LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
Sugar (and other) transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4H859_LEIBR
TriTrypDb:
LbrM.15.0900 , LBRM2903_150014700 *
Length:
645

Annotations

LeishMANIAdb annotations

A family with high similarity to plant sugar transporters.. Might be an extensive family that already diverged in free-living Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H859
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H859

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 8
GO:0022857 transmembrane transporter activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 279 283 PF00656 0.589
CLV_C14_Caspase3-7 5 9 PF00656 0.657
CLV_C14_Caspase3-7 65 69 PF00656 0.210
CLV_NRD_NRD_1 510 512 PF00675 0.530
CLV_NRD_NRD_1 583 585 PF00675 0.442
CLV_NRD_NRD_1 643 645 PF00675 0.545
CLV_PCSK_FUR_1 641 645 PF00082 0.413
CLV_PCSK_KEX2_1 510 512 PF00082 0.530
CLV_PCSK_KEX2_1 583 585 PF00082 0.451
CLV_PCSK_KEX2_1 643 645 PF00082 0.428
CLV_PCSK_SKI1_1 414 418 PF00082 0.406
CLV_PCSK_SKI1_1 528 532 PF00082 0.337
DEG_MDM2_SWIB_1 71 79 PF02201 0.255
DEG_SPOP_SBC_1 22 26 PF00917 0.658
DEG_SPOP_SBC_1 471 475 PF00917 0.304
DOC_ANK_TNKS_1 391 398 PF00023 0.636
DOC_CYCLIN_yCln2_LP_2 599 605 PF00134 0.454
DOC_MAPK_gen_1 219 228 PF00069 0.279
DOC_MAPK_HePTP_8 493 505 PF00069 0.210
DOC_MAPK_MEF2A_6 219 228 PF00069 0.283
DOC_MAPK_MEF2A_6 327 334 PF00069 0.588
DOC_MAPK_MEF2A_6 488 497 PF00069 0.491
DOC_MAPK_NFAT4_5 221 229 PF00069 0.327
DOC_PP1_SILK_1 252 257 PF00149 0.400
DOC_PP2B_LxvP_1 369 372 PF13499 0.653
DOC_PP2B_LxvP_1 599 602 PF13499 0.327
DOC_PP2B_LxvP_1 610 613 PF13499 0.529
DOC_SPAK_OSR1_1 327 331 PF12202 0.588
DOC_USP7_MATH_1 132 136 PF00917 0.210
DOC_USP7_MATH_1 18 22 PF00917 0.662
DOC_USP7_MATH_1 260 264 PF00917 0.740
DOC_USP7_MATH_1 292 296 PF00917 0.717
DOC_USP7_MATH_1 308 312 PF00917 0.587
DOC_USP7_MATH_1 373 377 PF00917 0.675
DOC_USP7_MATH_1 39 43 PF00917 0.678
DOC_USP7_MATH_1 434 438 PF00917 0.337
DOC_USP7_MATH_1 471 475 PF00917 0.352
DOC_USP7_MATH_1 557 561 PF00917 0.315
DOC_WW_Pin1_4 213 218 PF00397 0.209
DOC_WW_Pin1_4 256 261 PF00397 0.741
DOC_WW_Pin1_4 26 31 PF00397 0.636
DOC_WW_Pin1_4 44 49 PF00397 0.654
DOC_WW_Pin1_4 452 457 PF00397 0.263
DOC_WW_Pin1_4 626 631 PF00397 0.669
LIG_14-3-3_CanoR_1 221 227 PF00244 0.327
LIG_14-3-3_CanoR_1 244 248 PF00244 0.444
LIG_14-3-3_CanoR_1 261 265 PF00244 0.708
LIG_14-3-3_CanoR_1 327 331 PF00244 0.663
LIG_14-3-3_CanoR_1 409 416 PF00244 0.568
LIG_14-3-3_CanoR_1 50 59 PF00244 0.528
LIG_14-3-3_CanoR_1 510 519 PF00244 0.471
LIG_14-3-3_CanoR_1 552 561 PF00244 0.570
LIG_Actin_WH2_2 394 411 PF00022 0.621
LIG_BIR_II_1 1 5 PF00653 0.588
LIG_BIR_III_3 1 5 PF00653 0.588
LIG_BIR_III_4 348 352 PF00653 0.604
LIG_BRCT_BRCA1_1 316 320 PF00533 0.593
LIG_EH1_1 200 208 PF00400 0.210
LIG_eIF4E_1 201 207 PF01652 0.327
LIG_FHA_1 125 131 PF00498 0.263
LIG_FHA_1 160 166 PF00498 0.353
LIG_FHA_1 223 229 PF00498 0.366
LIG_FHA_1 272 278 PF00498 0.637
LIG_FHA_1 327 333 PF00498 0.643
LIG_FHA_1 336 342 PF00498 0.605
LIG_FHA_1 354 360 PF00498 0.651
LIG_FHA_1 498 504 PF00498 0.332
LIG_FHA_1 537 543 PF00498 0.443
LIG_FHA_1 587 593 PF00498 0.381
LIG_FHA_1 86 92 PF00498 0.238
LIG_FHA_2 165 171 PF00498 0.318
LIG_FHA_2 277 283 PF00498 0.708
LIG_FHA_2 338 344 PF00498 0.606
LIG_FHA_2 388 394 PF00498 0.632
LIG_FHA_2 634 640 PF00498 0.613
LIG_LIR_Gen_1 147 157 PF02991 0.262
LIG_LIR_Gen_1 287 296 PF02991 0.596
LIG_LIR_Gen_1 61 72 PF02991 0.424
LIG_LIR_Nem_3 147 152 PF02991 0.272
LIG_LIR_Nem_3 287 293 PF02991 0.594
LIG_LIR_Nem_3 403 408 PF02991 0.696
LIG_LIR_Nem_3 411 416 PF02991 0.624
LIG_LIR_Nem_3 440 446 PF02991 0.338
LIG_LIR_Nem_3 61 67 PF02991 0.432
LIG_NRBOX 427 433 PF00104 0.210
LIG_NRBOX 62 68 PF00104 0.210
LIG_PCNA_yPIPBox_3 528 536 PF02747 0.327
LIG_PCNA_yPIPBox_3 578 592 PF02747 0.239
LIG_Pex14_2 139 143 PF04695 0.414
LIG_Pex14_2 444 448 PF04695 0.255
LIG_Pex14_2 60 64 PF04695 0.309
LIG_Pex14_2 71 75 PF04695 0.234
LIG_PTAP_UEV_1 629 634 PF05743 0.581
LIG_SH2_CRK 161 165 PF00017 0.374
LIG_SH2_CRK 290 294 PF00017 0.600
LIG_SH2_STAP1 72 76 PF00017 0.349
LIG_SH2_STAT5 161 164 PF00017 0.444
LIG_SH2_STAT5 197 200 PF00017 0.423
LIG_SH2_STAT5 443 446 PF00017 0.327
LIG_SH2_STAT5 463 466 PF00017 0.175
LIG_SH2_STAT5 575 578 PF00017 0.339
LIG_SH2_STAT5 635 638 PF00017 0.611
LIG_SH3_3 327 333 PF00018 0.587
LIG_SH3_3 439 445 PF00018 0.332
LIG_SH3_3 45 51 PF00018 0.656
LIG_SH3_3 627 633 PF00018 0.706
LIG_SUMO_SIM_anti_2 427 433 PF11976 0.366
LIG_SUMO_SIM_anti_2 559 565 PF11976 0.309
LIG_SUMO_SIM_par_1 430 437 PF11976 0.331
LIG_SUMO_SIM_par_1 622 629 PF11976 0.686
LIG_TYR_ITIM 441 446 PF00017 0.300
LIG_UBA3_1 11 16 PF00899 0.611
LIG_Vh1_VBS_1 96 114 PF01044 0.210
MOD_CDC14_SPxK_1 216 219 PF00782 0.200
MOD_CDC14_SPxK_1 47 50 PF00782 0.616
MOD_CDK_SPK_2 256 261 PF00069 0.599
MOD_CDK_SPxK_1 213 219 PF00069 0.200
MOD_CDK_SPxK_1 44 50 PF00069 0.615
MOD_CDK_SPxxK_3 26 33 PF00069 0.627
MOD_CK1_1 21 27 PF00069 0.674
MOD_CK1_1 376 382 PF00069 0.679
MOD_CK1_1 387 393 PF00069 0.616
MOD_CK1_1 41 47 PF00069 0.627
MOD_CK1_1 418 424 PF00069 0.579
MOD_CK1_1 437 443 PF00069 0.268
MOD_CK1_1 513 519 PF00069 0.279
MOD_CK1_1 52 58 PF00069 0.538
MOD_CK1_1 562 568 PF00069 0.323
MOD_CK1_1 70 76 PF00069 0.496
MOD_CK1_1 89 95 PF00069 0.187
MOD_CK2_1 164 170 PF00069 0.330
MOD_CK2_1 243 249 PF00069 0.442
MOD_CK2_1 337 343 PF00069 0.615
MOD_CK2_1 387 393 PF00069 0.639
MOD_CK2_1 553 559 PF00069 0.576
MOD_CK2_1 633 639 PF00069 0.605
MOD_Cter_Amidation 641 644 PF01082 0.412
MOD_DYRK1A_RPxSP_1 256 260 PF00069 0.595
MOD_GlcNHglycan 20 23 PF01048 0.455
MOD_GlcNHglycan 290 293 PF01048 0.588
MOD_GlcNHglycan 294 297 PF01048 0.495
MOD_GlcNHglycan 369 372 PF01048 0.508
MOD_GlcNHglycan 436 439 PF01048 0.369
MOD_GlcNHglycan 555 558 PF01048 0.356
MOD_GlcNHglycan 568 571 PF01048 0.310
MOD_GlcNHglycan 594 597 PF01048 0.325
MOD_GSK3_1 159 166 PF00069 0.400
MOD_GSK3_1 18 25 PF00069 0.657
MOD_GSK3_1 256 263 PF00069 0.698
MOD_GSK3_1 271 278 PF00069 0.727
MOD_GSK3_1 284 291 PF00069 0.721
MOD_GSK3_1 337 344 PF00069 0.712
MOD_GSK3_1 35 42 PF00069 0.637
MOD_GSK3_1 383 390 PF00069 0.761
MOD_GSK3_1 404 411 PF00069 0.617
MOD_GSK3_1 414 421 PF00069 0.507
MOD_GSK3_1 463 470 PF00069 0.375
MOD_GSK3_1 510 517 PF00069 0.505
MOD_GSK3_1 553 560 PF00069 0.562
MOD_GSK3_1 562 569 PF00069 0.312
MOD_GSK3_1 58 65 PF00069 0.266
MOD_GSK3_1 624 631 PF00069 0.735
MOD_GSK3_1 85 92 PF00069 0.272
MOD_N-GLC_1 452 457 PF02516 0.497
MOD_N-GLC_1 615 620 PF02516 0.385
MOD_N-GLC_1 85 90 PF02516 0.445
MOD_N-GLC_2 482 484 PF02516 0.455
MOD_NEK2_1 173 178 PF00069 0.554
MOD_NEK2_1 326 331 PF00069 0.586
MOD_NEK2_1 404 409 PF00069 0.615
MOD_NEK2_1 497 502 PF00069 0.256
MOD_NEK2_1 531 536 PF00069 0.311
MOD_NEK2_1 586 591 PF00069 0.378
MOD_NEK2_1 592 597 PF00069 0.378
MOD_NEK2_1 62 67 PF00069 0.385
MOD_NEK2_1 84 89 PF00069 0.281
MOD_NEK2_1 96 101 PF00069 0.273
MOD_NEK2_2 337 342 PF00069 0.601
MOD_NEK2_2 415 420 PF00069 0.484
MOD_NEK2_2 633 638 PF00069 0.603
MOD_PIKK_1 294 300 PF00454 0.715
MOD_PIKK_1 376 382 PF00454 0.686
MOD_PIKK_1 615 621 PF00454 0.561
MOD_PKA_1 510 516 PF00069 0.306
MOD_PKA_2 12 18 PF00069 0.665
MOD_PKA_2 243 249 PF00069 0.516
MOD_PKA_2 260 266 PF00069 0.718
MOD_PKA_2 326 332 PF00069 0.670
MOD_PKA_2 341 347 PF00069 0.654
MOD_PKA_2 376 382 PF00069 0.740
MOD_PKA_2 408 414 PF00069 0.597
MOD_PKA_2 49 55 PF00069 0.703
MOD_PKA_2 510 516 PF00069 0.466
MOD_Plk_1 353 359 PF00069 0.604
MOD_Plk_1 615 621 PF00069 0.658
MOD_Plk_2-3 243 249 PF00069 0.417
MOD_Plk_4 144 150 PF00069 0.263
MOD_Plk_4 193 199 PF00069 0.288
MOD_Plk_4 302 308 PF00069 0.800
MOD_Plk_4 424 430 PF00069 0.242
MOD_Plk_4 464 470 PF00069 0.401
MOD_Plk_4 531 537 PF00069 0.327
MOD_Plk_4 559 565 PF00069 0.327
MOD_Plk_4 594 600 PF00069 0.261
MOD_Plk_4 67 73 PF00069 0.374
MOD_Plk_4 7 13 PF00069 0.602
MOD_Plk_4 92 98 PF00069 0.263
MOD_ProDKin_1 213 219 PF00069 0.209
MOD_ProDKin_1 256 262 PF00069 0.742
MOD_ProDKin_1 26 32 PF00069 0.633
MOD_ProDKin_1 44 50 PF00069 0.656
MOD_ProDKin_1 452 458 PF00069 0.262
MOD_ProDKin_1 626 632 PF00069 0.672
TRG_DiLeu_BaEn_1 559 564 PF01217 0.309
TRG_DiLeu_BaEn_3 249 255 PF01217 0.400
TRG_ENDOCYTIC_2 161 164 PF00928 0.373
TRG_ENDOCYTIC_2 290 293 PF00928 0.599
TRG_ENDOCYTIC_2 443 446 PF00928 0.287
TRG_ER_diArg_1 120 123 PF00400 0.483
TRG_ER_diArg_1 219 222 PF00400 0.275
TRG_ER_diArg_1 582 584 PF00400 0.244
TRG_ER_diArg_1 641 644 PF00400 0.624

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5K5 Leptomonas seymouri 25% 100%
A0A1X0NVK4 Trypanosomatidae 34% 100%
A0A3S7WTH9 Leishmania donovani 70% 100%
A4HWI5 Leishmania infantum 70% 100%
E9AQ86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 97%
Q4Q2S3 Leishmania major 26% 94%
Q4QF97 Leishmania major 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS