Putative inositol/phosphatidylinositol phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol/phosphatidylinositol phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H885_LEIBR

TriTrypDb:

LbrM.15.1160 , LBRM2903_150018800

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	11
GO:0012506	vesicle membrane	4	11
GO:0016020	membrane	2	11
GO:0030659	cytoplasmic vesicle membrane	5	11
GO:0030666	endocytic vesicle membrane	5	11
GO:0030670	phagocytic vesicle membrane	6	11
GO:0031090	organelle membrane	3	11
GO:0031901	early endosome membrane	6	11
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H885

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H885

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006650	glycerophospholipid metabolic process	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0007165	signal transduction	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0030258	lipid modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0046486	glycerolipid metabolic process	4	11
GO:0046488	phosphatidylinositol metabolic process	6	11
GO:0046839	phospholipid dephosphorylation	5	11
GO:0046856	phosphatidylinositol dephosphorylation	6	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	11
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	2
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	2
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	2
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	2
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	1
GO:0046030	inositol trisphosphate phosphatase activity	7	1
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	1
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	1
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	1
GO:0052745	inositol phosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.310
CLV_NRD_NRD_1	235	237	PF00675	0.336
CLV_NRD_NRD_1	255	257	PF00675	0.422
CLV_NRD_NRD_1	360	362	PF00675	0.407
CLV_NRD_NRD_1	374	376	PF00675	0.304
CLV_PCSK_KEX2_1	181	183	PF00082	0.310
CLV_PCSK_KEX2_1	237	239	PF00082	0.308
CLV_PCSK_KEX2_1	255	257	PF00082	0.310
CLV_PCSK_KEX2_1	359	361	PF00082	0.422
CLV_PCSK_KEX2_1	374	376	PF00082	0.294
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.310
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.422
CLV_PCSK_SKI1_1	182	186	PF00082	0.312
CLV_PCSK_SKI1_1	24	28	PF00082	0.383
CLV_PCSK_SKI1_1	427	431	PF00082	0.350
CLV_PCSK_SKI1_1	80	84	PF00082	0.548
CLV_Separin_Metazoa	591	595	PF03568	0.538
DEG_APCC_DBOX_1	181	189	PF00400	0.353
DEG_APCC_DBOX_1	380	388	PF00400	0.422
DEG_SCF_FBW7_2	574	581	PF00400	0.261
DEG_SPOP_SBC_1	151	155	PF00917	0.426
DOC_CKS1_1	327	332	PF01111	0.422
DOC_CKS1_1	575	580	PF01111	0.445
DOC_CKS1_1	781	786	PF01111	0.546
DOC_CYCLIN_RxL_1	179	189	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	664	670	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	724	730	PF00134	0.273
DOC_MAPK_gen_1	383	393	PF00069	0.443
DOC_MAPK_gen_1	425	433	PF00069	0.442
DOC_MAPK_gen_1	682	691	PF00069	0.377
DOC_MAPK_gen_1	79	85	PF00069	0.505
DOC_MAPK_JIP1_4	104	110	PF00069	0.329
DOC_MAPK_MEF2A_6	104	113	PF00069	0.331
DOC_MAPK_MEF2A_6	169	178	PF00069	0.310
DOC_MAPK_MEF2A_6	325	334	PF00069	0.448
DOC_MAPK_MEF2A_6	406	413	PF00069	0.486
DOC_MAPK_RevD_3	67	80	PF00069	0.393
DOC_PP1_RVXF_1	445	451	PF00149	0.495
DOC_PP2B_LxvP_1	295	298	PF13499	0.422
DOC_PP2B_LxvP_1	724	727	PF13499	0.182
DOC_PP4_FxxP_1	29	32	PF00568	0.656
DOC_PP4_FxxP_1	9	12	PF00568	0.389
DOC_SPAK_OSR1_1	346	350	PF12202	0.422
DOC_USP7_MATH_1	144	148	PF00917	0.421
DOC_USP7_MATH_1	151	155	PF00917	0.373
DOC_USP7_MATH_1	200	204	PF00917	0.329
DOC_USP7_MATH_1	34	38	PF00917	0.667
DOC_USP7_MATH_1	434	438	PF00917	0.505
DOC_USP7_MATH_1	503	507	PF00917	0.528
DOC_USP7_MATH_1	716	720	PF00917	0.444
DOC_USP7_MATH_1	84	88	PF00917	0.505
DOC_WW_Pin1_4	129	134	PF00397	0.205
DOC_WW_Pin1_4	158	163	PF00397	0.355
DOC_WW_Pin1_4	261	266	PF00397	0.320
DOC_WW_Pin1_4	326	331	PF00397	0.302
DOC_WW_Pin1_4	335	340	PF00397	0.294
DOC_WW_Pin1_4	492	497	PF00397	0.562
DOC_WW_Pin1_4	557	562	PF00397	0.463
DOC_WW_Pin1_4	574	579	PF00397	0.381
DOC_WW_Pin1_4	780	785	PF00397	0.524
LIG_14-3-3_CanoR_1	182	191	PF00244	0.234
LIG_14-3-3_CanoR_1	22	30	PF00244	0.584
LIG_14-3-3_CanoR_1	35	44	PF00244	0.458
LIG_14-3-3_CanoR_1	374	379	PF00244	0.370
LIG_14-3-3_CanoR_1	386	393	PF00244	0.401
LIG_14-3-3_CanoR_1	394	401	PF00244	0.124
LIG_14-3-3_CanoR_1	406	412	PF00244	0.187
LIG_14-3-3_CanoR_1	518	522	PF00244	0.506
LIG_14-3-3_CanoR_1	715	724	PF00244	0.419
LIG_Actin_WH2_2	699	717	PF00022	0.305
LIG_BIR_III_4	743	747	PF00653	0.422
LIG_BRCT_BRCA1_1	247	251	PF00533	0.422
LIG_BRCT_BRCA1_1	307	311	PF00533	0.202
LIG_CaM_NSCaTE_8	134	141	PF13499	0.353
LIG_deltaCOP1_diTrp_1	13	21	PF00928	0.572
LIG_FHA_1	104	110	PF00498	0.396
LIG_FHA_1	196	202	PF00498	0.299
LIG_FHA_1	223	229	PF00498	0.403
LIG_FHA_1	327	333	PF00498	0.468
LIG_FHA_1	364	370	PF00498	0.306
LIG_FHA_1	428	434	PF00498	0.380
LIG_FHA_1	458	464	PF00498	0.410
LIG_FHA_1	575	581	PF00498	0.265
LIG_FHA_1	84	90	PF00498	0.445
LIG_FHA_2	493	499	PF00498	0.532
LIG_FHA_2	60	66	PF00498	0.491
LIG_FHA_2	623	629	PF00498	0.359
LIG_GBD_Chelix_1	287	295	PF00786	0.383
LIG_LIR_Apic_2	161	167	PF02991	0.329
LIG_LIR_Gen_1	13	21	PF02991	0.474
LIG_LIR_Gen_1	271	279	PF02991	0.389
LIG_LIR_Gen_1	308	316	PF02991	0.333
LIG_LIR_Gen_1	329	339	PF02991	0.415
LIG_LIR_Gen_1	488	499	PF02991	0.350
LIG_LIR_Gen_1	58	69	PF02991	0.485
LIG_LIR_Gen_1	588	596	PF02991	0.534
LIG_LIR_Nem_3	13	17	PF02991	0.498
LIG_LIR_Nem_3	161	166	PF02991	0.316
LIG_LIR_Nem_3	25	30	PF02991	0.456
LIG_LIR_Nem_3	271	277	PF02991	0.389
LIG_LIR_Nem_3	308	314	PF02991	0.333
LIG_LIR_Nem_3	329	334	PF02991	0.307
LIG_LIR_Nem_3	488	494	PF02991	0.351
LIG_LIR_Nem_3	53	59	PF02991	0.277
LIG_LIR_Nem_3	588	592	PF02991	0.528
LIG_LIR_Nem_3	603	609	PF02991	0.457
LIG_LYPXL_S_1	1	5	PF13949	0.644
LIG_LYPXL_yS_3	2	5	PF13949	0.640
LIG_NRBOX	170	176	PF00104	0.310
LIG_NRBOX	709	715	PF00104	0.324
LIG_Pex14_1	605	609	PF04695	0.245
LIG_SH2_CRK	164	168	PF00017	0.329
LIG_SH2_NCK_1	61	65	PF00017	0.486
LIG_SH2_SRC	609	612	PF00017	0.241
LIG_SH2_STAP1	299	303	PF00017	0.326
LIG_SH2_STAP1	365	369	PF00017	0.329
LIG_SH2_STAP1	57	61	PF00017	0.387
LIG_SH2_STAP1	583	587	PF00017	0.506
LIG_SH2_STAP1	671	675	PF00017	0.348
LIG_SH2_STAT5	365	368	PF00017	0.316
LIG_SH2_STAT5	606	609	PF00017	0.418
LIG_SH2_STAT5	61	64	PF00017	0.368
LIG_SH2_STAT5	705	708	PF00017	0.305
LIG_SH2_STAT5	712	715	PF00017	0.299
LIG_SH2_STAT5	779	782	PF00017	0.390
LIG_SH3_3	262	268	PF00018	0.202
LIG_SH3_3	324	330	PF00018	0.348
LIG_SH3_3	408	414	PF00018	0.494
LIG_SH3_3	555	561	PF00018	0.447
LIG_SH3_3	595	601	PF00018	0.405
LIG_SH3_3	612	618	PF00018	0.353
LIG_SH3_3	664	670	PF00018	0.305
LIG_SH3_3	78	84	PF00018	0.513
LIG_SH3_3	99	105	PF00018	0.631
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.386
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.310
LIG_SUMO_SIM_anti_2	498	503	PF11976	0.487
LIG_SUMO_SIM_anti_2	569	577	PF11976	0.364
LIG_SUMO_SIM_anti_2	769	778	PF11976	0.506
LIG_SUMO_SIM_par_1	407	412	PF11976	0.473
LIG_TRAF2_1	495	498	PF00917	0.323
LIG_TRFH_1	712	716	PF08558	0.305
LIG_TYR_ITIM	54	59	PF00017	0.281
LIG_UBA3_1	633	640	PF00899	0.419
LIG_UBA3_1	657	662	PF00899	0.419
LIG_WRC_WIRS_1	71	76	PF05994	0.330
LIG_WRPW_2	526	529	PF00400	0.331
MOD_CK1_1	146	152	PF00069	0.450
MOD_CK1_1	186	192	PF00069	0.422
MOD_CK1_1	377	383	PF00069	0.422
MOD_CK1_1	487	493	PF00069	0.468
MOD_CK2_1	420	426	PF00069	0.442
MOD_CK2_1	492	498	PF00069	0.526
MOD_CK2_1	59	65	PF00069	0.484
MOD_CK2_1	622	628	PF00069	0.329
MOD_CK2_1	717	723	PF00069	0.374
MOD_GlcNHglycan	117	121	PF01048	0.312
MOD_GlcNHglycan	154	157	PF01048	0.442
MOD_GlcNHglycan	185	188	PF01048	0.422
MOD_GlcNHglycan	261	264	PF01048	0.374
MOD_GlcNHglycan	270	274	PF01048	0.306
MOD_GlcNHglycan	307	310	PF01048	0.202
MOD_GlcNHglycan	36	39	PF01048	0.672
MOD_GlcNHglycan	387	390	PF01048	0.454
MOD_GlcNHglycan	437	440	PF01048	0.403
MOD_GlcNHglycan	733	736	PF01048	0.458
MOD_GlcNHglycan	93	96	PF01048	0.591
MOD_GSK3_1	125	132	PF00069	0.210
MOD_GSK3_1	143	150	PF00069	0.338
MOD_GSK3_1	241	248	PF00069	0.357
MOD_GSK3_1	305	312	PF00069	0.379
MOD_GSK3_1	337	344	PF00069	0.310
MOD_GSK3_1	370	377	PF00069	0.350
MOD_GSK3_1	435	442	PF00069	0.432
MOD_GSK3_1	531	538	PF00069	0.277
MOD_GSK3_1	65	72	PF00069	0.292
MOD_GSK3_1	779	786	PF00069	0.522
MOD_GSK3_1	91	98	PF00069	0.456
MOD_N-GLC_1	147	152	PF02516	0.465
MOD_N-GLC_1	335	340	PF02516	0.454
MOD_N-GLC_1	59	64	PF02516	0.499
MOD_N-GLC_1	717	722	PF02516	0.182
MOD_NEK2_1	118	123	PF00069	0.310
MOD_NEK2_1	216	221	PF00069	0.301
MOD_NEK2_1	305	310	PF00069	0.202
MOD_NEK2_1	443	448	PF00069	0.457
MOD_NEK2_1	621	626	PF00069	0.436
MOD_NEK2_1	636	641	PF00069	0.411
MOD_NEK2_1	91	96	PF00069	0.353
MOD_PIKK_1	256	262	PF00454	0.202
MOD_PIKK_1	457	463	PF00454	0.505
MOD_PIKK_1	503	509	PF00454	0.518
MOD_PKA_1	374	380	PF00069	0.353
MOD_PKA_2	103	109	PF00069	0.522
MOD_PKA_2	217	223	PF00069	0.329
MOD_PKA_2	34	40	PF00069	0.439
MOD_PKA_2	374	380	PF00069	0.353
MOD_PKA_2	385	391	PF00069	0.353
MOD_PKA_2	393	399	PF00069	0.353
MOD_PKA_2	517	523	PF00069	0.449
MOD_PKA_2	531	537	PF00069	0.425
MOD_PKA_2	622	628	PF00069	0.450
MOD_PKA_2	739	745	PF00069	0.528
MOD_Plk_1	189	195	PF00069	0.264
MOD_Plk_1	269	275	PF00069	0.454
MOD_Plk_1	535	541	PF00069	0.372
MOD_Plk_1	59	65	PF00069	0.446
MOD_Plk_4	241	247	PF00069	0.353
MOD_Plk_4	487	493	PF00069	0.530
MOD_Plk_4	517	523	PF00069	0.547
MOD_Plk_4	536	542	PF00069	0.408
MOD_Plk_4	559	565	PF00069	0.338
MOD_Plk_4	705	711	PF00069	0.379
MOD_Plk_4	783	789	PF00069	0.516
MOD_Plk_4	84	90	PF00069	0.297
MOD_ProDKin_1	129	135	PF00069	0.205
MOD_ProDKin_1	158	164	PF00069	0.355
MOD_ProDKin_1	261	267	PF00069	0.320
MOD_ProDKin_1	326	332	PF00069	0.302
MOD_ProDKin_1	335	341	PF00069	0.294
MOD_ProDKin_1	492	498	PF00069	0.558
MOD_ProDKin_1	557	563	PF00069	0.459
MOD_ProDKin_1	574	580	PF00069	0.384
MOD_ProDKin_1	780	786	PF00069	0.536
MOD_SUMO_for_1	124	127	PF00179	0.310
MOD_SUMO_rev_2	318	327	PF00179	0.422
MOD_SUMO_rev_2	392	401	PF00179	0.310
MOD_SUMO_rev_2	635	642	PF00179	0.419
TRG_DiLeu_BaEn_1	569	574	PF01217	0.330
TRG_DiLeu_BaEn_1	603	608	PF01217	0.229
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.422
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.182
TRG_ENDOCYTIC_2	163	166	PF00928	0.296
TRG_ENDOCYTIC_2	2	5	PF00928	0.640
TRG_ENDOCYTIC_2	56	59	PF00928	0.358
TRG_ENDOCYTIC_2	61	64	PF00928	0.431
TRG_ER_diArg_1	180	182	PF00400	0.310
TRG_ER_diArg_1	21	24	PF00400	0.586
TRG_ER_diArg_1	235	238	PF00400	0.313
TRG_ER_diArg_1	293	296	PF00400	0.456
TRG_ER_diArg_1	360	362	PF00400	0.422
TRG_ER_diArg_1	381	384	PF00400	0.411
TRG_ER_diArg_1	479	482	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.182
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E8	Leptomonas seymouri	77%	100%
A0A1X0NU91	Trypanosomatidae	51%	100%
A0A3S5H6V6	Leishmania donovani	87%	100%
A0A422NRC5	Trypanosoma rangeli	49%	100%
C9ZXT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D3ZGS3	Rattus norvegicus	25%	88%
E9AGM3	Leishmania infantum	87%	100%
E9AQB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P32019	Homo sapiens	28%	80%
Q01968	Homo sapiens	26%	88%
Q4QF61	Leishmania major	86%	100%
Q6NVF0	Mus musculus	26%	88%
Q8K337	Mus musculus	28%	80%
V5DL78	Trypanosoma cruzi	49%	100%