Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8A0_LEIBR

TriTrypDb:

LbrM.15.1320 , LBRM2903_150020400

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.351
CLV_C14_Caspase3-7	610	614	PF00656	0.296
CLV_NRD_NRD_1	209	211	PF00675	0.475
CLV_NRD_NRD_1	369	371	PF00675	0.247
CLV_NRD_NRD_1	413	415	PF00675	0.535
CLV_NRD_NRD_1	422	424	PF00675	0.539
CLV_NRD_NRD_1	634	636	PF00675	0.590
CLV_PCSK_KEX2_1	23	25	PF00082	0.569
CLV_PCSK_KEX2_1	369	371	PF00082	0.247
CLV_PCSK_KEX2_1	421	423	PF00082	0.539
CLV_PCSK_KEX2_1	634	636	PF00082	0.590
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.569
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.619
CLV_PCSK_PC7_1	417	423	PF00082	0.561
CLV_PCSK_PC7_1	630	636	PF00082	0.581
CLV_PCSK_SKI1_1	157	161	PF00082	0.707
CLV_PCSK_SKI1_1	369	373	PF00082	0.242
CLV_PCSK_SKI1_1	387	391	PF00082	0.563
CLV_PCSK_SKI1_1	442	446	PF00082	0.540
CLV_PCSK_SKI1_1	509	513	PF00082	0.717
CLV_PCSK_SKI1_1	579	583	PF00082	0.446
CLV_PCSK_SKI1_1	602	606	PF00082	0.482
CLV_PCSK_SKI1_1	698	702	PF00082	0.329
DEG_APCC_DBOX_1	237	245	PF00400	0.596
DEG_APCC_DBOX_1	441	449	PF00400	0.377
DEG_APCC_DBOX_1	578	586	PF00400	0.246
DEG_APCC_DBOX_1	697	705	PF00400	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.390
DEG_SPOP_SBC_1	63	67	PF00917	0.369
DOC_ANK_TNKS_1	248	255	PF00023	0.564
DOC_CKS1_1	3	8	PF01111	0.462
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.331
DOC_MAPK_DCC_7	238	246	PF00069	0.584
DOC_MAPK_gen_1	436	445	PF00069	0.387
DOC_MAPK_MEF2A_6	238	246	PF00069	0.584
DOC_MAPK_MEF2A_6	375	383	PF00069	0.297
DOC_MAPK_MEF2A_6	590	599	PF00069	0.242
DOC_MAPK_MEF2A_6	680	689	PF00069	0.587
DOC_PP1_RVXF_1	191	197	PF00149	0.292
DOC_PP2B_LxvP_1	377	380	PF13499	0.341
DOC_PP2B_LxvP_1	580	583	PF13499	0.303
DOC_USP7_MATH_1	209	213	PF00917	0.522
DOC_USP7_MATH_1	331	335	PF00917	0.614
DOC_USP7_MATH_1	40	44	PF00917	0.475
DOC_USP7_MATH_1	64	68	PF00917	0.508
DOC_USP7_MATH_1	94	98	PF00917	0.467
DOC_WW_Pin1_4	2	7	PF00397	0.514
DOC_WW_Pin1_4	217	222	PF00397	0.725
DOC_WW_Pin1_4	560	565	PF00397	0.242
DOC_WW_Pin1_4	633	638	PF00397	0.360
DOC_WW_Pin1_4	651	656	PF00397	0.406
LIG_14-3-3_CanoR_1	210	217	PF00244	0.633
LIG_14-3-3_CanoR_1	227	234	PF00244	0.563
LIG_14-3-3_CanoR_1	48	55	PF00244	0.528
LIG_14-3-3_CanoR_1	635	641	PF00244	0.340
LIG_14-3-3_CanoR_1	696	701	PF00244	0.553
LIG_14-3-3_CanoR_1	73	83	PF00244	0.324
LIG_AP2alpha_1	611	615	PF02296	0.184
LIG_APCC_ABBAyCdc20_2	457	463	PF00400	0.285
LIG_BRCT_BRCA1_1	200	204	PF00533	0.539
LIG_deltaCOP1_diTrp_1	69	74	PF00928	0.499
LIG_DLG_GKlike_1	696	704	PF00625	0.571
LIG_EVH1_2	517	521	PF00568	0.241
LIG_FHA_1	333	339	PF00498	0.639
LIG_FHA_1	351	357	PF00498	0.638
LIG_FHA_1	396	402	PF00498	0.427
LIG_FHA_1	468	474	PF00498	0.262
LIG_FHA_1	561	567	PF00498	0.242
LIG_FHA_1	587	593	PF00498	0.243
LIG_FHA_2	230	236	PF00498	0.630
LIG_FHA_2	308	314	PF00498	0.440
LIG_FHA_2	679	685	PF00498	0.488
LIG_GBD_Chelix_1	118	126	PF00786	0.604
LIG_GBD_Chelix_1	356	364	PF00786	0.299
LIG_LIR_Gen_1	313	323	PF02991	0.567
LIG_LIR_Gen_1	344	352	PF02991	0.536
LIG_LIR_Gen_1	456	467	PF02991	0.308
LIG_LIR_Gen_1	502	511	PF02991	0.295
LIG_LIR_Gen_1	525	534	PF02991	0.366
LIG_LIR_Gen_1	543	553	PF02991	0.167
LIG_LIR_Gen_1	606	615	PF02991	0.250
LIG_LIR_Gen_1	619	629	PF02991	0.224
LIG_LIR_Gen_1	69	75	PF02991	0.344
LIG_LIR_Nem_3	300	304	PF02991	0.606
LIG_LIR_Nem_3	313	318	PF02991	0.488
LIG_LIR_Nem_3	344	349	PF02991	0.537
LIG_LIR_Nem_3	455	461	PF02991	0.263
LIG_LIR_Nem_3	498	503	PF02991	0.293
LIG_LIR_Nem_3	525	530	PF02991	0.277
LIG_LIR_Nem_3	543	548	PF02991	0.165
LIG_LIR_Nem_3	606	611	PF02991	0.226
LIG_LIR_Nem_3	613	618	PF02991	0.242
LIG_LIR_Nem_3	619	624	PF02991	0.242
LIG_LIR_Nem_3	69	74	PF02991	0.499
LIG_LIR_Nem_3	8	12	PF02991	0.546
LIG_MLH1_MIPbox_1	200	204	PF16413	0.427
LIG_MYND_3	305	309	PF01753	0.583
LIG_NRBOX	700	706	PF00104	0.469
LIG_PDZ_Class_2	703	708	PF00595	0.442
LIG_Pex14_2	611	615	PF04695	0.184
LIG_SH2_CRK	9	13	PF00017	0.554
LIG_SH2_NCK_1	545	549	PF00017	0.255
LIG_SH2_STAP1	373	377	PF00017	0.279
LIG_SH2_STAP1	545	549	PF00017	0.336
LIG_SH2_STAP1	664	668	PF00017	0.410
LIG_SH2_STAT5	203	206	PF00017	0.445
LIG_SH2_STAT5	314	317	PF00017	0.524
LIG_SH2_STAT5	408	411	PF00017	0.351
LIG_SH2_STAT5	458	461	PF00017	0.281
LIG_SH2_STAT5	500	503	PF00017	0.285
LIG_SH3_3	236	242	PF00018	0.619
LIG_SH3_3	287	293	PF00018	0.445
LIG_SH3_3	93	99	PF00018	0.486
LIG_SUMO_SIM_anti_2	243	248	PF11976	0.483
LIG_SUMO_SIM_anti_2	684	691	PF11976	0.588
LIG_SUMO_SIM_par_1	333	340	PF11976	0.631
LIG_SUMO_SIM_par_1	379	385	PF11976	0.324
LIG_TRAF2_1	131	134	PF00917	0.396
LIG_TRAF2_1	233	236	PF00917	0.644
LIG_TRAF2_1	431	434	PF00917	0.392
LIG_TYR_ITIM	7	12	PF00017	0.715
LIG_WRC_WIRS_1	617	622	PF05994	0.330
MOD_CDC14_SPxK_1	220	223	PF00782	0.631
MOD_CDK_SPxK_1	217	223	PF00069	0.639
MOD_CK1_1	107	113	PF00069	0.420
MOD_CK1_1	13	19	PF00069	0.593
MOD_CK1_1	144	150	PF00069	0.643
MOD_CK1_1	153	159	PF00069	0.569
MOD_CK1_1	198	204	PF00069	0.438
MOD_CK1_1	257	263	PF00069	0.282
MOD_CK1_1	499	505	PF00069	0.417
MOD_CK1_1	636	642	PF00069	0.438
MOD_CK1_1	67	73	PF00069	0.599
MOD_CK1_1	97	103	PF00069	0.521
MOD_CK2_1	229	235	PF00069	0.463
MOD_CK2_1	307	313	PF00069	0.536
MOD_CK2_1	331	337	PF00069	0.512
MOD_CK2_1	678	684	PF00069	0.353
MOD_GlcNHglycan	143	146	PF01048	0.723
MOD_GlcNHglycan	147	150	PF01048	0.754
MOD_GlcNHglycan	157	160	PF01048	0.632
MOD_GlcNHglycan	18	21	PF01048	0.651
MOD_GlcNHglycan	197	200	PF01048	0.386
MOD_GlcNHglycan	24	27	PF01048	0.605
MOD_GlcNHglycan	256	259	PF01048	0.348
MOD_GlcNHglycan	270	273	PF01048	0.518
MOD_GlcNHglycan	429	432	PF01048	0.366
MOD_GlcNHglycan	55	58	PF01048	0.560
MOD_GlcNHglycan	99	102	PF01048	0.546
MOD_GSK3_1	103	110	PF00069	0.455
MOD_GSK3_1	141	148	PF00069	0.743
MOD_GSK3_1	172	179	PF00069	0.459
MOD_GSK3_1	18	25	PF00069	0.589
MOD_GSK3_1	215	222	PF00069	0.680
MOD_GSK3_1	448	455	PF00069	0.410
MOD_GSK3_1	63	70	PF00069	0.573
MOD_GSK3_1	633	640	PF00069	0.326
MOD_GSK3_1	84	91	PF00069	0.510
MOD_N-GLC_1	160	165	PF02516	0.694
MOD_N-GLC_1	535	540	PF02516	0.381
MOD_NEK2_1	104	109	PF00069	0.493
MOD_NEK2_1	195	200	PF00069	0.314
MOD_NEK2_1	270	275	PF00069	0.470
MOD_NEK2_1	323	328	PF00069	0.577
MOD_NEK2_1	409	414	PF00069	0.427
MOD_NEK2_1	448	453	PF00069	0.517
MOD_NEK2_1	467	472	PF00069	0.186
MOD_NEK2_1	572	577	PF00069	0.269
MOD_NEK2_1	623	628	PF00069	0.287
MOD_NEK2_1	74	79	PF00069	0.546
MOD_NEK2_2	286	291	PF00069	0.380
MOD_NEK2_2	307	312	PF00069	0.272
MOD_PIKK_1	138	144	PF00454	0.613
MOD_PIKK_1	176	182	PF00454	0.454
MOD_PIKK_1	198	204	PF00454	0.473
MOD_PIKK_1	257	263	PF00454	0.369
MOD_PIKK_1	389	395	PF00454	0.400
MOD_PIKK_1	74	80	PF00454	0.593
MOD_PIKK_1	94	100	PF00454	0.497
MOD_PK_1	42	48	PF00069	0.477
MOD_PKA_1	210	216	PF00069	0.584
MOD_PKA_2	13	19	PF00069	0.641
MOD_PKA_2	209	215	PF00069	0.579
MOD_PKA_2	226	232	PF00069	0.447
MOD_PKA_2	47	53	PF00069	0.644
MOD_PKA_2	649	655	PF00069	0.431
MOD_Plk_1	160	166	PF00069	0.759
MOD_Plk_1	176	182	PF00069	0.480
MOD_Plk_1	275	281	PF00069	0.382
MOD_Plk_1	332	338	PF00069	0.560
MOD_Plk_1	474	480	PF00069	0.383
MOD_Plk_1	538	544	PF00069	0.382
MOD_Plk_2-3	616	622	PF00069	0.322
MOD_Plk_4	107	113	PF00069	0.374
MOD_Plk_4	275	281	PF00069	0.461
MOD_Plk_4	286	292	PF00069	0.364
MOD_Plk_4	496	502	PF00069	0.355
MOD_Plk_4	572	578	PF00069	0.357
MOD_Plk_4	616	622	PF00069	0.322
MOD_ProDKin_1	2	8	PF00069	0.662
MOD_ProDKin_1	217	223	PF00069	0.675
MOD_ProDKin_1	560	566	PF00069	0.279
MOD_ProDKin_1	633	639	PF00069	0.444
MOD_ProDKin_1	651	657	PF00069	0.497
MOD_SUMO_for_1	131	134	PF00179	0.471
MOD_SUMO_for_1	431	434	PF00179	0.422
TRG_DiLeu_BaEn_1	543	548	PF01217	0.226
TRG_DiLeu_BaEn_2	524	530	PF01217	0.222
TRG_DiLeu_BaEn_4	236	242	PF01217	0.527
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.197
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.305
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.497
TRG_ENDOCYTIC_2	503	506	PF00928	0.298
TRG_ENDOCYTIC_2	545	548	PF00928	0.201
TRG_ENDOCYTIC_2	9	12	PF00928	0.716
TRG_ER_diArg_1	368	370	PF00400	0.327
TRG_ER_diArg_1	422	424	PF00400	0.429
TRG_ER_diArg_1	436	439	PF00400	0.399
TRG_ER_diArg_1	695	698	PF00400	0.326
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA9	Leptomonas seymouri	67%	100%
A0A1X0NU07	Trypanosomatidae	41%	95%
A0A3Q8I980	Leishmania donovani	78%	100%
A0A3R7NA24	Trypanosoma rangeli	40%	100%
A4HWM2	Leishmania infantum	79%	100%
C9ZXR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E9AQC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QF46	Leishmania major	76%	100%
V5B4P0	Trypanosoma cruzi	35%	100%