Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4H893_LEIBR

TriTrypDb:

LbrM.15.1250 , LBRM2903_150022000

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H893

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H893

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.493
CLV_C14_Caspase3-7	923	927	PF00656	0.495
CLV_NRD_NRD_1	1	3	PF00675	0.489
CLV_NRD_NRD_1	226	228	PF00675	0.440
CLV_NRD_NRD_1	46	48	PF00675	0.632
CLV_NRD_NRD_1	670	672	PF00675	0.400
CLV_NRD_NRD_1	673	675	PF00675	0.434
CLV_NRD_NRD_1	820	822	PF00675	0.415
CLV_NRD_NRD_1	928	930	PF00675	0.624
CLV_PCSK_FUR_1	44	48	PF00082	0.538
CLV_PCSK_FUR_1	671	675	PF00082	0.480
CLV_PCSK_KEX2_1	46	48	PF00082	0.550
CLV_PCSK_KEX2_1	669	671	PF00082	0.510
CLV_PCSK_KEX2_1	673	675	PF00082	0.538
CLV_PCSK_KEX2_1	820	822	PF00082	0.415
CLV_PCSK_KEX2_1	928	930	PF00082	0.624
CLV_PCSK_PC7_1	669	675	PF00082	0.519
CLV_PCSK_SKI1_1	102	106	PF00082	0.423
CLV_PCSK_SKI1_1	166	170	PF00082	0.374
CLV_PCSK_SKI1_1	258	262	PF00082	0.341
CLV_PCSK_SKI1_1	330	334	PF00082	0.329
CLV_PCSK_SKI1_1	425	429	PF00082	0.327
CLV_PCSK_SKI1_1	432	436	PF00082	0.327
CLV_PCSK_SKI1_1	587	591	PF00082	0.600
CLV_PCSK_SKI1_1	802	806	PF00082	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	509	515	PF00134	0.327
DOC_MAPK_gen_1	399	408	PF00069	0.456
DOC_MAPK_gen_1	44	52	PF00069	0.515
DOC_MAPK_gen_1	587	597	PF00069	0.593
DOC_MAPK_gen_1	928	935	PF00069	0.471
DOC_MAPK_HePTP_8	925	937	PF00069	0.452
DOC_MAPK_MEF2A_6	330	339	PF00069	0.457
DOC_MAPK_MEF2A_6	571	578	PF00069	0.619
DOC_MAPK_MEF2A_6	602	610	PF00069	0.549
DOC_MAPK_MEF2A_6	928	937	PF00069	0.477
DOC_MAPK_NFAT4_5	330	338	PF00069	0.457
DOC_MAPK_NFAT4_5	571	579	PF00069	0.621
DOC_PP1_RVXF_1	121	128	PF00149	0.317
DOC_PP2B_LxvP_1	333	336	PF13499	0.327
DOC_PP4_FxxP_1	616	619	PF00568	0.510
DOC_USP7_MATH_1	25	29	PF00917	0.662
DOC_USP7_MATH_1	273	277	PF00917	0.451
DOC_USP7_MATH_1	382	386	PF00917	0.321
DOC_USP7_MATH_1	437	441	PF00917	0.359
DOC_USP7_MATH_1	604	608	PF00917	0.561
DOC_USP7_MATH_1	781	785	PF00917	0.288
DOC_USP7_MATH_1	795	799	PF00917	0.315
DOC_WW_Pin1_4	196	201	PF00397	0.569
DOC_WW_Pin1_4	595	600	PF00397	0.512
DOC_WW_Pin1_4	615	620	PF00397	0.367
DOC_WW_Pin1_4	732	737	PF00397	0.327
LIG_14-3-3_CanoR_1	102	107	PF00244	0.589
LIG_14-3-3_CanoR_1	316	322	PF00244	0.462
LIG_14-3-3_CanoR_1	439	443	PF00244	0.371
LIG_14-3-3_CanoR_1	492	501	PF00244	0.501
LIG_14-3-3_CanoR_1	580	589	PF00244	0.591
LIG_14-3-3_CanoR_1	6	12	PF00244	0.486
LIG_14-3-3_CanoR_1	629	633	PF00244	0.368
LIG_14-3-3_CanoR_1	928	937	PF00244	0.729
LIG_BIR_III_4	76	80	PF00653	0.487
LIG_BRCT_BRCA1_1	439	443	PF00533	0.327
LIG_BRCT_BRCA1_1	606	610	PF00533	0.564
LIG_BRCT_BRCA1_1	617	621	PF00533	0.397
LIG_Clathr_ClatBox_1	703	707	PF01394	0.244
LIG_eIF4E_1	780	786	PF01652	0.415
LIG_FHA_1	129	135	PF00498	0.424
LIG_FHA_1	14	20	PF00498	0.605
LIG_FHA_1	165	171	PF00498	0.515
LIG_FHA_1	327	333	PF00498	0.327
LIG_FHA_1	458	464	PF00498	0.496
LIG_FHA_1	503	509	PF00498	0.327
LIG_FHA_1	543	549	PF00498	0.327
LIG_FHA_1	712	718	PF00498	0.327
LIG_FHA_1	764	770	PF00498	0.244
LIG_FHA_2	114	120	PF00498	0.341
LIG_FHA_2	21	27	PF00498	0.706
LIG_FHA_2	241	247	PF00498	0.599
LIG_FHA_2	257	263	PF00498	0.379
LIG_FHA_2	472	478	PF00498	0.501
LIG_FHA_2	537	543	PF00498	0.379
LIG_FHA_2	596	602	PF00498	0.472
LIG_LIR_Apic_2	615	619	PF02991	0.520
LIG_LIR_Gen_1	119	129	PF02991	0.573
LIG_LIR_Gen_1	131	141	PF02991	0.514
LIG_LIR_Gen_1	372	383	PF02991	0.327
LIG_LIR_Gen_1	451	457	PF02991	0.371
LIG_LIR_Gen_1	536	546	PF02991	0.393
LIG_LIR_Gen_1	58	67	PF02991	0.456
LIG_LIR_Gen_1	618	626	PF02991	0.408
LIG_LIR_Gen_1	692	699	PF02991	0.271
LIG_LIR_Gen_1	707	717	PF02991	0.327
LIG_LIR_Gen_1	803	812	PF02991	0.416
LIG_LIR_Gen_1	95	104	PF02991	0.558
LIG_LIR_Nem_3	119	124	PF02991	0.570
LIG_LIR_Nem_3	131	136	PF02991	0.502
LIG_LIR_Nem_3	173	178	PF02991	0.453
LIG_LIR_Nem_3	372	378	PF02991	0.327
LIG_LIR_Nem_3	536	541	PF02991	0.352
LIG_LIR_Nem_3	544	549	PF02991	0.326
LIG_LIR_Nem_3	550	555	PF02991	0.355
LIG_LIR_Nem_3	58	63	PF02991	0.436
LIG_LIR_Nem_3	618	624	PF02991	0.387
LIG_LIR_Nem_3	692	696	PF02991	0.271
LIG_LIR_Nem_3	707	712	PF02991	0.327
LIG_LIR_Nem_3	768	773	PF02991	0.368
LIG_LIR_Nem_3	803	807	PF02991	0.391
LIG_LIR_Nem_3	95	99	PF02991	0.680
LIG_PCNA_yPIPBox_3	418	428	PF02747	0.244
LIG_PCNA_yPIPBox_3	516	528	PF02747	0.371
LIG_PDZ_Class_2	932	937	PF00595	0.490
LIG_PTB_Apo_2	169	176	PF02174	0.511
LIG_PTB_Apo_2	724	731	PF02174	0.327
LIG_PTB_Phospho_1	169	175	PF10480	0.519
LIG_PTB_Phospho_1	724	730	PF10480	0.327
LIG_Rb_pABgroove_1	866	874	PF01858	0.346
LIG_REV1ctd_RIR_1	893	901	PF16727	0.346
LIG_RPA_C_Fungi	575	587	PF08784	0.510
LIG_SH2_CRK	672	676	PF00017	0.390
LIG_SH2_CRK	782	786	PF00017	0.415
LIG_SH2_CRK	96	100	PF00017	0.587
LIG_SH2_GRB2like	133	136	PF00017	0.609
LIG_SH2_GRB2like	677	680	PF00017	0.327
LIG_SH2_PTP2	133	136	PF00017	0.502
LIG_SH2_PTP2	175	178	PF00017	0.384
LIG_SH2_PTP2	709	712	PF00017	0.457
LIG_SH2_SRC	133	136	PF00017	0.394
LIG_SH2_SRC	488	491	PF00017	0.327
LIG_SH2_SRC	693	696	PF00017	0.244
LIG_SH2_STAP1	204	208	PF00017	0.403
LIG_SH2_STAP1	453	457	PF00017	0.371
LIG_SH2_STAT3	204	207	PF00017	0.389
LIG_SH2_STAT3	503	506	PF00017	0.346
LIG_SH2_STAT5	133	136	PF00017	0.448
LIG_SH2_STAT5	175	178	PF00017	0.435
LIG_SH2_STAT5	298	301	PF00017	0.313
LIG_SH2_STAT5	693	696	PF00017	0.355
LIG_SH2_STAT5	709	712	PF00017	0.497
LIG_SH2_STAT5	730	733	PF00017	0.327
LIG_SH3_3	122	128	PF00018	0.371
LIG_SH3_3	284	290	PF00018	0.363
LIG_SH3_3	303	309	PF00018	0.457
LIG_SH3_3	833	839	PF00018	0.363
LIG_SUMO_SIM_anti_2	407	413	PF11976	0.472
LIG_SUMO_SIM_anti_2	518	524	PF11976	0.327
LIG_SUMO_SIM_anti_2	803	809	PF11976	0.254
LIG_SUMO_SIM_par_1	403	410	PF11976	0.441
LIG_SUMO_SIM_par_1	593	598	PF11976	0.543
LIG_SUMO_SIM_par_1	709	714	PF11976	0.327
LIG_TRAF2_1	243	246	PF00917	0.668
LIG_TRAF2_1	598	601	PF00917	0.567
LIG_TYR_ITIM	640	645	PF00017	0.375
LIG_TYR_ITSM	129	136	PF00017	0.284
LIG_UBA3_1	442	447	PF00899	0.457
LIG_WRC_WIRS_1	375	380	PF05994	0.327
LIG_WRC_WIRS_1	801	806	PF05994	0.213
LIG_WRC_WIRS_1	900	905	PF05994	0.244
MOD_CDK_SPxxK_3	595	602	PF00069	0.499
MOD_CK1_1	536	542	PF00069	0.442
MOD_CK1_1	68	74	PF00069	0.728
MOD_CK1_1	741	747	PF00069	0.327
MOD_CK1_1	763	769	PF00069	0.244
MOD_CK1_1	834	840	PF00069	0.367
MOD_CK1_1	875	881	PF00069	0.288
MOD_CK1_1	931	937	PF00069	0.718
MOD_CK2_1	240	246	PF00069	0.608
MOD_CK2_1	256	262	PF00069	0.422
MOD_CK2_1	456	462	PF00069	0.415
MOD_CK2_1	471	477	PF00069	0.223
MOD_CK2_1	50	56	PF00069	0.542
MOD_CK2_1	595	601	PF00069	0.468
MOD_CK2_1	745	751	PF00069	0.359
MOD_CK2_1	800	806	PF00069	0.399
MOD_Cter_Amidation	926	929	PF01082	0.589
MOD_GlcNHglycan	153	157	PF01048	0.478
MOD_GlcNHglycan	301	304	PF01048	0.415
MOD_GlcNHglycan	358	361	PF01048	0.371
MOD_GlcNHglycan	477	480	PF01048	0.387
MOD_GlcNHglycan	494	497	PF01048	0.424
MOD_GlcNHglycan	56	60	PF01048	0.489
MOD_GlcNHglycan	583	586	PF01048	0.503
MOD_GlcNHglycan	611	614	PF01048	0.377
MOD_GlcNHglycan	70	73	PF01048	0.638
MOD_GlcNHglycan	741	744	PF01048	0.327
MOD_GlcNHglycan	930	933	PF01048	0.471
MOD_GSK3_1	108	115	PF00069	0.549
MOD_GSK3_1	148	155	PF00069	0.675
MOD_GSK3_1	166	173	PF00069	0.535
MOD_GSK3_1	190	197	PF00069	0.552
MOD_GSK3_1	240	247	PF00069	0.529
MOD_GSK3_1	249	256	PF00069	0.357
MOD_GSK3_1	260	267	PF00069	0.292
MOD_GSK3_1	322	329	PF00069	0.331
MOD_GSK3_1	33	40	PF00069	0.528
MOD_GSK3_1	471	478	PF00069	0.377
MOD_GSK3_1	488	495	PF00069	0.369
MOD_GSK3_1	533	540	PF00069	0.265
MOD_GSK3_1	553	560	PF00069	0.331
MOD_GSK3_1	741	748	PF00069	0.327
MOD_GSK3_1	81	88	PF00069	0.709
MOD_GSK3_1	9	16	PF00069	0.648
MOD_N-GLC_1	317	322	PF02516	0.483
MOD_N-GLC_1	391	396	PF02516	0.533
MOD_N-GLC_1	557	562	PF02516	0.422
MOD_N-GLC_1	725	730	PF02516	0.352
MOD_N-GLC_1	745	750	PF02516	0.327
MOD_N-GLC_1	834	839	PF02516	0.378
MOD_N-GLC_1	85	90	PF02516	0.659
MOD_NEK2_1	152	157	PF00069	0.423
MOD_NEK2_1	170	175	PF00069	0.506
MOD_NEK2_1	195	200	PF00069	0.496
MOD_NEK2_1	244	249	PF00069	0.481
MOD_NEK2_1	339	344	PF00069	0.415
MOD_NEK2_1	37	42	PF00069	0.537
MOD_NEK2_1	374	379	PF00069	0.332
MOD_NEK2_1	456	461	PF00069	0.346
MOD_NEK2_1	645	650	PF00069	0.429
MOD_NEK2_1	711	716	PF00069	0.341
MOD_NEK2_1	840	845	PF00069	0.346
MOD_NEK2_1	872	877	PF00069	0.375
MOD_NEK2_2	209	214	PF00069	0.273
MOD_NEK2_2	273	278	PF00069	0.335
MOD_NEK2_2	382	387	PF00069	0.321
MOD_NEK2_2	533	538	PF00069	0.346
MOD_PIKK_1	502	508	PF00454	0.346
MOD_PIKK_1	81	87	PF00454	0.702
MOD_PIKK_1	97	103	PF00454	0.382
MOD_PK_1	504	510	PF00069	0.457
MOD_PKA_1	928	934	PF00069	0.639
MOD_PKA_2	240	246	PF00069	0.542
MOD_PKA_2	264	270	PF00069	0.327
MOD_PKA_2	438	444	PF00069	0.371
MOD_PKA_2	542	548	PF00069	0.277
MOD_PKA_2	579	585	PF00069	0.596
MOD_PKA_2	628	634	PF00069	0.399
MOD_PKA_2	81	87	PF00069	0.507
MOD_PKA_2	928	934	PF00069	0.649
MOD_Plk_1	244	250	PF00069	0.500
MOD_Plk_1	317	323	PF00069	0.353
MOD_Plk_1	391	397	PF00069	0.535
MOD_Plk_1	437	443	PF00069	0.327
MOD_Plk_1	55	61	PF00069	0.450
MOD_Plk_1	557	563	PF00069	0.427
MOD_Plk_1	657	663	PF00069	0.452
MOD_Plk_1	725	731	PF00069	0.331
MOD_Plk_1	745	751	PF00069	0.327
MOD_Plk_1	840	846	PF00069	0.406
MOD_Plk_2-3	800	806	PF00069	0.330
MOD_Plk_4	166	172	PF00069	0.499
MOD_Plk_4	190	196	PF00069	0.638
MOD_Plk_4	244	250	PF00069	0.472
MOD_Plk_4	264	270	PF00069	0.341
MOD_Plk_4	339	345	PF00069	0.327
MOD_Plk_4	37	43	PF00069	0.536
MOD_Plk_4	391	397	PF00069	0.537
MOD_Plk_4	407	413	PF00069	0.440
MOD_Plk_4	419	425	PF00069	0.397
MOD_Plk_4	438	444	PF00069	0.207
MOD_Plk_4	504	510	PF00069	0.327
MOD_Plk_4	657	663	PF00069	0.417
MOD_Plk_4	689	695	PF00069	0.335
MOD_Plk_4	725	731	PF00069	0.338
MOD_Plk_4	745	751	PF00069	0.352
MOD_Plk_4	800	806	PF00069	0.213
MOD_Plk_4	823	829	PF00069	0.511
MOD_Plk_4	899	905	PF00069	0.244
MOD_ProDKin_1	196	202	PF00069	0.557
MOD_ProDKin_1	595	601	PF00069	0.505
MOD_ProDKin_1	615	621	PF00069	0.362
MOD_ProDKin_1	732	738	PF00069	0.327
MOD_SUMO_rev_2	798	804	PF00179	0.213
TRG_DiLeu_BaEn_1	245	250	PF01217	0.505
TRG_DiLeu_BaEn_2	799	805	PF01217	0.213
TRG_ENDOCYTIC_2	133	136	PF00928	0.576
TRG_ENDOCYTIC_2	175	178	PF00928	0.394
TRG_ENDOCYTIC_2	453	456	PF00928	0.371
TRG_ENDOCYTIC_2	642	645	PF00928	0.380
TRG_ENDOCYTIC_2	672	675	PF00928	0.394
TRG_ENDOCYTIC_2	677	680	PF00928	0.327
TRG_ENDOCYTIC_2	681	684	PF00928	0.327
TRG_ENDOCYTIC_2	693	696	PF00928	0.327
TRG_ENDOCYTIC_2	709	712	PF00928	0.457
TRG_ENDOCYTIC_2	782	785	PF00928	0.406
TRG_ENDOCYTIC_2	96	99	PF00928	0.553
TRG_ER_diArg_1	45	47	PF00400	0.617
TRG_ER_diArg_1	669	671	PF00400	0.520
TRG_ER_diArg_1	672	674	PF00400	0.523
TRG_ER_diArg_1	820	822	PF00400	0.415
TRG_ER_diArg_1	928	930	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	783	787	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	820	825	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	65%	100%
A0A1X0NUP8	Trypanosomatidae	62%	100%
A0A3Q8I987	Leishmania donovani	77%	100%
A0A3R7RI37	Trypanosoma rangeli	69%	100%
A0A3S7WTN0	Leishmania donovani	84%	100%
A4H8B6	Leishmania braziliensis	82%	100%
A4HWN6	Leishmania infantum	84%	100%
A4HWN7	Leishmania infantum	77%	100%
B3P3K2	Drosophila erecta	29%	83%
B4JXX2	Drosophila grimshawi	28%	87%
B4K9L4	Drosophila mojavensis	28%	84%
B4LVU6	Drosophila virilis	28%	100%
B4NAL6	Drosophila willistoni	28%	83%
B4PSS5	Drosophila yakuba	29%	82%
B4QZU1	Drosophila simulans	29%	82%
C9ZXQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
C9ZXQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AQE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AQE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O00408	Homo sapiens	30%	100%
O54735	Rattus norvegicus	28%	100%
O76074	Homo sapiens	28%	100%
O77746	Canis lupus familiaris	28%	100%
P0C1Q2	Mus musculus	31%	100%
P11541	Bos taurus	24%	100%
P14099	Bos taurus	30%	100%
P16499	Homo sapiens	25%	100%
P16586	Bos taurus	26%	100%
P23439	Bos taurus	25%	100%
P23440	Mus musculus	25%	100%
P27664	Mus musculus	24%	100%
P33726	Canis lupus familiaris	25%	100%
P35913	Homo sapiens	24%	100%
P51160	Homo sapiens	25%	100%
P52731	Gallus gallus	25%	100%
Q01062	Rattus norvegicus	30%	100%
Q1KKS3	Takifugu rubripes	32%	100%
Q28156	Bos taurus	28%	100%
Q28263	Canis lupus familiaris	25%	100%
Q298P4	Drosophila pseudoobscura pseudoobscura	29%	84%
Q4QF31	Leishmania major	76%	100%
Q8CA95	Mus musculus	29%	100%
Q8CG03	Mus musculus	28%	100%
Q8VID6	Rattus norvegicus	31%	100%
Q91ZQ1	Mus musculus	26%	100%
Q922S4	Mus musculus	30%	100%
Q9HCR9	Homo sapiens	31%	100%
Q9QYJ6	Rattus norvegicus	29%	100%
Q9VFI9	Drosophila melanogaster	29%	84%
Q9Y233	Homo sapiens	29%	100%