Rab GDP dissociation inhibitor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GDP dissociation inhibitor, putative

Species:

Leishmania braziliensis

UniProt:

A4H854_LEIBR

TriTrypDb:

LbrM.15.0850 , LBRM2903_150015200

Length:

1050

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H854

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H854

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	11
GO:0007264	small GTPase mediated signal transduction	4	11
GO:0009987	cellular process	1	11
GO:0035556	intracellular signal transduction	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0006810	transport	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0005092	GDP-dissociation inhibitor activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11
GO:0005093	Rab GDP-dissociation inhibitor activity	4	1
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.349
CLV_C14_Caspase3-7	750	754	PF00656	0.540
CLV_C14_Caspase3-7	842	846	PF00656	0.733
CLV_NRD_NRD_1	177	179	PF00675	0.514
CLV_NRD_NRD_1	287	289	PF00675	0.487
CLV_NRD_NRD_1	314	316	PF00675	0.500
CLV_NRD_NRD_1	324	326	PF00675	0.473
CLV_NRD_NRD_1	424	426	PF00675	0.342
CLV_NRD_NRD_1	505	507	PF00675	0.282
CLV_NRD_NRD_1	663	665	PF00675	0.282
CLV_NRD_NRD_1	938	940	PF00675	0.552
CLV_PCSK_FUR_1	422	426	PF00082	0.386
CLV_PCSK_FUR_1	82	86	PF00082	0.355
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.519
CLV_PCSK_KEX2_1	102	104	PF00082	0.355
CLV_PCSK_KEX2_1	287	289	PF00082	0.468
CLV_PCSK_KEX2_1	314	316	PF00082	0.484
CLV_PCSK_KEX2_1	324	326	PF00082	0.490
CLV_PCSK_KEX2_1	422	424	PF00082	0.335
CLV_PCSK_KEX2_1	504	506	PF00082	0.283
CLV_PCSK_KEX2_1	663	665	PF00082	0.282
CLV_PCSK_KEX2_1	84	86	PF00082	0.355
CLV_PCSK_KEX2_1	938	940	PF00082	0.492
CLV_PCSK_PC1ET2_1	1012	1014	PF00082	0.553
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.355
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.296
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.324
CLV_PCSK_PC7_1	80	86	PF00082	0.480
CLV_PCSK_SKI1_1	1012	1016	PF00082	0.525
CLV_PCSK_SKI1_1	29	33	PF00082	0.506
CLV_PCSK_SKI1_1	315	319	PF00082	0.453
CLV_PCSK_SKI1_1	425	429	PF00082	0.283
CLV_PCSK_SKI1_1	461	465	PF00082	0.329
CLV_PCSK_SKI1_1	509	513	PF00082	0.290
CLV_PCSK_SKI1_1	620	624	PF00082	0.282
CLV_PCSK_SKI1_1	773	777	PF00082	0.481
DEG_APCC_DBOX_1	423	431	PF00400	0.515
DEG_APCC_DBOX_1	65	73	PF00400	0.564
DEG_APCC_DBOX_1	662	670	PF00400	0.524
DEG_APCC_DBOX_1	723	731	PF00400	0.702
DEG_SPOP_SBC_1	396	400	PF00917	0.467
DOC_CDC14_PxL_1	987	995	PF14671	0.448
DOC_CKS1_1	41	46	PF01111	0.379
DOC_CKS1_1	693	698	PF01111	0.599
DOC_CYCLIN_RxL_1	422	429	PF00134	0.498
DOC_CYCLIN_RxL_1	458	469	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	762	768	PF00134	0.460
DOC_MAPK_DCC_7	71	79	PF00069	0.578
DOC_MAPK_gen_1	1012	1020	PF00069	0.583
DOC_MAPK_gen_1	112	119	PF00069	0.355
DOC_MAPK_gen_1	504	510	PF00069	0.496
DOC_MAPK_gen_1	663	671	PF00069	0.544
DOC_MAPK_MEF2A_6	71	79	PF00069	0.557
DOC_MAPK_RevD_3	409	424	PF00069	0.405
DOC_PP1_RVXF_1	818	825	PF00149	0.568
DOC_PP2B_LxvP_1	1018	1021	PF13499	0.602
DOC_PP2B_LxvP_1	123	126	PF13499	0.335
DOC_PP2B_LxvP_1	18	21	PF13499	0.376
DOC_PP2B_LxvP_1	72	75	PF13499	0.571
DOC_PP4_FxxP_1	1044	1047	PF00568	0.518
DOC_SPAK_OSR1_1	338	342	PF12202	0.405
DOC_USP7_MATH_1	1029	1033	PF00917	0.477
DOC_USP7_MATH_1	197	201	PF00917	0.479
DOC_USP7_MATH_1	396	400	PF00917	0.534
DOC_USP7_MATH_1	594	598	PF00917	0.741
DOC_USP7_MATH_1	777	781	PF00917	0.422
DOC_USP7_MATH_2	916	922	PF00917	0.698
DOC_USP7_UBL2_3	179	183	PF12436	0.415
DOC_USP7_UBL2_3	748	752	PF12436	0.794
DOC_USP7_UBL2_3	98	102	PF12436	0.355
DOC_WW_Pin1_4	40	45	PF00397	0.554
DOC_WW_Pin1_4	630	635	PF00397	0.482
DOC_WW_Pin1_4	692	697	PF00397	0.595
DOC_WW_Pin1_4	722	727	PF00397	0.678
DOC_WW_Pin1_4	761	766	PF00397	0.722
DOC_WW_Pin1_4	956	961	PF00397	0.770
LIG_14-3-3_CanoR_1	112	117	PF00244	0.378
LIG_14-3-3_CanoR_1	490	494	PF00244	0.510
LIG_14-3-3_CanoR_1	651	659	PF00244	0.539
LIG_14-3-3_CanoR_1	663	667	PF00244	0.471
LIG_14-3-3_CanoR_1	85	89	PF00244	0.344
LIG_14-3-3_CanoR_1	924	928	PF00244	0.640
LIG_14-3-3_CanoR_1	950	960	PF00244	0.523
LIG_14-3-3_CanoR_1	980	988	PF00244	0.586
LIG_Actin_WH2_2	648	665	PF00022	0.496
LIG_AP2alpha_1	7	11	PF02296	0.557
LIG_APCC_ABBAyCdc20_2	287	293	PF00400	0.287
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BIR_III_2	957	961	PF00653	0.771
LIG_BIR_III_4	1016	1020	PF00653	0.594
LIG_BIR_III_4	3	7	PF00653	0.662
LIG_BIR_III_4	843	847	PF00653	0.704
LIG_BRCT_BRCA1_1	335	339	PF00533	0.564
LIG_BRCT_BRCA1_1	981	985	PF00533	0.608
LIG_deltaCOP1_diTrp_1	711	716	PF00928	0.591
LIG_deltaCOP1_diTrp_1	922	931	PF00928	0.628
LIG_eIF4E_1	143	149	PF01652	0.355
LIG_eIF4E_1	203	209	PF01652	0.290
LIG_FHA_1	22	28	PF00498	0.485
LIG_FHA_1	41	47	PF00498	0.308
LIG_FHA_1	564	570	PF00498	0.551
LIG_FHA_1	700	706	PF00498	0.449
LIG_FHA_1	723	729	PF00498	0.730
LIG_FHA_1	817	823	PF00498	0.578
LIG_FHA_1	973	979	PF00498	0.420
LIG_FHA_2	35	41	PF00498	0.487
LIG_FHA_2	562	568	PF00498	0.456
LIG_FHA_2	576	582	PF00498	0.472
LIG_FHA_2	693	699	PF00498	0.626
LIG_FHA_2	838	844	PF00498	0.732
LIG_FHA_2	876	882	PF00498	0.491
LIG_FHA_2	952	958	PF00498	0.743
LIG_GBD_Chelix_1	247	255	PF00786	0.399
LIG_IRF3_LxIS_1	21	28	PF10401	0.529
LIG_LIR_Apic_2	201	207	PF02991	0.508
LIG_LIR_Apic_2	38	44	PF02991	0.514
LIG_LIR_Apic_2	884	890	PF02991	0.493
LIG_LIR_Apic_2	922	928	PF02991	0.675
LIG_LIR_Gen_1	236	247	PF02991	0.400
LIG_LIR_Gen_1	278	286	PF02991	0.481
LIG_LIR_Gen_1	336	343	PF02991	0.363
LIG_LIR_Gen_1	47	56	PF02991	0.604
LIG_LIR_Gen_1	711	721	PF02991	0.592
LIG_LIR_Nem_3	1008	1014	PF02991	0.515
LIG_LIR_Nem_3	236	242	PF02991	0.404
LIG_LIR_Nem_3	278	282	PF02991	0.448
LIG_LIR_Nem_3	336	342	PF02991	0.363
LIG_LIR_Nem_3	40	45	PF02991	0.547
LIG_LIR_Nem_3	47	52	PF02991	0.582
LIG_LIR_Nem_3	5	10	PF02991	0.615
LIG_LIR_Nem_3	653	659	PF02991	0.562
LIG_LIR_Nem_3	676	682	PF02991	0.562
LIG_LIR_Nem_3	702	707	PF02991	0.513
LIG_LIR_Nem_3	711	717	PF02991	0.584
LIG_LIR_Nem_3	982	988	PF02991	0.546
LIG_LYPXL_SIV_4	1010	1018	PF13949	0.463
LIG_LYPXL_yS_3	300	303	PF13949	0.454
LIG_MAD2	1013	1021	PF02301	0.586
LIG_MYND_1	991	995	PF01753	0.518
LIG_NRBOX	250	256	PF00104	0.429
LIG_NRBOX	564	570	PF00104	0.508
LIG_PCNA_yPIPBox_3	555	569	PF02747	0.567
LIG_PCNA_yPIPBox_3	866	875	PF02747	0.463
LIG_Pex14_1	656	660	PF04695	0.482
LIG_Pex14_1	712	716	PF04695	0.619
LIG_Pex14_1	925	929	PF04695	0.641
LIG_Pex14_2	7	11	PF04695	0.532
LIG_PTB_Apo_2	993	1000	PF02174	0.532
LIG_PTB_Phospho_1	993	999	PF10480	0.532
LIG_REV1ctd_RIR_1	279	288	PF16727	0.410
LIG_SH2_CRK	1011	1015	PF00017	0.527
LIG_SH2_CRK	1042	1046	PF00017	0.589
LIG_SH2_CRK	229	233	PF00017	0.472
LIG_SH2_CRK	679	683	PF00017	0.550
LIG_SH2_CRK	714	718	PF00017	0.638
LIG_SH2_CRK	887	891	PF00017	0.557
LIG_SH2_NCK_1	292	296	PF00017	0.422
LIG_SH2_NCK_1	326	330	PF00017	0.538
LIG_SH2_NCK_1	803	807	PF00017	0.609
LIG_SH2_PTP2	204	207	PF00017	0.500
LIG_SH2_SRC	204	207	PF00017	0.500
LIG_SH2_SRC	229	232	PF00017	0.474
LIG_SH2_SRC	326	329	PF00017	0.321
LIG_SH2_STAP1	229	233	PF00017	0.472
LIG_SH2_STAP1	803	807	PF00017	0.609
LIG_SH2_STAT3	388	391	PF00017	0.562
LIG_SH2_STAT5	1003	1006	PF00017	0.413
LIG_SH2_STAT5	204	207	PF00017	0.545
LIG_SH2_STAT5	264	267	PF00017	0.362
LIG_SH2_STAT5	388	391	PF00017	0.496
LIG_SH2_STAT5	41	44	PF00017	0.583
LIG_SH2_STAT5	426	429	PF00017	0.503
LIG_SH2_STAT5	635	638	PF00017	0.562
LIG_SH2_STAT5	704	707	PF00017	0.570
LIG_SH2_STAT5	803	806	PF00017	0.621
LIG_SH2_STAT5	872	875	PF00017	0.531
LIG_SH2_STAT5	877	880	PF00017	0.526
LIG_SH2_STAT5	887	890	PF00017	0.272
LIG_SH2_STAT5	99	102	PF00017	0.335
LIG_SH3_3	310	316	PF00018	0.527
LIG_SH3_3	723	729	PF00018	0.698
LIG_SH3_3	910	916	PF00018	0.611
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.299
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.379
LIG_SUMO_SIM_anti_2	578	584	PF11976	0.462
LIG_SUMO_SIM_par_1	23	28	PF11976	0.494
LIG_SUMO_SIM_par_1	230	236	PF11976	0.344
LIG_SUMO_SIM_par_1	578	584	PF11976	0.521
LIG_SUMO_SIM_par_1	793	799	PF11976	0.594
LIG_SUMO_SIM_par_1	915	923	PF11976	0.684
LIG_SUMO_SIM_par_1	986	992	PF11976	0.553
LIG_TYR_ITIM	290	295	PF00017	0.478
LIG_UBA3_1	148	157	PF00899	0.289
LIG_WRC_WIRS_1	377	382	PF05994	0.447
MOD_CK1_1	351	357	PF00069	0.378
MOD_CK1_1	390	396	PF00069	0.468
MOD_CK1_1	398	404	PF00069	0.436
MOD_CK1_1	447	453	PF00069	0.427
MOD_CK1_1	54	60	PF00069	0.666
MOD_CK1_1	764	770	PF00069	0.582
MOD_CK1_1	829	835	PF00069	0.556
MOD_CK2_1	112	118	PF00069	0.355
MOD_CK2_1	168	174	PF00069	0.487
MOD_CK2_1	514	520	PF00069	0.480
MOD_CK2_1	561	567	PF00069	0.498
MOD_CK2_1	692	698	PF00069	0.534
MOD_CK2_1	875	881	PF00069	0.468
MOD_GlcNHglycan	1027	1030	PF01048	0.741
MOD_GlcNHglycan	190	193	PF01048	0.616
MOD_GlcNHglycan	353	356	PF01048	0.341
MOD_GlcNHglycan	447	450	PF01048	0.456
MOD_GlcNHglycan	53	56	PF01048	0.642
MOD_GlcNHglycan	574	578	PF01048	0.574
MOD_GlcNHglycan	601	604	PF01048	0.561
MOD_GlcNHglycan	652	655	PF01048	0.426
MOD_GlcNHglycan	735	738	PF01048	0.705
MOD_GlcNHglycan	759	762	PF01048	0.658
MOD_GlcNHglycan	766	769	PF01048	0.470
MOD_GlcNHglycan	779	782	PF01048	0.325
MOD_GlcNHglycan	969	972	PF01048	0.707
MOD_GSK3_1	1025	1032	PF00069	0.462
MOD_GSK3_1	184	191	PF00069	0.474
MOD_GSK3_1	21	28	PF00069	0.497
MOD_GSK3_1	387	394	PF00069	0.419
MOD_GSK3_1	395	402	PF00069	0.384
MOD_GSK3_1	467	474	PF00069	0.434
MOD_GSK3_1	489	496	PF00069	0.252
MOD_GSK3_1	50	57	PF00069	0.637
MOD_GSK3_1	531	538	PF00069	0.629
MOD_GSK3_1	592	599	PF00069	0.735
MOD_GSK3_1	699	706	PF00069	0.382
MOD_GSK3_1	728	735	PF00069	0.510
MOD_GSK3_1	757	764	PF00069	0.746
MOD_GSK3_1	956	963	PF00069	0.616
MOD_N-GLC_1	50	55	PF02516	0.615
MOD_N-GLC_1	536	541	PF02516	0.633
MOD_N-GLC_1	595	600	PF02516	0.647
MOD_N-GLC_2	648	650	PF02516	0.355
MOD_NEK2_1	220	225	PF00069	0.468
MOD_NEK2_1	247	252	PF00069	0.366
MOD_NEK2_1	25	30	PF00069	0.517
MOD_NEK2_1	333	338	PF00069	0.501
MOD_NEK2_1	343	348	PF00069	0.303
MOD_NEK2_1	395	400	PF00069	0.399
MOD_NEK2_1	445	450	PF00069	0.456
MOD_NEK2_1	494	499	PF00069	0.351
MOD_NEK2_1	568	573	PF00069	0.574
MOD_NEK2_1	575	580	PF00069	0.541
MOD_NEK2_1	622	627	PF00069	0.370
MOD_NEK2_1	636	641	PF00069	0.392
MOD_NEK2_1	662	667	PF00069	0.378
MOD_NEK2_1	699	704	PF00069	0.428
MOD_NEK2_1	967	972	PF00069	0.475
MOD_NEK2_2	931	936	PF00069	0.644
MOD_PIKK_1	209	215	PF00454	0.516
MOD_PIKK_1	387	393	PF00454	0.454
MOD_PIKK_1	674	680	PF00454	0.447
MOD_PIKK_1	862	868	PF00454	0.557
MOD_PIKK_1	901	907	PF00454	0.539
MOD_PK_1	112	118	PF00069	0.480
MOD_PKA_1	84	90	PF00069	0.355
MOD_PKA_2	489	495	PF00069	0.414
MOD_PKA_2	650	656	PF00069	0.384
MOD_PKA_2	662	668	PF00069	0.306
MOD_PKA_2	769	775	PF00069	0.430
MOD_PKA_2	837	843	PF00069	0.743
MOD_PKA_2	84	90	PF00069	0.346
MOD_PKA_2	923	929	PF00069	0.630
MOD_PKA_2	951	957	PF00069	0.505
MOD_PKA_2	979	985	PF00069	0.610
MOD_Plk_1	333	339	PF00069	0.528
MOD_Plk_1	514	520	PF00069	0.383
MOD_Plk_1	536	542	PF00069	0.655
MOD_Plk_1	595	601	PF00069	0.650
MOD_Plk_1	60	66	PF00069	0.529
MOD_Plk_2-3	168	174	PF00069	0.365
MOD_Plk_4	112	118	PF00069	0.336
MOD_Plk_4	21	27	PF00069	0.569
MOD_Plk_4	250	256	PF00069	0.343
MOD_Plk_4	348	354	PF00069	0.355
MOD_Plk_4	489	495	PF00069	0.392
MOD_Plk_4	514	520	PF00069	0.551
MOD_Plk_4	531	537	PF00069	0.367
MOD_Plk_4	575	581	PF00069	0.463
MOD_Plk_4	84	90	PF00069	0.344
MOD_Plk_4	989	995	PF00069	0.426
MOD_ProDKin_1	40	46	PF00069	0.547
MOD_ProDKin_1	630	636	PF00069	0.335
MOD_ProDKin_1	692	698	PF00069	0.497
MOD_ProDKin_1	722	728	PF00069	0.676
MOD_ProDKin_1	761	767	PF00069	0.709
MOD_ProDKin_1	956	962	PF00069	0.769
MOD_SUMO_for_1	169	172	PF00179	0.593
MOD_SUMO_rev_2	164	171	PF00179	0.483
MOD_SUMO_rev_2	672	677	PF00179	0.447
TRG_DiLeu_BaEn_1	983	988	PF01217	0.596
TRG_DiLeu_BaEn_1	989	994	PF01217	0.445
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.349
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.414
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.582
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.447
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.692
TRG_DiLeu_LyEn_5	983	988	PF01217	0.343
TRG_ENDOCYTIC_2	1011	1014	PF00928	0.440
TRG_ENDOCYTIC_2	1042	1045	PF00928	0.459
TRG_ENDOCYTIC_2	229	232	PF00928	0.474
TRG_ENDOCYTIC_2	264	267	PF00928	0.378
TRG_ENDOCYTIC_2	292	295	PF00928	0.346
TRG_ENDOCYTIC_2	300	303	PF00928	0.425
TRG_ENDOCYTIC_2	679	682	PF00928	0.386
TRG_ENDOCYTIC_2	713	716	PF00928	0.588
TRG_ER_diArg_1	286	288	PF00400	0.510
TRG_ER_diArg_1	313	315	PF00400	0.485
TRG_ER_diArg_1	324	326	PF00400	0.491
TRG_ER_diArg_1	422	425	PF00400	0.384
TRG_ER_diArg_1	505	507	PF00400	0.336
TRG_ER_diArg_1	65	68	PF00400	0.624
TRG_ER_diArg_1	662	664	PF00400	0.335
TRG_ER_diArg_1	937	939	PF00400	0.498
TRG_ER_diArg_1	949	952	PF00400	0.588
TRG_ER_FFAT_2	35	47	PF00635	0.369
TRG_NES_CRM1_1	9	23	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	452	457	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	461	466	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX4	Leptomonas seymouri	65%	100%
A0A0S4JKJ3	Bodo saltans	33%	100%
A0A1X0NTW1	Trypanosomatidae	37%	100%
A0A3R7KR10	Trypanosoma rangeli	40%	100%
A0A3S7WTI0	Leishmania donovani	83%	100%
A4HWH9	Leishmania infantum	83%	100%
C9ZXW9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQ80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFA2	Leishmania major	81%	98%