Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H838_LEIBR

TriTrypDb:

LbrM.15.0690 , LBRM2903_150012800

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H838

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H838

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.549
CLV_C14_Caspase3-7	95	99	PF00656	0.506
CLV_NRD_NRD_1	62	64	PF00675	0.448
CLV_NRD_NRD_1	68	70	PF00675	0.578
CLV_NRD_NRD_1	92	94	PF00675	0.465
CLV_PCSK_KEX2_1	92	94	PF00082	0.461
CLV_PCSK_SKI1_1	103	107	PF00082	0.621
CLV_PCSK_SKI1_1	181	185	PF00082	0.565
CLV_PCSK_SKI1_1	25	29	PF00082	0.545
DOC_MAPK_gen_1	128	136	PF00069	0.344
DOC_MAPK_MEF2A_6	128	136	PF00069	0.449
DOC_USP7_UBL2_3	180	184	PF12436	0.521
DOC_USP7_UBL2_3	21	25	PF12436	0.644
LIG_14-3-3_CanoR_1	103	111	PF00244	0.436
LIG_14-3-3_CanoR_1	63	69	PF00244	0.442
LIG_14-3-3_CanoR_1	92	100	PF00244	0.520
LIG_BRCT_BRCA1_1	178	182	PF00533	0.584
LIG_BRCT_BRCA1_2	178	184	PF00533	0.584
LIG_FHA_2	27	33	PF00498	0.576
LIG_FHA_2	47	53	PF00498	0.617
LIG_Integrin_RGD_1	161	163	PF01839	0.344
LIG_LIR_Gen_1	179	189	PF02991	0.547
LIG_LIR_Gen_1	6	15	PF02991	0.666
LIG_LIR_Nem_3	6	11	PF02991	0.672
LIG_LIR_Nem_3	77	83	PF02991	0.376
LIG_LIR_Nem_3	86	91	PF02991	0.372
LIG_LYPXL_yS_3	88	91	PF13949	0.391
LIG_REV1ctd_RIR_1	98	107	PF16727	0.492
LIG_SH2_STAT5	124	127	PF00017	0.328
LIG_SH2_STAT5	18	21	PF00017	0.653
LIG_SH2_STAT5	61	64	PF00017	0.420
LIG_SH2_STAT5	73	76	PF00017	0.466
LIG_SH2_STAT5	90	93	PF00017	0.305
LIG_TRAF2_1	50	53	PF00917	0.551
MOD_CK2_1	184	190	PF00069	0.526
MOD_CK2_1	46	52	PF00069	0.618
MOD_GSK3_1	27	34	PF00069	0.577
MOD_N-GLC_2	138	140	PF02516	0.328
MOD_NEK2_1	116	121	PF00069	0.417
MOD_PIKK_1	184	190	PF00454	0.494
MOD_PKA_1	63	69	PF00069	0.526
MOD_PKA_2	109	115	PF00069	0.316
MOD_PKA_2	91	97	PF00069	0.501
MOD_Plk_1	189	195	PF00069	0.533
MOD_Plk_4	116	122	PF00069	0.320
MOD_SUMO_rev_2	160	166	PF00179	0.344
MOD_SUMO_rev_2	190	197	PF00179	0.607
MOD_SUMO_rev_2	20	30	PF00179	0.445
TRG_ENDOCYTIC_2	80	83	PF00928	0.372
TRG_ENDOCYTIC_2	88	91	PF00928	0.370
TRG_ER_diArg_1	91	93	PF00400	0.467
TRG_ER_diLys_1	196	201	PF00400	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B2	Leptomonas seymouri	80%	100%
A0A0S4IW52	Bodo saltans	52%	100%
A0A1X0NTV3	Trypanosomatidae	65%	100%
A0A3R7NUR7	Trypanosoma rangeli	64%	100%
A0A3S7WTG2	Leishmania donovani	90%	100%
A4HWG5	Leishmania infantum	90%	100%
C9ZXY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	96%
E9AQ66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QFB7	Leishmania major	91%	100%
V5BPN5	Trypanosoma cruzi	62%	100%