TFIIB-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H880_LEIBR

TriTrypDb:

LbrM.15.1110 , LBRM2903_150018200

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005634	nucleus	5	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1
GO:0097550	transcription preinitiation complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H880

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H880

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0000992	RNA polymerase III cis-regulatory region sequence-specific DNA binding	7	1
GO:0000995	RNA polymerase III general transcription initiation factor activity	2	1
GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	8	1
GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140223	general transcription initiation factor activity	1	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.272
CLV_NRD_NRD_1	141	143	PF00675	0.338
CLV_NRD_NRD_1	162	164	PF00675	0.246
CLV_NRD_NRD_1	209	211	PF00675	0.226
CLV_NRD_NRD_1	406	408	PF00675	0.710
CLV_PCSK_KEX2_1	141	143	PF00082	0.319
CLV_PCSK_KEX2_1	162	164	PF00082	0.239
CLV_PCSK_KEX2_1	209	211	PF00082	0.226
CLV_PCSK_KEX2_1	408	410	PF00082	0.578
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.578
CLV_PCSK_SKI1_1	119	123	PF00082	0.420
CLV_PCSK_SKI1_1	53	57	PF00082	0.497
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.411
DOC_MAPK_gen_1	162	169	PF00069	0.354
DOC_MAPK_MEF2A_6	128	137	PF00069	0.414
DOC_MAPK_MEF2A_6	282	289	PF00069	0.263
DOC_PP1_RVXF_1	293	299	PF00149	0.377
DOC_PP2B_LxvP_1	242	245	PF13499	0.321
DOC_USP7_MATH_1	127	131	PF00917	0.328
DOC_USP7_MATH_1	17	21	PF00917	0.349
DOC_USP7_MATH_1	176	180	PF00917	0.248
DOC_USP7_MATH_1	269	273	PF00917	0.506
DOC_USP7_MATH_1	310	314	PF00917	0.346
DOC_WW_Pin1_4	411	416	PF00397	0.696
DOC_WW_Pin1_4	419	424	PF00397	0.657
LIG_14-3-3_CanoR_1	128	136	PF00244	0.248
LIG_14-3-3_CanoR_1	314	318	PF00244	0.343
LIG_14-3-3_CanoR_1	409	418	PF00244	0.670
LIG_14-3-3_CanoR_1	78	86	PF00244	0.509
LIG_Actin_WH2_2	189	206	PF00022	0.310
LIG_APCC_ABBA_1	274	279	PF00400	0.341
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_BIR_III_3	1	5	PF00653	0.394
LIG_FHA_1	359	365	PF00498	0.446
LIG_FHA_1	382	388	PF00498	0.603
LIG_FHA_2	1	7	PF00498	0.361
LIG_FHA_2	200	206	PF00498	0.407
LIG_FHA_2	364	370	PF00498	0.553
LIG_FHA_2	47	53	PF00498	0.480
LIG_FHA_2	54	60	PF00498	0.463
LIG_FHA_2	85	91	PF00498	0.567
LIG_LIR_Gen_1	316	325	PF02991	0.285
LIG_LIR_Gen_1	349	357	PF02991	0.459
LIG_LIR_Nem_3	134	139	PF02991	0.248
LIG_LIR_Nem_3	316	321	PF02991	0.396
LIG_LIR_Nem_3	349	353	PF02991	0.437
LIG_PTAP_UEV_1	396	401	PF05743	0.567
LIG_REV1ctd_RIR_1	134	142	PF16727	0.248
LIG_SH2_PTP2	238	241	PF00017	0.288
LIG_SH2_SRC	143	146	PF00017	0.174
LIG_SH2_STAP1	143	147	PF00017	0.174
LIG_SH2_STAP1	318	322	PF00017	0.313
LIG_SH2_STAT3	237	240	PF00017	0.256
LIG_SH2_STAT5	14	17	PF00017	0.395
LIG_SH2_STAT5	230	233	PF00017	0.269
LIG_SH2_STAT5	238	241	PF00017	0.271
LIG_SH2_STAT5	7	10	PF00017	0.434
LIG_SH3_3	296	302	PF00018	0.527
LIG_SH3_3	394	400	PF00018	0.753
LIG_SH3_3	412	418	PF00018	0.490
LIG_TRAF2_1	87	90	PF00917	0.561
LIG_WRC_WIRS_1	318	323	PF05994	0.300
MOD_CK1_1	20	26	PF00069	0.389
MOD_CK1_1	313	319	PF00069	0.442
MOD_CK1_1	320	326	PF00069	0.422
MOD_CK1_1	383	389	PF00069	0.645
MOD_CK1_1	395	401	PF00069	0.603
MOD_CK1_1	46	52	PF00069	0.467
MOD_CK2_1	363	369	PF00069	0.522
MOD_CK2_1	46	52	PF00069	0.580
MOD_CK2_1	84	90	PF00069	0.670
MOD_Cter_Amidation	405	408	PF01082	0.513
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.672
MOD_GlcNHglycan	129	132	PF01048	0.422
MOD_GlcNHglycan	307	311	PF01048	0.545
MOD_GlcNHglycan	394	397	PF01048	0.714
MOD_GlcNHglycan	401	404	PF01048	0.760
MOD_GSK3_1	306	313	PF00069	0.489
MOD_GSK3_1	316	323	PF00069	0.486
MOD_GSK3_1	388	395	PF00069	0.656
MOD_GSK3_1	409	416	PF00069	0.741
MOD_N-GLC_1	264	269	PF02516	0.370
MOD_N-GLC_1	409	414	PF02516	0.626
MOD_NEK2_1	114	119	PF00069	0.489
MOD_NEK2_1	137	142	PF00069	0.354
MOD_NEK2_1	199	204	PF00069	0.294
MOD_NEK2_1	317	322	PF00069	0.574
MOD_NEK2_1	43	48	PF00069	0.421
MOD_PKA_2	127	133	PF00069	0.354
MOD_PKA_2	137	143	PF00069	0.354
MOD_PKA_2	313	319	PF00069	0.348
MOD_PKA_2	77	83	PF00069	0.515
MOD_PKB_1	407	415	PF00069	0.579
MOD_Plk_1	43	49	PF00069	0.410
MOD_Plk_4	176	182	PF00069	0.248
MOD_Plk_4	313	319	PF00069	0.365
MOD_Plk_4	34	40	PF00069	0.465
MOD_ProDKin_1	411	417	PF00069	0.691
MOD_ProDKin_1	419	425	PF00069	0.660
MOD_SUMO_for_1	376	379	PF00179	0.569
MOD_SUMO_for_1	387	390	PF00179	0.579
MOD_SUMO_rev_2	379	384	PF00179	0.540
TRG_DiLeu_BaEn_1	349	354	PF01217	0.537
TRG_DiLeu_BaEn_2	272	278	PF01217	0.356
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.416
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.445
TRG_ENDOCYTIC_2	238	241	PF00928	0.395
TRG_ENDOCYTIC_2	318	321	PF00928	0.430
TRG_ER_diArg_1	141	143	PF00400	0.226
TRG_ER_diArg_1	161	163	PF00400	0.229
TRG_ER_diArg_1	209	211	PF00400	0.179
TRG_NLS_MonoExtC_3	406	411	PF00514	0.603
TRG_NLS_MonoExtN_4	407	412	PF00514	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I166	Leptomonas seymouri	64%	100%
A0A1X0NU06	Trypanosomatidae	37%	100%
A0A3R7MLE9	Trypanosoma rangeli	38%	100%
A0A3S5H6V5	Leishmania donovani	84%	100%
A4HWK6	Leishmania infantum	84%	100%
C9ZXT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QF67	Leishmania major	83%	100%
V5BK49	Trypanosoma cruzi	37%	100%