Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal membrane protein (Pex16), putative

Species:

Leishmania braziliensis

UniProt:

A4H843_LEIBR

TriTrypDb:

LbrM.15.0740 , LBRM2903_150015400

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0031903	microbody membrane	5	10
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0098588	bounding membrane of organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1

Expansion

Sequence features

A4H843

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H843

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0007031	peroxisome organization	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.250
CLV_NRD_NRD_1	130	132	PF00675	0.269
CLV_NRD_NRD_1	169	171	PF00675	0.368
CLV_NRD_NRD_1	182	184	PF00675	0.440
CLV_NRD_NRD_1	20	22	PF00675	0.526
CLV_NRD_NRD_1	255	257	PF00675	0.452
CLV_NRD_NRD_1	419	421	PF00675	0.286
CLV_NRD_NRD_1	97	99	PF00675	0.266
CLV_PCSK_KEX2_1	130	132	PF00082	0.287
CLV_PCSK_KEX2_1	169	171	PF00082	0.370
CLV_PCSK_KEX2_1	181	183	PF00082	0.445
CLV_PCSK_KEX2_1	20	22	PF00082	0.526
CLV_PCSK_KEX2_1	255	257	PF00082	0.452
CLV_PCSK_KEX2_1	419	421	PF00082	0.286
CLV_PCSK_KEX2_1	97	99	PF00082	0.290
CLV_PCSK_SKI1_1	152	156	PF00082	0.378
CLV_PCSK_SKI1_1	169	173	PF00082	0.319
CLV_PCSK_SKI1_1	3	7	PF00082	0.449
CLV_PCSK_SKI1_1	315	319	PF00082	0.503
CLV_PCSK_SKI1_1	324	328	PF00082	0.452
CLV_PCSK_SKI1_1	494	498	PF00082	0.384
CLV_PCSK_SKI1_1	59	63	PF00082	0.330
DEG_APCC_DBOX_1	168	176	PF00400	0.592
DEG_SCF_FBW7_1	386	393	PF00400	0.280
DOC_CDC14_PxL_1	154	162	PF14671	0.634
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.369
DOC_MAPK_DCC_7	419	428	PF00069	0.599
DOC_MAPK_gen_1	130	138	PF00069	0.590
DOC_MAPK_gen_1	416	425	PF00069	0.552
DOC_MAPK_gen_1	97	107	PF00069	0.585
DOC_MAPK_HePTP_8	481	493	PF00069	0.469
DOC_MAPK_MEF2A_6	315	322	PF00069	0.333
DOC_MAPK_MEF2A_6	419	428	PF00069	0.599
DOC_MAPK_MEF2A_6	484	493	PF00069	0.454
DOC_MAPK_RevD_3	155	170	PF00069	0.632
DOC_PP2B_LxvP_1	246	249	PF13499	0.602
DOC_PP2B_LxvP_1	328	331	PF13499	0.412
DOC_PP2B_LxvP_1	341	344	PF13499	0.463
DOC_PP4_FxxP_1	12	15	PF00568	0.591
DOC_PP4_FxxP_1	155	158	PF00568	0.566
DOC_USP7_MATH_1	476	480	PF00917	0.666
DOC_USP7_UBL2_3	143	147	PF12436	0.530
DOC_WW_Pin1_4	11	16	PF00397	0.737
DOC_WW_Pin1_4	176	181	PF00397	0.671
DOC_WW_Pin1_4	365	370	PF00397	0.524
DOC_WW_Pin1_4	386	391	PF00397	0.354
DOC_WW_Pin1_4	436	441	PF00397	0.644
LIG_14-3-3_CanoR_1	130	134	PF00244	0.495
LIG_14-3-3_CanoR_1	173	179	PF00244	0.627
LIG_14-3-3_CanoR_1	228	238	PF00244	0.577
LIG_14-3-3_CanoR_1	297	301	PF00244	0.465
LIG_14-3-3_CanoR_1	59	64	PF00244	0.471
LIG_14-3-3_CanoR_1	97	105	PF00244	0.507
LIG_AP2alpha_2	503	505	PF02296	0.502
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BRCT_BRCA1_1	294	298	PF00533	0.527
LIG_Clathr_ClatBox_1	136	140	PF01394	0.530
LIG_FHA_1	100	106	PF00498	0.477
LIG_FHA_1	462	468	PF00498	0.709
LIG_FHA_1	505	511	PF00498	0.619
LIG_FHA_1	536	542	PF00498	0.360
LIG_FHA_1	67	73	PF00498	0.492
LIG_FHA_2	221	227	PF00498	0.688
LIG_FHA_2	297	303	PF00498	0.447
LIG_FHA_2	463	469	PF00498	0.593
LIG_LIR_Apic_2	62	68	PF02991	0.502
LIG_LIR_Apic_2	9	15	PF02991	0.592
LIG_LIR_Gen_1	132	139	PF02991	0.495
LIG_LIR_Gen_1	295	306	PF02991	0.486
LIG_LIR_Gen_1	309	319	PF02991	0.271
LIG_LIR_Gen_1	503	514	PF02991	0.549
LIG_LIR_Gen_1	538	548	PF02991	0.408
LIG_LIR_Gen_1	87	94	PF02991	0.526
LIG_LIR_Nem_3	132	136	PF02991	0.469
LIG_LIR_Nem_3	295	301	PF02991	0.602
LIG_LIR_Nem_3	309	314	PF02991	0.291
LIG_LIR_Nem_3	503	509	PF02991	0.527
LIG_LIR_Nem_3	542	548	PF02991	0.386
LIG_LIR_Nem_3	87	92	PF02991	0.526
LIG_LRP6_Inhibitor_1	514	520	PF00058	0.252
LIG_NRBOX	409	415	PF00104	0.360
LIG_PCNA_PIPBox_1	490	499	PF02747	0.446
LIG_PCNA_yPIPBox_3	484	497	PF02747	0.507
LIG_Pex14_2	155	159	PF04695	0.563
LIG_Pex14_2	518	522	PF04695	0.608
LIG_PTB_Apo_2	492	499	PF02174	0.570
LIG_PTB_Phospho_1	492	498	PF10480	0.587
LIG_SH2_CRK	218	222	PF00017	0.693
LIG_SH2_CRK	546	550	PF00017	0.363
LIG_SH2_GRB2like	515	518	PF00017	0.507
LIG_SH2_STAP1	536	540	PF00017	0.383
LIG_SH2_STAP1	546	550	PF00017	0.301
LIG_SH2_STAT5	218	221	PF00017	0.677
LIG_SH2_STAT5	311	314	PF00017	0.393
LIG_SH2_STAT5	40	43	PF00017	0.511
LIG_SH2_STAT5	427	430	PF00017	0.677
LIG_SH2_STAT5	540	543	PF00017	0.360
LIG_SH2_STAT5	550	553	PF00017	0.335
LIG_SH3_3	235	241	PF00018	0.648
LIG_SH3_3	366	372	PF00018	0.538
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.298
LIG_SUMO_SIM_anti_2	448	455	PF11976	0.593
LIG_SUMO_SIM_par_1	135	140	PF11976	0.466
LIG_TRAF2_1	359	362	PF00917	0.359
LIG_TRAF2_2	372	377	PF00917	0.359
LIG_TRFH_1	327	331	PF08558	0.310
LIG_UBA3_1	118	125	PF00899	0.348
LIG_UBA3_1	136	143	PF00899	0.239
LIG_UBA3_1	33	42	PF00899	0.448
LIG_WRC_WIRS_1	104	109	PF05994	0.279
LIG_WRC_WIRS_1	545	550	PF05994	0.480
MOD_CDK_SPK_2	176	181	PF00069	0.598
MOD_CDK_SPxK_1	176	182	PF00069	0.603
MOD_CDK_SPxK_1	365	371	PF00069	0.621
MOD_CDK_SPxxK_3	13	20	PF00069	0.475
MOD_CDK_SPxxK_3	176	183	PF00069	0.609
MOD_CK1_1	13	19	PF00069	0.684
MOD_CK1_1	192	198	PF00069	0.716
MOD_CK1_1	207	213	PF00069	0.465
MOD_CK1_1	50	56	PF00069	0.442
MOD_CK1_1	66	72	PF00069	0.384
MOD_CK2_1	49	55	PF00069	0.360
MOD_CK2_1	97	103	PF00069	0.371
MOD_CMANNOS	398	401	PF00535	0.308
MOD_Cter_Amidation	95	98	PF01082	0.308
MOD_GlcNHglycan	192	195	PF01048	0.656
MOD_GlcNHglycan	197	200	PF01048	0.673
MOD_GlcNHglycan	206	209	PF01048	0.538
MOD_GlcNHglycan	386	389	PF01048	0.511
MOD_GlcNHglycan	430	433	PF01048	0.609
MOD_GlcNHglycan	49	52	PF01048	0.358
MOD_GlcNHglycan	92	95	PF01048	0.401
MOD_GSK3_1	160	167	PF00069	0.535
MOD_GSK3_1	195	202	PF00069	0.650
MOD_GSK3_1	292	299	PF00069	0.569
MOD_GSK3_1	386	393	PF00069	0.515
MOD_GSK3_1	4	11	PF00069	0.687
MOD_GSK3_1	455	462	PF00069	0.666
MOD_GSK3_1	476	483	PF00069	0.436
MOD_GSK3_1	531	538	PF00069	0.425
MOD_GSK3_1	544	551	PF00069	0.308
MOD_GSK3_1	55	62	PF00069	0.344
MOD_GSK3_1	66	73	PF00069	0.326
MOD_GSK3_1	99	106	PF00069	0.429
MOD_N-GLC_1	459	464	PF02516	0.519
MOD_N-GLC_2	217	219	PF02516	0.479
MOD_NEK2_1	160	165	PF00069	0.522
MOD_NEK2_1	477	482	PF00069	0.487
MOD_NEK2_1	5	10	PF00069	0.621
MOD_NEK2_1	528	533	PF00069	0.335
MOD_NEK2_1	535	540	PF00069	0.326
MOD_NEK2_1	548	553	PF00069	0.231
MOD_NEK2_1	57	62	PF00069	0.393
MOD_PIKK_1	220	226	PF00454	0.728
MOD_PIKK_1	370	376	PF00454	0.459
MOD_PKA_1	97	103	PF00069	0.400
MOD_PKA_2	129	135	PF00069	0.400
MOD_PKA_2	296	302	PF00069	0.241
MOD_PKA_2	96	102	PF00069	0.360
MOD_Plk_1	458	464	PF00069	0.559
MOD_Plk_1	477	483	PF00069	0.476
MOD_Plk_1	484	490	PF00069	0.330
MOD_Plk_4	103	109	PF00069	0.355
MOD_Plk_4	160	166	PF00069	0.435
MOD_Plk_4	390	396	PF00069	0.424
MOD_Plk_4	448	454	PF00069	0.467
MOD_Plk_4	477	483	PF00069	0.606
MOD_Plk_4	544	550	PF00069	0.467
MOD_Plk_4	59	65	PF00069	0.400
MOD_ProDKin_1	11	17	PF00069	0.685
MOD_ProDKin_1	176	182	PF00069	0.603
MOD_ProDKin_1	365	371	PF00069	0.677
MOD_ProDKin_1	386	392	PF00069	0.434
MOD_ProDKin_1	436	442	PF00069	0.559
MOD_SUMO_rev_2	361	366	PF00179	0.643
TRG_DiLeu_BaEn_1	114	119	PF01217	0.296
TRG_DiLeu_BaEn_2	102	108	PF01217	0.203
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.371
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.400
TRG_ENDOCYTIC_2	311	314	PF00928	0.374
TRG_ENDOCYTIC_2	498	501	PF00928	0.435
TRG_ENDOCYTIC_2	515	518	PF00928	0.434
TRG_ENDOCYTIC_2	540	543	PF00928	0.355
TRG_ENDOCYTIC_2	545	548	PF00928	0.311
TRG_ER_diArg_1	168	170	PF00400	0.439
TRG_ER_diArg_1	180	183	PF00400	0.601
TRG_ER_diArg_1	19	21	PF00400	0.564
TRG_ER_diArg_1	418	420	PF00400	0.329
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R8	Leptomonas seymouri	57%	99%
A0A1X0NUI4	Trypanosomatidae	34%	100%
A0A3Q8ICA1	Leishmania donovani	82%	98%
A4HWH7	Leishmania infantum	82%	98%
C9ZXX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AQ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QFA4	Leishmania major	82%	100%
V5DL46	Trypanosoma cruzi	33%	100%