Protein phosphatase 2A regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H865_LEIBR

TriTrypDb:

LbrM.15.0960 , LBRM2903_150014200

Length:

882

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0005737	cytoplasm	2	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4H865

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H865

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.549
CLV_C14_Caspase3-7	875	879	PF00656	0.743
CLV_NRD_NRD_1	152	154	PF00675	0.671
CLV_NRD_NRD_1	205	207	PF00675	0.417
CLV_NRD_NRD_1	26	28	PF00675	0.637
CLV_NRD_NRD_1	529	531	PF00675	0.487
CLV_NRD_NRD_1	617	619	PF00675	0.712
CLV_NRD_NRD_1	664	666	PF00675	0.559
CLV_NRD_NRD_1	796	798	PF00675	0.473
CLV_NRD_NRD_1	840	842	PF00675	0.477
CLV_PCSK_KEX2_1	152	154	PF00082	0.671
CLV_PCSK_KEX2_1	205	207	PF00082	0.417
CLV_PCSK_KEX2_1	26	28	PF00082	0.630
CLV_PCSK_KEX2_1	529	531	PF00082	0.487
CLV_PCSK_KEX2_1	617	619	PF00082	0.712
CLV_PCSK_KEX2_1	666	668	PF00082	0.480
CLV_PCSK_KEX2_1	795	797	PF00082	0.467
CLV_PCSK_KEX2_1	840	842	PF00082	0.297
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.521
CLV_PCSK_PC7_1	201	207	PF00082	0.325
CLV_PCSK_SKI1_1	205	209	PF00082	0.431
CLV_PCSK_SKI1_1	292	296	PF00082	0.486
CLV_PCSK_SKI1_1	311	315	PF00082	0.264
CLV_PCSK_SKI1_1	415	419	PF00082	0.399
CLV_PCSK_SKI1_1	436	440	PF00082	0.369
CLV_PCSK_SKI1_1	711	715	PF00082	0.438
CLV_PCSK_SKI1_1	734	738	PF00082	0.500
CLV_PCSK_SKI1_1	797	801	PF00082	0.429
CLV_Separin_Metazoa	545	549	PF03568	0.497
DEG_APCC_DBOX_1	390	398	PF00400	0.487
DEG_Nend_Nbox_1	1	3	PF02207	0.504
DEG_SCF_FBW7_1	87	93	PF00400	0.574
DEG_SPOP_SBC_1	293	297	PF00917	0.493
DEG_SPOP_SBC_1	431	435	PF00917	0.521
DEG_SPOP_SBC_1	70	74	PF00917	0.537
DOC_CKS1_1	87	92	PF01111	0.697
DOC_CYCLIN_RxL_1	412	421	PF00134	0.415
DOC_CYCLIN_RxL_1	794	803	PF00134	0.294
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.386
DOC_MAPK_gen_1	689	697	PF00069	0.403
DOC_MAPK_MEF2A_6	164	173	PF00069	0.752
DOC_PP1_RVXF_1	320	326	PF00149	0.484
DOC_PP1_RVXF_1	493	500	PF00149	0.273
DOC_PP2B_LxvP_1	313	316	PF13499	0.360
DOC_PP4_FxxP_1	611	614	PF00568	0.528
DOC_USP7_MATH_1	145	149	PF00917	0.765
DOC_USP7_MATH_1	151	155	PF00917	0.639
DOC_USP7_MATH_1	18	22	PF00917	0.589
DOC_USP7_MATH_1	362	366	PF00917	0.441
DOC_USP7_MATH_1	431	435	PF00917	0.400
DOC_USP7_MATH_1	47	51	PF00917	0.739
DOC_USP7_MATH_1	569	573	PF00917	0.452
DOC_USP7_MATH_1	592	596	PF00917	0.690
DOC_USP7_MATH_1	784	788	PF00917	0.424
DOC_USP7_MATH_1	82	86	PF00917	0.575
DOC_USP7_MATH_1	90	94	PF00917	0.686
DOC_USP7_UBL2_3	432	436	PF12436	0.487
DOC_WW_Pin1_4	13	18	PF00397	0.718
DOC_WW_Pin1_4	134	139	PF00397	0.718
DOC_WW_Pin1_4	141	146	PF00397	0.688
DOC_WW_Pin1_4	159	164	PF00397	0.613
DOC_WW_Pin1_4	37	42	PF00397	0.680
DOC_WW_Pin1_4	4	9	PF00397	0.661
DOC_WW_Pin1_4	43	48	PF00397	0.675
DOC_WW_Pin1_4	604	609	PF00397	0.619
DOC_WW_Pin1_4	610	615	PF00397	0.583
DOC_WW_Pin1_4	633	638	PF00397	0.724
DOC_WW_Pin1_4	703	708	PF00397	0.477
DOC_WW_Pin1_4	83	88	PF00397	0.729
LIG_14-3-3_CanoR_1	133	138	PF00244	0.731
LIG_14-3-3_CanoR_1	152	156	PF00244	0.639
LIG_14-3-3_CanoR_1	206	214	PF00244	0.463
LIG_14-3-3_CanoR_1	267	275	PF00244	0.516
LIG_14-3-3_CanoR_1	322	326	PF00244	0.492
LIG_14-3-3_CanoR_1	37	41	PF00244	0.635
LIG_14-3-3_CanoR_1	391	395	PF00244	0.459
LIG_14-3-3_CanoR_1	452	461	PF00244	0.404
LIG_14-3-3_CanoR_1	529	536	PF00244	0.485
LIG_14-3-3_CanoR_1	673	682	PF00244	0.484
LIG_14-3-3_CanoR_1	765	770	PF00244	0.494
LIG_14-3-3_CanoR_1	81	87	PF00244	0.732
LIG_Actin_WH2_2	721	739	PF00022	0.464
LIG_BIR_III_2	523	527	PF00653	0.550
LIG_BRCT_BRCA1_1	180	184	PF00533	0.579
LIG_BRCT_BRCA1_1	242	246	PF00533	0.407
LIG_BRCT_BRCA1_1	354	358	PF00533	0.436
LIG_EH1_1	273	281	PF00400	0.424
LIG_FHA_1	102	108	PF00498	0.638
LIG_FHA_1	220	226	PF00498	0.430
LIG_FHA_1	267	273	PF00498	0.446
LIG_FHA_1	293	299	PF00498	0.490
LIG_FHA_1	318	324	PF00498	0.462
LIG_FHA_1	405	411	PF00498	0.487
LIG_FHA_1	53	59	PF00498	0.703
LIG_FHA_1	675	681	PF00498	0.537
LIG_FHA_1	712	718	PF00498	0.432
LIG_FHA_1	801	807	PF00498	0.429
LIG_FHA_1	810	816	PF00498	0.395
LIG_FHA_2	163	169	PF00498	0.710
LIG_FHA_2	233	239	PF00498	0.462
LIG_FHA_2	391	397	PF00498	0.537
LIG_FHA_2	539	545	PF00498	0.305
LIG_FHA_2	55	61	PF00498	0.815
LIG_FHA_2	576	582	PF00498	0.399
LIG_FHA_2	62	68	PF00498	0.720
LIG_FHA_2	679	685	PF00498	0.282
LIG_FHA_2	733	739	PF00498	0.528
LIG_FHA_2	749	755	PF00498	0.316
LIG_FHA_2	834	840	PF00498	0.525
LIG_FHA_2	852	858	PF00498	0.417
LIG_GBD_Chelix_1	290	298	PF00786	0.454
LIG_GBD_Chelix_1	332	340	PF00786	0.430
LIG_GBD_Chelix_1	576	584	PF00786	0.313
LIG_GSK3_LRP6_1	43	48	PF00069	0.522
LIG_LIR_Apic_2	324	329	PF02991	0.373
LIG_LIR_Apic_2	610	614	PF02991	0.526
LIG_LIR_Gen_1	382	389	PF02991	0.458
LIG_LIR_Gen_1	413	423	PF02991	0.451
LIG_LIR_Nem_3	273	278	PF02991	0.383
LIG_LIR_Nem_3	312	317	PF02991	0.497
LIG_LIR_Nem_3	355	361	PF02991	0.448
LIG_LIR_Nem_3	382	386	PF02991	0.445
LIG_LIR_Nem_3	413	419	PF02991	0.451
LIG_LIR_Nem_3	768	774	PF02991	0.470
LIG_LIR_Nem_3	831	835	PF02991	0.396
LIG_LYPXL_SIV_4	842	850	PF13949	0.503
LIG_Pex14_1	451	455	PF04695	0.346
LIG_Pex14_1	829	833	PF04695	0.464
LIG_Pex3_1	226	237	PF04882	0.523
LIG_PTB_Apo_2	712	719	PF02174	0.267
LIG_SH2_NCK_1	455	459	PF00017	0.421
LIG_SH2_STAP1	242	246	PF00017	0.478
LIG_SH2_STAT5	274	277	PF00017	0.399
LIG_SH2_STAT5	339	342	PF00017	0.437
LIG_SH2_STAT5	416	419	PF00017	0.377
LIG_SH2_STAT5	437	440	PF00017	0.375
LIG_SH2_STAT5	455	458	PF00017	0.231
LIG_SH2_STAT5	810	813	PF00017	0.465
LIG_SH3_3	11	17	PF00018	0.705
LIG_SH3_3	139	145	PF00018	0.637
LIG_SH3_3	2	8	PF00018	0.727
LIG_SH3_3	38	44	PF00018	0.528
LIG_SH3_3	701	707	PF00018	0.441
LIG_SH3_3	778	784	PF00018	0.446
LIG_SH3_3	84	90	PF00018	0.784
LIG_SUMO_SIM_anti_2	473	480	PF11976	0.487
LIG_SUMO_SIM_anti_2	853	860	PF11976	0.476
LIG_SUMO_SIM_par_1	677	685	PF11976	0.542
LIG_TRAF2_1	564	567	PF00917	0.534
LIG_TRAF2_1	846	849	PF00917	0.298
LIG_TRFH_1	159	163	PF08558	0.654
LIG_TYR_ITIM	414	419	PF00017	0.372
LIG_WRC_WIRS_1	439	444	PF05994	0.463
LIG_WRC_WIRS_1	672	677	PF05994	0.539
LIG_WW_3	23	27	PF00397	0.523
MOD_CDK_SPK_2	159	164	PF00069	0.625
MOD_CDK_SPK_2	637	642	PF00069	0.534
MOD_CDK_SPxxK_3	610	617	PF00069	0.690
MOD_CK1_1	136	142	PF00069	0.689
MOD_CK1_1	162	168	PF00069	0.710
MOD_CK1_1	177	183	PF00069	0.516
MOD_CK1_1	324	330	PF00069	0.371
MOD_CK1_1	350	356	PF00069	0.404
MOD_CK1_1	366	372	PF00069	0.503
MOD_CK1_1	404	410	PF00069	0.520
MOD_CK1_1	50	56	PF00069	0.745
MOD_CK1_1	59	65	PF00069	0.813
MOD_CK1_1	596	602	PF00069	0.579
MOD_CK1_1	6	12	PF00069	0.753
MOD_CK1_1	607	613	PF00069	0.770
MOD_CK1_1	645	651	PF00069	0.637
MOD_CK1_1	674	680	PF00069	0.530
MOD_CK1_1	85	91	PF00069	0.674
MOD_CK1_1	870	876	PF00069	0.732
MOD_CK2_1	162	168	PF00069	0.705
MOD_CK2_1	232	238	PF00069	0.450
MOD_CK2_1	26	32	PF00069	0.726
MOD_CK2_1	390	396	PF00069	0.455
MOD_CK2_1	575	581	PF00069	0.463
MOD_CK2_1	596	602	PF00069	0.663
MOD_CK2_1	61	67	PF00069	0.661
MOD_CK2_1	678	684	PF00069	0.281
MOD_CK2_1	69	75	PF00069	0.803
MOD_CK2_1	732	738	PF00069	0.482
MOD_CK2_1	748	754	PF00069	0.312
MOD_CK2_1	833	839	PF00069	0.451
MOD_CMANNOS	829	832	PF00535	0.469
MOD_DYRK1A_RPxSP_1	13	17	PF00069	0.632
MOD_GlcNHglycan	113	116	PF01048	0.674
MOD_GlcNHglycan	147	150	PF01048	0.707
MOD_GlcNHglycan	284	287	PF01048	0.443
MOD_GlcNHglycan	326	329	PF01048	0.407
MOD_GlcNHglycan	349	352	PF01048	0.397
MOD_GlcNHglycan	367	371	PF01048	0.450
MOD_GlcNHglycan	373	376	PF01048	0.400
MOD_GlcNHglycan	530	533	PF01048	0.451
MOD_GlcNHglycan	595	598	PF01048	0.671
MOD_GlcNHglycan	621	624	PF01048	0.620
MOD_GlcNHglycan	644	647	PF01048	0.760
MOD_GlcNHglycan	650	653	PF01048	0.767
MOD_GlcNHglycan	859	862	PF01048	0.510
MOD_GlcNHglycan	869	872	PF01048	0.630
MOD_GSK3_1	13	20	PF00069	0.672
MOD_GSK3_1	132	139	PF00069	0.669
MOD_GSK3_1	141	148	PF00069	0.639
MOD_GSK3_1	174	181	PF00069	0.443
MOD_GSK3_1	26	33	PF00069	0.620
MOD_GSK3_1	266	273	PF00069	0.458
MOD_GSK3_1	3	10	PF00069	0.649
MOD_GSK3_1	317	324	PF00069	0.361
MOD_GSK3_1	35	42	PF00069	0.537
MOD_GSK3_1	362	369	PF00069	0.480
MOD_GSK3_1	404	411	PF00069	0.415
MOD_GSK3_1	43	50	PF00069	0.542
MOD_GSK3_1	52	59	PF00069	0.640
MOD_GSK3_1	592	599	PF00069	0.545
MOD_GSK3_1	600	607	PF00069	0.604
MOD_GSK3_1	619	626	PF00069	0.596
MOD_GSK3_1	629	636	PF00069	0.676
MOD_GSK3_1	66	73	PF00069	0.715
MOD_GSK3_1	674	681	PF00069	0.527
MOD_GSK3_1	723	730	PF00069	0.442
MOD_GSK3_1	82	89	PF00069	0.682
MOD_GSK3_1	867	874	PF00069	0.669
MOD_N-GLC_1	120	125	PF02516	0.782
MOD_N-GLC_1	270	275	PF02516	0.471
MOD_N-GLC_1	3	8	PF02516	0.509
MOD_N-GLC_1	659	664	PF02516	0.559
MOD_N-GLC_1	867	872	PF02516	0.533
MOD_NEK2_1	3	8	PF00069	0.606
MOD_NEK2_1	317	322	PF00069	0.333
MOD_NEK2_1	347	352	PF00069	0.481
MOD_NEK2_1	371	376	PF00069	0.352
MOD_NEK2_1	401	406	PF00069	0.468
MOD_NEK2_1	410	415	PF00069	0.437
MOD_NEK2_1	438	443	PF00069	0.351
MOD_NEK2_1	580	585	PF00069	0.459
MOD_NEK2_1	593	598	PF00069	0.593
MOD_NEK2_1	682	687	PF00069	0.463
MOD_NEK2_1	799	804	PF00069	0.478
MOD_NEK2_1	859	864	PF00069	0.499
MOD_NEK2_2	724	729	PF00069	0.517
MOD_NEK2_2	732	737	PF00069	0.448
MOD_PIKK_1	101	107	PF00454	0.749
MOD_PIKK_1	18	24	PF00454	0.671
MOD_PIKK_1	219	225	PF00454	0.430
MOD_PIKK_1	47	53	PF00454	0.675
MOD_PIKK_1	518	524	PF00454	0.543
MOD_PIKK_1	727	733	PF00454	0.474
MOD_PIKK_1	746	752	PF00454	0.473
MOD_PKA_1	26	32	PF00069	0.662
MOD_PKA_2	132	138	PF00069	0.613
MOD_PKA_2	151	157	PF00069	0.666
MOD_PKA_2	26	32	PF00069	0.575
MOD_PKA_2	266	272	PF00069	0.519
MOD_PKA_2	321	327	PF00069	0.480
MOD_PKA_2	36	42	PF00069	0.598
MOD_PKA_2	390	396	PF00069	0.491
MOD_PKA_2	453	459	PF00069	0.373
MOD_PKA_2	528	534	PF00069	0.441
MOD_PKA_2	629	635	PF00069	0.677
MOD_Plk_1	120	126	PF00069	0.782
MOD_Plk_1	169	175	PF00069	0.712
MOD_Plk_1	177	183	PF00069	0.632
MOD_Plk_1	270	276	PF00069	0.402
MOD_Plk_1	366	372	PF00069	0.487
MOD_Plk_1	659	665	PF00069	0.410
MOD_Plk_1	66	72	PF00069	0.732
MOD_Plk_1	74	80	PF00069	0.496
MOD_Plk_2-3	678	684	PF00069	0.281
MOD_Plk_4	270	276	PF00069	0.415
MOD_Plk_4	321	327	PF00069	0.379
MOD_Plk_4	438	444	PF00069	0.349
MOD_Plk_4	765	771	PF00069	0.515
MOD_Plk_4	828	834	PF00069	0.420
MOD_ProDKin_1	13	19	PF00069	0.718
MOD_ProDKin_1	134	140	PF00069	0.718
MOD_ProDKin_1	141	147	PF00069	0.688
MOD_ProDKin_1	159	165	PF00069	0.614
MOD_ProDKin_1	37	43	PF00069	0.676
MOD_ProDKin_1	4	10	PF00069	0.664
MOD_ProDKin_1	45	51	PF00069	0.698
MOD_ProDKin_1	604	610	PF00069	0.618
MOD_ProDKin_1	633	639	PF00069	0.722
MOD_ProDKin_1	703	709	PF00069	0.475
MOD_ProDKin_1	83	89	PF00069	0.729
TRG_DiLeu_BaEn_3	203	209	PF01217	0.511
TRG_DiLeu_BaEn_4	420	426	PF01217	0.450
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.472
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.486
TRG_ENDOCYTIC_2	339	342	PF00928	0.442
TRG_ENDOCYTIC_2	416	419	PF00928	0.394
TRG_ENDOCYTIC_2	536	539	PF00928	0.434
TRG_ENDOCYTIC_2	830	833	PF00928	0.489
TRG_ER_diArg_1	151	153	PF00400	0.683
TRG_ER_diArg_1	25	27	PF00400	0.621
TRG_ER_diArg_1	451	454	PF00400	0.322
TRG_ER_diArg_1	528	530	PF00400	0.482
TRG_ER_diArg_1	688	691	PF00400	0.378
TRG_ER_diArg_1	795	797	PF00400	0.469
TRG_NES_CRM1_1	408	421	PF08389	0.474
TRG_NES_CRM1_1	460	473	PF08389	0.256
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA72	Leptomonas seymouri	62%	90%
A0A3Q8IDF8	Leishmania donovani	83%	100%
A0A3R7N5C8	Trypanosoma rangeli	36%	100%
A4HWJ0	Leishmania infantum	83%	100%
C9ZXV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AQ91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%
Q4QF92	Leishmania major	84%	100%
Q9UT08	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
V5DL61	Trypanosoma cruzi	38%	100%