MGT1 magnesium transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MGT1 magnesium transporter

Species:

Leishmania braziliensis

UniProt:

A4H894_LEIBR

TriTrypDb:

LbrM.15.1260 , LBRM2903_150019800

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005886	plasma membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H894

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H894

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006811	monoatomic ion transport	4	6
GO:0006812	monoatomic cation transport	5	6
GO:0015693	magnesium ion transport	7	6
GO:0030001	metal ion transport	6	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7
GO:0000287	magnesium ion binding	5	1
GO:0005488	binding	1	1
GO:0015087	cobalt ion transmembrane transporter activity	7	1
GO:0015095	magnesium ion transmembrane transporter activity	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1
GO:0050897	cobalt ion binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.616
CLV_NRD_NRD_1	145	147	PF00675	0.553
CLV_NRD_NRD_1	149	151	PF00675	0.534
CLV_NRD_NRD_1	274	276	PF00675	0.572
CLV_NRD_NRD_1	370	372	PF00675	0.335
CLV_NRD_NRD_1	453	455	PF00675	0.496
CLV_NRD_NRD_1	468	470	PF00675	0.608
CLV_NRD_NRD_1	694	696	PF00675	0.346
CLV_PCSK_FUR_1	143	147	PF00082	0.612
CLV_PCSK_KEX2_1	135	137	PF00082	0.565
CLV_PCSK_KEX2_1	145	147	PF00082	0.586
CLV_PCSK_KEX2_1	148	150	PF00082	0.590
CLV_PCSK_KEX2_1	274	276	PF00082	0.572
CLV_PCSK_KEX2_1	370	372	PF00082	0.335
CLV_PCSK_KEX2_1	453	455	PF00082	0.524
CLV_PCSK_KEX2_1	468	470	PF00082	0.481
CLV_PCSK_KEX2_1	591	593	PF00082	0.505
CLV_PCSK_KEX2_1	653	655	PF00082	0.504
CLV_PCSK_KEX2_1	694	696	PF00082	0.346
CLV_PCSK_KEX2_1	791	793	PF00082	0.438
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.578
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.505
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.434
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.438
CLV_PCSK_PC7_1	141	147	PF00082	0.588
CLV_PCSK_PC7_1	366	372	PF00082	0.355
CLV_PCSK_PC7_1	587	593	PF00082	0.495
CLV_PCSK_SKI1_1	366	370	PF00082	0.397
CLV_PCSK_SKI1_1	501	505	PF00082	0.372
CLV_PCSK_SKI1_1	541	545	PF00082	0.386
CLV_PCSK_SKI1_1	653	657	PF00082	0.508
CLV_PCSK_SKI1_1	712	716	PF00082	0.346
CLV_PCSK_SKI1_1	747	751	PF00082	0.346
DEG_MDM2_SWIB_1	479	486	PF02201	0.657
DEG_SCF_FBW7_1	641	647	PF00400	0.783
DEG_SCF_TRCP1_1	121	126	PF00400	0.642
DEG_SPOP_SBC_1	44	48	PF00917	0.672
DEG_SPOP_SBC_1	70	74	PF00917	0.662
DOC_CKS1_1	297	302	PF01111	0.804
DOC_CKS1_1	30	35	PF01111	0.803
DOC_CKS1_1	641	646	PF01111	0.784
DOC_CKS1_1	774	779	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.411
DOC_MAPK_gen_1	370	377	PF00069	0.524
DOC_MAPK_MEF2A_6	309	316	PF00069	0.645
DOC_MAPK_MEF2A_6	560	567	PF00069	0.575
DOC_MAPK_MEF2A_6	568	575	PF00069	0.662
DOC_MAPK_MEF2A_6	747	756	PF00069	0.546
DOC_MAPK_NFAT4_5	747	755	PF00069	0.546
DOC_PP2B_LxvP_1	521	524	PF13499	0.587
DOC_SPAK_OSR1_1	199	203	PF12202	0.759
DOC_USP7_MATH_1	134	138	PF00917	0.704
DOC_USP7_MATH_1	186	190	PF00917	0.850
DOC_USP7_MATH_1	230	234	PF00917	0.659
DOC_USP7_MATH_1	286	290	PF00917	0.793
DOC_USP7_MATH_1	303	307	PF00917	0.679
DOC_USP7_MATH_1	327	331	PF00917	0.697
DOC_USP7_MATH_1	420	424	PF00917	0.827
DOC_USP7_MATH_1	437	441	PF00917	0.604
DOC_USP7_MATH_1	44	48	PF00917	0.672
DOC_USP7_MATH_1	470	474	PF00917	0.789
DOC_USP7_MATH_1	61	65	PF00917	0.697
DOC_USP7_MATH_1	644	648	PF00917	0.714
DOC_USP7_MATH_1	660	664	PF00917	0.648
DOC_USP7_MATH_1	70	74	PF00917	0.790
DOC_USP7_UBL2_3	131	135	PF12436	0.851
DOC_USP7_UBL2_3	629	633	PF12436	0.609
DOC_USP7_UBL2_3	712	716	PF12436	0.619
DOC_WW_Pin1_4	19	24	PF00397	0.778
DOC_WW_Pin1_4	236	241	PF00397	0.761
DOC_WW_Pin1_4	29	34	PF00397	0.779
DOC_WW_Pin1_4	296	301	PF00397	0.793
DOC_WW_Pin1_4	359	364	PF00397	0.654
DOC_WW_Pin1_4	526	531	PF00397	0.614
DOC_WW_Pin1_4	640	645	PF00397	0.786
DOC_WW_Pin1_4	662	667	PF00397	0.679
DOC_WW_Pin1_4	675	680	PF00397	0.639
DOC_WW_Pin1_4	773	778	PF00397	0.355
LIG_14-3-3_CanoR_1	152	158	PF00244	0.772
LIG_14-3-3_CanoR_1	205	209	PF00244	0.727
LIG_14-3-3_CanoR_1	419	423	PF00244	0.811
LIG_14-3-3_CanoR_1	43	50	PF00244	0.677
LIG_14-3-3_CanoR_1	469	475	PF00244	0.785
LIG_14-3-3_CanoR_1	495	501	PF00244	0.542
LIG_14-3-3_CanoR_1	541	549	PF00244	0.581
LIG_14-3-3_CanoR_1	694	699	PF00244	0.539
LIG_14-3-3_CanoR_1	760	768	PF00244	0.580
LIG_14-3-3_CanoR_1	77	86	PF00244	0.669
LIG_14-3-3_CanoR_1	770	774	PF00244	0.353
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BRCT_BRCA1_1	196	200	PF00533	0.765
LIG_BRCT_BRCA1_1	439	443	PF00533	0.753
LIG_BRCT_BRCA1_1	471	475	PF00533	0.768
LIG_CORNRBOX	605	613	PF00104	0.573
LIG_CORNRBOX	807	815	PF00104	0.261
LIG_deltaCOP1_diTrp_1	795	805	PF00928	0.346
LIG_eIF4E_1	532	538	PF01652	0.587
LIG_eIF4E_1	802	808	PF01652	0.261
LIG_FHA_1	297	303	PF00498	0.732
LIG_FHA_1	30	36	PF00498	0.677
LIG_FHA_1	395	401	PF00498	0.667
LIG_FHA_1	518	524	PF00498	0.669
LIG_FHA_1	542	548	PF00498	0.610
LIG_FHA_1	613	619	PF00498	0.611
LIG_FHA_1	622	628	PF00498	0.550
LIG_FHA_1	641	647	PF00498	0.711
LIG_FHA_1	704	710	PF00498	0.509
LIG_FHA_1	759	765	PF00498	0.529
LIG_FHA_1	816	822	PF00498	0.261
LIG_FHA_2	106	112	PF00498	0.681
LIG_FHA_2	20	26	PF00498	0.850
LIG_FHA_2	209	215	PF00498	0.768
LIG_FHA_2	44	50	PF00498	0.675
LIG_FHA_2	447	453	PF00498	0.780
LIG_FHA_2	485	491	PF00498	0.606
LIG_FHA_2	679	685	PF00498	0.545
LIG_IRF3_LxIS_1	749	755	PF10401	0.546
LIG_LIR_Apic_2	797	803	PF02991	0.292
LIG_LIR_Gen_1	197	208	PF02991	0.750
LIG_LIR_Gen_1	310	321	PF02991	0.648
LIG_LIR_Gen_1	558	567	PF02991	0.545
LIG_LIR_Gen_1	600	609	PF02991	0.573
LIG_LIR_Nem_3	197	203	PF02991	0.761
LIG_LIR_Nem_3	206	212	PF02991	0.725
LIG_LIR_Nem_3	310	316	PF02991	0.646
LIG_LIR_Nem_3	476	482	PF02991	0.614
LIG_LIR_Nem_3	558	564	PF02991	0.545
LIG_LIR_Nem_3	600	604	PF02991	0.620
LIG_LIR_Nem_3	772	778	PF02991	0.364
LIG_LIR_Nem_3	799	805	PF02991	0.419
LIG_LYPXL_L_2	531	540	PF13949	0.486
LIG_MLH1_MIPbox_1	471	475	PF16413	0.768
LIG_NRBOX	667	673	PF00104	0.633
LIG_Pex14_1	798	802	PF04695	0.346
LIG_Pex14_2	475	479	PF04695	0.698
LIG_Pex14_2	789	793	PF04695	0.346
LIG_REV1ctd_RIR_1	817	824	PF16727	0.404
LIG_SH2_CRK	243	247	PF00017	0.646
LIG_SH2_CRK	800	804	PF00017	0.300
LIG_SH2_GRB2like	379	382	PF00017	0.605
LIG_SH2_SRC	278	281	PF00017	0.825
LIG_SH2_STAP1	243	247	PF00017	0.646
LIG_SH2_STAP1	614	618	PF00017	0.584
LIG_SH2_STAT3	474	477	PF00017	0.611
LIG_SH2_STAT3	532	535	PF00017	0.601
LIG_SH2_STAT3	614	617	PF00017	0.473
LIG_SH2_STAT5	379	382	PF00017	0.605
LIG_SH2_STAT5	474	477	PF00017	0.611
LIG_SH2_STAT5	502	505	PF00017	0.631
LIG_SH2_STAT5	536	539	PF00017	0.575
LIG_SH2_STAT5	614	617	PF00017	0.654
LIG_SH2_STAT5	650	653	PF00017	0.660
LIG_SH2_STAT5	84	87	PF00017	0.663
LIG_SH3_3	24	30	PF00018	0.825
LIG_SH3_3	294	300	PF00018	0.757
LIG_SH3_3	355	361	PF00018	0.644
LIG_SH3_3	419	425	PF00018	0.762
LIG_SH3_3	430	436	PF00018	0.630
LIG_SH3_3	527	533	PF00018	0.534
LIG_SH3_3	53	59	PF00018	0.720
LIG_SH3_3	638	644	PF00018	0.747
LIG_SH3_3	64	70	PF00018	0.829
LIG_SUMO_SIM_par_1	561	566	PF11976	0.568
LIG_SUMO_SIM_par_1	87	94	PF11976	0.756
LIG_TRAF2_1	108	111	PF00917	0.691
LIG_TRAF2_1	215	218	PF00917	0.744
LIG_TRAF2_1	449	452	PF00917	0.725
LIG_TRAF2_1	600	603	PF00917	0.581
LIG_TRFH_1	84	88	PF08558	0.506
LIG_TYR_ITIM	241	246	PF00017	0.549
LIG_WRC_WIRS_1	685	690	PF05994	0.488
LIG_WRC_WIRS_1	756	761	PF05994	0.411
LIG_WRC_WIRS_1	816	821	PF05994	0.290
LIG_WW_2	56	59	PF00397	0.545
MOD_CDK_SPxxK_3	359	366	PF00069	0.555
MOD_CDK_SPxxK_3	675	682	PF00069	0.557
MOD_CK1_1	122	128	PF00069	0.635
MOD_CK1_1	156	162	PF00069	0.669
MOD_CK1_1	166	172	PF00069	0.650
MOD_CK1_1	187	193	PF00069	0.769
MOD_CK1_1	194	200	PF00069	0.663
MOD_CK1_1	245	251	PF00069	0.558
MOD_CK1_1	3	9	PF00069	0.821
MOD_CK1_1	315	321	PF00069	0.557
MOD_CK1_1	45	51	PF00069	0.849
MOD_CK1_1	463	469	PF00069	0.703
MOD_CK1_1	550	556	PF00069	0.552
MOD_CK1_1	640	646	PF00069	0.532
MOD_CK1_1	662	668	PF00069	0.535
MOD_CK1_1	678	684	PF00069	0.574
MOD_CK1_1	755	761	PF00069	0.408
MOD_CK1_1	80	86	PF00069	0.622
MOD_CK2_1	105	111	PF00069	0.611
MOD_CK2_1	257	263	PF00069	0.698
MOD_CK2_1	388	394	PF00069	0.457
MOD_CK2_1	43	49	PF00069	0.593
MOD_CK2_1	446	452	PF00069	0.748
MOD_CK2_1	470	476	PF00069	0.623
MOD_CK2_1	550	556	PF00069	0.654
MOD_CK2_1	597	603	PF00069	0.480
MOD_CK2_1	678	684	PF00069	0.424
MOD_CK2_1	69	75	PF00069	0.574
MOD_CK2_1	728	734	PF00069	0.513
MOD_Cter_Amidation	143	146	PF01082	0.787
MOD_GlcNHglycan	121	124	PF01048	0.743
MOD_GlcNHglycan	125	128	PF01048	0.740
MOD_GlcNHglycan	174	177	PF01048	0.731
MOD_GlcNHglycan	236	239	PF01048	0.662
MOD_GlcNHglycan	249	252	PF01048	0.510
MOD_GlcNHglycan	292	295	PF01048	0.831
MOD_GlcNHglycan	305	308	PF01048	0.753
MOD_GlcNHglycan	317	320	PF01048	0.687
MOD_GlcNHglycan	322	325	PF01048	0.708
MOD_GlcNHglycan	385	388	PF01048	0.543
MOD_GlcNHglycan	39	42	PF01048	0.728
MOD_GlcNHglycan	63	66	PF01048	0.585
MOD_GSK3_1	119	126	PF00069	0.604
MOD_GSK3_1	151	158	PF00069	0.702
MOD_GSK3_1	168	175	PF00069	0.677
MOD_GSK3_1	17	24	PF00069	0.687
MOD_GSK3_1	176	183	PF00069	0.732
MOD_GSK3_1	184	191	PF00069	0.511
MOD_GSK3_1	204	211	PF00069	0.551
MOD_GSK3_1	230	237	PF00069	0.678
MOD_GSK3_1	241	248	PF00069	0.761
MOD_GSK3_1	286	293	PF00069	0.737
MOD_GSK3_1	379	386	PF00069	0.482
MOD_GSK3_1	45	52	PF00069	0.848
MOD_GSK3_1	456	463	PF00069	0.684
MOD_GSK3_1	541	548	PF00069	0.343
MOD_GSK3_1	612	619	PF00069	0.457
MOD_GSK3_1	640	647	PF00069	0.600
MOD_GSK3_1	755	762	PF00069	0.485
MOD_GSK3_1	76	83	PF00069	0.650
MOD_GSK3_1	769	776	PF00069	0.309
MOD_N-GLC_1	3	8	PF02516	0.818
MOD_N-GLC_1	496	501	PF02516	0.491
MOD_N-GLC_1	597	602	PF02516	0.583
MOD_N-GLC_1	703	708	PF02516	0.375
MOD_NEK2_1	157	162	PF00069	0.587
MOD_NEK2_1	241	246	PF00069	0.667
MOD_NEK2_1	247	252	PF00069	0.783
MOD_NEK2_1	395	400	PF00069	0.698
MOD_NEK2_1	418	423	PF00069	0.578
MOD_NEK2_1	458	463	PF00069	0.694
MOD_NEK2_1	475	480	PF00069	0.507
MOD_NEK2_1	509	514	PF00069	0.492
MOD_NEK2_1	555	560	PF00069	0.440
MOD_NEK2_1	659	664	PF00069	0.546
MOD_NEK2_1	703	708	PF00069	0.252
MOD_NEK2_1	728	733	PF00069	0.433
MOD_NEK2_1	752	757	PF00069	0.408
MOD_NEK2_1	78	83	PF00069	0.557
MOD_NEK2_2	496	501	PF00069	0.491
MOD_PIKK_1	163	169	PF00454	0.567
MOD_PIKK_1	395	401	PF00454	0.693
MOD_PIKK_1	408	414	PF00454	0.569
MOD_PIKK_1	437	443	PF00454	0.700
MOD_PIKK_1	703	709	PF00454	0.411
MOD_PK_1	694	700	PF00069	0.402
MOD_PKA_1	694	700	PF00069	0.402
MOD_PKA_2	151	157	PF00069	0.743
MOD_PKA_2	184	190	PF00069	0.707
MOD_PKA_2	204	210	PF00069	0.669
MOD_PKA_2	418	424	PF00069	0.831
MOD_PKA_2	42	48	PF00069	0.620
MOD_PKA_2	461	467	PF00069	0.594
MOD_PKA_2	470	476	PF00069	0.489
MOD_PKA_2	693	699	PF00069	0.411
MOD_PKA_2	759	765	PF00069	0.459
MOD_PKA_2	76	82	PF00069	0.712
MOD_PKA_2	769	775	PF00069	0.337
MOD_Plk_1	446	452	PF00069	0.758
MOD_Plk_1	475	481	PF00069	0.508
MOD_Plk_1	496	502	PF00069	0.492
MOD_Plk_1	517	523	PF00069	0.650
MOD_Plk_1	550	556	PF00069	0.552
MOD_Plk_1	597	603	PF00069	0.436
MOD_Plk_1	703	709	PF00069	0.468
MOD_Plk_1	794	800	PF00069	0.411
MOD_Plk_2-3	280	286	PF00069	0.798
MOD_Plk_2-3	545	551	PF00069	0.393
MOD_Plk_4	204	210	PF00069	0.686
MOD_Plk_4	242	248	PF00069	0.550
MOD_Plk_4	428	434	PF00069	0.578
MOD_Plk_4	470	476	PF00069	0.623
MOD_Plk_4	509	515	PF00069	0.502
MOD_Plk_4	517	523	PF00069	0.520
MOD_Plk_4	550	556	PF00069	0.552
MOD_Plk_4	684	690	PF00069	0.486
MOD_Plk_4	745	751	PF00069	0.387
MOD_Plk_4	769	775	PF00069	0.381
MOD_Plk_4	776	782	PF00069	0.400
MOD_Plk_4	815	821	PF00069	0.290
MOD_ProDKin_1	19	25	PF00069	0.740
MOD_ProDKin_1	236	242	PF00069	0.711
MOD_ProDKin_1	29	35	PF00069	0.738
MOD_ProDKin_1	296	302	PF00069	0.758
MOD_ProDKin_1	359	365	PF00069	0.562
MOD_ProDKin_1	526	532	PF00069	0.507
MOD_ProDKin_1	640	646	PF00069	0.747
MOD_ProDKin_1	662	668	PF00069	0.591
MOD_ProDKin_1	675	681	PF00069	0.538
MOD_ProDKin_1	773	779	PF00069	0.355
MOD_SUMO_rev_2	628	635	PF00179	0.522
MOD_SUMO_rev_2	741	749	PF00179	0.411
TRG_DiLeu_BaEn_1	217	222	PF01217	0.556
TRG_DiLeu_BaEn_2	630	636	PF01217	0.521
TRG_DiLeu_BaEn_2	683	689	PF01217	0.523
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.526
TRG_ENDOCYTIC_2	243	246	PF00928	0.579
TRG_ENDOCYTIC_2	278	281	PF00928	0.739
TRG_ENDOCYTIC_2	346	349	PF00928	0.573
TRG_ENDOCYTIC_2	802	805	PF00928	0.411
TRG_ER_diArg_1	140	143	PF00400	0.745
TRG_ER_diArg_1	145	148	PF00400	0.752
TRG_ER_diArg_1	149	152	PF00400	0.754
TRG_ER_diArg_1	369	371	PF00400	0.403
TRG_ER_diArg_1	468	471	PF00400	0.546
TRG_ER_diArg_1	493	496	PF00400	0.426
TRG_NES_CRM1_1	441	452	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.764
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K4	Leptomonas seymouri	61%	99%
A0A3S7WTL5	Leishmania donovani	74%	99%
A4HWL6	Leishmania infantum	75%	99%
E9AQC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QF51	Leishmania major	74%	100%