DUF2871 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2871), putative

Species:

Leishmania braziliensis

UniProt:

A4H849_LEIBR

TriTrypDb:

LbrM.15.0800 , LBRM2903_150016000

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H849

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H849

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	143	147	PF00082	0.453
CLV_PCSK_SKI1_1	23	27	PF00082	0.445
DEG_Nend_UBRbox_2	1	3	PF02207	0.479
DOC_PP1_RVXF_1	104	111	PF00149	0.244
DOC_USP7_MATH_1	48	52	PF00917	0.324
DOC_USP7_UBL2_3	70	74	PF12436	0.444
LIG_14-3-3_CanoR_1	106	111	PF00244	0.244
LIG_14-3-3_CanoR_1	135	140	PF00244	0.561
LIG_14-3-3_CanoR_1	40	49	PF00244	0.244
LIG_14-3-3_CanoR_1	6	10	PF00244	0.275
LIG_BRCT_BRCA1_1	119	123	PF00533	0.324
LIG_BRCT_BRCA1_1	50	54	PF00533	0.324
LIG_eIF4E_1	125	131	PF01652	0.275
LIG_FHA_1	109	115	PF00498	0.244
LIG_FHA_1	24	30	PF00498	0.341
LIG_FHA_1	34	40	PF00498	0.347
LIG_FHA_1	76	82	PF00498	0.332
LIG_FHA_1	93	99	PF00498	0.199
LIG_LIR_Gen_1	51	60	PF02991	0.275
LIG_LIR_Gen_1	8	17	PF02991	0.313
LIG_LIR_Nem_3	120	126	PF02991	0.324
LIG_LIR_Nem_3	51	57	PF02991	0.337
LIG_LIR_Nem_3	8	14	PF02991	0.313
LIG_MLH1_MIPbox_1	50	54	PF16413	0.324
LIG_NRBOX	54	60	PF00104	0.275
LIG_Pex14_2	52	56	PF04695	0.275
LIG_SH2_CRK	127	131	PF00017	0.481
LIG_SH2_STAT5	11	14	PF00017	0.316
LIG_SH2_STAT5	125	128	PF00017	0.337
LIG_SH2_STAT5	31	34	PF00017	0.216
LIG_SH2_STAT5	76	79	PF00017	0.275
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.254
LIG_SUMO_SIM_par_1	56	61	PF11976	0.275
LIG_UBA3_1	55	62	PF00899	0.275
LIG_WRC_WIRS_1	49	54	PF05994	0.275
MOD_CK1_1	33	39	PF00069	0.327
MOD_GlcNHglycan	17	20	PF01048	0.275
MOD_GSK3_1	102	109	PF00069	0.244
MOD_GSK3_1	141	148	PF00069	0.646
MOD_GSK3_1	30	37	PF00069	0.244
MOD_GSK3_1	5	12	PF00069	0.461
MOD_GSK3_1	60	67	PF00069	0.566
MOD_LATS_1	28	34	PF00433	0.279
MOD_N-GLC_1	141	146	PF02516	0.339
MOD_N-GLC_1	33	38	PF02516	0.501
MOD_N-GLC_1	9	14	PF02516	0.324
MOD_NEK2_1	60	65	PF00069	0.479
MOD_NEK2_1	75	80	PF00069	0.426
MOD_NEK2_1	83	88	PF00069	0.420
MOD_NEK2_1	9	14	PF00069	0.275
MOD_NEK2_2	48	53	PF00069	0.324
MOD_PIKK_1	34	40	PF00454	0.244
MOD_PK_1	135	141	PF00069	0.508
MOD_PKA_2	134	140	PF00069	0.587
MOD_PKA_2	5	11	PF00069	0.483
MOD_Plk_1	141	147	PF00069	0.541
MOD_Plk_1	60	66	PF00069	0.419
MOD_Plk_1	9	15	PF00069	0.376
MOD_Plk_4	48	54	PF00069	0.275
MOD_Plk_4	9	15	PF00069	0.322
MOD_Plk_4	94	100	PF00069	0.324
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.279
TRG_ENDOCYTIC_2	11	14	PF00928	0.316
TRG_ENDOCYTIC_2	127	130	PF00928	0.481
TRG_ENDOCYTIC_2	72	75	PF00928	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV5	Leptomonas seymouri	72%	97%
E9AQ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%