Putative DNA repair helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8A1_LEIBR

TriTrypDb:

LbrM.15.1330 , LBRM2903_150018000

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004386	helicase activity	2	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.825
CLV_C14_Caspase3-7	37	41	PF00656	0.833
CLV_C14_Caspase3-7	526	530	PF00656	0.625
CLV_MEL_PAP_1	600	606	PF00089	0.425
CLV_NRD_NRD_1	407	409	PF00675	0.425
CLV_NRD_NRD_1	470	472	PF00675	0.425
CLV_NRD_NRD_1	532	534	PF00675	0.425
CLV_NRD_NRD_1	602	604	PF00675	0.425
CLV_NRD_NRD_1	72	74	PF00675	0.834
CLV_PCSK_FUR_1	70	74	PF00082	0.827
CLV_PCSK_KEX2_1	255	257	PF00082	0.815
CLV_PCSK_KEX2_1	395	397	PF00082	0.425
CLV_PCSK_KEX2_1	407	409	PF00082	0.275
CLV_PCSK_KEX2_1	470	472	PF00082	0.425
CLV_PCSK_KEX2_1	50	52	PF00082	0.840
CLV_PCSK_KEX2_1	532	534	PF00082	0.425
CLV_PCSK_KEX2_1	601	603	PF00082	0.425
CLV_PCSK_KEX2_1	72	74	PF00082	0.834
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.815
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.425
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.840
CLV_PCSK_PC7_1	597	603	PF00082	0.425
CLV_PCSK_SKI1_1	395	399	PF00082	0.425
CLV_PCSK_SKI1_1	471	475	PF00082	0.425
CLV_PCSK_SKI1_1	523	527	PF00082	0.425
CLV_PCSK_SKI1_1	626	630	PF00082	0.610
CLV_Separin_Metazoa	424	428	PF03568	0.625
DEG_APCC_DBOX_1	95	103	PF00400	0.770
DEG_Nend_UBRbox_1	1	4	PF02207	0.796
DEG_SCF_FBW7_1	156	163	PF00400	0.730
DEG_SPOP_SBC_1	160	164	PF00917	0.773
DEG_SPOP_SBC_1	288	292	PF00917	0.636
DOC_CKS1_1	157	162	PF01111	0.724
DOC_MAPK_gen_1	138	148	PF00069	0.689
DOC_MAPK_gen_1	470	476	PF00069	0.625
DOC_MAPK_gen_1	70	77	PF00069	0.832
DOC_MAPK_MEF2A_6	495	502	PF00069	0.625
DOC_PP1_RVXF_1	153	159	PF00149	0.671
DOC_PP1_RVXF_1	71	78	PF00149	0.834
DOC_PP2B_LxvP_1	221	224	PF13499	0.703
DOC_PP2B_LxvP_1	500	503	PF13499	0.625
DOC_PP2B_PxIxI_1	609	615	PF00149	0.680
DOC_USP7_MATH_1	160	164	PF00917	0.773
DOC_USP7_MATH_1	289	293	PF00917	0.629
DOC_USP7_MATH_1	454	458	PF00917	0.625
DOC_USP7_MATH_1	552	556	PF00917	0.625
DOC_WW_Pin1_4	156	161	PF00397	0.711
DOC_WW_Pin1_4	162	167	PF00397	0.706
DOC_WW_Pin1_4	336	341	PF00397	0.677
DOC_WW_Pin1_4	548	553	PF00397	0.625
DOC_WW_Pin1_4	90	95	PF00397	0.840
LIG_14-3-3_CanoR_1	42	46	PF00244	0.837
LIG_14-3-3_CanoR_1	482	489	PF00244	0.625
LIG_14-3-3_CanoR_1	593	600	PF00244	0.625
LIG_14-3-3_CanoR_1	601	610	PF00244	0.525
LIG_14-3-3_CanoR_1	613	619	PF00244	0.249
LIG_Actin_WH2_2	95	110	PF00022	0.751
LIG_BIR_III_2	442	446	PF00653	0.625
LIG_BRCT_BRCA1_1	549	553	PF00533	0.625
LIG_CSL_BTD_1	157	160	PF09270	0.710
LIG_eIF4E_1	191	197	PF01652	0.639
LIG_eIF4E_1	584	590	PF01652	0.625
LIG_FAT_LD_1	139	147	PF03623	0.686
LIG_FHA_1	152	158	PF00498	0.666
LIG_FHA_1	178	184	PF00498	0.684
LIG_FHA_1	325	331	PF00498	0.808
LIG_FHA_1	332	338	PF00498	0.632
LIG_FHA_1	44	50	PF00498	0.837
LIG_FHA_1	519	525	PF00498	0.625
LIG_FHA_1	584	590	PF00498	0.625
LIG_FHA_2	321	327	PF00498	0.806
LIG_FHA_2	368	374	PF00498	0.625
LIG_FHA_2	506	512	PF00498	0.625
LIG_FHA_2	524	530	PF00498	0.400
LIG_FHA_2	552	558	PF00498	0.625
LIG_FHA_2	85	91	PF00498	0.857
LIG_GBD_Chelix_1	99	107	PF00786	0.741
LIG_LIR_Apic_2	605	610	PF02991	0.625
LIG_LIR_Gen_1	278	287	PF02991	0.696
LIG_LIR_Gen_1	370	380	PF02991	0.625
LIG_LIR_Gen_1	385	394	PF02991	0.438
LIG_LIR_Gen_1	583	592	PF02991	0.625
LIG_LIR_Nem_3	190	196	PF02991	0.645
LIG_LIR_Nem_3	278	282	PF02991	0.686
LIG_LIR_Nem_3	370	375	PF02991	0.625
LIG_LIR_Nem_3	385	391	PF02991	0.438
LIG_LIR_Nem_3	557	562	PF02991	0.625
LIG_LIR_Nem_3	583	587	PF02991	0.625
LIG_MYND_1	445	449	PF01753	0.625
LIG_Pex14_2	618	622	PF04695	0.580
LIG_REV1ctd_RIR_1	626	633	PF16727	0.629
LIG_SH2_CRK	388	392	PF00017	0.625
LIG_SH2_CRK	504	508	PF00017	0.625
LIG_SH2_CRK	584	588	PF00017	0.625
LIG_SH2_GRB2like	504	507	PF00017	0.625
LIG_SH2_NCK_1	388	392	PF00017	0.625
LIG_SH2_NCK_1	504	508	PF00017	0.625
LIG_SH2_SRC	504	507	PF00017	0.625
LIG_SH2_STAP1	584	588	PF00017	0.625
LIG_SH2_STAP1	9	13	PF00017	0.774
LIG_SH2_STAT3	387	390	PF00017	0.625
LIG_SH2_STAT5	147	150	PF00017	0.695
LIG_SH2_STAT5	191	194	PF00017	0.643
LIG_SH2_STAT5	562	565	PF00017	0.625
LIG_SH2_STAT5	594	597	PF00017	0.625
LIG_SH3_2	465	470	PF14604	0.625
LIG_SH3_3	216	222	PF00018	0.668
LIG_SH3_3	334	340	PF00018	0.713
LIG_SH3_3	356	362	PF00018	0.625
LIG_SH3_3	462	468	PF00018	0.625
LIG_SH3_3	75	81	PF00018	0.837
LIG_SH3_3	89	95	PF00018	0.595
LIG_SUMO_SIM_anti_2	376	385	PF11976	0.625
LIG_SUMO_SIM_anti_2	586	591	PF11976	0.625
LIG_SUMO_SIM_par_1	376	385	PF11976	0.625
LIG_SUMO_SIM_par_1	585	591	PF11976	0.625
LIG_TRAF2_1	17	20	PF00917	0.797
LIG_TRAF2_1	555	558	PF00917	0.625
LIG_UBA3_1	103	108	PF00899	0.727
LIG_WRC_WIRS_1	276	281	PF05994	0.690
LIG_WW_3	93	97	PF00397	0.809
MOD_CDC14_SPxK_1	93	96	PF00782	0.824
MOD_CDK_SPxK_1	90	96	PF00069	0.838
MOD_CK1_1	149	155	PF00069	0.662
MOD_CK1_1	161	167	PF00069	0.591
MOD_CK1_1	228	234	PF00069	0.841
MOD_CK1_1	329	335	PF00069	0.799
MOD_CK1_1	457	463	PF00069	0.625
MOD_CK1_1	538	544	PF00069	0.625
MOD_CK1_1	546	552	PF00069	0.525
MOD_CK1_1	560	566	PF00069	0.450
MOD_CK2_1	14	20	PF00069	0.790
MOD_CK2_1	409	415	PF00069	0.625
MOD_CK2_1	505	511	PF00069	0.625
MOD_CK2_1	551	557	PF00069	0.625
MOD_CK2_1	84	90	PF00069	0.857
MOD_Cter_Amidation	405	408	PF01082	0.425
MOD_DYRK1A_RPxSP_1	336	340	PF00069	0.683
MOD_GlcNHglycan	227	230	PF01048	0.827
MOD_GlcNHglycan	242	246	PF01048	0.550
MOD_GlcNHglycan	273	276	PF01048	0.747
MOD_GlcNHglycan	302	305	PF01048	0.631
MOD_GlcNHglycan	36	39	PF01048	0.841
MOD_GlcNHglycan	411	414	PF01048	0.425
MOD_GlcNHglycan	417	420	PF01048	0.350
MOD_GlcNHglycan	433	436	PF01048	0.225
MOD_GlcNHglycan	454	457	PF01048	0.425
MOD_GlcNHglycan	537	540	PF01048	0.425
MOD_GlcNHglycan	54	57	PF01048	0.521
MOD_GlcNHglycan	542	545	PF01048	0.363
MOD_GlcNHglycan	554	557	PF01048	0.213
MOD_GlcNHglycan	604	607	PF01048	0.425
MOD_GlcNHglycan	622	625	PF01048	0.254
MOD_GSK3_1	146	153	PF00069	0.683
MOD_GSK3_1	156	163	PF00069	0.555
MOD_GSK3_1	26	33	PF00069	0.857
MOD_GSK3_1	271	278	PF00069	0.736
MOD_GSK3_1	320	327	PF00069	0.804
MOD_GSK3_1	448	455	PF00069	0.625
MOD_GSK3_1	519	526	PF00069	0.625
MOD_GSK3_1	538	545	PF00069	0.388
MOD_GSK3_1	547	554	PF00069	0.513
MOD_GSK3_1	59	66	PF00069	0.830
MOD_N-GLC_1	225	230	PF02516	0.817
MOD_N-GLC_1	82	87	PF02516	0.853
MOD_N-GLC_2	571	573	PF02516	0.425
MOD_NEK2_1	213	218	PF00069	0.670
MOD_NEK2_1	307	312	PF00069	0.631
MOD_NEK2_1	382	387	PF00069	0.625
MOD_NEK2_1	398	403	PF00069	0.425
MOD_NEK2_1	535	540	PF00069	0.625
MOD_NEK2_1	547	552	PF00069	0.475
MOD_NEK2_1	566	571	PF00069	0.388
MOD_PIKK_1	166	172	PF00454	0.834
MOD_PIKK_1	307	313	PF00454	0.634
MOD_PKA_1	407	413	PF00069	0.625
MOD_PKA_1	602	608	PF00069	0.625
MOD_PKA_2	31	37	PF00069	0.854
MOD_PKA_2	407	413	PF00069	0.625
MOD_PKA_2	41	47	PF00069	0.661
MOD_PKA_2	481	487	PF00069	0.625
MOD_PKA_2	52	58	PF00069	0.647
MOD_PKA_2	592	598	PF00069	0.625
MOD_PKA_2	602	608	PF00069	0.500
MOD_Plk_1	241	247	PF00069	0.815
MOD_Plk_1	262	268	PF00069	0.788
MOD_Plk_1	557	563	PF00069	0.625
MOD_Plk_2-3	14	20	PF00069	0.790
MOD_Plk_4	349	355	PF00069	0.557
MOD_Plk_4	374	380	PF00069	0.625
MOD_Plk_4	583	589	PF00069	0.625
MOD_ProDKin_1	156	162	PF00069	0.718
MOD_ProDKin_1	336	342	PF00069	0.664
MOD_ProDKin_1	548	554	PF00069	0.625
MOD_ProDKin_1	90	96	PF00069	0.838
MOD_SUMO_rev_2	14	24	PF00179	0.804
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.680
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.664
TRG_ENDOCYTIC_2	372	375	PF00928	0.625
TRG_ENDOCYTIC_2	388	391	PF00928	0.425
TRG_ENDOCYTIC_2	584	587	PF00928	0.625
TRG_ER_diArg_1	600	603	PF00400	0.625
TRG_ER_diArg_1	70	73	PF00400	0.828
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A1CJ34	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	87%
A1D8E4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	74%
A2QY22	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	73%
A5DUW8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	24%	71%
A7ERG1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	25%	71%
F1R345	Danio rerio	28%	71%
Q4WWE9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	81%
Q5AD67	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	76%
Q6AXC6	Mus musculus	27%	70%
Q6CAX3	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	79%
Q92771	Homo sapiens	26%	67%