Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H857_LEIBR

TriTrypDb:

LbrM.15.0880 , LBRM2903_150014900

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H857

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H857

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.661
CLV_NRD_NRD_1	114	116	PF00675	0.441
CLV_NRD_NRD_1	153	155	PF00675	0.440
CLV_NRD_NRD_1	24	26	PF00675	0.514
CLV_NRD_NRD_1	263	265	PF00675	0.319
CLV_NRD_NRD_1	389	391	PF00675	0.526
CLV_NRD_NRD_1	441	443	PF00675	0.531
CLV_NRD_NRD_1	465	467	PF00675	0.511
CLV_NRD_NRD_1	51	53	PF00675	0.512
CLV_NRD_NRD_1	582	584	PF00675	0.495
CLV_NRD_NRD_1	589	591	PF00675	0.472
CLV_NRD_NRD_1	645	647	PF00675	0.481
CLV_NRD_NRD_1	656	658	PF00675	0.540
CLV_NRD_NRD_1	703	705	PF00675	0.479
CLV_PCSK_FUR_1	642	646	PF00082	0.515
CLV_PCSK_KEX2_1	153	155	PF00082	0.440
CLV_PCSK_KEX2_1	263	265	PF00082	0.431
CLV_PCSK_KEX2_1	41	43	PF00082	0.555
CLV_PCSK_KEX2_1	51	53	PF00082	0.482
CLV_PCSK_KEX2_1	582	584	PF00082	0.495
CLV_PCSK_KEX2_1	644	646	PF00082	0.490
CLV_PCSK_KEX2_1	658	660	PF00082	0.512
CLV_PCSK_KEX2_1	703	705	PF00082	0.444
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.557
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.396
CLV_PCSK_PC7_1	259	265	PF00082	0.435
CLV_PCSK_PC7_1	47	53	PF00082	0.547
CLV_PCSK_SKI1_1	156	160	PF00082	0.437
CLV_PCSK_SKI1_1	219	223	PF00082	0.539
CLV_PCSK_SKI1_1	37	41	PF00082	0.641
CLV_PCSK_SKI1_1	590	594	PF00082	0.262
CLV_PCSK_SKI1_1	619	623	PF00082	0.312
CLV_PCSK_SKI1_1	674	678	PF00082	0.447
CLV_PCSK_SKI1_1	683	687	PF00082	0.456
CLV_PCSK_SKI1_1	703	707	PF00082	0.389
CLV_PCSK_SKI1_1	817	821	PF00082	0.467
CLV_Separin_Metazoa	168	172	PF03568	0.551
DEG_APCC_DBOX_1	155	163	PF00400	0.638
DEG_APCC_DBOX_1	618	626	PF00400	0.225
DEG_APCC_DBOX_1	846	854	PF00400	0.583
DOC_CDC14_PxL_1	294	302	PF14671	0.596
DOC_MAPK_gen_1	590	597	PF00069	0.529
DOC_MAPK_MEF2A_6	590	599	PF00069	0.475
DOC_PP1_RVXF_1	257	263	PF00149	0.649
DOC_PP2B_LxvP_1	890	893	PF13499	0.648
DOC_PP2B_PxIxI_1	807	813	PF00149	0.606
DOC_PP4_FxxP_1	130	133	PF00568	0.640
DOC_PP4_FxxP_1	316	319	PF00568	0.572
DOC_USP7_MATH_1	126	130	PF00917	0.701
DOC_USP7_MATH_1	334	338	PF00917	0.649
DOC_USP7_MATH_1	397	401	PF00917	0.678
DOC_USP7_MATH_1	449	453	PF00917	0.678
DOC_USP7_MATH_1	552	556	PF00917	0.581
DOC_USP7_MATH_1	568	572	PF00917	0.660
DOC_USP7_MATH_1	67	71	PF00917	0.697
DOC_USP7_MATH_1	694	698	PF00917	0.695
DOC_USP7_MATH_1	753	757	PF00917	0.648
DOC_USP7_MATH_1	838	842	PF00917	0.720
DOC_USP7_MATH_1	893	897	PF00917	0.733
DOC_USP7_UBL2_3	37	41	PF12436	0.732
DOC_WW_Pin1_4	131	136	PF00397	0.692
DOC_WW_Pin1_4	163	168	PF00397	0.751
DOC_WW_Pin1_4	321	326	PF00397	0.670
DOC_WW_Pin1_4	393	398	PF00397	0.646
DOC_WW_Pin1_4	419	424	PF00397	0.777
DOC_WW_Pin1_4	53	58	PF00397	0.719
DOC_WW_Pin1_4	743	748	PF00397	0.632
DOC_WW_Pin1_4	755	760	PF00397	0.631
DOC_WW_Pin1_4	775	780	PF00397	0.642
LIG_14-3-3_CanoR_1	118	123	PF00244	0.696
LIG_14-3-3_CanoR_1	153	159	PF00244	0.648
LIG_14-3-3_CanoR_1	25	33	PF00244	0.694
LIG_14-3-3_CanoR_1	273	277	PF00244	0.671
LIG_14-3-3_CanoR_1	299	309	PF00244	0.600
LIG_14-3-3_CanoR_1	3	7	PF00244	0.738
LIG_14-3-3_CanoR_1	474	484	PF00244	0.716
LIG_14-3-3_CanoR_1	570	578	PF00244	0.647
LIG_14-3-3_CanoR_1	590	599	PF00244	0.406
LIG_14-3-3_CanoR_1	601	610	PF00244	0.363
LIG_14-3-3_CanoR_1	847	851	PF00244	0.655
LIG_14-3-3_CanoR_1	852	856	PF00244	0.595
LIG_Actin_WH2_2	155	173	PF00022	0.543
LIG_Actin_WH2_2	812	827	PF00022	0.664
LIG_BRCT_BRCA1_1	126	130	PF00533	0.651
LIG_BRCT_BRCA1_1	172	176	PF00533	0.656
LIG_BRCT_BRCA1_1	268	272	PF00533	0.628
LIG_BRCT_BRCA1_1	312	316	PF00533	0.637
LIG_BRCT_BRCA1_1	757	761	PF00533	0.595
LIG_CaM_IQ_9	148	163	PF13499	0.643
LIG_DCNL_PONY_1	1	4	PF03556	0.684
LIG_deltaCOP1_diTrp_1	307	316	PF00928	0.577
LIG_FHA_1	272	278	PF00498	0.550
LIG_FHA_1	448	454	PF00498	0.642
LIG_FHA_1	567	573	PF00498	0.685
LIG_FHA_1	724	730	PF00498	0.570
LIG_FHA_1	79	85	PF00498	0.750
LIG_FHA_1	98	104	PF00498	0.596
LIG_FHA_2	237	243	PF00498	0.704
LIG_FHA_2	400	406	PF00498	0.746
LIG_FHA_2	552	558	PF00498	0.584
LIG_FHA_2	720	726	PF00498	0.760
LIG_FHA_2	776	782	PF00498	0.614
LIG_FHA_2	910	916	PF00498	0.655
LIG_LIR_Apic_2	127	133	PF02991	0.644
LIG_LIR_Apic_2	313	319	PF02991	0.558
LIG_LIR_Gen_1	307	316	PF02991	0.590
LIG_LIR_Gen_1	410	420	PF02991	0.722
LIG_LIR_Gen_1	557	568	PF02991	0.678
LIG_LIR_Gen_1	620	627	PF02991	0.225
LIG_LIR_Gen_1	806	815	PF02991	0.609
LIG_LIR_Gen_1	829	839	PF02991	0.621
LIG_LIR_Gen_1	875	883	PF02991	0.613
LIG_LIR_Nem_3	173	179	PF02991	0.600
LIG_LIR_Nem_3	307	312	PF02991	0.588
LIG_LIR_Nem_3	331	335	PF02991	0.656
LIG_LIR_Nem_3	410	416	PF02991	0.721
LIG_LIR_Nem_3	620	626	PF02991	0.312
LIG_LIR_Nem_3	684	688	PF02991	0.704
LIG_LIR_Nem_3	758	764	PF02991	0.637
LIG_LIR_Nem_3	806	812	PF02991	0.609
LIG_LIR_Nem_3	829	834	PF02991	0.609
LIG_LIR_Nem_3	875	881	PF02991	0.623
LIG_LYPXL_yS_3	332	335	PF13949	0.609
LIG_NRBOX	621	627	PF00104	0.227
LIG_PCNA_PIPBox_1	857	866	PF02747	0.536
LIG_PCNA_TLS_4	825	832	PF02747	0.543
LIG_PCNA_yPIPBox_3	852	864	PF02747	0.552
LIG_Pex14_1	864	868	PF04695	0.634
LIG_Pex14_1	928	932	PF04695	0.687
LIG_SH2_PTP2	809	812	PF00017	0.601
LIG_SH2_SRC	201	204	PF00017	0.638
LIG_SH2_STAP1	356	360	PF00017	0.633
LIG_SH2_STAT3	356	359	PF00017	0.632
LIG_SH2_STAT5	383	386	PF00017	0.693
LIG_SH2_STAT5	432	435	PF00017	0.677
LIG_SH2_STAT5	623	626	PF00017	0.225
LIG_SH2_STAT5	785	788	PF00017	0.678
LIG_SH2_STAT5	809	812	PF00017	0.601
LIG_SH2_STAT5	831	834	PF00017	0.660
LIG_SH3_1	741	747	PF00018	0.632
LIG_SH3_3	129	135	PF00018	0.725
LIG_SH3_3	166	172	PF00018	0.640
LIG_SH3_3	295	301	PF00018	0.641
LIG_SH3_3	327	333	PF00018	0.596
LIG_SH3_3	438	444	PF00018	0.614
LIG_SH3_3	70	76	PF00018	0.683
LIG_SH3_3	741	747	PF00018	0.691
LIG_SUMO_SIM_par_1	161	166	PF11976	0.744
LIG_SxIP_EBH_1	588	601	PF03271	0.434
LIG_TRAF2_1	403	406	PF00917	0.697
LIG_TRAF2_1	778	781	PF00917	0.614
LIG_TYR_ITIM	330	335	PF00017	0.598
LIG_UBA3_1	584	591	PF00899	0.542
LIG_WRC_WIRS_1	618	623	PF05994	0.388
MOD_CDC14_SPxK_1	56	59	PF00782	0.651
MOD_CDK_SPxK_1	53	59	PF00069	0.655
MOD_CK1_1	121	127	PF00069	0.842
MOD_CK1_1	147	153	PF00069	0.644
MOD_CK1_1	246	252	PF00069	0.757
MOD_CK1_1	28	34	PF00069	0.650
MOD_CK1_1	289	295	PF00069	0.642
MOD_CK1_1	324	330	PF00069	0.635
MOD_CK1_1	43	49	PF00069	0.684
MOD_CK1_1	445	451	PF00069	0.686
MOD_CK1_1	5	11	PF00069	0.741
MOD_CK1_1	503	509	PF00069	0.726
MOD_CK1_1	514	520	PF00069	0.607
MOD_CK1_1	98	104	PF00069	0.633
MOD_CK2_1	220	226	PF00069	0.742
MOD_CK2_1	314	320	PF00069	0.658
MOD_CK2_1	399	405	PF00069	0.712
MOD_CK2_1	719	725	PF00069	0.771
MOD_CK2_1	775	781	PF00069	0.615
MOD_CK2_1	798	804	PF00069	0.647
MOD_CK2_1	910	916	PF00069	0.655
MOD_Cter_Amidation	23	26	PF01082	0.546
MOD_Cter_Amidation	539	542	PF01082	0.503
MOD_Cter_Amidation	655	658	PF01082	0.419
MOD_GlcNHglycan	105	108	PF01048	0.548
MOD_GlcNHglycan	126	129	PF01048	0.544
MOD_GlcNHglycan	172	175	PF01048	0.405
MOD_GlcNHglycan	245	248	PF01048	0.565
MOD_GlcNHglycan	288	291	PF01048	0.606
MOD_GlcNHglycan	326	329	PF01048	0.422
MOD_GlcNHglycan	377	381	PF01048	0.492
MOD_GlcNHglycan	384	387	PF01048	0.518
MOD_GlcNHglycan	399	402	PF01048	0.475
MOD_GlcNHglycan	42	45	PF01048	0.574
MOD_GlcNHglycan	435	438	PF01048	0.588
MOD_GlcNHglycan	446	450	PF01048	0.512
MOD_GlcNHglycan	459	462	PF01048	0.576
MOD_GlcNHglycan	469	472	PF01048	0.404
MOD_GlcNHglycan	478	481	PF01048	0.417
MOD_GlcNHglycan	513	516	PF01048	0.510
MOD_GlcNHglycan	524	527	PF01048	0.430
MOD_GlcNHglycan	572	575	PF01048	0.437
MOD_GlcNHglycan	628	631	PF01048	0.231
MOD_GlcNHglycan	690	693	PF01048	0.484
MOD_GlcNHglycan	895	898	PF01048	0.531
MOD_GlcNHglycan	912	915	PF01048	0.462
MOD_GlcNHglycan	918	921	PF01048	0.514
MOD_GlcNHglycan	922	925	PF01048	0.483
MOD_GSK3_1	114	121	PF00069	0.705
MOD_GSK3_1	207	214	PF00069	0.647
MOD_GSK3_1	233	240	PF00069	0.789
MOD_GSK3_1	24	31	PF00069	0.650
MOD_GSK3_1	310	317	PF00069	0.596
MOD_GSK3_1	324	331	PF00069	0.723
MOD_GSK3_1	372	379	PF00069	0.678
MOD_GSK3_1	393	400	PF00069	0.721
MOD_GSK3_1	419	426	PF00069	0.750
MOD_GSK3_1	42	49	PF00069	0.742
MOD_GSK3_1	445	452	PF00069	0.734
MOD_GSK3_1	453	460	PF00069	0.746
MOD_GSK3_1	514	521	PF00069	0.631
MOD_GSK3_1	541	548	PF00069	0.591
MOD_GSK3_1	566	573	PF00069	0.687
MOD_GSK3_1	690	697	PF00069	0.699
MOD_GSK3_1	719	726	PF00069	0.589
MOD_GSK3_1	739	746	PF00069	0.645
MOD_GSK3_1	771	778	PF00069	0.644
MOD_GSK3_1	794	801	PF00069	0.676
MOD_GSK3_1	902	909	PF00069	0.728
MOD_GSK3_1	910	917	PF00069	0.729
MOD_GSK3_1	98	105	PF00069	0.692
MOD_N-GLC_1	144	149	PF02516	0.366
MOD_N-GLC_1	33	38	PF02516	0.449
MOD_N-GLC_1	60	65	PF02516	0.445
MOD_N-GLC_1	608	613	PF02516	0.636
MOD_N-GLC_1	98	103	PF02516	0.427
MOD_N-GLC_2	142	144	PF02516	0.454
MOD_N-GLC_2	189	191	PF02516	0.305
MOD_NEK2_1	103	108	PF00069	0.694
MOD_NEK2_1	19	24	PF00069	0.619
MOD_NEK2_1	2	7	PF00069	0.737
MOD_NEK2_1	272	277	PF00069	0.657
MOD_NEK2_1	310	315	PF00069	0.573
MOD_NEK2_1	33	38	PF00069	0.689
MOD_NEK2_1	339	344	PF00069	0.699
MOD_NEK2_1	384	389	PF00069	0.680
MOD_NEK2_1	433	438	PF00069	0.738
MOD_NEK2_1	465	470	PF00069	0.618
MOD_NEK2_1	488	493	PF00069	0.716
MOD_NEK2_1	511	516	PF00069	0.636
MOD_NEK2_1	60	65	PF00069	0.645
MOD_NEK2_1	625	630	PF00069	0.270
MOD_NEK2_1	688	693	PF00069	0.694
MOD_NEK2_1	97	102	PF00069	0.681
MOD_NEK2_2	851	856	PF00069	0.637
MOD_PIKK_1	266	272	PF00454	0.615
MOD_PIKK_1	500	506	PF00454	0.632
MOD_PK_1	25	31	PF00069	0.753
MOD_PKA_1	25	31	PF00069	0.753
MOD_PKA_1	40	46	PF00069	0.663
MOD_PKA_1	442	448	PF00069	0.633
MOD_PKA_1	541	547	PF00069	0.685
MOD_PKA_1	590	596	PF00069	0.441
MOD_PKA_2	114	120	PF00069	0.736
MOD_PKA_2	12	18	PF00069	0.669
MOD_PKA_2	170	176	PF00069	0.544
MOD_PKA_2	2	8	PF00069	0.738
MOD_PKA_2	233	239	PF00069	0.656
MOD_PKA_2	24	30	PF00069	0.686
MOD_PKA_2	272	278	PF00069	0.608
MOD_PKA_2	375	381	PF00069	0.656
MOD_PKA_2	46	52	PF00069	0.759
MOD_PKA_2	465	471	PF00069	0.712
MOD_PKA_2	522	528	PF00069	0.629
MOD_PKA_2	600	606	PF00069	0.308
MOD_PKA_2	846	852	PF00069	0.591
MOD_Plk_1	144	150	PF00069	0.562
MOD_Plk_1	292	298	PF00069	0.718
MOD_Plk_1	60	66	PF00069	0.661
MOD_Plk_1	608	614	PF00069	0.436
MOD_Plk_1	753	759	PF00069	0.610
MOD_Plk_1	798	804	PF00069	0.631
MOD_Plk_4	2	8	PF00069	0.625
MOD_Plk_4	272	278	PF00069	0.662
MOD_Plk_4	310	316	PF00069	0.560
MOD_Plk_4	334	340	PF00069	0.701
MOD_Plk_4	489	495	PF00069	0.710
MOD_Plk_4	719	725	PF00069	0.692
MOD_Plk_4	798	804	PF00069	0.599
MOD_ProDKin_1	131	137	PF00069	0.692
MOD_ProDKin_1	163	169	PF00069	0.752
MOD_ProDKin_1	321	327	PF00069	0.671
MOD_ProDKin_1	393	399	PF00069	0.647
MOD_ProDKin_1	419	425	PF00069	0.778
MOD_ProDKin_1	53	59	PF00069	0.720
MOD_ProDKin_1	743	749	PF00069	0.632
MOD_ProDKin_1	755	761	PF00069	0.630
MOD_ProDKin_1	775	781	PF00069	0.644
TRG_DiLeu_BaEn_1	807	812	PF01217	0.607
TRG_DiLeu_BaEn_2	306	312	PF01217	0.624
TRG_DiLeu_BaEn_2	506	512	PF01217	0.637
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.656
TRG_ENDOCYTIC_2	332	335	PF00928	0.609
TRG_ENDOCYTIC_2	369	372	PF00928	0.702
TRG_ENDOCYTIC_2	623	626	PF00928	0.318
TRG_ENDOCYTIC_2	809	812	PF00928	0.601
TRG_ENDOCYTIC_2	831	834	PF00928	0.660
TRG_ER_diArg_1	153	156	PF00400	0.640
TRG_ER_diArg_1	262	264	PF00400	0.525
TRG_ER_diArg_1	51	54	PF00400	0.733
TRG_ER_diArg_1	582	584	PF00400	0.664
TRG_ER_diArg_1	642	645	PF00400	0.653
TRG_ER_diArg_1	702	704	PF00400	0.682
TRG_ER_diArg_1	823	826	PF00400	0.663
TRG_NLS_Bipartite_1	25	44	PF00514	0.669
TRG_NLS_Bipartite_1	644	661	PF00514	0.593
TRG_NLS_MonoExtC_3	656	662	PF00514	0.598
TRG_NLS_MonoExtN_4	37	44	PF00514	0.741
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL01	Leptomonas seymouri	36%	100%
A0A3S5H6V1	Leishmania donovani	72%	97%
A4HWI3	Leishmania infantum	73%	97%
E9AQ84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4QF99	Leishmania major	72%	100%