LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

NAD-specific glutamate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NAD-specific glutamate dehydrogenase
Gene product:
glutamate dehydrogenase
Species:
Leishmania braziliensis
UniProt:
A4H874_LEIBR
TriTrypDb:
LbrM.15.1050 , LBRM2903_150017000 *
Length:
1020

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H874
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H874

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006103 2-oxoglutarate metabolic process 7 12
GO:0006106 fumarate metabolic process 7 12
GO:0006520 amino acid metabolic process 3 12
GO:0006536 glutamate metabolic process 6 12
GO:0006538 glutamate catabolic process 5 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009063 amino acid catabolic process 4 12
GO:0009064 glutamine family amino acid metabolic process 5 12
GO:0009065 glutamine family amino acid catabolic process 6 12
GO:0009987 cellular process 1 12
GO:0016054 organic acid catabolic process 4 12
GO:0019551 glutamate catabolic process to 2-oxoglutarate 6 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0043648 dicarboxylic acid metabolic process 6 12
GO:0043649 dicarboxylic acid catabolic process 6 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044281 small molecule metabolic process 2 12
GO:0044282 small molecule catabolic process 3 12
GO:0046395 carboxylic acid catabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
GO:1901606 alpha-amino acid catabolic process 5 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004352 glutamate dehydrogenase (NAD+) activity 6 12
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3 12
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 877 881 PF00656 0.574
CLV_C14_Caspase3-7 995 999 PF00656 0.430
CLV_NRD_NRD_1 141 143 PF00675 0.447
CLV_NRD_NRD_1 167 169 PF00675 0.606
CLV_NRD_NRD_1 219 221 PF00675 0.563
CLV_NRD_NRD_1 409 411 PF00675 0.369
CLV_NRD_NRD_1 511 513 PF00675 0.360
CLV_NRD_NRD_1 664 666 PF00675 0.358
CLV_NRD_NRD_1 705 707 PF00675 0.309
CLV_PCSK_KEX2_1 219 221 PF00082 0.539
CLV_PCSK_KEX2_1 409 411 PF00082 0.391
CLV_PCSK_KEX2_1 515 517 PF00082 0.337
CLV_PCSK_KEX2_1 972 974 PF00082 0.561
CLV_PCSK_PC1ET2_1 515 517 PF00082 0.356
CLV_PCSK_PC1ET2_1 972 974 PF00082 0.561
CLV_PCSK_PC7_1 215 221 PF00082 0.543
CLV_PCSK_SKI1_1 1006 1010 PF00082 0.546
CLV_PCSK_SKI1_1 124 128 PF00082 0.559
CLV_PCSK_SKI1_1 204 208 PF00082 0.582
CLV_PCSK_SKI1_1 215 219 PF00082 0.445
CLV_PCSK_SKI1_1 308 312 PF00082 0.507
CLV_PCSK_SKI1_1 350 354 PF00082 0.527
CLV_PCSK_SKI1_1 431 435 PF00082 0.410
CLV_PCSK_SKI1_1 454 458 PF00082 0.354
CLV_PCSK_SKI1_1 516 520 PF00082 0.384
CLV_PCSK_SKI1_1 58 62 PF00082 0.517
CLV_PCSK_SKI1_1 621 625 PF00082 0.396
CLV_PCSK_SKI1_1 63 67 PF00082 0.454
CLV_PCSK_SKI1_1 787 791 PF00082 0.310
CLV_PCSK_SKI1_1 830 834 PF00082 0.329
CLV_PCSK_SKI1_1 959 963 PF00082 0.473
DEG_APCC_DBOX_1 218 226 PF00400 0.580
DEG_APCC_DBOX_1 297 305 PF00400 0.573
DEG_APCC_DBOX_1 705 713 PF00400 0.499
DEG_SCF_FBW7_1 338 345 PF00400 0.549
DEG_SPOP_SBC_1 851 855 PF00917 0.488
DOC_CDC14_PxL_1 29 37 PF14671 0.490
DOC_CKS1_1 339 344 PF01111 0.426
DOC_CYCLIN_yClb5_NLxxxL_5 365 373 PF00134 0.580
DOC_MAPK_DCC_7 959 969 PF00069 0.487
DOC_MAPK_gen_1 142 150 PF00069 0.549
DOC_MAPK_gen_1 451 459 PF00069 0.341
DOC_MAPK_gen_1 685 694 PF00069 0.531
DOC_MAPK_gen_1 711 719 PF00069 0.496
DOC_MAPK_gen_1 959 969 PF00069 0.516
DOC_MAPK_MEF2A_6 962 971 PF00069 0.553
DOC_MAPK_RevD_3 55 69 PF00069 0.435
DOC_PP1_RVXF_1 465 472 PF00149 0.488
DOC_PP1_RVXF_1 899 905 PF00149 0.574
DOC_PP2B_LxvP_1 30 33 PF13499 0.489
DOC_PP2B_LxvP_1 574 577 PF13499 0.415
DOC_PP2B_LxvP_1 789 792 PF13499 0.522
DOC_PP4_FxxP_1 593 596 PF00568 0.404
DOC_USP7_MATH_1 619 623 PF00917 0.296
DOC_USP7_MATH_1 9 13 PF00917 0.681
DOC_USP7_MATH_1 915 919 PF00917 0.544
DOC_USP7_UBL2_3 656 660 PF12436 0.466
DOC_USP7_UBL2_3 972 976 PF12436 0.554
DOC_WW_Pin1_4 338 343 PF00397 0.409
DOC_WW_Pin1_4 403 408 PF00397 0.461
DOC_WW_Pin1_4 725 730 PF00397 0.513
DOC_WW_Pin1_4 805 810 PF00397 0.559
LIG_14-3-3_CanoR_1 1006 1015 PF00244 0.464
LIG_14-3-3_CanoR_1 219 229 PF00244 0.466
LIG_14-3-3_CanoR_1 298 302 PF00244 0.410
LIG_14-3-3_CanoR_1 3 13 PF00244 0.686
LIG_14-3-3_CanoR_1 370 378 PF00244 0.530
LIG_14-3-3_CanoR_1 40 50 PF00244 0.659
LIG_14-3-3_CanoR_1 647 657 PF00244 0.507
LIG_14-3-3_CanoR_1 776 781 PF00244 0.499
LIG_14-3-3_CanoR_1 89 97 PF00244 0.580
LIG_Actin_WH2_2 646 662 PF00022 0.532
LIG_Actin_WH2_2 946 964 PF00022 0.519
LIG_APCC_ABBA_1 257 262 PF00400 0.512
LIG_APCC_ABBA_1 387 392 PF00400 0.393
LIG_APCC_ABBAyCdc20_2 515 521 PF00400 0.341
LIG_BIR_III_4 793 797 PF00653 0.442
LIG_BRCT_BRCA1_1 222 226 PF00533 0.558
LIG_BRCT_BRCA1_1 272 276 PF00533 0.400
LIG_BRCT_BRCA1_1 939 943 PF00533 0.452
LIG_BRCT_BRCA1_1 998 1002 PF00533 0.492
LIG_Clathr_ClatBox_1 228 232 PF01394 0.307
LIG_EH1_1 240 248 PF00400 0.561
LIG_FHA_1 248 254 PF00498 0.574
LIG_FHA_1 325 331 PF00498 0.491
LIG_FHA_1 372 378 PF00498 0.575
LIG_FHA_1 381 387 PF00498 0.420
LIG_FHA_1 416 422 PF00498 0.480
LIG_FHA_1 526 532 PF00498 0.338
LIG_FHA_1 542 548 PF00498 0.290
LIG_FHA_1 60 66 PF00498 0.536
LIG_FHA_1 641 647 PF00498 0.488
LIG_FHA_2 243 249 PF00498 0.508
LIG_FHA_2 343 349 PF00498 0.504
LIG_FHA_2 623 629 PF00498 0.418
LIG_FHA_2 958 964 PF00498 0.432
LIG_FHA_2 993 999 PF00498 0.410
LIG_GBD_Chelix_1 413 421 PF00786 0.461
LIG_LIR_Apic_2 590 596 PF02991 0.401
LIG_LIR_Gen_1 1009 1019 PF02991 0.420
LIG_LIR_Gen_1 114 121 PF02991 0.440
LIG_LIR_Gen_1 258 268 PF02991 0.548
LIG_LIR_Gen_1 392 401 PF02991 0.432
LIG_LIR_Gen_1 432 440 PF02991 0.377
LIG_LIR_Gen_1 651 659 PF02991 0.574
LIG_LIR_Gen_1 730 738 PF02991 0.530
LIG_LIR_Gen_1 757 767 PF02991 0.571
LIG_LIR_Gen_1 801 812 PF02991 0.593
LIG_LIR_Gen_1 903 910 PF02991 0.499
LIG_LIR_Gen_1 999 1008 PF02991 0.429
LIG_LIR_Nem_3 1009 1015 PF02991 0.409
LIG_LIR_Nem_3 114 119 PF02991 0.438
LIG_LIR_Nem_3 125 131 PF02991 0.410
LIG_LIR_Nem_3 167 173 PF02991 0.500
LIG_LIR_Nem_3 201 206 PF02991 0.489
LIG_LIR_Nem_3 223 229 PF02991 0.509
LIG_LIR_Nem_3 258 263 PF02991 0.537
LIG_LIR_Nem_3 346 352 PF02991 0.495
LIG_LIR_Nem_3 392 396 PF02991 0.375
LIG_LIR_Nem_3 432 437 PF02991 0.358
LIG_LIR_Nem_3 468 474 PF02991 0.343
LIG_LIR_Nem_3 651 657 PF02991 0.549
LIG_LIR_Nem_3 730 735 PF02991 0.530
LIG_LIR_Nem_3 757 762 PF02991 0.525
LIG_LIR_Nem_3 801 807 PF02991 0.549
LIG_LIR_Nem_3 857 862 PF02991 0.499
LIG_LIR_Nem_3 883 888 PF02991 0.513
LIG_LIR_Nem_3 903 907 PF02991 0.357
LIG_LIR_Nem_3 999 1005 PF02991 0.440
LIG_LYPXL_S_1 389 393 PF13949 0.461
LIG_PCNA_yPIPBox_3 945 959 PF02747 0.425
LIG_PCNA_yPIPBox_3 972 986 PF02747 0.421
LIG_Pex14_2 180 184 PF04695 0.359
LIG_Pex14_2 336 340 PF04695 0.376
LIG_Pex14_2 489 493 PF04695 0.337
LIG_Pex14_2 904 908 PF04695 0.488
LIG_PTB_Apo_2 304 311 PF02174 0.550
LIG_Rb_LxCxE_1 318 331 PF01857 0.508
LIG_REV1ctd_RIR_1 1002 1010 PF16727 0.556
LIG_SH2_CRK 1012 1016 PF00017 0.298
LIG_SH2_CRK 804 808 PF00017 0.561
LIG_SH2_GRB2like 1012 1015 PF00017 0.390
LIG_SH2_GRB2like 551 554 PF00017 0.461
LIG_SH2_GRB2like 804 807 PF00017 0.593
LIG_SH2_NCK_1 1012 1016 PF00017 0.550
LIG_SH2_NCK_1 131 135 PF00017 0.338
LIG_SH2_NCK_1 764 768 PF00017 0.488
LIG_SH2_SRC 567 570 PF00017 0.367
LIG_SH2_SRC 978 981 PF00017 0.401
LIG_SH2_STAP1 1012 1016 PF00017 0.550
LIG_SH2_STAP1 429 433 PF00017 0.461
LIG_SH2_STAP1 87 91 PF00017 0.454
LIG_SH2_STAT3 991 994 PF00017 0.523
LIG_SH2_STAT5 1012 1015 PF00017 0.293
LIG_SH2_STAT5 118 121 PF00017 0.470
LIG_SH2_STAT5 128 131 PF00017 0.353
LIG_SH2_STAT5 163 166 PF00017 0.431
LIG_SH2_STAT5 173 176 PF00017 0.398
LIG_SH2_STAT5 252 255 PF00017 0.407
LIG_SH2_STAT5 339 342 PF00017 0.413
LIG_SH2_STAT5 382 385 PF00017 0.371
LIG_SH2_STAT5 551 554 PF00017 0.426
LIG_SH2_STAT5 567 570 PF00017 0.351
LIG_SH2_STAT5 649 652 PF00017 0.574
LIG_SH2_STAT5 804 807 PF00017 0.556
LIG_SH2_STAT5 87 90 PF00017 0.351
LIG_SH2_STAT5 888 891 PF00017 0.499
LIG_SH2_STAT5 951 954 PF00017 0.387
LIG_SH2_STAT5 991 994 PF00017 0.404
LIG_SH3_2 306 311 PF14604 0.482
LIG_SH3_3 189 195 PF00018 0.655
LIG_SH3_3 303 309 PF00018 0.440
LIG_SH3_3 469 475 PF00018 0.335
LIG_SH3_3 738 744 PF00018 0.499
LIG_SH3_3 766 772 PF00018 0.488
LIG_SUMO_SIM_anti_2 25 31 PF11976 0.641
LIG_SUMO_SIM_par_1 543 549 PF11976 0.341
LIG_SUMO_SIM_par_1 690 695 PF11976 0.522
LIG_TRAF2_1 323 326 PF00917 0.508
LIG_TRAF2_1 865 868 PF00917 0.488
LIG_TRFH_1 459 463 PF08558 0.341
LIG_UBA3_1 571 580 PF00899 0.543
LIG_UBA3_1 892 901 PF00899 0.574
LIG_WRC_WIRS_1 434 439 PF05994 0.375
MOD_CDK_SPxK_1 403 409 PF00069 0.488
MOD_CDK_SPxxK_3 403 410 PF00069 0.461
MOD_CK1_1 255 261 PF00069 0.533
MOD_CK1_1 343 349 PF00069 0.566
MOD_CK1_1 43 49 PF00069 0.680
MOD_CK1_1 541 547 PF00069 0.341
MOD_CK1_1 585 591 PF00069 0.503
MOD_CK1_1 622 628 PF00069 0.414
MOD_CK1_1 725 731 PF00069 0.499
MOD_CK1_1 798 804 PF00069 0.519
MOD_CK1_1 85 91 PF00069 0.389
MOD_CK1_1 874 880 PF00069 0.593
MOD_CK2_1 146 152 PF00069 0.492
MOD_CK2_1 242 248 PF00069 0.508
MOD_CK2_1 320 326 PF00069 0.517
MOD_CK2_1 402 408 PF00069 0.371
MOD_CK2_1 649 655 PF00069 0.585
MOD_CK2_1 77 83 PF00069 0.521
MOD_CK2_1 851 857 PF00069 0.488
MOD_CK2_1 862 868 PF00069 0.488
MOD_CK2_1 89 95 PF00069 0.408
MOD_CK2_1 957 963 PF00069 0.449
MOD_CMANNOS 908 911 PF00535 0.393
MOD_GlcNHglycan 43 46 PF01048 0.696
MOD_GlcNHglycan 693 697 PF01048 0.282
MOD_GlcNHglycan 79 82 PF01048 0.561
MOD_GlcNHglycan 843 847 PF01048 0.299
MOD_GlcNHglycan 873 876 PF01048 0.329
MOD_GSK3_1 1006 1013 PF00069 0.435
MOD_GSK3_1 18 25 PF00069 0.700
MOD_GSK3_1 268 275 PF00069 0.402
MOD_GSK3_1 320 327 PF00069 0.485
MOD_GSK3_1 338 345 PF00069 0.293
MOD_GSK3_1 376 383 PF00069 0.439
MOD_GSK3_1 429 436 PF00069 0.449
MOD_GSK3_1 541 548 PF00069 0.341
MOD_GSK3_1 70 77 PF00069 0.489
MOD_GSK3_1 798 805 PF00069 0.567
MOD_GSK3_1 85 92 PF00069 0.492
MOD_GSK3_1 932 939 PF00069 0.466
MOD_GSK3_1 992 999 PF00069 0.429
MOD_LATS_1 869 875 PF00433 0.574
MOD_N-GLC_1 805 810 PF02516 0.397
MOD_N-GLC_1 89 94 PF02516 0.567
MOD_N-GLC_2 448 450 PF02516 0.488
MOD_NEK2_1 2 7 PF00069 0.767
MOD_NEK2_1 369 374 PF00069 0.507
MOD_NEK2_1 41 46 PF00069 0.699
MOD_NEK2_1 433 438 PF00069 0.488
MOD_NEK2_1 525 530 PF00069 0.341
MOD_NEK2_1 546 551 PF00069 0.356
MOD_NEK2_1 722 727 PF00069 0.502
MOD_NEK2_1 74 79 PF00069 0.469
MOD_NEK2_1 82 87 PF00069 0.442
MOD_NEK2_2 324 329 PF00069 0.457
MOD_NEK2_2 429 434 PF00069 0.449
MOD_NEK2_2 649 654 PF00069 0.574
MOD_NEK2_2 9 14 PF00069 0.519
MOD_PIKK_1 196 202 PF00454 0.520
MOD_PIKK_1 371 377 PF00454 0.549
MOD_PIKK_1 4 10 PF00454 0.513
MOD_PIKK_1 525 531 PF00454 0.341
MOD_PIKK_1 823 829 PF00454 0.488
MOD_PIKK_1 89 95 PF00454 0.573
MOD_PK_1 776 782 PF00069 0.488
MOD_PKA_2 2 8 PF00069 0.709
MOD_PKA_2 297 303 PF00069 0.449
MOD_PKA_2 369 375 PF00069 0.516
MOD_PKA_2 380 386 PF00069 0.356
MOD_PKA_2 491 497 PF00069 0.341
MOD_Plk_1 324 330 PF00069 0.370
MOD_Plk_1 429 435 PF00069 0.449
MOD_Plk_1 707 713 PF00069 0.471
MOD_Plk_1 82 88 PF00069 0.523
MOD_Plk_4 221 227 PF00069 0.473
MOD_Plk_4 242 248 PF00069 0.488
MOD_Plk_4 252 258 PF00069 0.362
MOD_Plk_4 297 303 PF00069 0.519
MOD_Plk_4 324 330 PF00069 0.376
MOD_Plk_4 351 357 PF00069 0.509
MOD_Plk_4 382 388 PF00069 0.375
MOD_Plk_4 433 439 PF00069 0.351
MOD_Plk_4 461 467 PF00069 0.310
MOD_Plk_4 541 547 PF00069 0.341
MOD_Plk_4 649 655 PF00069 0.574
MOD_Plk_4 74 80 PF00069 0.544
MOD_Plk_4 744 750 PF00069 0.507
MOD_Plk_4 795 801 PF00069 0.521
MOD_Plk_4 836 842 PF00069 0.574
MOD_Plk_4 917 923 PF00069 0.465
MOD_ProDKin_1 338 344 PF00069 0.420
MOD_ProDKin_1 403 409 PF00069 0.461
MOD_ProDKin_1 725 731 PF00069 0.513
MOD_ProDKin_1 805 811 PF00069 0.559
MOD_SUMO_for_1 586 589 PF00179 0.586
MOD_SUMO_for_1 900 903 PF00179 0.571
MOD_SUMO_rev_2 165 171 PF00179 0.581
TRG_AP2beta_CARGO_1 730 739 PF09066 0.563
TRG_DiLeu_BaEn_1 297 302 PF01217 0.579
TRG_DiLeu_BaEn_1 392 397 PF01217 0.467
TRG_DiLeu_BaEn_2 324 330 PF01217 0.490
TRG_DiLeu_BaEn_2 588 594 PF01217 0.535
TRG_DiLeu_BaEn_4 589 595 PF01217 0.527
TRG_DiLeu_BaEn_4 897 903 PF01217 0.574
TRG_ENDOCYTIC_2 1012 1015 PF00928 0.293
TRG_ENDOCYTIC_2 349 352 PF00928 0.470
TRG_ENDOCYTIC_2 390 393 PF00928 0.360
TRG_ENDOCYTIC_2 398 401 PF00928 0.315
TRG_ENDOCYTIC_2 654 657 PF00928 0.488
TRG_ENDOCYTIC_2 804 807 PF00928 0.561
TRG_ER_diArg_1 13 16 PF00400 0.588
TRG_ER_diArg_1 218 220 PF00400 0.560
TRG_ER_diArg_1 714 717 PF00400 0.509
TRG_NLS_MonoExtC_3 511 516 PF00514 0.370
TRG_NLS_MonoExtN_4 134 140 PF00514 0.572
TRG_NLS_MonoExtN_4 509 516 PF00514 0.370
TRG_Pf-PMV_PEXEL_1 204 209 PF00026 0.604
TRG_Pf-PMV_PEXEL_1 959 963 PF00026 0.473

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZF0 Leptomonas seymouri 77% 100%
A0A0S4JKD0 Bodo saltans 52% 100%
A0A1X0NVM8 Trypanosomatidae 61% 100%
A0A3R7KF21 Trypanosoma rangeli 60% 100%
A0A3S7WTK6 Leishmania donovani 90% 100%
A4HWJ9 Leishmania infantum 90% 100%
C9ZXU0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AQA0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
P00365 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 38% 97%
P33327 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 93%
Q4QF83 Leishmania major 90% 100%
Q54VI3 Dictyostelium discoideum 42% 98%
Q9USN5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 92%
V5B4M0 Trypanosoma cruzi 60% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS