SKIP_SNW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKIP/SNW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H876_LEIBR

TriTrypDb:

LbrM.15.1070 , LBRM2903_150017200

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4H876

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H876

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.670
CLV_C14_Caspase3-7	338	342	PF00656	0.754
CLV_C14_Caspase3-7	51	55	PF00656	0.771
CLV_NRD_NRD_1	132	134	PF00675	0.409
CLV_NRD_NRD_1	146	148	PF00675	0.262
CLV_NRD_NRD_1	207	209	PF00675	0.358
CLV_NRD_NRD_1	237	239	PF00675	0.558
CLV_NRD_NRD_1	347	349	PF00675	0.643
CLV_PCSK_KEX2_1	207	209	PF00082	0.358
CLV_PCSK_KEX2_1	237	239	PF00082	0.667
CLV_PCSK_KEX2_1	89	91	PF00082	0.703
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.703
CLV_PCSK_SKI1_1	221	225	PF00082	0.482
CLV_PCSK_SKI1_1	259	263	PF00082	0.550
CLV_PCSK_SKI1_1	270	274	PF00082	0.464
CLV_PCSK_SKI1_1	72	76	PF00082	0.690
DEG_Nend_Nbox_1	1	3	PF02207	0.743
DEG_SPOP_SBC_1	104	108	PF00917	0.693
DEG_SPOP_SBC_1	46	50	PF00917	0.498
DOC_ANK_TNKS_1	164	171	PF00023	0.280
DOC_CYCLIN_RxL_1	218	225	PF00134	0.368
DOC_MAPK_gen_1	133	139	PF00069	0.392
DOC_MAPK_gen_1	147	154	PF00069	0.266
DOC_MAPK_gen_1	241	250	PF00069	0.529
DOC_MAPK_gen_1	268	277	PF00069	0.545
DOC_MAPK_HePTP_8	267	279	PF00069	0.584
DOC_MAPK_MEF2A_6	147	154	PF00069	0.350
DOC_MAPK_MEF2A_6	270	279	PF00069	0.541
DOC_PP2B_LxvP_1	150	153	PF13499	0.368
DOC_USP7_MATH_1	105	109	PF00917	0.767
DOC_USP7_MATH_1	115	119	PF00917	0.654
DOC_USP7_MATH_1	305	309	PF00917	0.736
DOC_USP7_MATH_1	45	49	PF00917	0.740
DOC_USP7_UBL2_3	197	201	PF12436	0.443
DOC_WW_Pin1_4	63	68	PF00397	0.624
LIG_14-3-3_CanoR_1	26	34	PF00244	0.576
LIG_14-3-3_CanoR_1	274	280	PF00244	0.494
LIG_Actin_WH2_2	275	292	PF00022	0.512
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.681
LIG_BRCT_BRCA1_1	405	409	PF00533	0.511
LIG_FHA_1	74	80	PF00498	0.654
LIG_FHA_2	276	282	PF00498	0.552
LIG_FHA_2	330	336	PF00498	0.545
LIG_FHA_2	49	55	PF00498	0.751
LIG_SH2_CRK	347	351	PF00017	0.501
LIG_SH3_3	132	138	PF00018	0.399
LIG_SH3_3	61	67	PF00018	0.622
LIG_SH3_4	33	40	PF00018	0.559
LIG_TRAF2_1	202	205	PF00917	0.403
LIG_TRAF2_1	291	294	PF00917	0.589
MOD_CDC14_SPxK_1	66	69	PF00782	0.503
MOD_CDK_SPxK_1	63	69	PF00069	0.508
MOD_CK1_1	106	112	PF00069	0.726
MOD_CK1_1	118	124	PF00069	0.649
MOD_CK1_1	129	135	PF00069	0.274
MOD_CK1_1	296	302	PF00069	0.546
MOD_CK1_1	48	54	PF00069	0.544
MOD_CK1_1	73	79	PF00069	0.638
MOD_CK1_1	95	101	PF00069	0.781
MOD_CK2_1	288	294	PF00069	0.600
MOD_CK2_1	404	410	PF00069	0.682
MOD_GlcNHglycan	119	123	PF01048	0.649
MOD_GlcNHglycan	128	131	PF01048	0.301
MOD_GlcNHglycan	301	304	PF01048	0.661
MOD_GlcNHglycan	307	310	PF01048	0.636
MOD_GlcNHglycan	358	361	PF01048	0.570
MOD_GlcNHglycan	393	399	PF01048	0.725
MOD_GlcNHglycan	82	85	PF01048	0.745
MOD_GlcNHglycan	95	98	PF01048	0.686
MOD_GSK3_1	103	110	PF00069	0.727
MOD_GSK3_1	22	29	PF00069	0.733
MOD_GSK3_1	305	312	PF00069	0.692
MOD_GSK3_1	356	363	PF00069	0.544
MOD_GSK3_1	93	100	PF00069	0.760
MOD_N-GLC_1	275	280	PF02516	0.591
MOD_NEK2_1	103	108	PF00069	0.751
MOD_NEK2_1	139	144	PF00069	0.399
MOD_NEK2_1	2	7	PF00069	0.732
MOD_NEK2_1	27	32	PF00069	0.693
MOD_NEK2_1	39	44	PF00069	0.674
MOD_NEK2_1	80	85	PF00069	0.765
MOD_PKA_1	237	243	PF00069	0.554
MOD_PKA_2	237	243	PF00069	0.654
MOD_PKA_2	27	33	PF00069	0.575
MOD_PKB_1	26	34	PF00069	0.747
MOD_PKB_1	268	276	PF00069	0.585
MOD_Plk_1	275	281	PF00069	0.591
MOD_Plk_1	293	299	PF00069	0.624
MOD_Plk_1	404	410	PF00069	0.578
MOD_Plk_2-3	405	411	PF00069	0.721
MOD_Plk_4	108	114	PF00069	0.764
MOD_Plk_4	17	23	PF00069	0.596
MOD_Plk_4	293	299	PF00069	0.661
MOD_Plk_4	70	76	PF00069	0.661
MOD_ProDKin_1	63	69	PF00069	0.622
MOD_SUMO_for_1	200	203	PF00179	0.443
MOD_SUMO_rev_2	66	74	PF00179	0.613
TRG_DiLeu_BaEn_2	409	415	PF01217	0.493
TRG_ER_diArg_1	247	250	PF00400	0.515
TRG_ER_diArg_1	388	391	PF00400	0.757
TRG_ER_diLys_1	416	421	PF00400	0.656
TRG_NLS_Bipartite_1	133	151	PF00514	0.443
TRG_NLS_MonoExtC_3	415	420	PF00514	0.617
TRG_NLS_MonoExtN_4	416	421	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X6	Leptomonas seymouri	62%	76%
A0A1X0NU15	Trypanosomatidae	41%	92%
A0A3S7WTI8	Leishmania donovani	83%	99%
A0A422N165	Trypanosoma rangeli	42%	88%
A4HWK1	Leishmania infantum	83%	99%
C9ZXT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
E9AQA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QF81	Leishmania major	84%	100%