Histidine protein methyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H852_LEIBR

TriTrypDb:

LbrM.15.0830 , LBRM2903_150013300

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H852

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H852

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.308
CLV_PCSK_KEX2_1	219	221	PF00082	0.308
CLV_PCSK_KEX2_1	358	360	PF00082	0.537
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.565
CLV_PCSK_SKI1_1	190	194	PF00082	0.346
CLV_PCSK_SKI1_1	220	224	PF00082	0.308
CLV_PCSK_SKI1_1	228	232	PF00082	0.308
CLV_PCSK_SKI1_1	97	101	PF00082	0.633
DEG_Nend_UBRbox_2	1	3	PF02207	0.629
DEG_SCF_FBW7_1	147	152	PF00400	0.601
DEG_SPOP_SBC_1	27	31	PF00917	0.630
DEG_SPOP_SBC_1	50	54	PF00917	0.442
DOC_CYCLIN_RxL_1	185	194	PF00134	0.420
DOC_MAPK_gen_1	84	94	PF00069	0.463
DOC_MAPK_JIP1_4	90	96	PF00069	0.530
DOC_MAPK_MEF2A_6	87	96	PF00069	0.489
DOC_PP1_RVXF_1	217	224	PF00149	0.308
DOC_USP7_MATH_1	111	115	PF00917	0.721
DOC_USP7_MATH_1	149	153	PF00917	0.726
DOC_USP7_MATH_1	50	54	PF00917	0.508
DOC_USP7_MATH_1	58	62	PF00917	0.319
DOC_USP7_MATH_1	77	81	PF00917	0.365
DOC_WW_Pin1_4	109	114	PF00397	0.748
DOC_WW_Pin1_4	127	132	PF00397	0.574
DOC_WW_Pin1_4	145	150	PF00397	0.712
DOC_WW_Pin1_4	281	286	PF00397	0.415
DOC_WW_Pin1_4	33	38	PF00397	0.720
DOC_WW_Pin1_4	40	45	PF00397	0.711
LIG_14-3-3_CanoR_1	22	28	PF00244	0.706
LIG_14-3-3_CanoR_1	255	262	PF00244	0.548
LIG_BRCT_BRCA1_1	149	153	PF00533	0.461
LIG_BRCT_BRCA1_1	283	287	PF00533	0.401
LIG_CSL_BTD_1	46	49	PF09270	0.616
LIG_deltaCOP1_diTrp_1	270	276	PF00928	0.325
LIG_FHA_1	22	28	PF00498	0.568
LIG_FHA_1	256	262	PF00498	0.577
LIG_FHA_1	322	328	PF00498	0.459
LIG_FHA_1	87	93	PF00498	0.601
LIG_FHA_2	127	133	PF00498	0.518
LIG_FHA_2	23	29	PF00498	0.664
LIG_GBD_Chelix_1	310	318	PF00786	0.308
LIG_HP1_1	58	62	PF01393	0.445
LIG_LIR_Gen_1	270	277	PF02991	0.356
LIG_LIR_Gen_1	288	296	PF02991	0.478
LIG_LIR_Gen_1	56	67	PF02991	0.452
LIG_LIR_Nem_3	270	274	PF02991	0.353
LIG_LIR_Nem_3	288	294	PF02991	0.493
LIG_LIR_Nem_3	54	60	PF02991	0.476
LIG_LIR_Nem_3	6	12	PF02991	0.582
LIG_Pex14_1	70	74	PF04695	0.354
LIG_Pex14_2	287	291	PF04695	0.332
LIG_Pex14_2	8	12	PF04695	0.572
LIG_SH2_CRK	166	170	PF00017	0.279
LIG_SH2_CRK	189	193	PF00017	0.417
LIG_SH2_CRK	76	80	PF00017	0.412
LIG_SH2_NCK_1	76	80	PF00017	0.412
LIG_SH2_STAT5	181	184	PF00017	0.286
LIG_SH2_STAT5	333	336	PF00017	0.388
LIG_SH2_STAT5	340	343	PF00017	0.419
LIG_SH2_STAT5	74	77	PF00017	0.458
LIG_SH3_3	38	44	PF00018	0.720
LIG_SUMO_SIM_par_1	229	235	PF11976	0.249
LIG_WRC_WIRS_1	9	14	PF05994	0.655
MOD_CK1_1	11	17	PF00069	0.712
MOD_CK1_1	256	262	PF00069	0.445
MOD_CK1_1	275	281	PF00069	0.590
MOD_CK1_1	298	304	PF00069	0.337
MOD_CK1_1	31	37	PF00069	0.538
MOD_CK1_1	346	352	PF00069	0.248
MOD_CK1_1	53	59	PF00069	0.527
MOD_CK1_1	61	67	PF00069	0.456
MOD_CK1_1	86	92	PF00069	0.588
MOD_CK2_1	11	17	PF00069	0.494
MOD_CK2_1	126	132	PF00069	0.527
MOD_CK2_1	188	194	PF00069	0.400
MOD_GlcNHglycan	113	116	PF01048	0.663
MOD_GlcNHglycan	13	16	PF01048	0.578
MOD_GlcNHglycan	2	6	PF01048	0.684
MOD_GlcNHglycan	345	348	PF01048	0.437
MOD_GSK3_1	11	18	PF00069	0.656
MOD_GSK3_1	135	142	PF00069	0.531
MOD_GSK3_1	145	152	PF00069	0.636
MOD_GSK3_1	22	29	PF00069	0.681
MOD_GSK3_1	249	256	PF00069	0.615
MOD_GSK3_1	281	288	PF00069	0.534
MOD_GSK3_1	32	39	PF00069	0.762
MOD_GSK3_1	49	56	PF00069	0.431
MOD_NEK2_1	249	254	PF00069	0.575
MOD_NEK2_1	341	346	PF00069	0.441
MOD_NEK2_1	371	376	PF00069	0.434
MOD_NEK2_1	8	13	PF00069	0.664
MOD_PIKK_1	139	145	PF00454	0.685
MOD_PIKK_1	249	255	PF00454	0.444
MOD_PIKK_1	275	281	PF00454	0.495
MOD_PKA_2	21	27	PF00069	0.703
MOD_PKA_2	254	260	PF00069	0.582
MOD_PKA_2	371	377	PF00069	0.503
MOD_PKA_2	86	92	PF00069	0.400
MOD_PKB_1	20	28	PF00069	0.675
MOD_Plk_1	272	278	PF00069	0.432
MOD_Plk_1	298	304	PF00069	0.311
MOD_ProDKin_1	109	115	PF00069	0.747
MOD_ProDKin_1	127	133	PF00069	0.573
MOD_ProDKin_1	145	151	PF00069	0.713
MOD_ProDKin_1	281	287	PF00069	0.414
MOD_ProDKin_1	33	39	PF00069	0.719
MOD_ProDKin_1	40	46	PF00069	0.708
TRG_ENDOCYTIC_2	166	169	PF00928	0.344
TRG_ENDOCYTIC_2	189	192	PF00928	0.417
TRG_ENDOCYTIC_2	340	343	PF00928	0.470
TRG_ER_diArg_1	219	221	PF00400	0.308
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G2	Leptomonas seymouri	56%	100%
A0A0S4JZQ6	Bodo saltans	33%	100%
A0A1X0NU45	Trypanosomatidae	35%	100%
A0A3S7WTG3	Leishmania donovani	81%	79%
A0A422NRE8	Trypanosoma rangeli	37%	100%
A4HWH0	Leishmania infantum	81%	79%
C9ZXY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	67%
Q4QFB2	Leishmania major	83%	100%
V5B4I9	Trypanosoma cruzi	38%	100%