Arginine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginine N-methyltransferase

Species:

Leishmania braziliensis

UniProt:

A4H8A2_LEIBR

TriTrypDb:

LbrM.15.1340 , LBRM2903_030010600

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A2

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0008213	protein alkylation	5	14
GO:0009987	cellular process	1	14
GO:0018193	peptidyl-amino acid modification	5	14
GO:0018195	peptidyl-arginine modification	6	14
GO:0018216	peptidyl-arginine methylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0032259	methylation	2	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0043414	macromolecule methylation	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0008168	methyltransferase activity	4	14
GO:0008170	N-methyltransferase activity	5	14
GO:0008276	protein methyltransferase activity	3	14
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	14
GO:0016273	arginine N-methyltransferase activity	6	14
GO:0016274	protein-arginine N-methyltransferase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016741	transferase activity, transferring one-carbon groups	3	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.605
CLV_PCSK_KEX2_1	14	16	PF00082	0.647
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.686
CLV_PCSK_SKI1_1	164	168	PF00082	0.432
CLV_PCSK_SKI1_1	25	29	PF00082	0.641
CLV_PCSK_SKI1_1	306	310	PF00082	0.507
CLV_PCSK_SKI1_1	39	43	PF00082	0.474
CLV_PCSK_SKI1_1	80	84	PF00082	0.384
CLV_Separin_Metazoa	221	225	PF03568	0.550
DEG_APCC_DBOX_1	186	194	PF00400	0.384
DOC_CDC14_PxL_1	237	245	PF14671	0.417
DOC_CKS1_1	368	373	PF01111	0.558
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.397
DOC_MAPK_gen_1	374	383	PF00069	0.481
DOC_MAPK_gen_1	66	74	PF00069	0.482
DOC_MAPK_gen_1	75	85	PF00069	0.299
DOC_MAPK_HePTP_8	95	107	PF00069	0.412
DOC_MAPK_MEF2A_6	98	107	PF00069	0.379
DOC_PP1_RVXF_1	124	131	PF00149	0.457
DOC_USP7_MATH_1	13	17	PF00917	0.710
DOC_USP7_MATH_1	320	324	PF00917	0.508
DOC_WW_Pin1_4	367	372	PF00397	0.536
LIG_14-3-3_CanoR_1	164	171	PF00244	0.466
LIG_14-3-3_CanoR_1	187	191	PF00244	0.435
LIG_14-3-3_CanoR_1	25	33	PF00244	0.509
LIG_14-3-3_CanoR_1	306	311	PF00244	0.538
LIG_14-3-3_CanoR_1	53	61	PF00244	0.508
LIG_14-3-3_CanoR_1	78	83	PF00244	0.480
LIG_deltaCOP1_diTrp_1	205	214	PF00928	0.385
LIG_eIF4E_1	171	177	PF01652	0.427
LIG_FHA_1	165	171	PF00498	0.434
LIG_FHA_1	27	33	PF00498	0.634
LIG_FHA_1	299	305	PF00498	0.549
LIG_FHA_1	312	318	PF00498	0.340
LIG_FHA_1	363	369	PF00498	0.528
LIG_FHA_2	254	260	PF00498	0.565
LIG_FHA_2	33	39	PF00498	0.539
LIG_FHA_2	368	374	PF00498	0.523
LIG_FHA_2	377	383	PF00498	0.310
LIG_FHA_2	58	64	PF00498	0.364
LIG_LIR_Apic_2	154	158	PF02991	0.412
LIG_LIR_Gen_1	145	156	PF02991	0.401
LIG_LIR_Gen_1	205	216	PF02991	0.427
LIG_LIR_Gen_1	309	320	PF02991	0.343
LIG_LIR_Nem_3	145	151	PF02991	0.417
LIG_LIR_Nem_3	205	211	PF02991	0.422
LIG_LIR_Nem_3	309	315	PF02991	0.340
LIG_LIR_Nem_3	395	400	PF02991	0.403
LIG_LIR_Nem_3	71	77	PF02991	0.522
LIG_Pex14_1	208	212	PF04695	0.394
LIG_PTB_Apo_2	124	131	PF02174	0.319
LIG_SH2_CRK	92	96	PF00017	0.457
LIG_SH2_NCK_1	296	300	PF00017	0.460
LIG_SH2_NCK_1	369	373	PF00017	0.383
LIG_SH2_NCK_1	70	74	PF00017	0.512
LIG_SH2_SRC	316	319	PF00017	0.442
LIG_SH2_STAP1	198	202	PF00017	0.382
LIG_SH2_STAP1	263	267	PF00017	0.487
LIG_SH2_STAP1	296	300	PF00017	0.468
LIG_SH2_STAP1	70	74	PF00017	0.467
LIG_SH2_STAP1	92	96	PF00017	0.457
LIG_SH2_STAT3	212	215	PF00017	0.579
LIG_SH2_STAT3	263	266	PF00017	0.488
LIG_SH2_STAT3	400	403	PF00017	0.388
LIG_SH2_STAT5	150	153	PF00017	0.452
LIG_SH2_STAT5	312	315	PF00017	0.340
LIG_SH2_STAT5	316	319	PF00017	0.328
LIG_SH2_STAT5	369	372	PF00017	0.601
LIG_SH3_3	235	241	PF00018	0.514
LIG_SH3_3	365	371	PF00018	0.530
LIG_SUMO_SIM_par_1	157	163	PF11976	0.457
LIG_SUMO_SIM_par_1	191	197	PF11976	0.383
LIG_SUMO_SIM_par_1	379	384	PF11976	0.471
LIG_TRAF2_1	256	259	PF00917	0.597
LIG_WRC_WIRS_1	312	317	PF05994	0.354
LIG_WRC_WIRS_1	394	399	PF05994	0.267
MOD_CDK_SPxxK_3	367	374	PF00069	0.532
MOD_CK1_1	3	9	PF00069	0.620
MOD_CK1_1	56	62	PF00069	0.409
MOD_CK2_1	253	259	PF00069	0.570
MOD_CK2_1	32	38	PF00069	0.538
MOD_CK2_1	367	373	PF00069	0.452
MOD_CK2_1	376	382	PF00069	0.438
MOD_DYRK1A_RPxSP_1	367	371	PF00069	0.431
MOD_GlcNHglycan	108	112	PF01048	0.319
MOD_GlcNHglycan	11	14	PF01048	0.704
MOD_GlcNHglycan	179	182	PF01048	0.518
MOD_GlcNHglycan	19	22	PF01048	0.657
MOD_GlcNHglycan	238	241	PF01048	0.495
MOD_GlcNHglycan	306	309	PF01048	0.412
MOD_GlcNHglycan	49	52	PF01048	0.486
MOD_GSK3_1	13	20	PF00069	0.625
MOD_GSK3_1	232	239	PF00069	0.408
MOD_GSK3_1	253	260	PF00069	0.513
MOD_GSK3_1	28	35	PF00069	0.597
MOD_GSK3_1	3	10	PF00069	0.638
MOD_GSK3_1	300	307	PF00069	0.417
MOD_GSK3_1	52	59	PF00069	0.481
MOD_N-GLC_1	341	346	PF02516	0.552
MOD_N-GLC_1	39	44	PF02516	0.594
MOD_N-GLC_1	56	61	PF02516	0.470
MOD_NEK2_1	177	182	PF00069	0.517
MOD_NEK2_1	243	248	PF00069	0.385
MOD_NEK2_1	28	33	PF00069	0.642
MOD_NEK2_1	300	305	PF00069	0.532
MOD_NEK2_1	9	14	PF00069	0.729
MOD_PKA_1	4	10	PF00069	0.656
MOD_PKA_2	186	192	PF00069	0.425
MOD_PKA_2	3	9	PF00069	0.737
MOD_PKA_2	52	58	PF00069	0.464
MOD_Plk_1	107	113	PF00069	0.307
MOD_Plk_1	344	350	PF00069	0.395
MOD_Plk_1	56	62	PF00069	0.532
MOD_Plk_2-3	259	265	PF00069	0.509
MOD_Plk_4	28	34	PF00069	0.603
MOD_Plk_4	311	317	PF00069	0.338
MOD_Plk_4	376	382	PF00069	0.320
MOD_Plk_4	396	402	PF00069	0.419
MOD_Plk_4	42	48	PF00069	0.565
MOD_Plk_4	78	84	PF00069	0.397
MOD_Plk_4	90	96	PF00069	0.367
MOD_ProDKin_1	367	373	PF00069	0.550
MOD_SUMO_rev_2	144	148	PF00179	0.412
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.380
TRG_ENDOCYTIC_2	312	315	PF00928	0.370
TRG_ENDOCYTIC_2	70	73	PF00928	0.406
TRG_ENDOCYTIC_2	92	95	PF00928	0.457
TRG_ER_diArg_1	131	134	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A7	Leptomonas seymouri	82%	100%
A0A0S4JDH7	Bodo saltans	44%	100%
A0A0S4JWH9	Bodo saltans	27%	100%
A0A1X0NMC6	Trypanosomatidae	29%	100%
A0A1X0PA69	Trypanosomatidae	52%	97%
A0A3R7NHM3	Trypanosoma rangeli	51%	100%
A0A3S5H6M7	Leishmania donovani	27%	100%
A0A422NV18	Trypanosoma rangeli	28%	100%
A0A451EJR0	Leishmania donovani	90%	100%
A2XYY8	Oryza sativa subsp. indica	22%	100%
A2Y953	Oryza sativa subsp. indica	25%	100%
A2YPT7	Oryza sativa subsp. indica	24%	77%
A2Z0C0	Oryza sativa subsp. indica	29%	100%
A2Z8S0	Oryza sativa subsp. indica	26%	100%
A3KPF2	Arabidopsis thaliana	24%	77%
A4H8D0	Leishmania braziliensis	22%	100%
A8IEF3	Chlamydomonas reinhardtii	28%	100%
B0JYW5	Xenopus tropicalis	24%	100%
B0W3L6	Culex quinquefasciatus	25%	68%
B3DLB3	Xenopus tropicalis	28%	94%
B3M1E1	Drosophila ananassae	23%	76%
B3P4N5	Drosophila erecta	23%	76%
B4GZ20	Drosophila persimilis	23%	76%
B4HJC0	Drosophila sechellia	23%	76%
B4JXV2	Drosophila grimshawi	24%	74%
B4KA23	Drosophila mojavensis	23%	75%
B4LVS8	Drosophila virilis	23%	75%
B4NKI9	Drosophila willistoni	23%	76%
B4PVH6	Drosophila yakuba	23%	76%
B4QVW6	Drosophila simulans	23%	76%
D0A264	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D9IVE5	Xenopus laevis	25%	94%
E9ACK5	Leishmania major	88%	100%
E9AG49	Leishmania infantum	89%	100%
E9AGI9	Leishmania infantum	26%	100%
E9AIN9	Leishmania braziliensis	25%	100%
E9AJU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AP27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O13648	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	75%
O60678	Homo sapiens	29%	76%
O70467	Rattus norvegicus	27%	77%
O82210	Arabidopsis thaliana	26%	100%
P38074	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P55345	Homo sapiens	25%	94%
Q08A71	Arabidopsis thaliana	27%	93%
Q0J2C6	Oryza sativa subsp. japonica	29%	100%
Q0WVD6	Arabidopsis thaliana	25%	67%
Q174R2	Aedes aegypti	25%	68%
Q28F07	Xenopus tropicalis	27%	100%
Q29B63	Drosophila pseudoobscura pseudoobscura	23%	76%
Q4QF17	Leishmania major	22%	100%
Q4QGG2	Leishmania major	27%	100%
Q54EF2	Dictyostelium discoideum	27%	100%
Q5E9L5	Bos taurus	27%	100%
Q5RGQ2	Danio rerio	27%	97%
Q5XK84	Xenopus laevis	22%	67%
Q63009	Rattus norvegicus	26%	100%
Q6DC04	Danio rerio	23%	69%
Q6NWG4	Danio rerio	24%	100%
Q6NZB1	Mus musculus	28%	100%
Q6PAK3	Mus musculus	28%	100%
Q6VRB0	Xenopus laevis	27%	100%
Q75G68	Oryza sativa subsp. japonica	26%	100%
Q7XI75	Oryza sativa subsp. japonica	24%	77%
Q7XKC0	Oryza sativa subsp. japonica	23%	100%
Q86X55	Homo sapiens	22%	67%
Q8AV13	Xenopus laevis	28%	100%
Q922H1	Mus musculus	27%	77%
Q96LA8	Homo sapiens	28%	100%
Q99873	Homo sapiens	26%	100%
Q9JIF0	Mus musculus	26%	100%
Q9NR22	Homo sapiens	28%	100%
Q9R144	Mus musculus	25%	90%
Q9SNQ2	Oryza sativa subsp. japonica	25%	100%
Q9SU94	Arabidopsis thaliana	27%	100%
Q9U2X0	Caenorhabditis elegans	25%	100%
Q9URX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9VH48	Drosophila melanogaster	23%	76%
Q9WVG6	Mus musculus	22%	67%
V5BXE6	Trypanosoma cruzi	52%	100%