Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H867_LEIBR

TriTrypDb:

LbrM.15.0980 , LBRM2903_150014000

Length:

1228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H867

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H867

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.359
CLV_C14_Caspase3-7	416	420	PF00656	0.802
CLV_C14_Caspase3-7	431	435	PF00656	0.528
CLV_C14_Caspase3-7	729	733	PF00656	0.696
CLV_C14_Caspase3-7	850	854	PF00656	0.504
CLV_NRD_NRD_1	1090	1092	PF00675	0.849
CLV_NRD_NRD_1	1106	1108	PF00675	0.721
CLV_NRD_NRD_1	1197	1199	PF00675	0.620
CLV_NRD_NRD_1	276	278	PF00675	0.574
CLV_NRD_NRD_1	363	365	PF00675	0.783

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI9	Leptomonas seymouri	44%	100%
A0A3Q8I962	Leishmania donovani	71%	100%
A4HWJ2	Leishmania infantum	71%	100%
E9AQ93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QF90	Leishmania major	72%	100%

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