Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

ERV/ALR sulfhydryl oxidase domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4H869_LEIBR

TriTrypDb:

LbrM.15.1000 , LBRM2903_150013700

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H869

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H869

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	9
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	9
GO:0016972	thiol oxidase activity	5	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.646
CLV_NRD_NRD_1	116	118	PF00675	0.492
CLV_NRD_NRD_1	151	153	PF00675	0.546
CLV_NRD_NRD_1	158	160	PF00675	0.609
CLV_PCSK_FUR_1	299	303	PF00082	0.618
CLV_PCSK_KEX2_1	116	118	PF00082	0.490
CLV_PCSK_KEX2_1	150	152	PF00082	0.542
CLV_PCSK_KEX2_1	158	160	PF00082	0.613
CLV_PCSK_KEX2_1	301	303	PF00082	0.611
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.506
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.611
CLV_PCSK_SKI1_1	104	108	PF00082	0.560
CLV_PCSK_SKI1_1	147	151	PF00082	0.670
CLV_PCSK_SKI1_1	201	205	PF00082	0.766
DEG_MDM2_SWIB_1	53	60	PF02201	0.310
DOC_CKS1_1	204	209	PF01111	0.660
DOC_CKS1_1	238	243	PF01111	0.675
DOC_CKS1_1	278	283	PF01111	0.725
DOC_MAPK_gen_1	158	165	PF00069	0.533
DOC_USP7_MATH_1	208	212	PF00917	0.722
DOC_USP7_MATH_1	245	249	PF00917	0.767
DOC_USP7_MATH_1	279	283	PF00917	0.581
DOC_USP7_UBL2_3	125	129	PF12436	0.503
DOC_USP7_UBL2_3	143	147	PF12436	0.612
DOC_WW_Pin1_4	107	112	PF00397	0.360
DOC_WW_Pin1_4	16	21	PF00397	0.488
DOC_WW_Pin1_4	203	208	PF00397	0.617
DOC_WW_Pin1_4	237	242	PF00397	0.803
DOC_WW_Pin1_4	256	261	PF00397	0.595
DOC_WW_Pin1_4	277	282	PF00397	0.765
LIG_14-3-3_CanoR_1	158	165	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_CtBP_PxDLS_1	20	24	PF00389	0.537
LIG_FHA_1	241	247	PF00498	0.784
LIG_FHA_2	129	135	PF00498	0.563
LIG_FHA_2	143	149	PF00498	0.541
LIG_FHA_2	17	23	PF00498	0.473
LIG_FHA_2	289	295	PF00498	0.660
LIG_LIR_Gen_1	26	36	PF02991	0.360
LIG_LIR_Gen_1	55	62	PF02991	0.327
LIG_LIR_Nem_3	26	31	PF02991	0.360
LIG_LIR_Nem_3	55	60	PF02991	0.299
LIG_LIR_Nem_3	64	68	PF02991	0.299
LIG_PCNA_yPIPBox_3	41	54	PF02747	0.360
LIG_Pex14_1	118	122	PF04695	0.456
LIG_Pex14_1	57	61	PF04695	0.301
LIG_Pex14_2	53	57	PF04695	0.290
LIG_SH2_STAP1	61	65	PF00017	0.360
LIG_SH2_STAT5	306	309	PF00017	0.622
LIG_SH2_STAT5	73	76	PF00017	0.301
LIG_SH2_STAT5	90	93	PF00017	0.301
LIG_SH3_1	117	123	PF00018	0.378
LIG_SH3_2	120	125	PF14604	0.575
LIG_SH3_3	117	123	PF00018	0.378
LIG_SH3_3	302	308	PF00018	0.605
LIG_SH3_3	36	42	PF00018	0.301
LIG_SxIP_EBH_1	9	19	PF03271	0.560
LIG_TRAF2_1	131	134	PF00917	0.526
LIG_WW_3	259	263	PF00397	0.538
MOD_CDK_SPxK_1	256	262	PF00069	0.542
MOD_CDK_SPxK_1	277	283	PF00069	0.734
MOD_CDK_SPxxK_3	203	210	PF00069	0.538
MOD_CK1_1	217	223	PF00069	0.757
MOD_CK1_1	231	237	PF00069	0.674
MOD_CK2_1	128	134	PF00069	0.527
MOD_CK2_1	136	142	PF00069	0.523
MOD_CK2_1	16	22	PF00069	0.518
MOD_CK2_1	265	271	PF00069	0.708
MOD_CMANNOS	194	197	PF00535	0.610
MOD_GlcNHglycan	198	201	PF01048	0.595
MOD_GlcNHglycan	219	222	PF01048	0.652
MOD_GlcNHglycan	234	237	PF01048	0.801
MOD_GlcNHglycan	247	250	PF01048	0.622
MOD_GlcNHglycan	25	28	PF01048	0.406
MOD_GlcNHglycan	33	36	PF01048	0.510
MOD_GlcNHglycan	42	45	PF01048	0.478
MOD_GSK3_1	179	186	PF00069	0.775
MOD_GSK3_1	192	199	PF00069	0.572
MOD_GSK3_1	228	235	PF00069	0.793
MOD_GSK3_1	236	243	PF00069	0.752
MOD_GSK3_1	273	280	PF00069	0.729
MOD_N-GLC_1	217	222	PF02516	0.793
MOD_NEK2_1	23	28	PF00069	0.503
MOD_NEK2_1	31	36	PF00069	0.360
MOD_NEK2_1	53	58	PF00069	0.325
MOD_NEK2_1	85	90	PF00069	0.350
MOD_PIKK_1	223	229	PF00454	0.806
MOD_PKA_1	158	164	PF00069	0.600
MOD_PKA_2	158	164	PF00069	0.603
MOD_PKA_2	8	14	PF00069	0.681
MOD_Plk_1	273	279	PF00069	0.718
MOD_Plk_2-3	128	134	PF00069	0.524
MOD_Plk_4	273	279	PF00069	0.804
MOD_ProDKin_1	107	113	PF00069	0.360
MOD_ProDKin_1	16	22	PF00069	0.484
MOD_ProDKin_1	203	209	PF00069	0.621
MOD_ProDKin_1	237	243	PF00069	0.804
MOD_ProDKin_1	256	262	PF00069	0.597
MOD_ProDKin_1	277	283	PF00069	0.764
TRG_ER_diArg_1	115	117	PF00400	0.291
TRG_ER_diArg_1	158	160	PF00400	0.586
TRG_NLS_MonoExtC_3	149	155	PF00514	0.500
TRG_NLS_MonoExtN_4	147	154	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T9	Leptomonas seymouri	55%	100%
A0A3Q8ICB2	Leishmania donovani	78%	100%
A4HWJ4	Leishmania infantum	78%	100%
C9ZXU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQ95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QF88	Leishmania major	76%	99%
V5DL65	Trypanosoma cruzi	38%	93%