Calmodulin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-like protein

Species:

Leishmania braziliensis

UniProt:

A4H866_LEIBR

TriTrypDb:

LbrM.15.0970 , LBRM2903_150014100

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H866

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H866

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.489
CLV_NRD_NRD_1	55	57	PF00675	0.447
CLV_PCSK_KEX2_1	55	57	PF00082	0.462
CLV_PCSK_PC7_1	51	57	PF00082	0.462
CLV_PCSK_SKI1_1	131	135	PF00082	0.473
CLV_PCSK_SKI1_1	47	51	PF00082	0.493
DEG_APCC_DBOX_1	107	115	PF00400	0.502
DEG_APCC_DBOX_1	130	138	PF00400	0.560
DEG_SCF_FBW7_1	15	20	PF00400	0.467
DEG_SCF_FBW7_1	154	160	PF00400	0.523
DEG_SPOP_SBC_1	158	162	PF00917	0.674
DEG_SPOP_SBC_1	17	21	PF00917	0.595
DOC_CKS1_1	154	159	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.548
DOC_MAPK_gen_1	108	117	PF00069	0.505
DOC_MAPK_gen_1	36	46	PF00069	0.327
DOC_USP7_MATH_1	17	21	PF00917	0.569
DOC_USP7_MATH_1	179	183	PF00917	0.460
DOC_USP7_MATH_2	23	29	PF00917	0.578
DOC_WW_Pin1_4	11	16	PF00397	0.742
DOC_WW_Pin1_4	153	158	PF00397	0.499
DOC_WW_Pin1_4	159	164	PF00397	0.550
LIG_14-3-3_CanoR_1	108	118	PF00244	0.520
LIG_14-3-3_CanoR_1	55	62	PF00244	0.457
LIG_deltaCOP1_diTrp_1	25	33	PF00928	0.435
LIG_FHA_1	160	166	PF00498	0.556
LIG_FHA_1	17	23	PF00498	0.559
LIG_FHA_1	27	33	PF00498	0.418
LIG_FHA_1	36	42	PF00498	0.424
LIG_FHA_2	118	124	PF00498	0.603
LIG_FHA_2	159	165	PF00498	0.627
LIG_FHA_2	56	62	PF00498	0.447
LIG_FHA_2	88	94	PF00498	0.545
LIG_LIR_Gen_1	27	35	PF02991	0.433
LIG_LIR_Gen_1	59	70	PF02991	0.348
LIG_LIR_Gen_1	74	82	PF02991	0.424
LIG_LIR_Nem_3	27	33	PF02991	0.430
LIG_LIR_Nem_3	59	65	PF02991	0.345
LIG_LIR_Nem_3	74	78	PF02991	0.419
LIG_NRBOX	113	119	PF00104	0.426
LIG_OCRL_FandH_1	32	44	PF00620	0.373
LIG_SH2_CRK	86	90	PF00017	0.499
LIG_SH2_NCK_1	57	61	PF00017	0.466
LIG_SH2_STAP1	75	79	PF00017	0.537
LIG_SH2_STAT5	153	156	PF00017	0.597
LIG_SH2_STAT5	57	60	PF00017	0.457
LIG_SH2_STAT5	86	89	PF00017	0.555
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.455
LIG_SUMO_SIM_par_1	112	120	PF11976	0.455
LIG_UBA3_1	117	124	PF00899	0.480
LIG_UBA3_1	165	170	PF00899	0.412
MOD_CK2_1	117	123	PF00069	0.468
MOD_CK2_1	55	61	PF00069	0.450
MOD_Cter_Amidation	53	56	PF01082	0.453
MOD_GlcNHglycan	105	108	PF01048	0.450
MOD_GlcNHglycan	181	184	PF01048	0.614
MOD_GSK3_1	109	116	PF00069	0.429
MOD_GSK3_1	13	20	PF00069	0.695
MOD_GSK3_1	149	156	PF00069	0.477
MOD_GSK3_1	175	182	PF00069	0.586
MOD_GSK3_1	35	42	PF00069	0.451
MOD_LATS_1	37	43	PF00433	0.325
MOD_NEK2_1	117	122	PF00069	0.476
MOD_NEK2_1	24	29	PF00069	0.603
MOD_PKA_1	55	61	PF00069	0.463
MOD_PKA_2	35	41	PF00069	0.470
MOD_PKA_2	55	61	PF00069	0.477
MOD_Plk_2-3	136	142	PF00069	0.508
MOD_Plk_2-3	71	77	PF00069	0.322
MOD_Plk_4	149	155	PF00069	0.547
MOD_ProDKin_1	11	17	PF00069	0.742
MOD_ProDKin_1	153	159	PF00069	0.509
MOD_SUMO_rev_2	42	49	PF00179	0.455
TRG_DiLeu_BaEn_1	113	118	PF01217	0.420
TRG_DiLeu_BaEn_1	61	66	PF01217	0.465
TRG_ENDOCYTIC_2	75	78	PF00928	0.475
TRG_ER_diArg_1	144	147	PF00400	0.539
TRG_ER_diArg_1	55	57	PF00400	0.457
TRG_NES_CRM1_1	92	105	PF08389	0.580
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.505
TRG_PTS2	1	44	PF00400	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P206	Leptomonas seymouri	26%	100%
A0A0N1HZV4	Leptomonas seymouri	87%	98%
A0A0S4IS38	Bodo saltans	26%	100%
A0A0S4IUE7	Bodo saltans	69%	100%
A0A0S4JFC8	Bodo saltans	26%	100%
A0A0S4JFY6	Bodo saltans	31%	100%
A0A0S4JGZ3	Bodo saltans	27%	100%
A0A0S4KHL8	Bodo saltans	31%	76%
A0A1X0NMM5	Trypanosomatidae	26%	100%
A0A1X0NU74	Trypanosomatidae	69%	100%
A0A1X0NXW5	Trypanosomatidae	29%	100%
A0A1X0P9X3	Trypanosomatidae	25%	100%
A0A3R7RDM4	Trypanosoma rangeli	73%	100%
A0A3S7WTH8	Leishmania donovani	90%	99%
A0A422MQ47	Trypanosoma rangeli	26%	100%
A0A422NIM0	Trypanosoma rangeli	31%	100%
A0A422P0I1	Trypanosoma rangeli	24%	100%
A2WN93	Oryza sativa subsp. indica	27%	100%
A2WNH1	Oryza sativa subsp. indica	27%	100%
A2Y609	Oryza sativa subsp. indica	27%	100%
A3E3H0	Pfiesteria piscicida	26%	100%
A3E4D8	Prorocentrum minimum	26%	100%
A3E4F9	Karlodinium veneficum	26%	100%
A4H5R9	Leishmania braziliensis	26%	100%
A4HAV0	Leishmania braziliensis	24%	100%
A4HU13	Leishmania infantum	26%	100%
A4HWJ1	Leishmania infantum	90%	100%
A4IF97	Bos taurus	27%	100%
A4UHC0	Alexandrium fundyense	26%	100%
A8CEP3	Saccharina japonica	24%	100%
A8I1Q0	Heterocapsa triquetra	26%	100%
B1PSN3	Leishmania donovani	26%	100%
C9ZML6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZXV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A9H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A9H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AMU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AQ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
O00897	Dictyostelium discoideum	25%	100%
O02367	Ciona intestinalis	25%	100%
O14950	Homo sapiens	27%	100%
O16305	Caenorhabditis elegans	27%	100%
O23320	Arabidopsis thaliana	27%	100%
O60041	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
O82018	Mougeotia scalaris	25%	100%
O82659	Arabidopsis thaliana	24%	100%
O94739	Pleurotus ostreatus	24%	100%
O96081	Halocynthia roretzi	27%	100%
O96102	Physarum polycephalum	26%	100%
O97341	Suberites domuncula	26%	100%
P02588	Gallus gallus	25%	100%
P02594	Electrophorus electricus	26%	100%
P02595	Patinopecten sp.	26%	100%
P02597	Gallus gallus	27%	100%
P02598	Tetrahymena pyriformis	26%	100%
P02599	Dictyostelium discoideum	26%	100%
P02607	Gallus gallus	29%	100%
P02612	Gallus gallus	25%	100%
P04352	Chlamydomonas reinhardtii	27%	100%
P04353	Spinacia oleracea	27%	100%
P04464	Triticum aestivum	27%	100%
P05419	Gallus gallus	27%	100%
P05932	Arbacia punctulata	25%	100%
P05933	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P06787	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P07462	Halocynthia roretzi	30%	100%
P07463	Paramecium tetraurelia	25%	100%
P08053	Physarum polycephalum	30%	100%
P09540	Gallus gallus	29%	100%
P0DH95	Arabidopsis thaliana	27%	100%
P0DH96	Arabidopsis thaliana	27%	100%
P0DH97	Arabidopsis thaliana	27%	100%
P0DH98	Arabidopsis thaliana	27%	100%
P0DP23	Homo sapiens	26%	100%
P0DP24	Homo sapiens	26%	100%
P0DP25	Homo sapiens	26%	100%
P0DP26	Mus musculus	26%	100%
P0DP27	Mus musculus	26%	100%
P0DP28	Mus musculus	26%	100%
P0DP29	Rattus norvegicus	26%	100%
P0DP30	Rattus norvegicus	26%	100%
P0DP31	Rattus norvegicus	26%	100%
P0DP33	Xenopus laevis	26%	100%
P0DP34	Xenopus laevis	26%	100%
P0DP35	Xenopus laevis	26%	100%
P10246	Meleagris gallopavo	24%	100%
P11118	Euglena gracilis	27%	100%
P11120	Pleurotus cornucopiae	24%	100%
P11121	Pyuridae sp.	26%	100%
P13832	Rattus norvegicus	24%	100%
P13868	Solanum tuberosum	27%	100%
P15094	Achlya klebsiana	23%	100%
P15159	Tachypleus tridentatus	26%	100%
P17928	Medicago sativa	27%	100%
P18061	Trypanosoma cruzi	26%	100%
P18666	Rattus norvegicus	26%	100%
P19105	Homo sapiens	26%	100%
P19625	Caenorhabditis elegans	24%	100%
P19626	Caenorhabditis elegans	25%	100%
P21251	Stichopus japonicus	26%	100%
P23286	Candida albicans	29%	100%
P24032	Gallus gallus	25%	100%
P24044	Plasmodium falciparum	27%	100%
P24844	Homo sapiens	26%	100%
P27161	Solanum lycopersicum	27%	100%
P27163	Petunia hybrida	25%	100%
P27164	Petunia hybrida	27%	100%
P27165	Phytophthora infestans	24%	100%
P27166	Stylonychia lemnae	27%	100%
P27482	Homo sapiens	26%	100%
P29269	Sus scrofa	26%	100%
P41040	Zea mays	26%	100%
P41041	Pneumocystis carinii	24%	100%
P48976	Malus domestica	26%	100%
P49258	Drosophila melanogaster	25%	100%
P53440	Naegleria gruberi	23%	100%
P54357	Drosophila melanogaster	35%	100%
P59220	Arabidopsis thaliana	27%	100%
P60204	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
P60205	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
P60206	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	24%	100%
P61859	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
P61860	Colletotrichum trifolii	24%	100%
P61861	Colletotrichum gloeosporioides	24%	100%
P62144	Anas platyrhynchos	26%	100%
P62145	Aplysia californica	26%	100%
P62146	Arbacia punctulata	27%	100%
P62147	Branchiostoma floridae	26%	100%
P62148	Branchiostoma lanceolatum	26%	100%
P62149	Gallus gallus	26%	100%
P62150	Oryzias latipes	27%	100%
P62151	Tetronarce californica	26%	100%
P62152	Drosophila melanogaster	26%	100%
P62153	Halocynthia roretzi	26%	100%
P62154	Locusta migratoria	26%	100%
P62156	Oncorhynchus sp.	26%	100%
P62157	Bos taurus	26%	100%
P62160	Oryctolagus cuniculus	26%	100%
P62162	Hordeum vulgare	27%	100%
P62163	Glycine max	27%	100%
P62184	Renilla reniformis	25%	100%
P62199	Petunia hybrida	27%	100%
P62200	Daucus carota	27%	100%
P62201	Lilium longiflorum	27%	100%
P62202	Bryonia dioica	27%	100%
P62203	Plasmodium falciparum (isolate 3D7)	27%	100%
P69097	Trypanosoma brucei brucei	26%	100%
P69098	Trypanosoma brucei gambiense	26%	100%
P82159	Chelon ramada	30%	100%
P82160	Chelon ramada	27%	100%
P84339	Agaricus bisporus	22%	100%
P85100	Bos taurus	30%	94%
P93087	Capsicum annuum	27%	100%
P93171	Helianthus annuus	27%	100%
Q03509	Arabidopsis thaliana	27%	100%
Q0IQB6	Oryza sativa subsp. japonica	26%	100%
Q0IUU4	Oryza sativa subsp. japonica	27%	100%
Q0JNL7	Oryza sativa subsp. japonica	27%	100%
Q0JNS6	Oryza sativa subsp. japonica	27%	100%
Q2R1Z5	Oryza sativa subsp. japonica	22%	100%
Q39752	Fagus sylvatica	27%	100%
Q3THE2	Mus musculus	27%	100%
Q40302	Macrocystis pyrifera	24%	100%
Q40642	Oryza sativa subsp. indica	23%	100%
Q4QF91	Leishmania major	89%	100%
Q4QHT2	Leishmania major	26%	100%
Q5E9E2	Bos taurus	25%	100%
Q5RAD2	Pongo abelii	26%	100%
Q5RBA4	Pongo abelii	26%	100%
Q5RC34	Pongo abelii	26%	100%
Q5U206	Rattus norvegicus	26%	100%
Q64119	Rattus norvegicus	30%	100%
Q64122	Rattus norvegicus	25%	100%
Q682T9	Arabidopsis thaliana	27%	100%
Q6F332	Oryza sativa subsp. japonica	27%	100%
Q6IT78	Ctenopharyngodon idella	26%	100%
Q6P0G6	Danio rerio	29%	98%
Q6PI52	Danio rerio	26%	100%
Q6R520	Oreochromis mossambicus	26%	100%
Q6YNX6	Ovis aries	26%	100%
Q71UH5	Globisporangium splendens	24%	100%
Q71UH6	Perca flavescens	26%	100%
Q7DMN9	Solanum tuberosum	27%	100%
Q7T3T2	Epinephelus akaara	26%	100%
Q7Y052	Euphorbia characias	27%	100%
Q84MN0	Oryza sativa subsp. japonica	28%	100%
Q8S1Y9	Oryza sativa subsp. japonica	23%	100%
Q8STF0	Strongylocentrotus intermedius	26%	100%
Q8X187	Paxillus involutus	24%	100%
Q948R0	Oryza sativa subsp. japonica	23%	100%
Q95NI4	Halichondria okadai	25%	100%
Q95NR9	Metridium senile	25%	100%
Q9BUA6	Homo sapiens	23%	83%
Q9CQ19	Mus musculus	26%	100%
Q9D6P8	Mus musculus	25%	100%
Q9GRJ1	Lumbricus rubellus	26%	100%
Q9HFY6	Blastocladiella emersonii	24%	100%
Q9LE22	Arabidopsis thaliana	26%	100%
Q9LIK5	Arabidopsis thaliana	26%	100%
Q9M7R0	Olea europaea	24%	100%
Q9NZT1	Homo sapiens	23%	100%
Q9QVP4	Mus musculus	27%	100%
Q9U6D3	Myxine glutinosa	26%	100%
Q9UB37	Branchiostoma lanceolatum	25%	100%
Q9UWF0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	100%
Q9XVI9	Caenorhabditis elegans	31%	100%
Q9XZP2	Branchiostoma floridae	23%	100%
V5BPQ4	Trypanosoma cruzi	73%	100%