Putative myo-inositol-1 phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myo-inositol-1 phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H860_LEIBR

TriTrypDb:

LbrM.15.0910 , LBRM2903_150014600

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H860

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H860

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0006066	alcohol metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019751	polyol metabolic process	4	7
GO:0043647	inositol phosphate metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044262	obsolete cellular carbohydrate metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0046164	alcohol catabolic process	4	7
GO:0046174	polyol catabolic process	5	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	7
GO:0046855	obsolete inositol phosphate dephosphorylation	5	7
GO:0071545	inositol phosphate catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7
GO:1901615	organic hydroxy compound metabolic process	3	7
GO:1901616	organic hydroxy compound catabolic process	4	7
GO:0006020	inositol metabolic process	4	1
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008934	inositol monophosphate 1-phosphatase activity	8	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0052832	inositol monophosphate 3-phosphatase activity	8	5
GO:0052833	inositol monophosphate 4-phosphatase activity	8	5
GO:0052834	inositol monophosphate phosphatase activity	7	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.346
CLV_NRD_NRD_1	299	301	PF00675	0.328
CLV_NRD_NRD_1	53	55	PF00675	0.220
CLV_PCSK_KEX2_1	298	300	PF00082	0.281
CLV_PCSK_KEX2_1	53	55	PF00082	0.220
CLV_PCSK_SKI1_1	67	71	PF00082	0.383
CLV_Separin_Metazoa	315	319	PF03568	0.383
DEG_APCC_DBOX_1	312	320	PF00400	0.383
DEG_SCF_FBW7_1	120	127	PF00400	0.383
DEG_SCF_FBW7_1	180	186	PF00400	0.518
DEG_SPOP_SBC_1	268	272	PF00917	0.333
DEG_SPOP_SBC_1	4	8	PF00917	0.439
DOC_CKS1_1	121	126	PF01111	0.310
DOC_CKS1_1	180	185	PF01111	0.615
DOC_CKS1_1	284	289	PF01111	0.220
DOC_CKS1_1	76	81	PF01111	0.299
DOC_CYCLIN_yCln2_LP_2	317	323	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.383
DOC_MAPK_gen_1	113	120	PF00069	0.348
DOC_MAPK_gen_1	61	68	PF00069	0.277
DOC_MAPK_HePTP_8	110	122	PF00069	0.310
DOC_MAPK_MEF2A_6	113	122	PF00069	0.346
DOC_MAPK_MEF2A_6	313	321	PF00069	0.383
DOC_MAPK_MEF2A_6	61	68	PF00069	0.310
DOC_PP2B_LxvP_1	181	184	PF13499	0.502
DOC_PP2B_LxvP_1	209	212	PF13499	0.480
DOC_PP2B_LxvP_1	317	320	PF13499	0.458
DOC_PP4_FxxP_1	276	279	PF00568	0.383
DOC_USP7_MATH_1	159	163	PF00917	0.230
DOC_USP7_MATH_1	171	175	PF00917	0.516
DOC_USP7_MATH_1	184	188	PF00917	0.522
DOC_USP7_MATH_1	195	199	PF00917	0.527
DOC_USP7_MATH_1	269	273	PF00917	0.319
DOC_WW_Pin1_4	120	125	PF00397	0.310
DOC_WW_Pin1_4	155	160	PF00397	0.383
DOC_WW_Pin1_4	176	181	PF00397	0.604
DOC_WW_Pin1_4	283	288	PF00397	0.469
DOC_WW_Pin1_4	75	80	PF00397	0.299
LIG_14-3-3_CanoR_1	131	135	PF00244	0.310
LIG_14-3-3_CanoR_1	219	227	PF00244	0.496
LIG_Actin_WH2_2	309	327	PF00022	0.220
LIG_CtBP_PxDLS_1	376	380	PF00389	0.320
LIG_FHA_1	121	127	PF00498	0.331
LIG_FHA_1	184	190	PF00498	0.676
LIG_FHA_1	224	230	PF00498	0.589
LIG_FHA_1	232	238	PF00498	0.619
LIG_FHA_1	268	274	PF00498	0.321
LIG_FHA_1	47	53	PF00498	0.289
LIG_FHA_1	5	11	PF00498	0.501
LIG_FHA_1	83	89	PF00498	0.359
LIG_Integrin_isoDGR_2	257	259	PF01839	0.310
LIG_LIR_Apic_2	343	348	PF02991	0.310
LIG_LIR_Gen_1	244	254	PF02991	0.335
LIG_LIR_Gen_1	81	91	PF02991	0.310
LIG_LIR_Nem_3	244	249	PF02991	0.335
LIG_LIR_Nem_3	81	87	PF02991	0.310
LIG_Pex14_2	406	410	PF04695	0.387
LIG_SH2_CRK	302	306	PF00017	0.220
LIG_SH2_CRK	370	374	PF00017	0.220
LIG_SH2_SRC	345	348	PF00017	0.310
LIG_SH2_STAP1	302	306	PF00017	0.220
LIG_SH2_STAP1	55	59	PF00017	0.383
LIG_SH2_STAP1	84	88	PF00017	0.310
LIG_SH2_STAT3	112	115	PF00017	0.383
LIG_SH2_STAT3	40	43	PF00017	0.236
LIG_SH2_STAT5	345	348	PF00017	0.310
LIG_SH2_STAT5	84	87	PF00017	0.326
LIG_SH3_3	118	124	PF00018	0.320
LIG_SH3_3	177	183	PF00018	0.540
LIG_SH3_3	73	79	PF00018	0.304
LIG_SH3_3	84	90	PF00018	0.322
LIG_TYR_ITIM	368	373	PF00017	0.333
LIG_UBA3_1	245	250	PF00899	0.383
MOD_CK1_1	158	164	PF00069	0.345
MOD_CK1_1	16	22	PF00069	0.559
MOD_CK1_1	179	185	PF00069	0.517
MOD_CK1_1	218	224	PF00069	0.641
MOD_CK1_1	329	335	PF00069	0.219
MOD_CK2_1	282	288	PF00069	0.299
MOD_GlcNHglycan	127	130	PF01048	0.310
MOD_GlcNHglycan	196	200	PF01048	0.605
MOD_GlcNHglycan	209	212	PF01048	0.453
MOD_GlcNHglycan	220	223	PF01048	0.588
MOD_GlcNHglycan	293	296	PF01048	0.275
MOD_GlcNHglycan	31	34	PF01048	0.451
MOD_GlcNHglycan	326	329	PF01048	0.220
MOD_GSK3_1	104	111	PF00069	0.310
MOD_GSK3_1	12	19	PF00069	0.550
MOD_GSK3_1	120	127	PF00069	0.426
MOD_GSK3_1	154	161	PF00069	0.378
MOD_GSK3_1	179	186	PF00069	0.599
MOD_GSK3_1	31	38	PF00069	0.342
MOD_GSK3_1	326	333	PF00069	0.331
MOD_GSK3_1	42	49	PF00069	0.220
MOD_GSK3_1	78	85	PF00069	0.328
MOD_N-GLC_2	354	356	PF02516	0.283
MOD_NEK2_1	125	130	PF00069	0.310
MOD_NEK2_1	213	218	PF00069	0.553
MOD_NEK2_1	324	329	PF00069	0.220
MOD_PIKK_1	35	41	PF00454	0.310
MOD_PKA_1	53	59	PF00069	0.220
MOD_PKA_2	130	136	PF00069	0.310
MOD_PKA_2	218	224	PF00069	0.493
MOD_PKA_2	324	330	PF00069	0.220
MOD_PKA_2	53	59	PF00069	0.310
MOD_Plk_1	306	312	PF00069	0.383
MOD_Plk_1	381	387	PF00069	0.299
MOD_Plk_1	82	88	PF00069	0.310
MOD_Plk_4	171	177	PF00069	0.515
MOD_Plk_4	233	239	PF00069	0.535
MOD_Plk_4	269	275	PF00069	0.310
MOD_Plk_4	356	362	PF00069	0.310
MOD_Plk_4	381	387	PF00069	0.315
MOD_Plk_4	82	88	PF00069	0.306
MOD_ProDKin_1	120	126	PF00069	0.310
MOD_ProDKin_1	155	161	PF00069	0.383
MOD_ProDKin_1	176	182	PF00069	0.602
MOD_ProDKin_1	283	289	PF00069	0.469
MOD_ProDKin_1	75	81	PF00069	0.299
MOD_SUMO_rev_2	24	32	PF00179	0.319
TRG_DiLeu_BaEn_1	392	397	PF01217	0.383
TRG_DiLeu_BaEn_4	314	320	PF01217	0.299
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.484
TRG_ENDOCYTIC_2	302	305	PF00928	0.220
TRG_ENDOCYTIC_2	370	373	PF00928	0.333
TRG_ENDOCYTIC_2	84	87	PF00928	0.310
TRG_ER_diArg_1	297	300	PF00400	0.299
TRG_ER_diArg_1	52	54	PF00400	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI7	Leptomonas seymouri	56%	89%
A0A3Q8IA90	Leishmania donovani	76%	88%
A4HWI6	Leishmania infantum	76%	88%
E9AQ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	88%
Q4QF96	Leishmania major	76%	100%