LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H848_LEIBR
TriTrypDb:
LbrM.15.0790 , LBRM2903_150015900 *
Length:
674

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H848
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H848

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0004713 protein tyrosine kinase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 495 499 PF00656 0.560
CLV_MEL_PAP_1 422 428 PF00089 0.543
CLV_NRD_NRD_1 14 16 PF00675 0.695
CLV_NRD_NRD_1 151 153 PF00675 0.328
CLV_NRD_NRD_1 387 389 PF00675 0.526
CLV_NRD_NRD_1 455 457 PF00675 0.521
CLV_NRD_NRD_1 8 10 PF00675 0.678
CLV_PCSK_KEX2_1 151 153 PF00082 0.328
CLV_PCSK_KEX2_1 206 208 PF00082 0.354
CLV_PCSK_KEX2_1 261 263 PF00082 0.335
CLV_PCSK_KEX2_1 387 389 PF00082 0.526
CLV_PCSK_KEX2_1 94 96 PF00082 0.335
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.227
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.335
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.335
CLV_PCSK_SKI1_1 504 508 PF00082 0.751
CLV_PCSK_SKI1_1 95 99 PF00082 0.335
DEG_APCC_DBOX_1 387 395 PF00400 0.522
DEG_APCC_KENBOX_2 293 297 PF00400 0.480
DEG_Nend_UBRbox_3 1 3 PF02207 0.742
DEG_SPOP_SBC_1 417 421 PF00917 0.649
DOC_CKS1_1 531 536 PF01111 0.581
DOC_CYCLIN_yCln2_LP_2 282 288 PF00134 0.427
DOC_CYCLIN_yCln2_LP_2 53 59 PF00134 0.410
DOC_MAPK_gen_1 194 203 PF00069 0.426
DOC_MAPK_MEF2A_6 131 140 PF00069 0.355
DOC_MAPK_MEF2A_6 283 292 PF00069 0.227
DOC_PP2B_LxvP_1 282 285 PF13499 0.324
DOC_PP2B_LxvP_1 53 56 PF13499 0.414
DOC_PP4_FxxP_1 249 252 PF00568 0.378
DOC_PP4_FxxP_1 511 514 PF00568 0.707
DOC_PP4_FxxP_1 548 551 PF00568 0.597
DOC_PP4_FxxP_1 640 643 PF00568 0.755
DOC_USP7_MATH_1 176 180 PF00917 0.355
DOC_USP7_MATH_1 252 256 PF00917 0.227
DOC_USP7_MATH_1 379 383 PF00917 0.781
DOC_USP7_MATH_1 481 485 PF00917 0.673
DOC_USP7_MATH_1 525 529 PF00917 0.624
DOC_USP7_MATH_1 69 73 PF00917 0.323
DOC_USP7_UBL2_3 457 461 PF12436 0.443
DOC_WW_Pin1_4 243 248 PF00397 0.289
DOC_WW_Pin1_4 382 387 PF00397 0.671
DOC_WW_Pin1_4 512 517 PF00397 0.698
DOC_WW_Pin1_4 518 523 PF00397 0.718
DOC_WW_Pin1_4 530 535 PF00397 0.706
DOC_WW_Pin1_4 555 560 PF00397 0.536
DOC_WW_Pin1_4 641 646 PF00397 0.547
DOC_WW_Pin1_4 660 665 PF00397 0.543
LIG_14-3-3_CanoR_1 115 121 PF00244 0.330
LIG_14-3-3_CanoR_1 164 170 PF00244 0.389
LIG_14-3-3_CanoR_1 18 26 PF00244 0.491
LIG_14-3-3_CanoR_1 380 386 PF00244 0.531
LIG_14-3-3_CanoR_1 477 481 PF00244 0.545
LIG_AP2alpha_1 507 511 PF02296 0.648
LIG_AP2alpha_1 669 673 PF02296 0.662
LIG_AP2alpha_2 256 258 PF02296 0.447
LIG_AP2alpha_2 667 669 PF02296 0.606
LIG_APCC_ABBAyCdc20_2 503 509 PF00400 0.593
LIG_BIR_III_2 488 492 PF00653 0.544
LIG_BRCT_BRCA1_1 245 249 PF00533 0.349
LIG_BRCT_BRCA1_1 288 292 PF00533 0.295
LIG_BRCT_BRCA1_1 636 640 PF00533 0.685
LIG_BRCT_BRCA1_2 288 294 PF00533 0.392
LIG_deltaCOP1_diTrp_1 326 332 PF00928 0.298
LIG_deltaCOP1_diTrp_1 357 362 PF00928 0.570
LIG_FHA_1 176 182 PF00498 0.351
LIG_FHA_1 308 314 PF00498 0.464
LIG_FHA_1 32 38 PF00498 0.380
LIG_FHA_1 333 339 PF00498 0.322
LIG_FHA_1 519 525 PF00498 0.652
LIG_FHA_1 542 548 PF00498 0.583
LIG_FHA_2 164 170 PF00498 0.447
LIG_FHA_2 228 234 PF00498 0.447
LIG_FHA_2 352 358 PF00498 0.586
LIG_IBAR_NPY_1 564 566 PF08397 0.536
LIG_LIR_Apic_2 246 252 PF02991 0.237
LIG_LIR_Apic_2 382 386 PF02991 0.778
LIG_LIR_Apic_2 411 417 PF02991 0.527
LIG_LIR_Apic_2 508 514 PF02991 0.709
LIG_LIR_Apic_2 546 551 PF02991 0.603
LIG_LIR_Apic_2 637 643 PF02991 0.756
LIG_LIR_Gen_1 326 337 PF02991 0.397
LIG_LIR_Gen_1 400 409 PF02991 0.507
LIG_LIR_Gen_1 505 514 PF02991 0.701
LIG_LIR_Gen_1 667 673 PF02991 0.615
LIG_LIR_Gen_1 72 78 PF02991 0.340
LIG_LIR_Nem_3 326 332 PF02991 0.404
LIG_LIR_Nem_3 335 340 PF02991 0.397
LIG_LIR_Nem_3 400 405 PF02991 0.627
LIG_LIR_Nem_3 505 510 PF02991 0.705
LIG_LIR_Nem_3 667 672 PF02991 0.613
LIG_LIR_Nem_3 72 77 PF02991 0.356
LIG_LIR_Nem_3 96 100 PF02991 0.355
LIG_LRP6_Inhibitor_1 333 339 PF00058 0.287
LIG_MAD2 368 376 PF02301 0.641
LIG_MYND_1 516 520 PF01753 0.540
LIG_NRBOX 316 322 PF00104 0.281
LIG_Pex14_1 297 301 PF04695 0.545
LIG_Pex14_2 507 511 PF04695 0.648
LIG_Pex14_2 669 673 PF04695 0.619
LIG_PTAP_UEV_1 526 531 PF05743 0.771
LIG_SH2_CRK 150 154 PF00017 0.378
LIG_SH2_CRK 383 387 PF00017 0.529
LIG_SH2_CRK 414 418 PF00017 0.529
LIG_SH2_CRK 614 618 PF00017 0.790
LIG_SH2_NCK_1 414 418 PF00017 0.529
LIG_SH2_NCK_1 614 618 PF00017 0.754
LIG_SH2_PTP2 74 77 PF00017 0.355
LIG_SH2_SRC 414 417 PF00017 0.531
LIG_SH2_SRC 614 617 PF00017 0.786
LIG_SH2_STAT3 455 458 PF00017 0.651
LIG_SH2_STAT3 593 596 PF00017 0.794
LIG_SH2_STAT3 626 629 PF00017 0.681
LIG_SH2_STAT5 144 147 PF00017 0.335
LIG_SH2_STAT5 183 186 PF00017 0.334
LIG_SH2_STAT5 281 284 PF00017 0.349
LIG_SH2_STAT5 309 312 PF00017 0.388
LIG_SH2_STAT5 337 340 PF00017 0.414
LIG_SH2_STAT5 404 407 PF00017 0.508
LIG_SH2_STAT5 74 77 PF00017 0.355
LIG_SH3_2 661 666 PF14604 0.603
LIG_SH3_3 282 288 PF00018 0.447
LIG_SH3_3 373 379 PF00018 0.630
LIG_SH3_3 514 520 PF00018 0.660
LIG_SH3_3 524 530 PF00018 0.760
LIG_SH3_3 531 537 PF00018 0.683
LIG_SH3_3 583 589 PF00018 0.630
LIG_SH3_3 610 616 PF00018 0.703
LIG_SH3_3 658 664 PF00018 0.631
LIG_SH3_3 82 88 PF00018 0.408
LIG_SUMO_SIM_anti_2 109 114 PF11976 0.369
LIG_SUMO_SIM_anti_2 34 41 PF11976 0.438
LIG_SUMO_SIM_par_1 436 444 PF11976 0.499
LIG_TRAF2_1 230 233 PF00917 0.447
LIG_TRAF2_1 433 436 PF00917 0.719
LIG_TRAF2_1 617 620 PF00917 0.550
LIG_WRC_WIRS_1 348 353 PF05994 0.504
LIG_WW_1 54 57 PF00397 0.613
MOD_CDC14_SPxK_1 385 388 PF00782 0.525
MOD_CDC14_SPxK_1 663 666 PF00782 0.538
MOD_CDK_SPK_2 382 387 PF00069 0.649
MOD_CDK_SPK_2 660 665 PF00069 0.543
MOD_CDK_SPxK_1 382 388 PF00069 0.525
MOD_CDK_SPxK_1 660 666 PF00069 0.542
MOD_CDK_SPxxK_3 243 250 PF00069 0.289
MOD_CDK_SPxxK_3 641 648 PF00069 0.546
MOD_CK1_1 114 120 PF00069 0.405
MOD_CK1_1 127 133 PF00069 0.365
MOD_CK1_1 156 162 PF00069 0.441
MOD_CK1_1 219 225 PF00069 0.271
MOD_CK1_1 382 388 PF00069 0.709
MOD_CK1_1 557 563 PF00069 0.659
MOD_CK1_1 579 585 PF00069 0.587
MOD_CK2_1 127 133 PF00069 0.390
MOD_CK2_1 163 169 PF00069 0.447
MOD_CK2_1 227 233 PF00069 0.463
MOD_CK2_1 351 357 PF00069 0.563
MOD_GlcNHglycan 178 181 PF01048 0.378
MOD_GlcNHglycan 426 429 PF01048 0.657
MOD_GlcNHglycan 527 530 PF01048 0.786
MOD_GlcNHglycan 548 551 PF01048 0.667
MOD_GlcNHglycan 578 581 PF01048 0.684
MOD_GlcNHglycan 582 585 PF01048 0.674
MOD_GlcNHglycan 589 592 PF01048 0.686
MOD_GSK3_1 152 159 PF00069 0.441
MOD_GSK3_1 216 223 PF00069 0.363
MOD_GSK3_1 248 255 PF00069 0.227
MOD_GSK3_1 264 271 PF00069 0.324
MOD_GSK3_1 286 293 PF00069 0.263
MOD_GSK3_1 305 312 PF00069 0.532
MOD_GSK3_1 347 354 PF00069 0.526
MOD_GSK3_1 576 583 PF00069 0.537
MOD_GSK3_1 656 663 PF00069 0.752
MOD_N-GLC_1 216 221 PF02516 0.423
MOD_N-GLC_1 498 503 PF02516 0.549
MOD_N-GLC_1 79 84 PF02516 0.334
MOD_NEK2_1 136 141 PF00069 0.335
MOD_NEK2_1 332 337 PF00069 0.387
MOD_NEK2_1 351 356 PF00069 0.564
MOD_NEK2_1 4 9 PF00069 0.673
MOD_NEK2_1 656 661 PF00069 0.777
MOD_NEK2_1 93 98 PF00069 0.378
MOD_NEK2_2 309 314 PF00069 0.364
MOD_NEK2_2 418 423 PF00069 0.679
MOD_PIKK_1 183 189 PF00454 0.324
MOD_PIKK_1 481 487 PF00454 0.618
MOD_PKA_2 114 120 PF00069 0.330
MOD_PKA_2 153 159 PF00069 0.451
MOD_PKA_2 163 169 PF00069 0.359
MOD_PKA_2 379 385 PF00069 0.680
MOD_PKA_2 424 430 PF00069 0.726
MOD_PKA_2 476 482 PF00069 0.637
MOD_PKA_2 62 68 PF00069 0.486
MOD_PKB_1 152 160 PF00069 0.289
MOD_Plk_1 79 85 PF00069 0.454
MOD_Plk_4 33 39 PF00069 0.452
MOD_Plk_4 557 563 PF00069 0.737
MOD_Plk_4 70 76 PF00069 0.355
MOD_ProDKin_1 243 249 PF00069 0.289
MOD_ProDKin_1 382 388 PF00069 0.670
MOD_ProDKin_1 512 518 PF00069 0.700
MOD_ProDKin_1 523 529 PF00069 0.787
MOD_ProDKin_1 530 536 PF00069 0.693
MOD_ProDKin_1 555 561 PF00069 0.539
MOD_ProDKin_1 641 647 PF00069 0.546
MOD_ProDKin_1 660 666 PF00069 0.542
MOD_SUMO_for_1 470 473 PF00179 0.457
MOD_SUMO_rev_2 498 506 PF00179 0.770
TRG_ENDOCYTIC_2 150 153 PF00928 0.355
TRG_ENDOCYTIC_2 277 280 PF00928 0.323
TRG_ENDOCYTIC_2 281 284 PF00928 0.324
TRG_ENDOCYTIC_2 337 340 PF00928 0.539
TRG_ENDOCYTIC_2 74 77 PF00928 0.376
TRG_ER_diArg_1 150 152 PF00400 0.329
TRG_ER_diArg_1 386 388 PF00400 0.525
TRG_ER_diArg_1 422 425 PF00400 0.688
TRG_NLS_MonoExtC_3 259 265 PF00514 0.447
TRG_NLS_MonoExtN_4 257 264 PF00514 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7R8 Leptomonas seymouri 60% 96%
A0A1X0NUC1 Trypanosomatidae 46% 89%
A0A3S7WTG9 Leishmania donovani 67% 100%
A0A422NRC0 Trypanosoma rangeli 40% 99%
A4HWH3 Leishmania infantum 67% 100%
C9ZXX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AQ75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
Q4QFA8 Leishmania major 65% 96%
V5BK24 Trypanosoma cruzi 42% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS