1E1Q5	Coccidioides immitis (strain RS)	48%	73%
Q21276	Caenorhabditis elegans	39%	91%
Q2UC04	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	49%	77%
Q3SZ63	Bos taurus	41%	74%
Q4PBF2	Ustilago maydis (strain 521 / FGSC 9021)	45%	76%
Q4Q4L0	Leishmania major	23%	100%
Q4QF42	Leishmania major	96%	100%
Q4QHJ7	Leishmania major	37%	100%
Q4R779	Macaca fascicularis	49%	84%
Q4WYK9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	48%	75%
Q54MT2	Dictyostelium discoideum	40%	82%
Q55FI4	Dictyostelium discoideum	48%	70%
Q59S06	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	86%
Q5B8G3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	76%
Q5RA29	Pongo abelii	41%	75%
Q6BIX6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	49%	86%
Q6CG46	Yarrowia lipolytica (strain CLIB 122 / E 150)	53%	86%
Q6CKR8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	49%	87%
Q6DFW4	Mus musculus	49%	83%
Q6FQ21	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	87%
Q753I4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	50%	87%
Q8X066	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	74%
Q95K50	Macaca fascicularis	41%	75%
Q9D6Z1	Mus musculus	41%	77%
Q9MAB3	Arabidopsis thaliana	50%	83%
Q9P7S7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	87%
Q9QZ86	Rattus norvegicus	49%	83%
Q9Y2X3	Homo sapiens	49%	84%
V5AU06	Trypanosoma cruzi	38%	92%
V5BK67	Trypanosoma cruzi	83%	100%