SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H888_LEIBR

TriTrypDb:

LbrM.15.1200 , LBRM2903_150019200

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H888

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H888

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.283
CLV_NRD_NRD_1	242	244	PF00675	0.283
CLV_NRD_NRD_1	245	247	PF00675	0.283
CLV_NRD_NRD_1	378	380	PF00675	0.692
CLV_PCSK_FUR_1	243	247	PF00082	0.337
CLV_PCSK_KEX2_1	238	240	PF00082	0.285
CLV_PCSK_KEX2_1	242	244	PF00082	0.279
CLV_PCSK_KEX2_1	245	247	PF00082	0.279
CLV_PCSK_KEX2_1	378	380	PF00082	0.690
CLV_PCSK_PC7_1	238	244	PF00082	0.334
CLV_PCSK_SKI1_1	216	220	PF00082	0.393
CLV_PCSK_SKI1_1	295	299	PF00082	0.386
CLV_PCSK_SKI1_1	344	348	PF00082	0.706
CLV_PCSK_SKI1_1	52	56	PF00082	0.387
DEG_APCC_DBOX_1	215	223	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_CYCLIN_RxL_1	47	59	PF00134	0.454
DOC_MAPK_gen_1	133	140	PF00069	0.548
DOC_MAPK_gen_1	189	195	PF00069	0.484
DOC_PP4_FxxP_1	202	205	PF00568	0.423
DOC_USP7_MATH_1	175	179	PF00917	0.519
DOC_WW_Pin1_4	149	154	PF00397	0.514
DOC_WW_Pin1_4	59	64	PF00397	0.538
LIG_14-3-3_CanoR_1	133	140	PF00244	0.571
LIG_14-3-3_CanoR_1	181	185	PF00244	0.441
LIG_14-3-3_CanoR_1	313	320	PF00244	0.459
LIG_14-3-3_CanoR_1	348	355	PF00244	0.593
LIG_14-3-3_CanoR_1	47	55	PF00244	0.420
LIG_Actin_WH2_2	233	250	PF00022	0.363
LIG_APCC_ABBA_1	258	263	PF00400	0.562
LIG_APCC_ABBA_1	36	41	PF00400	0.442
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.294
LIG_BRCT_BRCA1_1	314	318	PF00533	0.489
LIG_BRCT_BRCA1_1	7	11	PF00533	0.657
LIG_BRCT_BRCA1_2	7	13	PF00533	0.637
LIG_CaM_IQ_9	208	223	PF13499	0.489
LIG_eIF4E_1	230	236	PF01652	0.544
LIG_FHA_1	199	205	PF00498	0.462
LIG_FHA_1	213	219	PF00498	0.372
LIG_FHA_1	59	65	PF00498	0.516
LIG_FHA_1	70	76	PF00498	0.299
LIG_FHA_2	291	297	PF00498	0.586
LIG_Integrin_RGD_1	379	381	PF01839	0.468
LIG_LIR_Apic_2	200	205	PF02991	0.428
LIG_LIR_Gen_1	152	158	PF02991	0.489
LIG_LIR_Gen_1	183	191	PF02991	0.408
LIG_LIR_Nem_3	166	172	PF02991	0.603
LIG_PDZ_Class_1	386	391	PF00595	0.740
LIG_Pex14_2	163	167	PF04695	0.459
LIG_Pex14_2	202	206	PF04695	0.399
LIG_Pex14_2	318	322	PF04695	0.387
LIG_SH2_CRK	320	324	PF00017	0.401
LIG_SH2_STAP1	154	158	PF00017	0.494
LIG_SH2_STAT5	116	119	PF00017	0.363
LIG_SH2_STAT5	261	264	PF00017	0.553
LIG_SH3_5	226	230	PF00018	0.518
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.515
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.541
LIG_SUMO_SIM_par_1	290	296	PF11976	0.488
LIG_SUMO_SIM_par_1	326	332	PF11976	0.541
LIG_SUMO_SIM_par_1	76	82	PF11976	0.540
LIG_TRAF2_1	183	186	PF00917	0.459
LIG_TRAF2_1	299	302	PF00917	0.482
LIG_TYR_ITIM	259	264	PF00017	0.482
MOD_CDK_SPxxK_3	149	156	PF00069	0.511
MOD_CK1_1	59	65	PF00069	0.519
MOD_CK2_1	133	139	PF00069	0.580
MOD_CK2_1	180	186	PF00069	0.422
MOD_GlcNHglycan	121	124	PF01048	0.364
MOD_GlcNHglycan	135	138	PF01048	0.431
MOD_GlcNHglycan	147	150	PF01048	0.528
MOD_GlcNHglycan	314	317	PF01048	0.491
MOD_GlcNHglycan	381	384	PF01048	0.637
MOD_GlcNHglycan	75	78	PF01048	0.301
MOD_GSK3_1	129	136	PF00069	0.507
MOD_GSK3_1	145	152	PF00069	0.529
MOD_GSK3_1	39	46	PF00069	0.540
MOD_GSK3_1	54	61	PF00069	0.429
MOD_GSK3_1	69	76	PF00069	0.263
MOD_GSK3_1	79	86	PF00069	0.405
MOD_N-GLC_1	265	270	PF02516	0.335
MOD_NEK2_1	119	124	PF00069	0.358
MOD_NEK2_1	193	198	PF00069	0.426
MOD_NEK2_1	2	7	PF00069	0.599
MOD_NEK2_1	43	48	PF00069	0.523
MOD_NEK2_1	54	59	PF00069	0.377
MOD_NEK2_1	79	84	PF00069	0.537
MOD_NEK2_2	231	236	PF00069	0.402
MOD_PIKK_1	138	144	PF00454	0.327
MOD_PIKK_1	46	52	PF00454	0.457
MOD_PKA_2	180	186	PF00069	0.421
MOD_PKA_2	212	218	PF00069	0.389
MOD_PKA_2	312	318	PF00069	0.509
MOD_PKA_2	46	52	PF00069	0.457
MOD_Plk_1	129	135	PF00069	0.347
MOD_Plk_1	39	45	PF00069	0.515
MOD_Plk_2-3	326	332	PF00069	0.541
MOD_Plk_4	231	237	PF00069	0.365
MOD_Plk_4	278	284	PF00069	0.405
MOD_Plk_4	39	45	PF00069	0.392
MOD_ProDKin_1	149	155	PF00069	0.510
MOD_ProDKin_1	59	65	PF00069	0.538
MOD_SUMO_for_1	206	209	PF00179	0.516
MOD_SUMO_for_1	349	352	PF00179	0.626
MOD_SUMO_rev_2	356	365	PF00179	0.650
TRG_ENDOCYTIC_2	116	119	PF00928	0.344
TRG_ENDOCYTIC_2	154	157	PF00928	0.489
TRG_ENDOCYTIC_2	184	187	PF00928	0.432
TRG_ENDOCYTIC_2	261	264	PF00928	0.434
TRG_ENDOCYTIC_2	320	323	PF00928	0.396
TRG_ER_diArg_1	237	239	PF00400	0.340
TRG_ER_diArg_1	242	244	PF00400	0.330
TRG_ER_diArg_1	245	248	PF00400	0.328
TRG_NES_CRM1_1	130	142	PF08389	0.348
TRG_NES_CRM1_1	209	223	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL6	Leptomonas seymouri	71%	96%
A0A0S4JNX3	Bodo saltans	51%	96%
A0A1X0P9L0	Trypanosomatidae	60%	100%
A0A3S5H6V7	Leishmania donovani	86%	96%
A4HWL1	Leishmania infantum	86%	96%
C9ZMN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
Q4QF56	Leishmania major	86%	100%
V5BKH7	Trypanosoma cruzi	62%	100%