Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H856_LEIBR

TriTrypDb:

LbrM.15.0870 , LBRM2903_150015000

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H856

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H856

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.630
CLV_C14_Caspase3-7	773	777	PF00656	0.582
CLV_NRD_NRD_1	201	203	PF00675	0.667
CLV_NRD_NRD_1	265	267	PF00675	0.606
CLV_NRD_NRD_1	273	275	PF00675	0.574
CLV_NRD_NRD_1	315	317	PF00675	0.655
CLV_NRD_NRD_1	43	45	PF00675	0.639
CLV_NRD_NRD_1	516	518	PF00675	0.720
CLV_NRD_NRD_1	623	625	PF00675	0.421
CLV_PCSK_FUR_1	263	267	PF00082	0.610
CLV_PCSK_FUR_1	621	625	PF00082	0.428
CLV_PCSK_KEX2_1	263	265	PF00082	0.633
CLV_PCSK_KEX2_1	273	275	PF00082	0.593
CLV_PCSK_KEX2_1	315	317	PF00082	0.655
CLV_PCSK_KEX2_1	516	518	PF00082	0.692
CLV_PCSK_KEX2_1	609	611	PF00082	0.419
CLV_PCSK_KEX2_1	623	625	PF00082	0.372
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.419
CLV_PCSK_PC7_1	269	275	PF00082	0.594
CLV_PCSK_SKI1_1	202	206	PF00082	0.659
CLV_PCSK_SKI1_1	361	365	PF00082	0.569
CLV_PCSK_SKI1_1	376	380	PF00082	0.592
CLV_PCSK_SKI1_1	392	396	PF00082	0.417
CLV_PCSK_SKI1_1	447	451	PF00082	0.512
CLV_PCSK_SKI1_1	507	511	PF00082	0.653
CLV_PCSK_SKI1_1	516	520	PF00082	0.524
CLV_PCSK_SKI1_1	561	565	PF00082	0.461
CLV_PCSK_SKI1_1	623	627	PF00082	0.561
CLV_PCSK_SKI1_1	631	635	PF00082	0.666
CLV_PCSK_SKI1_1	648	652	PF00082	0.468
CLV_PCSK_SKI1_1	848	852	PF00082	0.707
DEG_APCC_DBOX_1	201	209	PF00400	0.657
DEG_APCC_DBOX_1	375	383	PF00400	0.649
DEG_APCC_DBOX_1	446	454	PF00400	0.437
DEG_SPOP_SBC_1	111	115	PF00917	0.555
DEG_SPOP_SBC_1	142	146	PF00917	0.466
DOC_CKS1_1	362	367	PF01111	0.518
DOC_CKS1_1	470	475	PF01111	0.583
DOC_CKS1_1	786	791	PF01111	0.566
DOC_CYCLIN_RxL_1	198	206	PF00134	0.647
DOC_CYCLIN_RxL_1	207	220	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	666	672	PF00134	0.577
DOC_MAPK_gen_1	207	217	PF00069	0.433
DOC_MAPK_gen_1	682	692	PF00069	0.580
DOC_MAPK_HePTP_8	31	43	PF00069	0.588
DOC_MAPK_MEF2A_6	34	43	PF00069	0.589
DOC_PP2B_LxvP_1	37	40	PF13499	0.810
DOC_PP2B_LxvP_1	799	802	PF13499	0.679
DOC_PP4_FxxP_1	786	789	PF00568	0.564
DOC_USP7_MATH_1	10	14	PF00917	0.783
DOC_USP7_MATH_1	111	115	PF00917	0.747
DOC_USP7_MATH_1	142	146	PF00917	0.466
DOC_USP7_MATH_1	193	197	PF00917	0.600
DOC_USP7_MATH_1	20	24	PF00917	0.724
DOC_USP7_MATH_1	251	255	PF00917	0.817
DOC_USP7_MATH_1	303	307	PF00917	0.626
DOC_USP7_MATH_1	349	353	PF00917	0.718
DOC_USP7_MATH_1	435	439	PF00917	0.631
DOC_USP7_MATH_1	476	480	PF00917	0.641
DOC_USP7_MATH_1	733	737	PF00917	0.707
DOC_USP7_MATH_1	79	83	PF00917	0.655
DOC_USP7_MATH_1	802	806	PF00917	0.589
DOC_USP7_MATH_2	116	122	PF00917	0.746
DOC_USP7_UBL2_3	203	207	PF12436	0.657
DOC_WW_Pin1_4	112	117	PF00397	0.556
DOC_WW_Pin1_4	247	252	PF00397	0.635
DOC_WW_Pin1_4	280	285	PF00397	0.578
DOC_WW_Pin1_4	299	304	PF00397	0.549
DOC_WW_Pin1_4	361	366	PF00397	0.533
DOC_WW_Pin1_4	469	474	PF00397	0.654
DOC_WW_Pin1_4	62	67	PF00397	0.856
DOC_WW_Pin1_4	712	717	PF00397	0.636
DOC_WW_Pin1_4	729	734	PF00397	0.737
DOC_WW_Pin1_4	737	742	PF00397	0.706
DOC_WW_Pin1_4	74	79	PF00397	0.685
DOC_WW_Pin1_4	785	790	PF00397	0.684
DOC_WW_Pin1_4	832	837	PF00397	0.781
DOC_WW_Pin1_4	86	91	PF00397	0.642
LIG_14-3-3_CanoR_1	233	239	PF00244	0.654
LIG_14-3-3_CanoR_1	430	439	PF00244	0.669
LIG_14-3-3_CanoR_1	44	54	PF00244	0.599
LIG_14-3-3_CanoR_1	496	503	PF00244	0.670
LIG_14-3-3_CanoR_1	516	524	PF00244	0.482
LIG_14-3-3_CanoR_1	623	628	PF00244	0.500
LIG_14-3-3_CanoR_1	685	694	PF00244	0.595
LIG_14-3-3_CanoR_1	7	16	PF00244	0.600
LIG_14-3-3_CanoR_1	735	740	PF00244	0.822
LIG_Actin_WH2_2	117	134	PF00022	0.547
LIG_APCC_ABBAyCdc20_2	507	513	PF00400	0.672
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BIR_III_4	27	31	PF00653	0.814
LIG_EVH1_1	281	285	PF00568	0.573
LIG_EVH1_1	786	790	PF00568	0.565
LIG_EVH1_2	39	43	PF00568	0.813
LIG_FHA_1	306	312	PF00498	0.667
LIG_FHA_1	362	368	PF00498	0.522
LIG_FHA_1	724	730	PF00498	0.581
LIG_FHA_1	767	773	PF00498	0.651
LIG_FHA_1	786	792	PF00498	0.515
LIG_FHA_2	113	119	PF00498	0.554
LIG_FHA_2	496	502	PF00498	0.646
LIG_FHA_2	549	555	PF00498	0.426
LIG_FHA_2	632	638	PF00498	0.653
LIG_FHA_2	822	828	PF00498	0.605
LIG_GBD_Chelix_1	419	427	PF00786	0.423
LIG_LIR_Apic_2	279	284	PF02991	0.581
LIG_LIR_Apic_2	736	742	PF02991	0.653
LIG_LIR_Apic_2	784	789	PF02991	0.569
LIG_LIR_Gen_1	150	157	PF02991	0.619
LIG_LIR_Gen_1	616	625	PF02991	0.423
LIG_LIR_Gen_1	805	814	PF02991	0.573
LIG_LIR_Nem_3	150	155	PF02991	0.628
LIG_LIR_Nem_3	616	620	PF02991	0.419
LIG_LIR_Nem_3	726	731	PF02991	0.578
LIG_LIR_Nem_3	805	810	PF02991	0.571
LIG_LIR_Nem_3	844	850	PF02991	0.710
LIG_Pex14_1	186	190	PF04695	0.628
LIG_Pex14_1	843	847	PF04695	0.716
LIG_SH2_CRK	617	621	PF00017	0.422
LIG_SH2_CRK	739	743	PF00017	0.621
LIG_SH2_GRB2like	818	821	PF00017	0.591
LIG_SH2_NCK_1	739	743	PF00017	0.601
LIG_SH2_SRC	807	810	PF00017	0.573
LIG_SH2_STAT3	163	166	PF00017	0.642
LIG_SH2_STAT5	399	402	PF00017	0.475
LIG_SH3_2	730	735	PF14604	0.573
LIG_SH3_3	279	285	PF00018	0.578
LIG_SH3_3	33	39	PF00018	0.816
LIG_SH3_3	359	365	PF00018	0.548
LIG_SH3_3	470	476	PF00018	0.605
LIG_SH3_3	478	484	PF00018	0.604
LIG_SH3_3	727	733	PF00018	0.574
LIG_SH3_3	784	790	PF00018	0.729
LIG_SH3_3	99	105	PF00018	0.664
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.479
LIG_SUMO_SIM_anti_2	646	653	PF11976	0.492
LIG_SUMO_SIM_anti_2	688	694	PF11976	0.568
LIG_SUMO_SIM_par_1	153	159	PF11976	0.608
LIG_SUMO_SIM_par_1	442	448	PF11976	0.584
LIG_SUMO_SIM_par_1	661	667	PF11976	0.570
LIG_TRAF2_1	47	50	PF00917	0.596
LIG_TRAF2_1	842	845	PF00917	0.674
LIG_UBA3_1	200	207	PF00899	0.622
LIG_WRC_WIRS_1	246	251	PF05994	0.587
MOD_CDC14_SPxK_1	732	735	PF00782	0.801
MOD_CDK_SPxK_1	729	735	PF00069	0.799
MOD_CDK_SPxxK_3	832	839	PF00069	0.771
MOD_CK1_1	110	116	PF00069	0.769
MOD_CK1_1	18	24	PF00069	0.772
MOD_CK1_1	196	202	PF00069	0.657
MOD_CK1_1	235	241	PF00069	0.741
MOD_CK1_1	242	248	PF00069	0.695
MOD_CK1_1	283	289	PF00069	0.663
MOD_CK1_1	305	311	PF00069	0.674
MOD_CK1_1	383	389	PF00069	0.698
MOD_CK1_1	433	439	PF00069	0.618
MOD_CK1_1	469	475	PF00069	0.797
MOD_CK1_1	48	54	PF00069	0.595
MOD_CK1_1	604	610	PF00069	0.414
MOD_CK1_1	65	71	PF00069	0.715
MOD_CK1_1	721	727	PF00069	0.591
MOD_CK1_1	86	92	PF00069	0.674
MOD_CK2_1	112	118	PF00069	0.556
MOD_CK2_1	289	295	PF00069	0.612
MOD_CK2_1	44	50	PF00069	0.601
MOD_CK2_1	445	451	PF00069	0.664
MOD_CK2_1	495	501	PF00069	0.657
MOD_CK2_1	548	554	PF00069	0.425
MOD_CK2_1	631	637	PF00069	0.628
MOD_CK2_1	685	691	PF00069	0.578
MOD_CK2_1	742	748	PF00069	0.609
MOD_CK2_1	821	827	PF00069	0.605
MOD_DYRK1A_RPxSP_1	74	78	PF00069	0.602
MOD_GlcNHglycan	109	112	PF01048	0.623
MOD_GlcNHglycan	145	148	PF01048	0.665
MOD_GlcNHglycan	17	20	PF01048	0.772
MOD_GlcNHglycan	23	26	PF01048	0.670
MOD_GlcNHglycan	235	238	PF01048	0.773
MOD_GlcNHglycan	253	256	PF01048	0.854
MOD_GlcNHglycan	291	294	PF01048	0.636
MOD_GlcNHglycan	346	349	PF01048	0.791
MOD_GlcNHglycan	425	430	PF01048	0.580
MOD_GlcNHglycan	447	450	PF01048	0.639
MOD_GlcNHglycan	478	481	PF01048	0.733
MOD_GlcNHglycan	603	606	PF01048	0.407
MOD_GlcNHglycan	67	70	PF01048	0.687
MOD_GlcNHglycan	670	673	PF01048	0.609
MOD_GlcNHglycan	699	702	PF01048	0.714
MOD_GlcNHglycan	720	723	PF01048	0.822
MOD_GlcNHglycan	764	767	PF01048	0.755
MOD_GlcNHglycan	776	779	PF01048	0.696
MOD_GlcNHglycan	803	807	PF01048	0.575
MOD_GlcNHglycan	90	93	PF01048	0.723
MOD_GSK3_1	10	17	PF00069	0.807
MOD_GSK3_1	107	114	PF00069	0.757
MOD_GSK3_1	137	144	PF00069	0.531
MOD_GSK3_1	189	196	PF00069	0.556
MOD_GSK3_1	231	238	PF00069	0.762
MOD_GSK3_1	241	248	PF00069	0.667
MOD_GSK3_1	291	298	PF00069	0.661
MOD_GSK3_1	299	306	PF00069	0.644
MOD_GSK3_1	324	331	PF00069	0.647
MOD_GSK3_1	430	437	PF00069	0.707
MOD_GSK3_1	44	51	PF00069	0.601
MOD_GSK3_1	465	472	PF00069	0.682
MOD_GSK3_1	575	582	PF00069	0.684
MOD_GSK3_1	619	626	PF00069	0.423
MOD_GSK3_1	64	71	PF00069	0.867
MOD_GSK3_1	664	671	PF00069	0.593
MOD_GSK3_1	681	688	PF00069	0.621
MOD_GSK3_1	729	736	PF00069	0.756
MOD_GSK3_1	737	744	PF00069	0.662
MOD_GSK3_1	762	769	PF00069	0.775
MOD_GSK3_1	770	777	PF00069	0.742
MOD_GSK3_1	781	788	PF00069	0.569
MOD_GSK3_1	79	86	PF00069	0.607
MOD_LATS_1	629	635	PF00433	0.465
MOD_N-GLC_1	295	300	PF02516	0.623
MOD_N-GLC_1	324	329	PF02516	0.645
MOD_N-GLC_1	344	349	PF02516	0.475
MOD_N-GLC_1	540	545	PF02516	0.516
MOD_N-GLC_1	631	636	PF02516	0.698
MOD_N-GLC_1	819	824	PF02516	0.600
MOD_NEK2_1	137	142	PF00069	0.508
MOD_NEK2_1	143	148	PF00069	0.429
MOD_NEK2_1	217	222	PF00069	0.473
MOD_NEK2_1	239	244	PF00069	0.559
MOD_NEK2_1	328	333	PF00069	0.522
MOD_NEK2_1	439	444	PF00069	0.494
MOD_NEK2_1	466	471	PF00069	0.764
MOD_NEK2_1	564	569	PF00069	0.708
MOD_NEK2_1	619	624	PF00069	0.650
MOD_NEK2_1	652	657	PF00069	0.498
MOD_NEK2_1	695	700	PF00069	0.573
MOD_NEK2_1	723	728	PF00069	0.590
MOD_PIKK_1	316	322	PF00454	0.588
MOD_PIKK_1	466	472	PF00454	0.543
MOD_PIKK_1	540	546	PF00454	0.517
MOD_PIKK_1	564	570	PF00454	0.443
MOD_PIKK_1	598	604	PF00454	0.428
MOD_PIKK_1	715	721	PF00454	0.595
MOD_PIKK_1	83	89	PF00454	0.618
MOD_PKA_1	44	50	PF00069	0.601
MOD_PKA_1	516	522	PF00069	0.505
MOD_PKA_1	623	629	PF00069	0.432
MOD_PKA_2	232	238	PF00069	0.790
MOD_PKA_2	383	389	PF00069	0.686
MOD_PKA_2	495	501	PF00069	0.657
MOD_PKA_2	516	522	PF00069	0.502
MOD_PKA_2	579	585	PF00069	0.591
MOD_PKA_2	623	629	PF00069	0.468
MOD_PKA_2	652	658	PF00069	0.502
MOD_PKA_2	766	772	PF00069	0.683
MOD_PKB_1	621	629	PF00069	0.433
MOD_Plk_1	309	315	PF00069	0.654
MOD_Plk_1	324	330	PF00069	0.596
MOD_Plk_1	540	546	PF00069	0.529
MOD_Plk_2-3	548	554	PF00069	0.425
MOD_Plk_4	181	187	PF00069	0.414
MOD_Plk_4	196	202	PF00069	0.445
MOD_Plk_4	324	330	PF00069	0.614
MOD_Plk_4	435	441	PF00069	0.513
MOD_Plk_4	724	730	PF00069	0.614
MOD_Plk_4	794	800	PF00069	0.709
MOD_ProDKin_1	112	118	PF00069	0.556
MOD_ProDKin_1	247	253	PF00069	0.638
MOD_ProDKin_1	280	286	PF00069	0.581
MOD_ProDKin_1	299	305	PF00069	0.545
MOD_ProDKin_1	361	367	PF00069	0.527
MOD_ProDKin_1	469	475	PF00069	0.658
MOD_ProDKin_1	62	68	PF00069	0.856
MOD_ProDKin_1	712	718	PF00069	0.636
MOD_ProDKin_1	729	735	PF00069	0.740
MOD_ProDKin_1	737	743	PF00069	0.706
MOD_ProDKin_1	74	80	PF00069	0.688
MOD_ProDKin_1	785	791	PF00069	0.685
MOD_ProDKin_1	832	838	PF00069	0.775
MOD_ProDKin_1	86	92	PF00069	0.643
MOD_SUMO_for_1	545	548	PF00179	0.644
MOD_SUMO_rev_2	803	813	PF00179	0.572
TRG_DiLeu_BaEn_1	324	329	PF01217	0.672
TRG_DiLeu_BaLyEn_6	778	783	PF01217	0.579
TRG_ENDOCYTIC_2	152	155	PF00928	0.623
TRG_ENDOCYTIC_2	617	620	PF00928	0.415
TRG_ENDOCYTIC_2	807	810	PF00928	0.573
TRG_ER_diArg_1	164	167	PF00400	0.648
TRG_ER_diArg_1	263	266	PF00400	0.615
TRG_ER_diArg_1	273	275	PF00400	0.569
TRG_ER_diArg_1	314	316	PF00400	0.666
TRG_ER_diArg_1	620	623	PF00400	0.424
TRG_ER_diArg_1	711	714	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	174	179	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIQ6	Leishmania donovani	54%	100%
A4HWI1	Leishmania infantum	54%	100%
E9AQ82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4QFA0	Leishmania major	54%	93%