Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H863_LEIBR

TriTrypDb:

LbrM.15.0940 , LBRM2903_150014400

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H863

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H863

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.339
CLV_NRD_NRD_1	106	108	PF00675	0.493
CLV_NRD_NRD_1	251	253	PF00675	0.411
CLV_NRD_NRD_1	316	318	PF00675	0.447
CLV_NRD_NRD_1	352	354	PF00675	0.357
CLV_NRD_NRD_1	36	38	PF00675	0.480
CLV_NRD_NRD_1	473	475	PF00675	0.424
CLV_PCSK_FUR_1	313	317	PF00082	0.444
CLV_PCSK_KEX2_1	105	107	PF00082	0.520
CLV_PCSK_KEX2_1	251	253	PF00082	0.398
CLV_PCSK_KEX2_1	313	315	PF00082	0.426
CLV_PCSK_KEX2_1	316	318	PF00082	0.435
CLV_PCSK_KEX2_1	36	38	PF00082	0.440
CLV_PCSK_KEX2_1	473	475	PF00082	0.516
CLV_PCSK_KEX2_1	71	73	PF00082	0.562
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.451
CLV_PCSK_SKI1_1	107	111	PF00082	0.395
CLV_PCSK_SKI1_1	125	129	PF00082	0.301
CLV_PCSK_SKI1_1	203	207	PF00082	0.447
CLV_PCSK_SKI1_1	211	215	PF00082	0.492
CLV_PCSK_SKI1_1	335	339	PF00082	0.450
DEG_APCC_DBOX_1	316	324	PF00400	0.367
DEG_APCC_DBOX_1	367	375	PF00400	0.336
DEG_SPOP_SBC_1	162	166	PF00917	0.728
DEG_SPOP_SBC_1	3	7	PF00917	0.589
DOC_CDC14_PxL_1	128	136	PF14671	0.447
DOC_CKS1_1	156	161	PF01111	0.537
DOC_CYCLIN_RxL_1	222	233	PF00134	0.383
DOC_MAPK_FxFP_2	397	400	PF00069	0.496
DOC_MAPK_gen_1	313	323	PF00069	0.367
DOC_MAPK_gen_1	353	361	PF00069	0.334
DOC_MAPK_MEF2A_6	353	361	PF00069	0.281
DOC_PP1_RVXF_1	199	205	PF00149	0.426
DOC_PP1_RVXF_1	284	290	PF00149	0.308
DOC_PP1_RVXF_1	466	473	PF00149	0.422
DOC_PP2B_LxvP_1	134	137	PF13499	0.522
DOC_PP2B_LxvP_1	454	457	PF13499	0.418
DOC_PP4_FxxP_1	397	400	PF00568	0.496
DOC_USP7_MATH_1	154	158	PF00917	0.643
DOC_USP7_MATH_1	2	6	PF00917	0.671
DOC_USP7_MATH_1	259	263	PF00917	0.514
DOC_USP7_MATH_1	393	397	PF00917	0.449
DOC_USP7_MATH_1	436	440	PF00917	0.535
DOC_USP7_MATH_2	342	348	PF00917	0.389
DOC_WW_Pin1_4	144	149	PF00397	0.778
DOC_WW_Pin1_4	155	160	PF00397	0.677
DOC_WW_Pin1_4	273	278	PF00397	0.512
DOC_WW_Pin1_4	388	393	PF00397	0.437
DOC_WW_Pin1_4	404	409	PF00397	0.509
LIG_14-3-3_CanoR_1	111	119	PF00244	0.434
LIG_14-3-3_CanoR_1	203	208	PF00244	0.393
LIG_14-3-3_CanoR_1	225	230	PF00244	0.394
LIG_14-3-3_CanoR_1	24	32	PF00244	0.365
LIG_14-3-3_CanoR_1	265	270	PF00244	0.576
LIG_14-3-3_CanoR_1	314	323	PF00244	0.468
LIG_14-3-3_CanoR_1	375	381	PF00244	0.365
LIG_14-3-3_CanoR_1	468	473	PF00244	0.297
LIG_14-3-3_CanoR_1	481	491	PF00244	0.622
LIG_14-3-3_CanoR_1	91	95	PF00244	0.412
LIG_Actin_WH2_2	249	267	PF00022	0.444
LIG_APCC_ABBA_1	227	232	PF00400	0.482
LIG_APCC_ABBA_1	362	367	PF00400	0.376
LIG_APCC_ABBAyCdc20_2	211	217	PF00400	0.384
LIG_BRCT_BRCA1_1	463	467	PF00533	0.486
LIG_EVH1_1	134	138	PF00568	0.535
LIG_FHA_1	236	242	PF00498	0.473
LIG_FHA_1	316	322	PF00498	0.485
LIG_FHA_1	343	349	PF00498	0.395
LIG_FHA_1	39	45	PF00498	0.376
LIG_FHA_2	111	117	PF00498	0.429
LIG_FHA_2	156	162	PF00498	0.681
LIG_FHA_2	214	220	PF00498	0.414
LIG_FXI_DFP_1	215	219	PF00024	0.554
LIG_GBD_Chelix_1	245	253	PF00786	0.418
LIG_Integrin_isoDGR_2	284	286	PF01839	0.331
LIG_LIR_Apic_2	396	400	PF02991	0.491
LIG_LIR_Gen_1	184	195	PF02991	0.519
LIG_LIR_Gen_1	216	224	PF02991	0.460
LIG_LIR_Gen_1	336	342	PF02991	0.431
LIG_LIR_Gen_1	65	73	PF02991	0.479
LIG_LIR_Nem_3	184	190	PF02991	0.516
LIG_LIR_Nem_3	206	210	PF02991	0.350
LIG_LIR_Nem_3	336	340	PF02991	0.438
LIG_LIR_Nem_3	396	402	PF02991	0.502
LIG_LIR_Nem_3	411	416	PF02991	0.508
LIG_LIR_Nem_3	464	470	PF02991	0.437
LIG_LIR_Nem_3	471	475	PF02991	0.440
LIG_LIR_Nem_3	65	70	PF02991	0.468
LIG_LYPXL_yS_3	399	402	PF13949	0.571
LIG_MYND_1	132	136	PF01753	0.491
LIG_MYND_1	478	482	PF01753	0.685
LIG_Pex14_1	39	43	PF04695	0.353
LIG_Pex14_2	337	341	PF04695	0.391
LIG_Pex14_2	397	401	PF04695	0.519
LIG_SH2_CRK	187	191	PF00017	0.498
LIG_SH2_CRK	355	359	PF00017	0.261
LIG_SH2_SRC	133	136	PF00017	0.486
LIG_SH2_SRC	43	46	PF00017	0.348
LIG_SH2_SRC	453	456	PF00017	0.404
LIG_SH2_STAP1	237	241	PF00017	0.450
LIG_SH2_STAP1	442	446	PF00017	0.505
LIG_SH2_STAT3	176	179	PF00017	0.589
LIG_SH2_STAT5	133	136	PF00017	0.521
LIG_SH2_STAT5	230	233	PF00017	0.523
LIG_SH2_STAT5	237	240	PF00017	0.481
LIG_SH2_STAT5	248	251	PF00017	0.350
LIG_SH2_STAT5	370	373	PF00017	0.378
LIG_SH2_STAT5	43	46	PF00017	0.348
LIG_SH2_STAT5	446	449	PF00017	0.458
LIG_SH2_STAT5	453	456	PF00017	0.429
LIG_SH2_STAT5	86	89	PF00017	0.376
LIG_SH3_2	145	150	PF14604	0.711
LIG_SH3_3	129	135	PF00018	0.538
LIG_SH3_3	142	148	PF00018	0.549
LIG_SH3_3	301	307	PF00018	0.369
LIG_SH3_3	472	478	PF00018	0.540
LIG_SH3_3	499	505	PF00018	0.523
LIG_SUMO_SIM_par_1	344	350	PF11976	0.424
LIG_SUMO_SIM_par_1	357	363	PF11976	0.395
LIG_TRAF2_1	183	186	PF00917	0.588
LIG_TRAF2_1	93	96	PF00917	0.275
LIG_TRFH_1	128	132	PF08558	0.477
LIG_WRC_WIRS_1	269	274	PF05994	0.559
LIG_WRC_WIRS_1	394	399	PF05994	0.469
LIG_WRC_WIRS_1	401	406	PF05994	0.521
MOD_CDC14_SPxK_1	147	150	PF00782	0.712
MOD_CDK_SPxK_1	144	150	PF00069	0.710
MOD_CK1_1	152	158	PF00069	0.674
MOD_CK1_1	164	170	PF00069	0.757
MOD_CK1_1	268	274	PF00069	0.485
MOD_CK1_1	336	342	PF00069	0.377
MOD_CK1_1	84	90	PF00069	0.504
MOD_CK2_1	120	126	PF00069	0.490
MOD_CK2_1	376	382	PF00069	0.355
MOD_CK2_1	490	496	PF00069	0.659
MOD_CK2_1	90	96	PF00069	0.273
MOD_GlcNHglycan	166	169	PF01048	0.671
MOD_GlcNHglycan	448	453	PF01048	0.417
MOD_GlcNHglycan	46	49	PF01048	0.493
MOD_GSK3_1	140	147	PF00069	0.607
MOD_GSK3_1	160	167	PF00069	0.691
MOD_GSK3_1	213	220	PF00069	0.481
MOD_GSK3_1	329	336	PF00069	0.593
MOD_GSK3_1	400	407	PF00069	0.559
MOD_GSK3_1	482	489	PF00069	0.699
MOD_GSK3_1	490	497	PF00069	0.743
MOD_N-GLC_2	458	460	PF02516	0.405
MOD_N-GLC_2	90	92	PF02516	0.468
MOD_NEK2_1	494	499	PF00069	0.678
MOD_NEK2_2	376	381	PF00069	0.401
MOD_PIKK_1	152	158	PF00454	0.666
MOD_PIKK_1	181	187	PF00454	0.501
MOD_PIKK_1	436	442	PF00454	0.512
MOD_PK_1	329	335	PF00069	0.369
MOD_PKA_1	315	321	PF00069	0.566
MOD_PKA_2	110	116	PF00069	0.489
MOD_PKA_2	23	29	PF00069	0.389
MOD_PKA_2	315	321	PF00069	0.566
MOD_PKA_2	90	96	PF00069	0.413
MOD_PKB_1	105	113	PF00069	0.480
MOD_PKB_1	201	209	PF00069	0.335
MOD_PKB_1	313	321	PF00069	0.561
MOD_Plk_1	120	126	PF00069	0.328
MOD_Plk_1	259	265	PF00069	0.484
MOD_Plk_1	329	335	PF00069	0.369
MOD_Plk_1	448	454	PF00069	0.385
MOD_Plk_1	84	90	PF00069	0.371
MOD_Plk_2-3	344	350	PF00069	0.347
MOD_Plk_4	225	231	PF00069	0.374
MOD_Plk_4	259	265	PF00069	0.576
MOD_Plk_4	336	342	PF00069	0.398
MOD_Plk_4	409	415	PF00069	0.520
MOD_Plk_4	84	90	PF00069	0.371
MOD_ProDKin_1	144	150	PF00069	0.779
MOD_ProDKin_1	155	161	PF00069	0.678
MOD_ProDKin_1	273	279	PF00069	0.497
MOD_ProDKin_1	388	394	PF00069	0.436
MOD_ProDKin_1	404	410	PF00069	0.500
MOD_SUMO_for_1	257	260	PF00179	0.314
TRG_ENDOCYTIC_2	175	178	PF00928	0.531
TRG_ENDOCYTIC_2	187	190	PF00928	0.415
TRG_ENDOCYTIC_2	355	358	PF00928	0.264
TRG_ENDOCYTIC_2	377	380	PF00928	0.487
TRG_ENDOCYTIC_2	399	402	PF00928	0.571
TRG_ENDOCYTIC_2	67	70	PF00928	0.435
TRG_ER_diArg_1	105	107	PF00400	0.526
TRG_ER_diArg_1	201	204	PF00400	0.336
TRG_ER_diArg_1	251	253	PF00400	0.351
TRG_ER_diArg_1	313	316	PF00400	0.470
TRG_ER_diArg_1	472	474	PF00400	0.495
TRG_NES_CRM1_1	219	233	PF08389	0.442
TRG_NLS_MonoExtC_3	352	357	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J4	Leptomonas seymouri	70%	96%
A0A1X0NTX1	Trypanosomatidae	49%	100%
A0A3Q8IA36	Leishmania donovani	85%	98%
A4HWI8	Leishmania infantum	86%	84%
C9ZXV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZXV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
E9AQ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4QF94	Leishmania major	84%	100%
V5AMI4	Trypanosoma cruzi	49%	98%