Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H897_LEIBR

TriTrypDb:

LbrM.15.1290 , LBRM2903_150020100

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H897

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H897

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005509	calcium ion binding	5	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.380
CLV_NRD_NRD_1	132	134	PF00675	0.483
CLV_NRD_NRD_1	366	368	PF00675	0.665
CLV_PCSK_KEX2_1	118	120	PF00082	0.379
CLV_PCSK_KEX2_1	132	134	PF00082	0.495
CLV_PCSK_KEX2_1	366	368	PF00082	0.665
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.511
CLV_PCSK_PC7_1	128	134	PF00082	0.363
CLV_PCSK_SKI1_1	110	114	PF00082	0.385
CLV_PCSK_SKI1_1	20	24	PF00082	0.532
CLV_PCSK_SKI1_1	300	304	PF00082	0.567
DOC_MAPK_gen_1	16	24	PF00069	0.547
DOC_MAPK_gen_1	300	310	PF00069	0.649
DOC_MAPK_MEF2A_6	303	312	PF00069	0.574
DOC_MAPK_NFAT4_5	303	311	PF00069	0.572
DOC_USP7_MATH_1	126	130	PF00917	0.532
DOC_USP7_MATH_1	159	163	PF00917	0.558
DOC_USP7_MATH_1	184	188	PF00917	0.498
DOC_USP7_MATH_1	43	47	PF00917	0.567
DOC_USP7_UBL2_3	16	20	PF12436	0.531
DOC_WW_Pin1_4	180	185	PF00397	0.711
DOC_WW_Pin1_4	250	255	PF00397	0.449
DOC_WW_Pin1_4	81	86	PF00397	0.527
LIG_14-3-3_CanoR_1	144	150	PF00244	0.444
LIG_14-3-3_CanoR_1	239	243	PF00244	0.445
LIG_14-3-3_CanoR_1	347	353	PF00244	0.543
LIG_14-3-3_CanoR_1	42	48	PF00244	0.293
LIG_Actin_WH2_2	105	123	PF00022	0.452
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	214	218	PF00533	0.469
LIG_BRCT_BRCA1_1	252	256	PF00533	0.435
LIG_eIF4E_1	69	75	PF01652	0.258
LIG_FHA_1	107	113	PF00498	0.449
LIG_FHA_1	27	33	PF00498	0.519
LIG_FHA_1	98	104	PF00498	0.425
LIG_FHA_2	277	283	PF00498	0.522
LIG_FHA_2	59	65	PF00498	0.615
LIG_FHA_2	82	88	PF00498	0.463
LIG_HCF-1_HBM_1	325	328	PF13415	0.670
LIG_LIR_Apic_2	325	331	PF02991	0.652
LIG_LIR_Gen_1	147	157	PF02991	0.499
LIG_LIR_Gen_1	241	250	PF02991	0.344
LIG_LIR_Gen_1	316	327	PF02991	0.538
LIG_LIR_Gen_1	68	76	PF02991	0.364
LIG_LIR_Nem_3	147	152	PF02991	0.624
LIG_LIR_Nem_3	241	245	PF02991	0.393
LIG_LIR_Nem_3	68	72	PF02991	0.316
LIG_LRP6_Inhibitor_1	4	10	PF00058	0.637
LIG_RPA_C_Fungi	114	126	PF08784	0.417
LIG_SH2_CRK	149	153	PF00017	0.332
LIG_SH2_CRK	249	253	PF00017	0.421
LIG_SH2_NCK_1	149	153	PF00017	0.372
LIG_SH2_PTP2	328	331	PF00017	0.533
LIG_SH2_SRC	328	331	PF00017	0.544
LIG_SH2_STAP1	149	153	PF00017	0.332
LIG_SH2_STAP1	242	246	PF00017	0.489
LIG_SH2_STAP1	69	73	PF00017	0.324
LIG_SH2_STAT5	301	304	PF00017	0.601
LIG_SH2_STAT5	328	331	PF00017	0.548
LIG_SH2_STAT5	90	93	PF00017	0.403
LIG_SH3_1	328	334	PF00018	0.534
LIG_SH3_3	161	167	PF00018	0.536
LIG_SH3_3	328	334	PF00018	0.514
LIG_SUMO_SIM_par_1	292	297	PF11976	0.534
MOD_CK1_1	104	110	PF00069	0.515
MOD_CK1_1	313	319	PF00069	0.516
MOD_CK2_1	184	190	PF00069	0.392
MOD_CK2_1	238	244	PF00069	0.477
MOD_CK2_1	276	282	PF00069	0.527
MOD_CK2_1	81	87	PF00069	0.448
MOD_GlcNHglycan	103	106	PF01048	0.523
MOD_GlcNHglycan	161	164	PF01048	0.673
MOD_GlcNHglycan	186	189	PF01048	0.417
MOD_GlcNHglycan	214	217	PF01048	0.693
MOD_GlcNHglycan	230	235	PF01048	0.603
MOD_GSK3_1	106	113	PF00069	0.475
MOD_GSK3_1	180	187	PF00069	0.615
MOD_GSK3_1	22	29	PF00069	0.489
MOD_GSK3_1	276	283	PF00069	0.455
MOD_GSK3_1	313	320	PF00069	0.523
MOD_GSK3_1	341	348	PF00069	0.623
MOD_GSK3_1	53	60	PF00069	0.619
MOD_GSK3_1	77	84	PF00069	0.471
MOD_GSK3_1	97	104	PF00069	0.582
MOD_N-GLC_1	317	322	PF02516	0.524
MOD_NEK2_1	145	150	PF00069	0.454
MOD_NEK2_1	189	194	PF00069	0.476
MOD_NEK2_1	212	217	PF00069	0.577
MOD_NEK2_1	280	285	PF00069	0.564
MOD_NEK2_1	310	315	PF00069	0.595
MOD_NEK2_1	341	346	PF00069	0.588
MOD_NEK2_2	43	48	PF00069	0.297
MOD_PIKK_1	48	54	PF00454	0.372
MOD_PKA_1	133	139	PF00069	0.502
MOD_PKA_2	238	244	PF00069	0.453
MOD_PKA_2	276	282	PF00069	0.453
MOD_PKB_1	142	150	PF00069	0.326
MOD_Plk_1	189	195	PF00069	0.396
MOD_Plk_1	317	323	PF00069	0.528
MOD_Plk_1	77	83	PF00069	0.277
MOD_Plk_2-3	238	244	PF00069	0.483
MOD_Plk_4	207	213	PF00069	0.608
MOD_ProDKin_1	180	186	PF00069	0.705
MOD_ProDKin_1	250	256	PF00069	0.450
MOD_ProDKin_1	81	87	PF00069	0.523
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.323
TRG_ENDOCYTIC_2	149	152	PF00928	0.330
TRG_ENDOCYTIC_2	242	245	PF00928	0.434
TRG_ENDOCYTIC_2	249	252	PF00928	0.417
TRG_ENDOCYTIC_2	319	322	PF00928	0.581
TRG_ENDOCYTIC_2	69	72	PF00928	0.323
TRG_ER_diArg_1	118	121	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG2	Leptomonas seymouri	54%	100%
A0A0S4JMV6	Bodo saltans	30%	100%
A0A1X0NUM9	Trypanosomatidae	36%	100%
A0A3R7MLD6	Trypanosoma rangeli	34%	100%
A0A3S7WTM7	Leishmania donovani	75%	100%
A4HWL9	Leishmania infantum	75%	100%
C9ZXR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AQC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QF48	Leishmania major	75%	100%
V5BUD9	Trypanosoma cruzi	34%	100%