Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4H8A3_LEIBR

TriTrypDb:

LbrM.15.1350 , LBRM2903_150020500

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.514
CLV_NRD_NRD_1	145	147	PF00675	0.436
CLV_NRD_NRD_1	75	77	PF00675	0.558
CLV_PCSK_KEX2_1	26	28	PF00082	0.584
CLV_PCSK_KEX2_1	312	314	PF00082	0.462
CLV_PCSK_KEX2_1	75	77	PF00082	0.551
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.584
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.462
CLV_PCSK_SKI1_1	147	151	PF00082	0.365
DOC_CKS1_1	13	18	PF01111	0.436
DOC_CKS1_1	265	270	PF01111	0.487
DOC_CKS1_1	6	11	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.454
DOC_MAPK_gen_1	146	152	PF00069	0.342
DOC_MAPK_MEF2A_6	299	306	PF00069	0.339
DOC_MAPK_MEF2A_6	84	91	PF00069	0.381
DOC_MAPK_NFAT4_5	84	92	PF00069	0.447
DOC_PP4_FxxP_1	14	17	PF00568	0.433
DOC_PP4_FxxP_1	6	9	PF00568	0.447
DOC_SPAK_OSR1_1	299	303	PF12202	0.402
DOC_USP7_MATH_1	130	134	PF00917	0.397
DOC_USP7_MATH_1	156	160	PF00917	0.452
DOC_USP7_MATH_1	192	196	PF00917	0.635
DOC_USP7_MATH_1	213	217	PF00917	0.668
DOC_USP7_MATH_1	316	320	PF00917	0.474
DOC_WW_Pin1_4	12	17	PF00397	0.433
DOC_WW_Pin1_4	204	209	PF00397	0.566
DOC_WW_Pin1_4	264	269	PF00397	0.616
DOC_WW_Pin1_4	272	277	PF00397	0.616
DOC_WW_Pin1_4	319	324	PF00397	0.543
DOC_WW_Pin1_4	326	331	PF00397	0.664
DOC_WW_Pin1_4	37	42	PF00397	0.461
DOC_WW_Pin1_4	5	10	PF00397	0.448
LIG_14-3-3_CanoR_1	146	150	PF00244	0.403
LIG_14-3-3_CanoR_1	286	294	PF00244	0.700
LIG_Actin_WH2_2	232	247	PF00022	0.287
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_BIR_III_2	187	191	PF00653	0.405
LIG_BRCT_BRCA1_1	294	298	PF00533	0.525
LIG_CtBP_PxDLS_1	330	334	PF00389	0.498
LIG_EVH1_2	17	21	PF00568	0.451
LIG_FHA_1	169	175	PF00498	0.349
LIG_FHA_1	184	190	PF00498	0.563
LIG_FHA_1	199	205	PF00498	0.504
LIG_FHA_1	278	284	PF00498	0.661
LIG_FHA_1	289	295	PF00498	0.591
LIG_FHA_1	6	12	PF00498	0.449
LIG_FHA_2	38	44	PF00498	0.542
LIG_LIR_Gen_1	297	308	PF02991	0.341
LIG_LIR_Nem_3	297	303	PF02991	0.355
LIG_LIR_Nem_3	319	324	PF02991	0.515
LIG_LIR_Nem_3	36	42	PF02991	0.348
LIG_SH2_CRK	101	105	PF00017	0.348
LIG_SH2_STAP1	122	126	PF00017	0.442
LIG_SH2_STAP1	200	204	PF00017	0.487
LIG_SH2_STAP1	95	99	PF00017	0.479
LIG_SH2_STAT5	200	203	PF00017	0.483
LIG_SH3_1	320	326	PF00018	0.461
LIG_SH3_3	10	16	PF00018	0.448
LIG_SH3_3	186	192	PF00018	0.539
LIG_SH3_3	262	268	PF00018	0.419
LIG_SH3_3	320	326	PF00018	0.674
LIG_SH3_3	65	71	PF00018	0.521
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.271
LIG_UBA3_1	140	147	PF00899	0.339
LIG_WW_2	17	20	PF00397	0.449
MOD_CDK_SPK_2	264	269	PF00069	0.528
MOD_CK1_1	206	212	PF00069	0.642
MOD_CK1_1	277	283	PF00069	0.553
MOD_CK1_1	285	291	PF00069	0.568
MOD_CK1_1	319	325	PF00069	0.555
MOD_CK1_1	62	68	PF00069	0.539
MOD_CK2_1	37	43	PF00069	0.486
MOD_GlcNHglycan	158	161	PF01048	0.446
MOD_GlcNHglycan	176	179	PF01048	0.403
MOD_GlcNHglycan	232	235	PF01048	0.369
MOD_GlcNHglycan	247	250	PF01048	0.474
MOD_GlcNHglycan	294	297	PF01048	0.536
MOD_GlcNHglycan	61	64	PF01048	0.689
MOD_GSK3_1	199	206	PF00069	0.539
MOD_GSK3_1	272	279	PF00069	0.636
MOD_GSK3_1	288	295	PF00069	0.724
MOD_GSK3_1	322	329	PF00069	0.583
MOD_GSK3_1	59	66	PF00069	0.541
MOD_NEK2_1	174	179	PF00069	0.389
MOD_NEK2_1	181	186	PF00069	0.391
MOD_NEK2_1	61	66	PF00069	0.486
MOD_PK_1	128	134	PF00069	0.503
MOD_PKA_2	145	151	PF00069	0.436
MOD_PKA_2	285	291	PF00069	0.494
MOD_Plk_4	145	151	PF00069	0.432
MOD_Plk_4	206	212	PF00069	0.537
MOD_ProDKin_1	12	18	PF00069	0.435
MOD_ProDKin_1	204	210	PF00069	0.568
MOD_ProDKin_1	264	270	PF00069	0.624
MOD_ProDKin_1	272	278	PF00069	0.615
MOD_ProDKin_1	319	325	PF00069	0.545
MOD_ProDKin_1	326	332	PF00069	0.665
MOD_ProDKin_1	37	43	PF00069	0.460
MOD_ProDKin_1	5	11	PF00069	0.449
MOD_SUMO_rev_2	139	149	PF00179	0.308
TRG_ENDOCYTIC_2	101	104	PF00928	0.460
TRG_ENDOCYTIC_2	315	318	PF00928	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL8	Leptomonas seymouri	51%	99%
A0A3R7RI28	Trypanosoma rangeli	32%	100%
A0A3S7WTT4	Leishmania donovani	75%	100%
A4HWM3	Leishmania infantum	75%	100%
E9AQD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QF45	Leishmania major	73%	100%