Deacetylase sirtuin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania braziliensis

UniProt:

A4H8A5_LEIBR

TriTrypDb:

LbrM.15.1370 , LBRM2903_150020700

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	149	155	PF00089	0.282
CLV_NRD_NRD_1	121	123	PF00675	0.295
CLV_NRD_NRD_1	282	284	PF00675	0.559
CLV_NRD_NRD_1	339	341	PF00675	0.522
CLV_NRD_NRD_1	81	83	PF00675	0.353
CLV_PCSK_KEX2_1	121	123	PF00082	0.436
CLV_PCSK_KEX2_1	282	284	PF00082	0.532
CLV_PCSK_KEX2_1	339	341	PF00082	0.453
CLV_PCSK_KEX2_1	81	83	PF00082	0.384
CLV_PCSK_SKI1_1	129	133	PF00082	0.450
CLV_PCSK_SKI1_1	214	218	PF00082	0.380
CLV_PCSK_SKI1_1	304	308	PF00082	0.410
CLV_PCSK_SKI1_1	92	96	PF00082	0.456
CLV_PCSK_SKI1_1	98	102	PF00082	0.385
DEG_APCC_DBOX_1	151	159	PF00400	0.362
DEG_APCC_DBOX_1	17	25	PF00400	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.220
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.413
DOC_MAPK_gen_1	121	128	PF00069	0.399
DOC_MAPK_MEF2A_6	121	128	PF00069	0.295
DOC_PP1_RVXF_1	127	133	PF00149	0.389
DOC_PP1_RVXF_1	90	97	PF00149	0.413
DOC_PP2B_LxvP_1	87	90	PF13499	0.244
DOC_PP4_FxxP_1	36	39	PF00568	0.278
DOC_USP7_MATH_1	151	155	PF00917	0.367
DOC_USP7_MATH_1	239	243	PF00917	0.372
DOC_USP7_MATH_1	269	273	PF00917	0.622
DOC_USP7_MATH_1	366	370	PF00917	0.567
DOC_WW_Pin1_4	147	152	PF00397	0.426
DOC_WW_Pin1_4	160	165	PF00397	0.508
DOC_WW_Pin1_4	196	201	PF00397	0.499
DOC_WW_Pin1_4	364	369	PF00397	0.701
LIG_14-3-3_CanoR_1	152	156	PF00244	0.371
LIG_14-3-3_CanoR_1	18	22	PF00244	0.337
LIG_14-3-3_CanoR_1	298	306	PF00244	0.465
LIG_14-3-3_CanoR_1	56	65	PF00244	0.277
LIG_14-3-3_CanoR_1	98	105	PF00244	0.334
LIG_BRCT_BRCA1_1	124	128	PF00533	0.402
LIG_FHA_1	223	229	PF00498	0.535
LIG_FHA_1	263	269	PF00498	0.422
LIG_FHA_1	340	346	PF00498	0.495
LIG_FHA_2	165	171	PF00498	0.484
LIG_FHA_2	305	311	PF00498	0.425
LIG_FHA_2	321	327	PF00498	0.401
LIG_HP1_1	151	155	PF01393	0.286
LIG_LIR_Apic_2	34	39	PF02991	0.333
LIG_LIR_Gen_1	15	24	PF02991	0.451
LIG_LIR_Gen_1	227	238	PF02991	0.330
LIG_LIR_Gen_1	342	351	PF02991	0.512
LIG_LIR_Gen_1	60	70	PF02991	0.293
LIG_LIR_Nem_3	125	131	PF02991	0.283
LIG_LIR_Nem_3	15	19	PF02991	0.377
LIG_LIR_Nem_3	186	192	PF02991	0.482
LIG_LIR_Nem_3	227	233	PF02991	0.325
LIG_LIR_Nem_3	342	346	PF02991	0.478
LIG_LIR_Nem_3	60	65	PF02991	0.287
LIG_LIR_Nem_3	95	100	PF02991	0.311
LIG_PCNA_PIPBox_1	312	321	PF02747	0.441
LIG_PDZ_Class_1	366	371	PF00595	0.468
LIG_Pex14_1	156	160	PF04695	0.324
LIG_Pex14_2	128	132	PF04695	0.315
LIG_Pex14_2	32	36	PF04695	0.277
LIG_REV1ctd_RIR_1	94	102	PF16727	0.312
LIG_SH2_CRK	176	180	PF00017	0.441
LIG_SH2_CRK	319	323	PF00017	0.447
LIG_SH2_STAT5	287	290	PF00017	0.482
LIG_SH2_STAT5	319	322	PF00017	0.320
LIG_SH2_STAT5	351	354	PF00017	0.439
LIG_SH3_3	145	151	PF00018	0.384
LIG_SH3_3	195	201	PF00018	0.510
LIG_SH3_3	35	41	PF00018	0.325
LIG_SH3_3	362	368	PF00018	0.683
LIG_SH3_3	87	93	PF00018	0.298
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.436
LIG_SUMO_SIM_anti_2	307	317	PF11976	0.415
LIG_TRAF2_1	105	108	PF00917	0.337
LIG_TRAF2_1	307	310	PF00917	0.405
LIG_WW_1	41	44	PF00397	0.317
MOD_CDK_SPK_2	147	152	PF00069	0.404
MOD_CK1_1	17	23	PF00069	0.312
MOD_CK2_1	180	186	PF00069	0.405
MOD_CK2_1	304	310	PF00069	0.422
MOD_GlcNHglycan	205	208	PF01048	0.495
MOD_GlcNHglycan	270	274	PF01048	0.637
MOD_GSK3_1	147	154	PF00069	0.365
MOD_GSK3_1	160	167	PF00069	0.542
MOD_GSK3_1	196	203	PF00069	0.536
MOD_GSK3_1	251	258	PF00069	0.388
MOD_GSK3_1	350	357	PF00069	0.554
MOD_GSK3_1	92	99	PF00069	0.358
MOD_N-GLC_1	231	236	PF02516	0.285
MOD_N-GLC_1	289	294	PF02516	0.295
MOD_N-GLC_1	353	358	PF02516	0.531
MOD_NEK2_1	14	19	PF00069	0.317
MOD_NEK2_1	169	174	PF00069	0.464
MOD_NEK2_1	180	185	PF00069	0.497
MOD_NEK2_1	352	357	PF00069	0.492
MOD_NEK2_1	96	101	PF00069	0.328
MOD_NEK2_2	164	169	PF00069	0.468
MOD_PKA_1	339	345	PF00069	0.301
MOD_PKA_2	151	157	PF00069	0.379
MOD_PKA_2	17	23	PF00069	0.320
MOD_PKA_2	339	345	PF00069	0.467
MOD_Plk_1	14	20	PF00069	0.450
MOD_Plk_1	164	170	PF00069	0.371
MOD_Plk_1	269	275	PF00069	0.357
MOD_Plk_1	289	295	PF00069	0.426
MOD_Plk_4	151	157	PF00069	0.367
MOD_Plk_4	164	170	PF00069	0.523
MOD_Plk_4	317	323	PF00069	0.413
MOD_Plk_4	92	98	PF00069	0.337
MOD_ProDKin_1	147	153	PF00069	0.422
MOD_ProDKin_1	160	166	PF00069	0.508
MOD_ProDKin_1	196	202	PF00069	0.495
MOD_ProDKin_1	364	370	PF00069	0.579
TRG_AP2beta_CARGO_1	227	237	PF09066	0.297
TRG_DiLeu_BaEn_1	213	218	PF01217	0.285
TRG_DiLeu_BaEn_1	309	314	PF01217	0.363
TRG_ENDOCYTIC_2	176	179	PF00928	0.383
TRG_ENDOCYTIC_2	319	322	PF00928	0.443
TRG_ENDOCYTIC_2	343	346	PF00928	0.501
TRG_ER_diArg_1	235	238	PF00400	0.547
TRG_ER_diArg_1	281	283	PF00400	0.584
TRG_ER_diArg_1	338	340	PF00400	0.519
TRG_ER_diArg_1	80	82	PF00400	0.402
TRG_NLS_MonoExtN_4	282	287	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	68%	92%
A0A0S4JE30	Bodo saltans	34%	100%
A0A0S4JK16	Bodo saltans	54%	85%
A0A1X0NVQ6	Trypanosomatidae	63%	97%
A0A1X0P1X9	Trypanosomatidae	31%	100%
A0A3Q8IFT0	Leishmania donovani	28%	89%
A0A3R7KWZ0	Trypanosoma rangeli	63%	97%
A0A3R7KYN0	Trypanosoma rangeli	31%	100%
A0A3S7WTN3	Leishmania donovani	88%	92%
A4HIA2	Leishmania braziliensis	28%	89%
A4HWM5	Leishmania infantum	88%	92%
A4I5I6	Leishmania infantum	28%	89%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	92%
E9B0T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
Q4Q7E7	Leishmania major	28%	100%
Q4QF43	Leishmania major	88%	100%
V5BPI9	Trypanosoma cruzi	32%	100%
V5BUE5	Trypanosoma cruzi	60%	100%