Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H855_LEIBR

TriTrypDb:

LbrM.15.0860 , LBRM2903_150015100

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H855

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H855

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.690
CLV_C14_Caspase3-7	97	101	PF00656	0.614
CLV_MEL_PAP_1	299	305	PF00089	0.654
CLV_NRD_NRD_1	117	119	PF00675	0.780
CLV_NRD_NRD_1	163	165	PF00675	0.782
CLV_NRD_NRD_1	358	360	PF00675	0.661
CLV_PCSK_KEX2_1	117	119	PF00082	0.780
CLV_PCSK_KEX2_1	146	148	PF00082	0.701
CLV_PCSK_KEX2_1	163	165	PF00082	0.782
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.701
CLV_PCSK_SKI1_1	143	147	PF00082	0.698
CLV_PCSK_SKI1_1	33	37	PF00082	0.748
CLV_PCSK_SKI1_1	400	404	PF00082	0.514
DEG_SCF_FBW7_1	156	162	PF00400	0.584
DEG_SPOP_SBC_1	230	234	PF00917	0.608
DEG_SPOP_SBC_1	93	97	PF00917	0.621
DOC_CDC14_PxL_1	420	428	PF14671	0.652
DOC_CKS1_1	156	161	PF01111	0.584
DOC_CKS1_1	184	189	PF01111	0.603
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.698
DOC_MAPK_DCC_7	183	192	PF00069	0.601
DOC_MAPK_gen_1	321	330	PF00069	0.582
DOC_MAPK_MEF2A_6	183	192	PF00069	0.606
DOC_PP2B_LxvP_1	328	331	PF13499	0.629
DOC_PP2B_LxvP_1	54	57	PF13499	0.673
DOC_PP4_FxxP_1	82	85	PF00568	0.812
DOC_USP7_MATH_1	159	163	PF00917	0.614
DOC_USP7_MATH_1	230	234	PF00917	0.608
DOC_USP7_MATH_1	252	256	PF00917	0.784
DOC_USP7_MATH_1	281	285	PF00917	0.688
DOC_USP7_MATH_1	345	349	PF00917	0.789
DOC_USP7_MATH_1	350	354	PF00917	0.700
DOC_USP7_MATH_1	85	89	PF00917	0.675
DOC_USP7_MATH_1	93	97	PF00917	0.797
DOC_USP7_MATH_1	98	102	PF00917	0.613
DOC_WW_Pin1_4	155	160	PF00397	0.638
DOC_WW_Pin1_4	183	188	PF00397	0.654
DOC_WW_Pin1_4	191	196	PF00397	0.623
DOC_WW_Pin1_4	27	32	PF00397	0.554
DOC_WW_Pin1_4	312	317	PF00397	0.739
DOC_WW_Pin1_4	333	338	PF00397	0.589
DOC_WW_Pin1_4	81	86	PF00397	0.655
DOC_WW_Pin1_4	99	104	PF00397	0.604
LIG_14-3-3_CanoR_1	117	124	PF00244	0.781
LIG_14-3-3_CanoR_1	135	139	PF00244	0.740
LIG_14-3-3_CanoR_1	223	230	PF00244	0.603
LIG_14-3-3_CanoR_1	33	41	PF00244	0.576
LIG_14-3-3_CanoR_1	381	386	PF00244	0.590
LIG_14-3-3_CanoR_1	69	75	PF00244	0.706
LIG_14-3-3_CanoR_1	77	85	PF00244	0.675
LIG_APCC_ABBAyCdc20_2	400	406	PF00400	0.711
LIG_BIR_III_2	338	342	PF00653	0.744
LIG_BRCT_BRCA1_1	61	65	PF00533	0.681
LIG_deltaCOP1_diTrp_1	354	361	PF00928	0.565
LIG_FHA_1	104	110	PF00498	0.630
LIG_FHA_1	184	190	PF00498	0.607
LIG_FHA_1	203	209	PF00498	0.610
LIG_FHA_1	275	281	PF00498	0.718
LIG_FHA_2	109	115	PF00498	0.624
LIG_FHA_2	204	210	PF00498	0.608
LIG_FHA_2	361	367	PF00498	0.508
LIG_LIR_Apic_2	42	47	PF02991	0.662
LIG_LIR_Apic_2	80	85	PF02991	0.593
LIG_LIR_Gen_1	137	145	PF02991	0.545
LIG_LIR_Nem_3	137	141	PF02991	0.722
LIG_LIR_Nem_3	291	296	PF02991	0.443
LIG_LIR_Nem_3	30	35	PF02991	0.566
LIG_Pex14_1	61	65	PF04695	0.681
LIG_REV1ctd_RIR_1	174	180	PF16727	0.613
LIG_SH2_CRK	72	76	PF00017	0.679
LIG_SH2_NCK_1	247	251	PF00017	0.582
LIG_SH2_SRC	44	47	PF00017	0.725
LIG_SH2_STAP1	247	251	PF00017	0.582
LIG_SH2_STAT3	344	347	PF00017	0.588
LIG_SH2_STAT5	34	37	PF00017	0.745
LIG_SH2_STAT5	395	398	PF00017	0.663
LIG_SH2_STAT5	72	75	PF00017	0.559
LIG_SH3_2	316	321	PF14604	0.554
LIG_SH3_3	153	159	PF00018	0.568
LIG_SH3_3	178	184	PF00018	0.638
LIG_SH3_3	23	29	PF00018	0.784
LIG_SH3_3	313	319	PF00018	0.744
LIG_SH3_3	339	345	PF00018	0.806
LIG_SUMO_SIM_par_1	188	194	PF11976	0.607
LIG_TRAF2_1	111	114	PF00917	0.828
LIG_TRAF2_1	148	151	PF00917	0.505
LIG_TRFH_1	72	76	PF08558	0.572
LIG_UBA3_1	393	400	PF00899	0.458
LIG_WW_1	341	344	PF00397	0.590
LIG_WW_3	315	319	PF00397	0.704
MOD_CDC14_SPxK_1	315	318	PF00782	0.699
MOD_CDK_SPxK_1	27	33	PF00069	0.576
MOD_CDK_SPxK_1	312	318	PF00069	0.688
MOD_CK1_1	101	107	PF00069	0.806
MOD_CK1_1	137	143	PF00069	0.506
MOD_CK1_1	16	22	PF00069	0.746
MOD_CK1_1	191	197	PF00069	0.604
MOD_CK1_1	228	234	PF00069	0.811
MOD_CK1_1	39	45	PF00069	0.616
MOD_CK1_1	48	54	PF00069	0.507
MOD_CK1_1	59	65	PF00069	0.508
MOD_CK1_1	80	86	PF00069	0.662
MOD_CK1_1	94	100	PF00069	0.666
MOD_CK2_1	108	114	PF00069	0.680
MOD_CK2_1	201	207	PF00069	0.830
MOD_CK2_1	233	239	PF00069	0.663
MOD_CK2_1	360	366	PF00069	0.499
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.593
MOD_GlcNHglycan	120	123	PF01048	0.835
MOD_GlcNHglycan	128	131	PF01048	0.675
MOD_GlcNHglycan	429	432	PF01048	0.611
MOD_GlcNHglycan	85	88	PF01048	0.699
MOD_GlcNHglycan	96	99	PF01048	0.746
MOD_GSK3_1	13	20	PF00069	0.732
MOD_GSK3_1	151	158	PF00069	0.595
MOD_GSK3_1	191	198	PF00069	0.657
MOD_GSK3_1	224	231	PF00069	0.802
MOD_GSK3_1	233	240	PF00069	0.594
MOD_GSK3_1	270	277	PF00069	0.662
MOD_GSK3_1	302	309	PF00069	0.454
MOD_GSK3_1	35	42	PF00069	0.779
MOD_GSK3_1	4	11	PF00069	0.733
MOD_GSK3_1	77	84	PF00069	0.581
MOD_GSK3_1	87	94	PF00069	0.632
MOD_GSK3_1	98	105	PF00069	0.658
MOD_NEK2_1	190	195	PF00069	0.653
MOD_NEK2_1	225	230	PF00069	0.607
MOD_NEK2_1	396	401	PF00069	0.674
MOD_PIKK_1	109	115	PF00454	0.624
MOD_PIKK_1	267	273	PF00454	0.580
MOD_PIKK_1	77	83	PF00454	0.656
MOD_PKA_1	117	123	PF00069	0.780
MOD_PKA_1	359	365	PF00069	0.504
MOD_PKA_2	116	122	PF00069	0.771
MOD_PKA_2	134	140	PF00069	0.609
MOD_PKA_2	182	188	PF00069	0.587
MOD_PKA_2	301	307	PF00069	0.659
MOD_PKA_2	70	76	PF00069	0.723
MOD_PKA_2	98	104	PF00069	0.711
MOD_PKB_1	6	14	PF00069	0.756
MOD_Plk_1	39	45	PF00069	0.753
MOD_Plk_4	137	143	PF00069	0.511
MOD_Plk_4	151	157	PF00069	0.621
MOD_Plk_4	259	265	PF00069	0.765
MOD_Plk_4	381	387	PF00069	0.543
MOD_Plk_4	56	62	PF00069	0.485
MOD_Plk_4	70	76	PF00069	0.723
MOD_Plk_4	87	93	PF00069	0.534
MOD_ProDKin_1	155	161	PF00069	0.641
MOD_ProDKin_1	183	189	PF00069	0.655
MOD_ProDKin_1	191	197	PF00069	0.622
MOD_ProDKin_1	27	33	PF00069	0.558
MOD_ProDKin_1	312	318	PF00069	0.742
MOD_ProDKin_1	333	339	PF00069	0.590
MOD_ProDKin_1	81	87	PF00069	0.655
MOD_ProDKin_1	99	105	PF00069	0.607
MOD_SUMO_rev_2	397	402	PF00179	0.686
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.498
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.644
TRG_ENDOCYTIC_2	142	145	PF00928	0.712
TRG_ENDOCYTIC_2	72	75	PF00928	0.714
TRG_ER_diArg_1	5	8	PF00400	0.646
TRG_ER_diArg_1	69	72	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTN4	Leishmania donovani	64%	99%
A4HWI0	Leishmania infantum	63%	99%
E9AQ81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%