Putative 60S ribosomal protein L6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L6, putative

Species:

Leishmania braziliensis

UniProt:

A4H873_LEIBR

TriTrypDb:

LbrM.15.1040 , LBRM2903_330013000

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A4H873

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H873

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17
GO:0000027	ribosomal large subunit assembly	7	2
GO:0002181	cytoplasmic translation	5	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.630
CLV_NRD_NRD_1	18	20	PF00675	0.557
CLV_NRD_NRD_1	27	29	PF00675	0.502
CLV_NRD_NRD_1	47	49	PF00675	0.331
CLV_NRD_NRD_1	75	77	PF00675	0.292
CLV_PCSK_FUR_1	45	49	PF00082	0.521
CLV_PCSK_KEX2_1	10	12	PF00082	0.714
CLV_PCSK_KEX2_1	47	49	PF00082	0.510
CLV_PCSK_KEX2_1	75	77	PF00082	0.292
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.714
CLV_PCSK_PC7_1	43	49	PF00082	0.517
CLV_PCSK_SKI1_1	12	16	PF00082	0.616
CLV_PCSK_SKI1_1	130	134	PF00082	0.402
CLV_PCSK_SKI1_1	177	181	PF00082	0.348
DEG_SPOP_SBC_1	94	98	PF00917	0.467
DOC_MAPK_gen_1	43	52	PF00069	0.528
DOC_MAPK_RevD_3	61	76	PF00069	0.529
DOC_PP4_FxxP_1	104	107	PF00568	0.500
DOC_USP7_UBL2_3	12	16	PF12436	0.622
DOC_USP7_UBL2_3	123	127	PF12436	0.527
DOC_USP7_UBL2_3	130	134	PF12436	0.486
DOC_USP7_UBL2_3	137	141	PF12436	0.456
DOC_USP7_UBL2_3	6	10	PF12436	0.592
DOC_WW_Pin1_4	18	23	PF00397	0.624
DOC_WW_Pin1_4	97	102	PF00397	0.545
LIG_14-3-3_CanoR_1	177	183	PF00244	0.587
LIG_14-3-3_CanoR_1	28	36	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_BIR_III_3	1	5	PF00653	0.661
LIG_BIR_III_4	166	170	PF00653	0.587
LIG_FHA_1	94	100	PF00498	0.485
LIG_FHA_2	111	117	PF00498	0.597
LIG_FHA_2	85	91	PF00498	0.492
LIG_LIR_Apic_2	102	107	PF02991	0.500
LIG_LIR_Gen_1	21	32	PF02991	0.672
LIG_LIR_Nem_3	21	27	PF02991	0.611
LIG_SH2_CRK	24	28	PF00017	0.654
LIG_SH2_CRK	69	73	PF00017	0.343
LIG_SH2_SRC	81	84	PF00017	0.492
LIG_SH2_STAT5	175	178	PF00017	0.486
LIG_SH2_STAT5	24	27	PF00017	0.702
LIG_SH2_STAT5	81	84	PF00017	0.492
LIG_SH3_3	60	66	PF00018	0.644
LIG_SUMO_SIM_par_1	59	64	PF11976	0.527
MOD_CK1_1	178	184	PF00069	0.492
MOD_CK1_1	18	24	PF00069	0.587
MOD_CK1_1	93	99	PF00069	0.509
MOD_CK2_1	110	116	PF00069	0.506
MOD_CK2_1	133	139	PF00069	0.424
MOD_Cter_Amidation	45	48	PF01082	0.537
MOD_GlcNHglycan	63	66	PF01048	0.522
MOD_GlcNHglycan	69	72	PF01048	0.343
MOD_GSK3_1	18	25	PF00069	0.616
MOD_GSK3_1	89	96	PF00069	0.509
MOD_NEK2_1	27	32	PF00069	0.656
MOD_NEK2_1	61	66	PF00069	0.510
MOD_NEK2_1	67	72	PF00069	0.550
MOD_NEK2_2	175	180	PF00069	0.492
MOD_PKA_1	133	139	PF00069	0.548
MOD_PKA_1	15	21	PF00069	0.635
MOD_PKA_2	27	33	PF00069	0.607
MOD_Plk_1	22	28	PF00069	0.637
MOD_Plk_1	89	95	PF00069	0.530
MOD_Plk_2-3	90	96	PF00069	0.566
MOD_Plk_4	139	145	PF00069	0.574
MOD_ProDKin_1	18	24	PF00069	0.627
MOD_ProDKin_1	97	103	PF00069	0.545
MOD_SUMO_for_1	107	110	PF00179	0.493
MOD_SUMO_for_1	126	129	PF00179	0.457
MOD_SUMO_rev_2	136	143	PF00179	0.525
TRG_ENDOCYTIC_2	24	27	PF00928	0.657
TRG_ENDOCYTIC_2	69	72	PF00928	0.343
TRG_ER_diArg_1	44	47	PF00400	0.514
TRG_ER_diArg_1	74	76	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT06	Leptomonas seymouri	91%	100%
A0A0S4JL50	Bodo saltans	73%	97%
A0A0S4JLI9	Bodo saltans	73%	97%
A0A1D8PCX8	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0NVD8	Trypanosomatidae	77%	100%
A0A1X0P118	Trypanosomatidae	79%	98%
A0A3Q8IAA6	Leishmania donovani	94%	99%
A0A3R7KR31	Trypanosoma rangeli	75%	100%
A0A3R7LKV1	Trypanosoma rangeli	76%	100%
A4HLB2	Leishmania braziliensis	99%	100%
A4HWJ8	Leishmania infantum	94%	99%
D0A4T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AQ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B3Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
P05739	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P0DJ56	Tetrahymena thermophila (strain SB210)	41%	100%
P34091	Mesembryanthemum crystallinum	41%	82%
P47991	Caenorhabditis elegans	36%	89%
P79071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	99%
Q02326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q02878	Homo sapiens	40%	67%
Q2YGT9	Sus scrofa	40%	68%
Q4Q4D3	Leishmania major	94%	100%
Q4QF84	Leishmania major	95%	100%
Q54D63	Dictyostelium discoideum	42%	82%
Q58DQ3	Bos taurus	40%	67%
Q6QMZ4	Chinchilla lanigera	39%	67%
Q9C9C5	Arabidopsis thaliana	38%	83%
Q9C9C6	Arabidopsis thaliana	37%	83%