Ubiquitin-fold modifier-conjugating enzyme 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

E2-like ubiquitin-conjugation enzyme, putative

Species:

Leishmania braziliensis

UniProt:

A4H887_LEIBR

TriTrypDb:

LbrM.15.1190 , LBRM2903_150019100

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H887

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H887

PDB structure(s): 3kpa_A , 3kpa_B , 3kpa_C

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0032446	protein modification by small protein conjugation	6	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071569	protein ufmylation	7	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1990564	protein polyufmylation	8	1
GO:1990592	protein K69-linked ufmylation	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	11
GO:0061657	UFM1 conjugating enzyme activity	5	11
GO:0071568	UFM1 transferase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	104	108	PF00082	0.221
DEG_Nend_UBRbox_2	1	3	PF02207	0.501
DEG_SPOP_SBC_1	165	169	PF00917	0.414
DOC_MAPK_gen_1	73	83	PF00069	0.221
DOC_PP4_FxxP_1	83	86	PF00568	0.352
DOC_USP7_MATH_1	170	174	PF00917	0.573
DOC_USP7_MATH_1	47	51	PF00917	0.378
LIG_Actin_WH2_2	146	161	PF00022	0.264
LIG_BRCT_BRCA1_1	49	53	PF00533	0.352
LIG_FHA_1	26	32	PF00498	0.227
LIG_FHA_2	166	172	PF00498	0.415
LIG_LIR_Apic_2	80	86	PF02991	0.297
LIG_LIR_Gen_1	33	42	PF02991	0.221
LIG_LIR_Nem_3	117	123	PF02991	0.221
LIG_LIR_Nem_3	33	38	PF02991	0.225
LIG_LIR_Nem_3	49	55	PF02991	0.330
LIG_LIR_Nem_3	67	72	PF02991	0.287
LIG_MYND_3	98	102	PF01753	0.221
LIG_Pex14_2	120	124	PF04695	0.221
LIG_Pex14_2	79	83	PF04695	0.221
LIG_PTB_Apo_2	71	78	PF02174	0.221
LIG_PTB_Phospho_1	71	77	PF10480	0.221
LIG_SH2_CRK	35	39	PF00017	0.221
LIG_SH2_STAP1	35	39	PF00017	0.301
LIG_SH2_STAP1	77	81	PF00017	0.221
LIG_SH2_STAT5	130	133	PF00017	0.221
LIG_SH2_STAT5	41	44	PF00017	0.248
LIG_SH3_3	84	90	PF00018	0.221
LIG_TYR_ITIM	128	133	PF00017	0.221
MOD_CK2_1	1	7	PF00069	0.539
MOD_CK2_1	165	171	PF00069	0.546
MOD_GlcNHglycan	161	164	PF01048	0.636
MOD_GSK3_1	1	8	PF00069	0.532
MOD_GSK3_1	166	173	PF00069	0.520
MOD_NEK2_1	131	136	PF00069	0.221
MOD_NEK2_1	14	19	PF00069	0.221
MOD_PKA_2	5	11	PF00069	0.234
MOD_Plk_4	34	40	PF00069	0.234
MOD_SUMO_for_1	31	34	PF00179	0.221
TRG_DiLeu_BaEn_1	34	39	PF01217	0.221
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.221
TRG_ENDOCYTIC_2	130	133	PF00928	0.221
TRG_ENDOCYTIC_2	35	38	PF00928	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA4	Leptomonas seymouri	90%	100%
A0A1X0NU03	Trypanosomatidae	85%	100%
A0A3R7KJX9	Trypanosoma rangeli	86%	100%
A0A3S7WTK9	Leishmania donovani	93%	100%
A2Z5S8	Oryza sativa subsp. indica	58%	94%
A4HWL0	Leishmania infantum	94%	100%
A7SM54	Nematostella vectensis	63%	100%
A8Q8J2	Brugia malayi	60%	100%
A8XAF4	Caenorhabditis briggsae	58%	100%
A9UR29	Monosiga brevicollis	61%	100%
B0WVC4	Culex quinquefasciatus	64%	100%
B3MC02	Drosophila ananassae	63%	100%
B3NPZ0	Drosophila erecta	63%	100%
B3RTL9	Trichoplax adhaerens	64%	100%
B4H538	Drosophila persimilis	63%	100%
B4HSI1	Drosophila sechellia	63%	100%
B4J9W6	Drosophila grimshawi	62%	100%
B4KQQ4	Drosophila mojavensis	63%	100%
B4LL39	Drosophila virilis	63%	100%
B4MIX7	Drosophila willistoni	63%	100%
B4P6S9	Drosophila yakuba	63%	100%
B4QHD6	Drosophila simulans	63%	100%
B9EM04	Salmo salar	63%	100%
C1BKD1	Osmerus mordax	62%	100%
C1BZU2	Esox lucius	61%	100%
C3ZDX5	Branchiostoma floridae	63%	100%
C9ZXS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AQB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q03598	Caenorhabditis elegans	59%	100%
Q178A5	Aedes aegypti	63%	100%
Q1ZXC9	Dictyostelium discoideum	64%	100%
Q28X71	Drosophila pseudoobscura pseudoobscura	63%	100%
Q4QF57	Leishmania major	95%	100%
Q5E953	Bos taurus	62%	100%
Q6BBI8	Rattus norvegicus	62%	100%
Q6DEN0	Danio rerio	62%	100%
Q7K1Z5	Drosophila melanogaster	63%	100%
Q7PND3	Anopheles gambiae	65%	100%
Q8S625	Oryza sativa subsp. japonica	58%	94%
Q9CR09	Mus musculus	63%	100%
Q9SXC8	Arabidopsis thaliana	58%	100%
Q9Y3C8	Homo sapiens	62%	100%
V5BUD0	Trypanosoma cruzi	87%	69%