Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H889_LEIBR

TriTrypDb:

LbrM.15.1210 , LBRM2903_150019400

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H889

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H889

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.478
CLV_C14_Caspase3-7	415	419	PF00656	0.453
CLV_NRD_NRD_1	305	307	PF00675	0.401
CLV_NRD_NRD_1	376	378	PF00675	0.554
CLV_NRD_NRD_1	70	72	PF00675	0.401
CLV_NRD_NRD_1	89	91	PF00675	0.382
CLV_PCSK_KEX2_1	376	378	PF00082	0.615
CLV_PCSK_KEX2_1	380	382	PF00082	0.622
CLV_PCSK_KEX2_1	44	46	PF00082	0.405
CLV_PCSK_KEX2_1	474	476	PF00082	0.784
CLV_PCSK_KEX2_1	89	91	PF00082	0.485
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.539
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.420
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.769
CLV_PCSK_PC7_1	376	382	PF00082	0.405
CLV_PCSK_SKI1_1	215	219	PF00082	0.391
CLV_PCSK_SKI1_1	291	295	PF00082	0.566
CLV_PCSK_SKI1_1	307	311	PF00082	0.293
CLV_PCSK_SKI1_1	312	316	PF00082	0.336
CLV_PCSK_SKI1_1	319	323	PF00082	0.392
CLV_PCSK_SKI1_1	377	381	PF00082	0.586
DEG_APCC_DBOX_1	123	131	PF00400	0.445
DEG_APCC_DBOX_1	311	319	PF00400	0.363
DEG_SPOP_SBC_1	235	239	PF00917	0.473
DEG_SPOP_SBC_1	257	261	PF00917	0.651
DEG_SPOP_SBC_1	270	274	PF00917	0.553
DOC_CYCLIN_RxL_1	316	325	PF00134	0.381
DOC_CYCLIN_yClb1_LxF_4	189	195	PF00134	0.321
DOC_MAPK_FxFP_2	332	335	PF00069	0.544
DOC_MAPK_gen_1	71	79	PF00069	0.449
DOC_MAPK_MEF2A_6	364	372	PF00069	0.600
DOC_PP2B_LxvP_1	21	24	PF13499	0.536
DOC_PP2B_LxvP_1	321	324	PF13499	0.405
DOC_PP4_FxxP_1	332	335	PF00568	0.544
DOC_PP4_FxxP_1	49	52	PF00568	0.449
DOC_USP7_MATH_1	236	240	PF00917	0.533
DOC_USP7_MATH_1	255	259	PF00917	0.603
DOC_USP7_MATH_1	263	267	PF00917	0.751
DOC_USP7_MATH_1	271	275	PF00917	0.689
DOC_USP7_MATH_1	455	459	PF00917	0.558
DOC_USP7_MATH_1	461	465	PF00917	0.510
DOC_USP7_MATH_2	26	32	PF00917	0.459
DOC_USP7_UBL2_3	294	298	PF12436	0.475
DOC_WW_Pin1_4	223	228	PF00397	0.508
LIG_14-3-3_CanoR_1	306	314	PF00244	0.479
LIG_14-3-3_CanoR_1	396	400	PF00244	0.589
LIG_14-3-3_CanoR_1	4	10	PF00244	0.636
LIG_14-3-3_CanoR_1	475	481	PF00244	0.489
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_Clathr_ClatBox_1	131	135	PF01394	0.342
LIG_deltaCOP1_diTrp_1	366	372	PF00928	0.509
LIG_deltaCOP1_diTrp_1	86	91	PF00928	0.571
LIG_FHA_1	279	285	PF00498	0.401
LIG_FHA_2	201	207	PF00498	0.303
LIG_FHA_2	338	344	PF00498	0.555
LIG_FHA_2	97	103	PF00498	0.405
LIG_GBD_Chelix_1	350	358	PF00786	0.368
LIG_LIR_Gen_1	110	119	PF02991	0.612
LIG_LIR_Gen_1	125	134	PF02991	0.233
LIG_LIR_Gen_1	187	195	PF02991	0.331
LIG_LIR_Gen_1	366	374	PF02991	0.455
LIG_LIR_Gen_1	78	88	PF02991	0.384
LIG_LIR_Nem_3	110	115	PF02991	0.523
LIG_LIR_Nem_3	125	131	PF02991	0.241
LIG_LIR_Nem_3	187	191	PF02991	0.341
LIG_LIR_Nem_3	366	372	PF02991	0.435
LIG_LIR_Nem_3	78	84	PF02991	0.410
LIG_NRBOX	317	323	PF00104	0.489
LIG_PCNA_yPIPBox_3	59	72	PF02747	0.386
LIG_Pex14_2	176	180	PF04695	0.484
LIG_SH2_CRK	112	116	PF00017	0.452
LIG_SH2_CRK	128	132	PF00017	0.314
LIG_SH2_CRK	188	192	PF00017	0.361
LIG_SH2_CRK	81	85	PF00017	0.408
LIG_SH2_GRB2like	188	191	PF00017	0.363
LIG_SH2_GRB2like	245	248	PF00017	0.493
LIG_SH2_STAP1	128	132	PF00017	0.336
LIG_SH2_STAP1	188	192	PF00017	0.361
LIG_SH2_STAP1	245	249	PF00017	0.487
LIG_SH2_STAP1	81	85	PF00017	0.365
LIG_SH2_STAT3	410	413	PF00017	0.503
LIG_SH2_STAT5	149	152	PF00017	0.491
LIG_SH2_STAT5	211	214	PF00017	0.369
LIG_SH3_3	17	23	PF00018	0.690
LIG_SH3_3	221	227	PF00018	0.487
LIG_SUMO_SIM_par_1	337	343	PF11976	0.415
LIG_SUMO_SIM_par_1	349	355	PF11976	0.316
LIG_TRAF2_1	299	302	PF00917	0.647
LIG_TRAF2_1	324	327	PF00917	0.484
LIG_TYR_ITIM	79	84	PF00017	0.505
LIG_WRC_WIRS_1	97	102	PF05994	0.590
MOD_CK1_1	145	151	PF00069	0.537
MOD_CK1_1	239	245	PF00069	0.549
MOD_CK1_1	258	264	PF00069	0.690
MOD_CK1_1	278	284	PF00069	0.496
MOD_CK1_1	305	311	PF00069	0.467
MOD_CK1_1	470	476	PF00069	0.681
MOD_CK2_1	296	302	PF00069	0.682
MOD_CK2_1	337	343	PF00069	0.474
MOD_CK2_1	96	102	PF00069	0.608
MOD_GlcNHglycan	239	242	PF01048	0.522
MOD_GlcNHglycan	260	263	PF01048	0.703
MOD_GlcNHglycan	273	276	PF01048	0.686
MOD_GlcNHglycan	307	310	PF01048	0.429
MOD_GlcNHglycan	414	417	PF01048	0.552
MOD_GlcNHglycan	444	447	PF01048	0.685
MOD_GlcNHglycan	464	467	PF01048	0.742
MOD_GlcNHglycan	469	472	PF01048	0.720
MOD_GSK3_1	141	148	PF00069	0.466
MOD_GSK3_1	235	242	PF00069	0.567
MOD_GSK3_1	24	31	PF00069	0.540
MOD_GSK3_1	257	264	PF00069	0.686
MOD_GSK3_1	265	272	PF00069	0.678
MOD_GSK3_1	275	282	PF00069	0.501
MOD_GSK3_1	408	415	PF00069	0.698
MOD_GSK3_1	475	482	PF00069	0.492
MOD_N-GLC_1	255	260	PF02516	0.511
MOD_N-GLC_1	275	280	PF02516	0.430
MOD_NEK2_1	195	200	PF00069	0.318
MOD_NEK2_1	249	254	PF00069	0.473
MOD_NEK2_1	409	414	PF00069	0.546
MOD_NEK2_1	476	481	PF00069	0.729
MOD_NEK2_1	79	84	PF00069	0.413
MOD_PIKK_1	409	415	PF00454	0.684
MOD_PIKK_1	79	85	PF00454	0.357
MOD_PKA_2	145	151	PF00069	0.387
MOD_PKA_2	305	311	PF00069	0.543
MOD_PKA_2	395	401	PF00069	0.531
MOD_PKA_2	461	467	PF00069	0.657
MOD_PKA_2	5	11	PF00069	0.657
MOD_PKB_1	460	468	PF00069	0.634
MOD_Plk_4	145	151	PF00069	0.438
MOD_Plk_4	200	206	PF00069	0.313
MOD_Plk_4	33	39	PF00069	0.567
MOD_Plk_4	476	482	PF00069	0.488
MOD_Plk_4	96	102	PF00069	0.487
MOD_ProDKin_1	223	229	PF00069	0.510
MOD_SUMO_for_1	132	135	PF00179	0.392
TRG_ENDOCYTIC_2	112	115	PF00928	0.621
TRG_ENDOCYTIC_2	128	131	PF00928	0.330
TRG_ENDOCYTIC_2	188	191	PF00928	0.362
TRG_ENDOCYTIC_2	35	38	PF00928	0.577
TRG_ENDOCYTIC_2	399	402	PF00928	0.508
TRG_ENDOCYTIC_2	81	84	PF00928	0.348
TRG_ER_diArg_1	4	7	PF00400	0.645
TRG_ER_diArg_1	460	463	PF00400	0.644
TRG_ER_diArg_1	88	90	PF00400	0.450
TRG_NES_CRM1_1	313	327	PF08389	0.377
TRG_NLS_MonoExtC_3	426	431	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	312	317	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	25%	87%
A0A0N1ILX4	Leptomonas seymouri	60%	100%
A0A0S4JKE9	Bodo saltans	51%	100%
A0A1X0NTZ8	Trypanosomatidae	54%	100%
A0A1X0NZT5	Trypanosomatidae	25%	100%
A0A3Q8IAB6	Leishmania donovani	84%	89%
A0A3S5IRP3	Trypanosoma rangeli	54%	100%
A0A3S7X2J5	Leishmania donovani	26%	90%
A4HHF5	Leishmania braziliensis	26%	96%
A4HWL2	Leishmania infantum	85%	89%
A4I4K3	Leishmania infantum	26%	90%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AE02	Leishmania major	25%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	89%
Q4QF55	Leishmania major	86%	100%
V5B4N1	Trypanosoma cruzi	54%	100%
V5D9T1	Trypanosoma cruzi	25%	100%