DNA_repair_recombination_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein Rad9, putative

Species:

Leishmania braziliensis

UniProt:

A4H871_LEIBR

TriTrypDb:

LbrM.15.1020 , LBRM2903_150013500

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0030896	checkpoint clamp complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H871

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H871

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	8
GO:0000077	DNA damage checkpoint signaling	5	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0007165	signal transduction	2	8
GO:0009987	cellular process	1	8
GO:0010564	regulation of cell cycle process	5	8
GO:0010948	negative regulation of cell cycle process	6	8
GO:0031570	DNA integrity checkpoint signaling	5	8
GO:0033554	cellular response to stress	3	8
GO:0035556	intracellular signal transduction	3	8
GO:0042770	signal transduction in response to DNA damage	4	8
GO:0045786	negative regulation of cell cycle	5	8
GO:0048519	negative regulation of biological process	3	8
GO:0048523	negative regulation of cellular process	4	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0051726	regulation of cell cycle	4	8
GO:0065007	biological regulation	1	8
GO:1901987	regulation of cell cycle phase transition	6	8
GO:1901988	negative regulation of cell cycle phase transition	7	8
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010212	response to ionizing radiation	4	1
GO:0022402	cell cycle process	2	1
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.717
CLV_C14_Caspase3-7	670	674	PF00656	0.648
CLV_PCSK_SKI1_1	13	17	PF00082	0.485
CLV_PCSK_SKI1_1	175	179	PF00082	0.472
CLV_PCSK_SKI1_1	366	370	PF00082	0.469
CLV_PCSK_SKI1_1	419	423	PF00082	0.700
CLV_PCSK_SKI1_1	603	607	PF00082	0.546
CLV_PCSK_SKI1_1	62	66	PF00082	0.608
CLV_PCSK_SKI1_1	677	681	PF00082	0.558
DEG_APCC_DBOX_1	12	20	PF00400	0.473
DEG_SCF_FBW7_1	561	566	PF00400	0.566
DEG_SCF_FBW7_1	96	102	PF00400	0.439
DEG_SPOP_SBC_1	243	247	PF00917	0.656
DEG_SPOP_SBC_1	629	633	PF00917	0.592
DOC_CKS1_1	560	565	PF01111	0.752
DOC_CKS1_1	96	101	PF01111	0.452
DOC_CYCLIN_RxL_1	416	425	PF00134	0.458
DOC_MAPK_gen_1	333	342	PF00069	0.570
DOC_MAPK_MEF2A_6	47	55	PF00069	0.443
DOC_PP2B_LxvP_1	227	230	PF13499	0.604
DOC_PP2B_LxvP_1	599	602	PF13499	0.556
DOC_PP2B_LxvP_1	65	68	PF13499	0.638
DOC_PP2B_LxvP_1	80	83	PF13499	0.714
DOC_PP2B_PxIxI_1	9	15	PF00149	0.576
DOC_PP4_FxxP_1	291	294	PF00568	0.521
DOC_SPAK_OSR1_1	201	205	PF12202	0.543
DOC_USP7_MATH_1	131	135	PF00917	0.717
DOC_USP7_MATH_1	243	247	PF00917	0.671
DOC_USP7_MATH_1	252	256	PF00917	0.653
DOC_USP7_MATH_1	263	267	PF00917	0.600
DOC_USP7_MATH_1	272	276	PF00917	0.411
DOC_USP7_MATH_1	281	285	PF00917	0.376
DOC_USP7_MATH_1	299	303	PF00917	0.585
DOC_USP7_MATH_1	444	448	PF00917	0.554
DOC_USP7_MATH_1	454	458	PF00917	0.762
DOC_USP7_MATH_1	465	469	PF00917	0.623
DOC_USP7_MATH_1	472	476	PF00917	0.481
DOC_USP7_MATH_1	480	484	PF00917	0.755
DOC_USP7_MATH_1	567	571	PF00917	0.803
DOC_USP7_MATH_1	611	615	PF00917	0.605
DOC_USP7_MATH_1	629	633	PF00917	0.650
DOC_USP7_MATH_1	91	95	PF00917	0.525
DOC_USP7_MATH_1	99	103	PF00917	0.352
DOC_WW_Pin1_4	294	299	PF00397	0.701
DOC_WW_Pin1_4	315	320	PF00397	0.733
DOC_WW_Pin1_4	322	327	PF00397	0.760
DOC_WW_Pin1_4	396	401	PF00397	0.522
DOC_WW_Pin1_4	41	46	PF00397	0.507
DOC_WW_Pin1_4	424	429	PF00397	0.615
DOC_WW_Pin1_4	445	450	PF00397	0.416
DOC_WW_Pin1_4	476	481	PF00397	0.744
DOC_WW_Pin1_4	499	504	PF00397	0.826
DOC_WW_Pin1_4	559	564	PF00397	0.700
DOC_WW_Pin1_4	565	570	PF00397	0.683
DOC_WW_Pin1_4	578	583	PF00397	0.733
DOC_WW_Pin1_4	95	100	PF00397	0.477
LIG_14-3-3_CanoR_1	13	19	PF00244	0.438
LIG_14-3-3_CanoR_1	168	174	PF00244	0.502
LIG_14-3-3_CanoR_1	481	485	PF00244	0.830
LIG_14-3-3_CanoR_1	603	611	PF00244	0.711
LIG_14-3-3_CanoR_1	654	660	PF00244	0.610
LIG_14-3-3_CanoR_1	71	75	PF00244	0.604
LIG_BIR_II_1	1	5	PF00653	0.481
LIG_BRCT_BRCA1_1	1	5	PF00533	0.490
LIG_BRCT_BRCA1_1	122	126	PF00533	0.507
LIG_BRCT_BRCA1_1	359	363	PF00533	0.314
LIG_FHA_1	105	111	PF00498	0.461
LIG_FHA_1	178	184	PF00498	0.511
LIG_FHA_1	283	289	PF00498	0.543
LIG_FHA_1	348	354	PF00498	0.676
LIG_FHA_1	360	366	PF00498	0.513
LIG_FHA_1	465	471	PF00498	0.520
LIG_FHA_2	226	232	PF00498	0.557
LIG_FHA_2	278	284	PF00498	0.528
LIG_FHA_2	306	312	PF00498	0.561
LIG_FHA_2	384	390	PF00498	0.531
LIG_FHA_2	397	403	PF00498	0.378
LIG_FHA_2	664	670	PF00498	0.655
LIG_GBD_Chelix_1	374	382	PF00786	0.495
LIG_LIR_Apic_2	558	563	PF02991	0.789
LIG_LIR_Gen_1	191	202	PF02991	0.604
LIG_LIR_Gen_1	283	294	PF02991	0.534
LIG_LIR_Gen_1	352	363	PF02991	0.394
LIG_LIR_Gen_1	434	443	PF02991	0.535
LIG_LIR_Gen_1	635	646	PF02991	0.685
LIG_LIR_Gen_1	648	656	PF02991	0.551
LIG_LIR_Nem_3	191	197	PF02991	0.627
LIG_LIR_Nem_3	210	214	PF02991	0.238
LIG_LIR_Nem_3	283	289	PF02991	0.516
LIG_LIR_Nem_3	352	358	PF02991	0.704
LIG_LIR_Nem_3	434	438	PF02991	0.495
LIG_LIR_Nem_3	635	641	PF02991	0.698
LIG_LIR_Nem_3	648	652	PF02991	0.546
LIG_Pex14_1	169	173	PF04695	0.488
LIG_Pex14_2	282	286	PF04695	0.523
LIG_SH2_CRK	211	215	PF00017	0.474
LIG_SH2_CRK	50	54	PF00017	0.295
LIG_SH2_PTP2	560	563	PF00017	0.572
LIG_SH2_STAP1	173	177	PF00017	0.506
LIG_SH2_STAT5	30	33	PF00017	0.466
LIG_SH2_STAT5	441	444	PF00017	0.477
LIG_SH2_STAT5	560	563	PF00017	0.572
LIG_SH2_STAT5	656	659	PF00017	0.662
LIG_SH3_3	337	343	PF00018	0.763
LIG_SH3_3	353	359	PF00018	0.389
LIG_SH3_3	4	10	PF00018	0.566
LIG_SH3_3	613	619	PF00018	0.737
LIG_SH3_3	93	99	PF00018	0.496
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.785
LIG_SUMO_SIM_par_1	14	20	PF11976	0.498
LIG_SUMO_SIM_par_1	391	397	PF11976	0.493
LIG_SUMO_SIM_par_1	419	425	PF11976	0.454
LIG_SUMO_SIM_par_1	570	577	PF11976	0.716
LIG_TRAF2_1	386	389	PF00917	0.495
LIG_TRAF2_1	399	402	PF00917	0.422
LIG_TRAF2_1	666	669	PF00917	0.728
LIG_TRFH_1	63	67	PF08558	0.365
LIG_WRC_WIRS_1	435	440	PF05994	0.460
MOD_CDC14_SPxK_1	44	47	PF00782	0.614
MOD_CDK_SPK_2	476	481	PF00069	0.744
MOD_CDK_SPK_2	559	564	PF00069	0.754
MOD_CDK_SPxK_1	41	47	PF00069	0.517
MOD_CDK_SPxxK_3	578	585	PF00069	0.712
MOD_CK1_1	133	139	PF00069	0.748
MOD_CK1_1	17	23	PF00069	0.529
MOD_CK1_1	217	223	PF00069	0.546
MOD_CK1_1	245	251	PF00069	0.756
MOD_CK1_1	256	262	PF00069	0.493
MOD_CK1_1	266	272	PF00069	0.540
MOD_CK1_1	284	290	PF00069	0.540
MOD_CK1_1	315	321	PF00069	0.697
MOD_CK1_1	357	363	PF00069	0.345
MOD_CK1_1	41	47	PF00069	0.517
MOD_CK1_1	427	433	PF00069	0.663
MOD_CK1_1	447	453	PF00069	0.657
MOD_CK1_1	468	474	PF00069	0.686
MOD_CK1_1	475	481	PF00069	0.745
MOD_CK1_1	521	527	PF00069	0.736
MOD_CK1_1	531	537	PF00069	0.709
MOD_CK1_1	549	555	PF00069	0.744
MOD_CK1_1	583	589	PF00069	0.695
MOD_CK1_1	614	620	PF00069	0.557
MOD_CK1_1	632	638	PF00069	0.507
MOD_CK1_1	69	75	PF00069	0.734
MOD_CK1_1	95	101	PF00069	0.602
MOD_CK2_1	225	231	PF00069	0.539
MOD_CK2_1	252	258	PF00069	0.804
MOD_CK2_1	277	283	PF00069	0.551
MOD_CK2_1	305	311	PF00069	0.561
MOD_CK2_1	383	389	PF00069	0.478
MOD_CK2_1	396	402	PF00069	0.409
MOD_CK2_1	523	529	PF00069	0.804
MOD_CK2_1	565	571	PF00069	0.708
MOD_CK2_1	655	661	PF00069	0.743
MOD_CK2_1	663	669	PF00069	0.676
MOD_GlcNHglycan	133	136	PF01048	0.747
MOD_GlcNHglycan	220	223	PF01048	0.535
MOD_GlcNHglycan	231	234	PF01048	0.484
MOD_GlcNHglycan	249	252	PF01048	0.541
MOD_GlcNHglycan	258	261	PF01048	0.726
MOD_GlcNHglycan	265	268	PF01048	0.717
MOD_GlcNHglycan	39	43	PF01048	0.483
MOD_GlcNHglycan	414	417	PF01048	0.738
MOD_GlcNHglycan	430	433	PF01048	0.705
MOD_GlcNHglycan	449	452	PF01048	0.622
MOD_GlcNHglycan	454	457	PF01048	0.725
MOD_GlcNHglycan	474	477	PF01048	0.464
MOD_GlcNHglycan	521	524	PF01048	0.814
MOD_GlcNHglycan	557	560	PF01048	0.757
MOD_GlcNHglycan	576	579	PF01048	0.706
MOD_GlcNHglycan	585	588	PF01048	0.797
MOD_GlcNHglycan	624	627	PF01048	0.767
MOD_GlcNHglycan	7	10	PF01048	0.460
MOD_GlcNHglycan	77	80	PF01048	0.681
MOD_GSK3_1	106	113	PF00069	0.448
MOD_GSK3_1	127	134	PF00069	0.580
MOD_GSK3_1	210	217	PF00069	0.494
MOD_GSK3_1	225	232	PF00069	0.525
MOD_GSK3_1	242	249	PF00069	0.542
MOD_GSK3_1	252	259	PF00069	0.662
MOD_GSK3_1	273	280	PF00069	0.569
MOD_GSK3_1	406	413	PF00069	0.592
MOD_GSK3_1	424	431	PF00069	0.710
MOD_GSK3_1	464	471	PF00069	0.674
MOD_GSK3_1	472	479	PF00069	0.666
MOD_GSK3_1	519	526	PF00069	0.739
MOD_GSK3_1	528	535	PF00069	0.689
MOD_GSK3_1	551	558	PF00069	0.777
MOD_GSK3_1	559	566	PF00069	0.654
MOD_GSK3_1	574	581	PF00069	0.752
MOD_GSK3_1	628	635	PF00069	0.717
MOD_GSK3_1	636	643	PF00069	0.744
MOD_GSK3_1	66	73	PF00069	0.692
MOD_GSK3_1	679	686	PF00069	0.551
MOD_GSK3_1	91	98	PF00069	0.663
MOD_N-GLC_1	175	180	PF02516	0.351
MOD_N-GLC_1	552	557	PF02516	0.815
MOD_N-GLC_2	223	225	PF02516	0.606
MOD_NEK2_1	106	111	PF00069	0.467
MOD_NEK2_1	177	182	PF00069	0.589
MOD_NEK2_1	214	219	PF00069	0.511
MOD_NEK2_1	282	287	PF00069	0.592
MOD_NEK2_1	3	8	PF00069	0.426
MOD_NEK2_1	338	343	PF00069	0.559
MOD_NEK2_1	410	415	PF00069	0.653
MOD_NEK2_1	421	426	PF00069	0.708
MOD_NEK2_1	518	523	PF00069	0.571
MOD_NEK2_1	532	537	PF00069	0.738
MOD_NEK2_1	574	579	PF00069	0.797
MOD_NEK2_1	652	657	PF00069	0.624
MOD_NEK2_1	679	684	PF00069	0.481
MOD_NEK2_2	480	485	PF00069	0.575
MOD_NEK2_2	640	645	PF00069	0.770
MOD_PKA_2	256	262	PF00069	0.810
MOD_PKA_2	406	412	PF00069	0.635
MOD_PKA_2	452	458	PF00069	0.753
MOD_PKA_2	480	486	PF00069	0.758
MOD_PKA_2	546	552	PF00069	0.766
MOD_PKA_2	563	569	PF00069	0.819
MOD_PKA_2	70	76	PF00069	0.661
MOD_Plk_1	195	201	PF00069	0.594
MOD_Plk_1	282	288	PF00069	0.570
MOD_Plk_1	38	44	PF00069	0.482
MOD_Plk_1	465	471	PF00069	0.711
MOD_Plk_1	528	534	PF00069	0.810
MOD_Plk_1	552	558	PF00069	0.815
MOD_Plk_1	91	97	PF00069	0.624
MOD_Plk_2-3	663	669	PF00069	0.556
MOD_Plk_2-3	92	98	PF00069	0.648
MOD_Plk_4	106	112	PF00069	0.468
MOD_Plk_4	14	20	PF00069	0.456
MOD_Plk_4	177	183	PF00069	0.506
MOD_Plk_4	189	195	PF00069	0.562
MOD_Plk_4	210	216	PF00069	0.488
MOD_Plk_4	274	280	PF00069	0.520
MOD_Plk_4	431	437	PF00069	0.520
MOD_Plk_4	465	471	PF00069	0.520
MOD_Plk_4	640	646	PF00069	0.768
MOD_ProDKin_1	294	300	PF00069	0.706
MOD_ProDKin_1	315	321	PF00069	0.729
MOD_ProDKin_1	322	328	PF00069	0.759
MOD_ProDKin_1	396	402	PF00069	0.520
MOD_ProDKin_1	41	47	PF00069	0.517
MOD_ProDKin_1	424	430	PF00069	0.618
MOD_ProDKin_1	445	451	PF00069	0.430
MOD_ProDKin_1	476	482	PF00069	0.746
MOD_ProDKin_1	499	505	PF00069	0.822
MOD_ProDKin_1	559	565	PF00069	0.698
MOD_ProDKin_1	578	584	PF00069	0.793
MOD_ProDKin_1	95	101	PF00069	0.461
MOD_SUMO_rev_2	360	368	PF00179	0.311
TRG_DiLeu_BaEn_2	674	680	PF01217	0.563
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.454
TRG_DiLeu_LyEn_5	389	394	PF01217	0.337
TRG_ENDOCYTIC_2	194	197	PF00928	0.626
TRG_ENDOCYTIC_2	211	214	PF00928	0.326
TRG_ENDOCYTIC_2	50	53	PF00928	0.291
TRG_ENDOCYTIC_2	656	659	PF00928	0.481
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I126	Leptomonas seymouri	45%	88%
A0A1X0NTX6	Trypanosomatidae	22%	92%
A0A3Q8IIS7	Leishmania donovani	73%	96%
A4HWJ6	Leishmania infantum	73%	80%
E9AQ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%
Q4QF86	Leishmania major	73%	100%