Putative succinate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4H872_LEIBR

TriTrypDb:

LbrM.15.1030 , LBRM2903_150013400

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H872

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H872

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.492
CLV_C14_Caspase3-7	66	70	PF00656	0.476
CLV_NRD_NRD_1	50	52	PF00675	0.616
CLV_PCSK_KEX2_1	163	165	PF00082	0.343
CLV_PCSK_KEX2_1	171	173	PF00082	0.390
CLV_PCSK_KEX2_1	50	52	PF00082	0.617
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.343
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.390
CLV_PCSK_SKI1_1	160	164	PF00082	0.335
CLV_PCSK_SKI1_1	180	184	PF00082	0.478
DEG_APCC_DBOX_1	72	80	PF00400	0.374
DOC_MAPK_MEF2A_6	171	179	PF00069	0.527
DOC_PP4_FxxP_1	102	105	PF00568	0.239
DOC_PP4_FxxP_1	152	155	PF00568	0.317
DOC_USP7_UBL2_3	38	42	PF12436	0.489
DOC_WW_Pin1_4	12	17	PF00397	0.414
DOC_WW_Pin1_4	164	169	PF00397	0.356
LIG_14-3-3_CanoR_1	164	168	PF00244	0.428
LIG_eIF4E_1	18	24	PF01652	0.537
LIG_FHA_1	130	136	PF00498	0.371
LIG_FHA_1	168	174	PF00498	0.367
LIG_FHA_2	34	40	PF00498	0.494
LIG_LIR_Apic_2	100	105	PF02991	0.239
LIG_LIR_Gen_1	77	86	PF02991	0.239
LIG_LIR_Nem_3	111	115	PF02991	0.284
LIG_LIR_Nem_3	77	83	PF02991	0.321
LIG_PCNA_yPIPBox_3	50	63	PF02747	0.593
LIG_PTAP_UEV_1	1	6	PF05743	0.499
LIG_SH2_CRK	13	17	PF00017	0.439
LIG_SH2_STAP1	80	84	PF00017	0.239
LIG_SH2_STAT5	35	38	PF00017	0.534
LIG_SH2_STAT5	57	60	PF00017	0.472
LIG_SH2_STAT5	63	66	PF00017	0.458
MOD_CDK_SPxxK_3	164	171	PF00069	0.491
MOD_CK1_1	166	172	PF00069	0.409
MOD_GlcNHglycan	2	5	PF01048	0.497
MOD_GSK3_1	163	170	PF00069	0.387
MOD_GSK3_1	84	91	PF00069	0.258
MOD_N-GLC_1	11	16	PF02516	0.572
MOD_N-GLC_1	143	148	PF02516	0.239
MOD_N-GLC_1	25	30	PF02516	0.419
MOD_N-GLC_1	55	60	PF02516	0.582
MOD_N-GLC_2	137	139	PF02516	0.268
MOD_NEK2_1	108	113	PF00069	0.260
MOD_NEK2_1	129	134	PF00069	0.354
MOD_NEK2_1	143	148	PF00069	0.200
MOD_NEK2_1	24	29	PF00069	0.466
MOD_NEK2_1	84	89	PF00069	0.239
MOD_OFUCOSY	82	88	PF10250	0.239
MOD_PKA_1	163	169	PF00069	0.434
MOD_PKA_2	163	169	PF00069	0.454
MOD_Plk_1	143	149	PF00069	0.239
MOD_Plk_1	55	61	PF00069	0.588
MOD_Plk_4	131	137	PF00069	0.327
MOD_ProDKin_1	12	18	PF00069	0.410
MOD_ProDKin_1	164	170	PF00069	0.353
MOD_SUMO_rev_2	159	165	PF00179	0.343
TRG_DiLeu_BaEn_1	131	136	PF01217	0.318
TRG_ENDOCYTIC_2	112	115	PF00928	0.268
TRG_ENDOCYTIC_2	20	23	PF00928	0.431
TRG_ENDOCYTIC_2	80	83	PF00928	0.239
TRG_ER_diArg_1	126	129	PF00400	0.371
TRG_ER_diArg_1	73	76	PF00400	0.351
TRG_NES_CRM1_1	117	131	PF08389	0.283
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW5	Leptomonas seymouri	87%	100%
A0A0S4JJX0	Bodo saltans	71%	100%
A0A1X0NUF3	Trypanosomatidae	74%	94%
A0A3S5H6V4	Leishmania donovani	92%	93%
A0A422N147	Trypanosoma rangeli	71%	99%
A4HWJ7	Leishmania infantum	92%	93%
C9ZXU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	98%
E9AQ98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	93%
Q4QF85	Leishmania major	93%	100%
Q59662	Paracoccus denitrificans	39%	71%