Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H846_LEIBR

TriTrypDb:

LbrM.15.0770 , LBRM2903_150015700

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H846

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H846

PDB structure(s): 7ane_ae

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.517
CLV_C14_Caspase3-7	420	424	PF00656	0.473
CLV_NRD_NRD_1	169	171	PF00675	0.380
CLV_NRD_NRD_1	181	183	PF00675	0.277
CLV_NRD_NRD_1	222	224	PF00675	0.481
CLV_NRD_NRD_1	296	298	PF00675	0.305
CLV_NRD_NRD_1	454	456	PF00675	0.506
CLV_NRD_NRD_1	494	496	PF00675	0.408
CLV_PCSK_FUR_1	452	456	PF00082	0.506
CLV_PCSK_KEX2_1	169	171	PF00082	0.380
CLV_PCSK_KEX2_1	181	183	PF00082	0.277
CLV_PCSK_KEX2_1	203	205	PF00082	0.432
CLV_PCSK_KEX2_1	222	224	PF00082	0.374
CLV_PCSK_KEX2_1	296	298	PF00082	0.305
CLV_PCSK_KEX2_1	454	456	PF00082	0.540
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.384
CLV_PCSK_SKI1_1	222	226	PF00082	0.398
CLV_PCSK_SKI1_1	234	238	PF00082	0.356
CLV_PCSK_SKI1_1	436	440	PF00082	0.579
DEG_SPOP_SBC_1	577	581	PF00917	0.451
DOC_CKS1_1	102	107	PF01111	0.393
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.407
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.404
DOC_MAPK_DCC_7	100	108	PF00069	0.402
DOC_MAPK_DCC_7	188	196	PF00069	0.565
DOC_MAPK_DCC_7	222	232	PF00069	0.364
DOC_MAPK_gen_1	185	194	PF00069	0.585
DOC_MAPK_gen_1	279	286	PF00069	0.367
DOC_MAPK_gen_1	296	303	PF00069	0.474
DOC_MAPK_gen_1	312	320	PF00069	0.351
DOC_MAPK_MEF2A_6	188	196	PF00069	0.582
DOC_MAPK_MEF2A_6	223	232	PF00069	0.349
DOC_MAPK_MEF2A_6	90	97	PF00069	0.428
DOC_PP1_RVXF_1	283	289	PF00149	0.341
DOC_PP1_RVXF_1	505	511	PF00149	0.394
DOC_USP7_MATH_1	576	580	PF00917	0.587
DOC_USP7_MATH_1	592	596	PF00917	0.686
DOC_USP7_MATH_1	618	622	PF00917	0.651
DOC_WW_Pin1_4	101	106	PF00397	0.390
DOC_WW_Pin1_4	588	593	PF00397	0.524
DOC_WW_Pin1_4	629	634	PF00397	0.789
LIG_14-3-3_CanoR_1	116	122	PF00244	0.383
LIG_14-3-3_CanoR_1	222	228	PF00244	0.369
LIG_14-3-3_CanoR_1	234	242	PF00244	0.336
LIG_14-3-3_CanoR_1	314	319	PF00244	0.453
LIG_14-3-3_CanoR_1	452	461	PF00244	0.458
LIG_14-3-3_CanoR_1	596	604	PF00244	0.480
LIG_Actin_WH2_2	199	217	PF00022	0.370
LIG_Actin_WH2_2	346	364	PF00022	0.488
LIG_APCC_ABBA_1	250	255	PF00400	0.340
LIG_BIR_II_1	1	5	PF00653	0.467
LIG_BIR_III_4	410	414	PF00653	0.649
LIG_BRCT_BRCA1_1	257	261	PF00533	0.450
LIG_CaM_NSCaTE_8	475	482	PF13499	0.472
LIG_CSL_BTD_1	509	512	PF09270	0.487
LIG_FHA_1	116	122	PF00498	0.473
LIG_FHA_1	364	370	PF00498	0.496
LIG_FHA_1	534	540	PF00498	0.470
LIG_FHA_1	563	569	PF00498	0.497
LIG_FHA_1	598	604	PF00498	0.596
LIG_FHA_1	632	638	PF00498	0.782
LIG_FHA_1	70	76	PF00498	0.486
LIG_FHA_1	77	83	PF00498	0.482
LIG_FHA_2	142	148	PF00498	0.459
LIG_FHA_2	418	424	PF00498	0.523
LIG_FHA_2	72	78	PF00498	0.613
LIG_Integrin_isoDGR_2	645	647	PF01839	0.532
LIG_LIR_Nem_3	124	128	PF02991	0.489
LIG_LIR_Nem_3	219	224	PF02991	0.411
LIG_LIR_Nem_3	231	236	PF02991	0.336
LIG_NRBOX	319	325	PF00104	0.324
LIG_SH2_CRK	221	225	PF00017	0.393
LIG_SH2_CRK	233	237	PF00017	0.326
LIG_SH2_CRK	336	340	PF00017	0.364
LIG_SH2_CRK	531	535	PF00017	0.540
LIG_SH2_GRB2like	298	301	PF00017	0.380
LIG_SH2_SRC	298	301	PF00017	0.380
LIG_SH2_STAP1	298	302	PF00017	0.388
LIG_SH2_STAP1	336	340	PF00017	0.389
LIG_SH2_STAP1	395	399	PF00017	0.496
LIG_SH2_STAT3	554	557	PF00017	0.596
LIG_SH2_STAT5	128	131	PF00017	0.502
LIG_SH2_STAT5	179	182	PF00017	0.411
LIG_SH2_STAT5	24	27	PF00017	0.430
LIG_SH2_STAT5	262	265	PF00017	0.329
LIG_SH2_STAT5	322	325	PF00017	0.348
LIG_SH2_STAT5	338	341	PF00017	0.374
LIG_SH2_STAT5	398	401	PF00017	0.516
LIG_SH2_STAT5	468	471	PF00017	0.361
LIG_SH2_STAT5	493	496	PF00017	0.546
LIG_SH2_STAT5	554	557	PF00017	0.548
LIG_SH3_2	31	36	PF14604	0.454
LIG_SH3_3	142	148	PF00018	0.452
LIG_SH3_3	28	34	PF00018	0.446
LIG_SH3_3	583	589	PF00018	0.653
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.406
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.334
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.487
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.492
LIG_SUMO_SIM_par_1	192	198	PF11976	0.533
LIG_TRAF2_1	217	220	PF00917	0.364
LIG_TRAF2_1	328	331	PF00917	0.476
LIG_TRAF2_1	485	488	PF00917	0.505
LIG_TYR_ITIM	334	339	PF00017	0.299
MOD_CK1_1	17	23	PF00069	0.536
MOD_CK1_1	497	503	PF00069	0.487
MOD_CK1_1	580	586	PF00069	0.726
MOD_CK1_1	609	615	PF00069	0.643
MOD_CK1_1	621	627	PF00069	0.618
MOD_CK1_1	65	71	PF00069	0.501
MOD_CK1_1	96	102	PF00069	0.502
MOD_CK2_1	192	198	PF00069	0.533
MOD_Cter_Amidation	294	297	PF01082	0.284
MOD_GlcNHglycan	480	483	PF01048	0.494
MOD_GlcNHglycan	531	534	PF01048	0.341
MOD_GlcNHglycan	580	583	PF01048	0.677
MOD_GlcNHglycan	608	611	PF01048	0.558
MOD_GlcNHglycan	613	616	PF01048	0.629
MOD_GlcNHglycan	620	623	PF01048	0.705
MOD_GlcNHglycan	637	640	PF01048	0.583
MOD_GlcNHglycan	64	67	PF01048	0.471
MOD_GSK3_1	10	17	PF00069	0.493
MOD_GSK3_1	419	426	PF00069	0.553
MOD_GSK3_1	529	536	PF00069	0.449
MOD_GSK3_1	576	583	PF00069	0.512
MOD_GSK3_1	588	595	PF00069	0.481
MOD_GSK3_1	604	611	PF00069	0.669
MOD_GSK3_1	62	69	PF00069	0.456
MOD_GSK3_1	623	630	PF00069	0.668
MOD_GSK3_1	631	638	PF00069	0.678
MOD_N-GLC_1	141	146	PF02516	0.469
MOD_NEK2_1	180	185	PF00069	0.444
MOD_NEK2_1	377	382	PF00069	0.438
MOD_NEK2_1	453	458	PF00069	0.611
MOD_NEK2_1	478	483	PF00069	0.495
MOD_NEK2_1	494	499	PF00069	0.406
MOD_NEK2_1	50	55	PF00069	0.478
MOD_NEK2_1	529	534	PF00069	0.431
MOD_NEK2_1	598	603	PF00069	0.610
MOD_NEK2_1	608	613	PF00069	0.625
MOD_NEK2_2	623	628	PF00069	0.504
MOD_PK_1	223	229	PF00069	0.429
MOD_PK_1	463	469	PF00069	0.299
MOD_PKA_1	181	187	PF00069	0.548
MOD_PKA_1	222	228	PF00069	0.358
MOD_PKA_1	454	460	PF00069	0.529
MOD_PKA_2	10	16	PF00069	0.556
MOD_PKA_2	115	121	PF00069	0.378
MOD_PKA_2	180	186	PF00069	0.440
MOD_PKA_2	222	228	PF00069	0.402
MOD_PKA_2	453	459	PF00069	0.561
MOD_PKA_2	494	500	PF00069	0.423
MOD_PKA_2	639	645	PF00069	0.719
MOD_PKB_1	312	320	PF00069	0.452
MOD_PKB_1	452	460	PF00069	0.521
MOD_Plk_1	141	147	PF00069	0.461
MOD_Plk_1	463	469	PF00069	0.299
MOD_Plk_1	539	545	PF00069	0.469
MOD_Plk_1	546	552	PF00069	0.518
MOD_Plk_1	76	82	PF00069	0.461
MOD_Plk_1	93	99	PF00069	0.401
MOD_Plk_2-3	141	147	PF00069	0.461
MOD_Plk_4	104	110	PF00069	0.448
MOD_Plk_4	14	20	PF00069	0.454
MOD_Plk_4	489	495	PF00069	0.465
MOD_Plk_4	598	604	PF00069	0.631
MOD_ProDKin_1	101	107	PF00069	0.395
MOD_ProDKin_1	588	594	PF00069	0.524
MOD_ProDKin_1	629	635	PF00069	0.791
MOD_SUMO_for_1	84	87	PF00179	0.429
MOD_SUMO_rev_2	337	345	PF00179	0.473
TRG_DiLeu_BaEn_2	86	92	PF01217	0.538
TRG_ENDOCYTIC_2	165	168	PF00928	0.366
TRG_ENDOCYTIC_2	221	224	PF00928	0.391
TRG_ENDOCYTIC_2	233	236	PF00928	0.328
TRG_ENDOCYTIC_2	290	293	PF00928	0.410
TRG_ENDOCYTIC_2	298	301	PF00928	0.380
TRG_ENDOCYTIC_2	336	339	PF00928	0.336
TRG_ER_diArg_1	161	164	PF00400	0.371
TRG_ER_diArg_1	168	170	PF00400	0.385
TRG_ER_diArg_1	180	182	PF00400	0.260
TRG_ER_diArg_1	221	223	PF00400	0.425
TRG_ER_diArg_1	26	29	PF00400	0.432
TRG_ER_diArg_1	283	286	PF00400	0.350
TRG_ER_diArg_1	296	298	PF00400	0.305
TRG_ER_diArg_1	453	455	PF00400	0.510
TRG_NLS_MonoExtC_3	494	499	PF00514	0.406
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.489
TRG_PTS1	652	655	PF00515	0.704

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I655	Leptomonas seymouri	77%	99%
A0A0S4JKP6	Bodo saltans	54%	100%
A0A1X0NU53	Trypanosomatidae	64%	95%
A0A3R7NKZ5	Trypanosoma rangeli	61%	96%
A0A3S7WTG4	Leishmania donovani	90%	100%
A4HWH4	Leishmania infantum	90%	100%
C9ZXX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
E9AQ76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QFA7	Leishmania major	90%	100%