PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H836_LEIBR

TriTrypDb:

LbrM.15.0670 , LBRM2903_150012600

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H836

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H836

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.770
CLV_C14_Caspase3-7	246	250	PF00656	0.668
CLV_C14_Caspase3-7	425	429	PF00656	0.573
CLV_NRD_NRD_1	308	310	PF00675	0.563
CLV_NRD_NRD_1	678	680	PF00675	0.581
CLV_NRD_NRD_1	845	847	PF00675	0.737
CLV_PCSK_KEX2_1	307	309	PF00082	0.554
CLV_PCSK_KEX2_1	338	340	PF00082	0.611
CLV_PCSK_KEX2_1	678	680	PF00082	0.581
CLV_PCSK_KEX2_1	844	846	PF00082	0.804
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.611
CLV_PCSK_SKI1_1	230	234	PF00082	0.699
CLV_PCSK_SKI1_1	297	301	PF00082	0.631
CLV_PCSK_SKI1_1	368	372	PF00082	0.758
CLV_PCSK_SKI1_1	392	396	PF00082	0.583
CLV_PCSK_SKI1_1	470	474	PF00082	0.644
CLV_PCSK_SKI1_1	587	591	PF00082	0.576
CLV_PCSK_SKI1_1	72	76	PF00082	0.650
CLV_PCSK_SKI1_1	912	916	PF00082	0.716
DEG_Nend_UBRbox_2	1	3	PF02207	0.793
DEG_SPOP_SBC_1	235	239	PF00917	0.555
DEG_SPOP_SBC_1	288	292	PF00917	0.826
DEG_SPOP_SBC_1	512	516	PF00917	0.555
DOC_CKS1_1	137	142	PF01111	0.604
DOC_CKS1_1	73	78	PF01111	0.608
DOC_CKS1_1	86	91	PF01111	0.638
DOC_MAPK_MEF2A_6	781	788	PF00069	0.583
DOC_PP4_FxxP_1	137	140	PF00568	0.640
DOC_PP4_FxxP_1	15	18	PF00568	0.570
DOC_PP4_FxxP_1	169	172	PF00568	0.589
DOC_PP4_FxxP_1	451	454	PF00568	0.559
DOC_USP7_MATH_1	11	15	PF00917	0.801
DOC_USP7_MATH_1	143	147	PF00917	0.647
DOC_USP7_MATH_1	235	239	PF00917	0.773
DOC_USP7_MATH_1	275	279	PF00917	0.760
DOC_USP7_MATH_1	286	290	PF00917	0.726
DOC_USP7_MATH_1	314	318	PF00917	0.675
DOC_USP7_MATH_1	343	347	PF00917	0.763
DOC_USP7_MATH_1	413	417	PF00917	0.653
DOC_USP7_MATH_1	426	430	PF00917	0.586
DOC_USP7_MATH_1	454	458	PF00917	0.820
DOC_USP7_MATH_1	512	516	PF00917	0.788
DOC_USP7_MATH_1	523	527	PF00917	0.528
DOC_USP7_MATH_1	538	542	PF00917	0.528
DOC_USP7_MATH_1	552	556	PF00917	0.573
DOC_USP7_MATH_1	559	563	PF00917	0.704
DOC_USP7_MATH_1	61	65	PF00917	0.646
DOC_USP7_MATH_1	627	631	PF00917	0.540
DOC_USP7_MATH_1	829	833	PF00917	0.696
DOC_USP7_MATH_1	872	876	PF00917	0.740
DOC_USP7_MATH_1	92	96	PF00917	0.817
DOC_USP7_MATH_1	922	926	PF00917	0.735
DOC_USP7_UBL2_3	908	912	PF12436	0.549
DOC_WW_Pin1_4	100	105	PF00397	0.738
DOC_WW_Pin1_4	136	141	PF00397	0.719
DOC_WW_Pin1_4	14	19	PF00397	0.797
DOC_WW_Pin1_4	240	245	PF00397	0.636
DOC_WW_Pin1_4	573	578	PF00397	0.669
DOC_WW_Pin1_4	612	617	PF00397	0.557
DOC_WW_Pin1_4	72	77	PF00397	0.690
DOC_WW_Pin1_4	800	805	PF00397	0.596
DOC_WW_Pin1_4	85	90	PF00397	0.723
DOC_WW_Pin1_4	889	894	PF00397	0.713
DOC_WW_Pin1_4	94	99	PF00397	0.747
LIG_14-3-3_CanoR_1	135	140	PF00244	0.632
LIG_14-3-3_CanoR_1	171	180	PF00244	0.809
LIG_14-3-3_CanoR_1	182	192	PF00244	0.675
LIG_14-3-3_CanoR_1	297	302	PF00244	0.697
LIG_14-3-3_CanoR_1	307	313	PF00244	0.628
LIG_14-3-3_CanoR_1	452	461	PF00244	0.579
LIG_14-3-3_CanoR_1	587	593	PF00244	0.574
LIG_14-3-3_CanoR_1	733	743	PF00244	0.774
LIG_14-3-3_CanoR_1	886	893	PF00244	0.697
LIG_AP2alpha_2	902	904	PF02296	0.682
LIG_BRCT_BRCA1_1	228	232	PF00533	0.719
LIG_BRCT_BRCA1_1	540	544	PF00533	0.560
LIG_Clathr_ClatBox_1	298	302	PF01394	0.478
LIG_CSL_BTD_1	567	570	PF09270	0.804
LIG_DLG_GKlike_1	63	71	PF00625	0.582
LIG_eIF4E_1	228	234	PF01652	0.700
LIG_FHA_1	160	166	PF00498	0.689
LIG_FHA_1	235	241	PF00498	0.560
LIG_FHA_1	252	258	PF00498	0.510
LIG_FHA_1	34	40	PF00498	0.808
LIG_FHA_1	348	354	PF00498	0.595
LIG_FHA_1	515	521	PF00498	0.542
LIG_FHA_1	528	534	PF00498	0.495
LIG_FHA_1	79	85	PF00498	0.846
LIG_FHA_1	914	920	PF00498	0.807
LIG_FHA_2	137	143	PF00498	0.645
LIG_FHA_2	184	190	PF00498	0.703
LIG_FHA_2	298	304	PF00498	0.611
LIG_FHA_2	369	375	PF00498	0.728
LIG_FHA_2	890	896	PF00498	0.705
LIG_LIR_Apic_2	136	140	PF02991	0.598
LIG_LIR_Apic_2	14	18	PF02991	0.572
LIG_LIR_Apic_2	168	172	PF02991	0.590
LIG_LIR_Gen_1	563	573	PF02991	0.705
LIG_LIR_Gen_1	588	598	PF02991	0.567
LIG_LIR_LC3C_4	761	764	PF02991	0.584
LIG_LIR_Nem_3	14	19	PF02991	0.678
LIG_LIR_Nem_3	26	32	PF02991	0.766
LIG_LIR_Nem_3	473	477	PF02991	0.572
LIG_LIR_Nem_3	563	569	PF02991	0.706
LIG_LIR_Nem_3	588	593	PF02991	0.573
LIG_LIR_Nem_3	611	617	PF02991	0.544
LIG_LIR_Nem_3	66	71	PF02991	0.737
LIG_LIR_Nem_3	901	907	PF02991	0.682
LIG_LYPXL_yS_3	29	32	PF13949	0.587
LIG_PTAP_UEV_1	593	598	PF05743	0.560
LIG_SH2_CRK	614	618	PF00017	0.543
LIG_SH2_CRK	68	72	PF00017	0.633
LIG_SH2_NCK_1	614	618	PF00017	0.543
LIG_SH2_NCK_1	681	685	PF00017	0.623
LIG_SH2_SRC	633	636	PF00017	0.545
LIG_SH2_STAT5	633	636	PF00017	0.545
LIG_SH2_STAT5	898	901	PF00017	0.643
LIG_SH3_2	340	345	PF14604	0.598
LIG_SH3_2	728	733	PF14604	0.566
LIG_SH3_3	194	200	PF00018	0.600
LIG_SH3_3	322	328	PF00018	0.776
LIG_SH3_3	337	343	PF00018	0.591
LIG_SH3_3	591	597	PF00018	0.812
LIG_SH3_3	629	635	PF00018	0.732
LIG_SH3_3	725	731	PF00018	0.603
LIG_SH3_3	73	79	PF00018	0.723
LIG_SH3_3	771	777	PF00018	0.589
LIG_SH3_3	81	87	PF00018	0.753
LIG_SH3_3	916	922	PF00018	0.760
LIG_SUMO_SIM_par_1	297	303	PF11976	0.475
LIG_SUMO_SIM_par_1	719	725	PF11976	0.629
LIG_TRAF2_1	300	303	PF00917	0.490
LIG_TRAF2_1	371	374	PF00917	0.617
LIG_TRAF2_1	892	895	PF00917	0.700
LIG_WRC_WIRS_1	524	529	PF05994	0.550
LIG_WRC_WIRS_1	589	594	PF05994	0.818
LIG_WW_3	267	271	PF00397	0.590
LIG_WW_3	730	734	PF00397	0.568
MOD_CDK_SPK_2	100	105	PF00069	0.818
MOD_CDK_SPxxK_3	94	101	PF00069	0.757
MOD_CK1_1	136	142	PF00069	0.749
MOD_CK1_1	14	20	PF00069	0.711
MOD_CK1_1	183	189	PF00069	0.703
MOD_CK1_1	22	28	PF00069	0.664
MOD_CK1_1	243	249	PF00069	0.709
MOD_CK1_1	278	284	PF00069	0.753
MOD_CK1_1	289	295	PF00069	0.715
MOD_CK1_1	346	352	PF00069	0.716
MOD_CK1_1	354	360	PF00069	0.643
MOD_CK1_1	41	47	PF00069	0.668
MOD_CK1_1	416	422	PF00069	0.629
MOD_CK1_1	424	430	PF00069	0.584
MOD_CK1_1	457	463	PF00069	0.839
MOD_CK1_1	514	520	PF00069	0.754
MOD_CK1_1	547	553	PF00069	0.569
MOD_CK1_1	604	610	PF00069	0.704
MOD_CK1_1	636	642	PF00069	0.652
MOD_CK1_1	78	84	PF00069	0.687
MOD_CK1_1	815	821	PF00069	0.822
MOD_CK1_1	832	838	PF00069	0.578
MOD_CK1_1	925	931	PF00069	0.766
MOD_CK2_1	120	126	PF00069	0.811
MOD_CK2_1	136	142	PF00069	0.555
MOD_CK2_1	297	303	PF00069	0.622
MOD_CK2_1	368	374	PF00069	0.642
MOD_CK2_1	889	895	PF00069	0.710
MOD_GlcNHglycan	322	325	PF01048	0.719
MOD_GlcNHglycan	345	348	PF01048	0.804
MOD_GlcNHglycan	356	359	PF01048	0.724
MOD_GlcNHglycan	418	421	PF01048	0.748
MOD_GlcNHglycan	424	427	PF01048	0.702
MOD_GlcNHglycan	435	438	PF01048	0.640
MOD_GlcNHglycan	456	459	PF01048	0.618
MOD_GlcNHglycan	462	465	PF01048	0.616
MOD_GlcNHglycan	480	483	PF01048	0.648
MOD_GlcNHglycan	486	489	PF01048	0.708
MOD_GlcNHglycan	520	523	PF01048	0.609
MOD_GlcNHglycan	53	56	PF01048	0.718
MOD_GlcNHglycan	540	543	PF01048	0.797
MOD_GlcNHglycan	563	566	PF01048	0.597
MOD_GlcNHglycan	594	597	PF01048	0.751
MOD_GlcNHglycan	603	606	PF01048	0.732
MOD_GlcNHglycan	621	624	PF01048	0.589
MOD_GlcNHglycan	63	66	PF01048	0.607
MOD_GlcNHglycan	701	704	PF01048	0.578
MOD_GlcNHglycan	815	818	PF01048	0.830
MOD_GlcNHglycan	855	858	PF01048	0.841
MOD_GlcNHglycan	875	878	PF01048	0.666
MOD_GlcNHglycan	927	930	PF01048	0.691
MOD_GSK3_1	116	123	PF00069	0.716
MOD_GSK3_1	17	24	PF00069	0.693
MOD_GSK3_1	176	183	PF00069	0.833
MOD_GSK3_1	222	229	PF00069	0.803
MOD_GSK3_1	236	243	PF00069	0.583
MOD_GSK3_1	273	280	PF00069	0.773
MOD_GSK3_1	284	291	PF00069	0.720
MOD_GSK3_1	308	315	PF00069	0.492
MOD_GSK3_1	316	323	PF00069	0.585
MOD_GSK3_1	33	40	PF00069	0.800
MOD_GSK3_1	343	350	PF00069	0.724
MOD_GSK3_1	422	429	PF00069	0.684
MOD_GSK3_1	433	440	PF00069	0.770
MOD_GSK3_1	453	460	PF00069	0.493
MOD_GSK3_1	466	473	PF00069	0.574
MOD_GSK3_1	49	56	PF00069	0.759
MOD_GSK3_1	514	521	PF00069	0.603
MOD_GSK3_1	523	530	PF00069	0.545
MOD_GSK3_1	569	576	PF00069	0.706
MOD_GSK3_1	588	595	PF00069	0.627
MOD_GSK3_1	59	66	PF00069	0.672
MOD_GSK3_1	604	611	PF00069	0.783
MOD_GSK3_1	621	628	PF00069	0.681
MOD_GSK3_1	697	704	PF00069	0.729
MOD_GSK3_1	712	719	PF00069	0.695
MOD_GSK3_1	811	818	PF00069	0.792
MOD_GSK3_1	848	855	PF00069	0.684
MOD_GSK3_1	881	888	PF00069	0.810
MOD_GSK3_1	898	905	PF00069	0.647
MOD_GSK3_1	921	928	PF00069	0.724
MOD_N-GLC_1	11	16	PF02516	0.581
MOD_N-GLC_1	116	121	PF02516	0.685
MOD_N-GLC_1	351	356	PF02516	0.736
MOD_N-GLC_1	392	397	PF02516	0.691
MOD_N-GLC_1	413	418	PF02516	0.789
MOD_N-GLC_1	42	47	PF02516	0.710
MOD_N-GLC_1	518	523	PF02516	0.632
MOD_N-GLC_1	853	858	PF02516	0.720
MOD_N-GLC_2	253	255	PF02516	0.572
MOD_N-GLC_2	885	887	PF02516	0.749
MOD_NEK2_1	115	120	PF00069	0.736
MOD_NEK2_1	133	138	PF00069	0.676
MOD_NEK2_1	176	181	PF00069	0.716
MOD_NEK2_1	233	238	PF00069	0.706
MOD_NEK2_1	38	43	PF00069	0.562
MOD_NEK2_1	405	410	PF00069	0.642
MOD_NEK2_1	477	482	PF00069	0.683
MOD_NEK2_1	492	497	PF00069	0.807
MOD_NEK2_1	527	532	PF00069	0.580
MOD_NEK2_1	544	549	PF00069	0.731
MOD_NEK2_1	621	626	PF00069	0.726
MOD_NEK2_1	813	818	PF00069	0.595
MOD_NEK2_1	913	918	PF00069	0.623
MOD_NEK2_2	11	16	PF00069	0.581
MOD_NEK2_2	493	498	PF00069	0.555
MOD_NEK2_2	523	528	PF00069	0.545
MOD_PIKK_1	106	112	PF00454	0.729
MOD_PIKK_1	143	149	PF00454	0.647
MOD_PIKK_1	17	23	PF00454	0.793
MOD_PIKK_1	275	281	PF00454	0.807
MOD_PIKK_1	316	322	PF00454	0.773
MOD_PIKK_1	552	558	PF00454	0.570
MOD_PIKK_1	644	650	PF00454	0.707
MOD_PIKK_1	848	854	PF00454	0.588
MOD_PIKK_1	87	93	PF00454	0.758
MOD_PKA_1	308	314	PF00069	0.736
MOD_PKA_2	159	165	PF00069	0.712
MOD_PKA_2	170	176	PF00069	0.798
MOD_PKA_2	308	314	PF00069	0.736
MOD_PKA_2	477	483	PF00069	0.684
MOD_PKA_2	506	512	PF00069	0.809
MOD_PKA_2	832	838	PF00069	0.583
MOD_PKA_2	852	858	PF00069	0.659
MOD_PKA_2	885	891	PF00069	0.743
MOD_Plk_1	11	17	PF00069	0.581
MOD_Plk_1	116	122	PF00069	0.685
MOD_Plk_1	251	257	PF00069	0.577
MOD_Plk_1	273	279	PF00069	0.855
MOD_Plk_1	34	40	PF00069	0.716
MOD_Plk_1	493	499	PF00069	0.677
MOD_Plk_2-3	793	799	PF00069	0.600
MOD_Plk_4	11	17	PF00069	0.623
MOD_Plk_4	223	229	PF00069	0.705
MOD_Plk_4	289	295	PF00069	0.569
MOD_Plk_4	308	314	PF00069	0.468
MOD_Plk_4	34	40	PF00069	0.707
MOD_Plk_4	523	529	PF00069	0.547
MOD_Plk_4	63	69	PF00069	0.580
MOD_Plk_4	716	722	PF00069	0.763
MOD_ProDKin_1	136	142	PF00069	0.721
MOD_ProDKin_1	14	20	PF00069	0.796
MOD_ProDKin_1	240	246	PF00069	0.637
MOD_ProDKin_1	573	579	PF00069	0.669
MOD_ProDKin_1	612	618	PF00069	0.556
MOD_ProDKin_1	72	78	PF00069	0.690
MOD_ProDKin_1	800	806	PF00069	0.596
MOD_ProDKin_1	85	91	PF00069	0.726
MOD_ProDKin_1	889	895	PF00069	0.710
MOD_ProDKin_1	94	100	PF00069	0.748
MOD_SUMO_rev_2	537	547	PF00179	0.560
MOD_SUMO_rev_2	890	899	PF00179	0.704
TRG_DiLeu_BaEn_1	668	673	PF01217	0.640
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.673
TRG_ENDOCYTIC_2	29	32	PF00928	0.733
TRG_ENDOCYTIC_2	614	617	PF00928	0.544
TRG_ENDOCYTIC_2	68	71	PF00928	0.740
TRG_ER_diArg_1	307	309	PF00400	0.618
TRG_ER_diArg_1	678	680	PF00400	0.682
TRG_ER_diArg_1	844	846	PF00400	0.800
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ58	Leptomonas seymouri	33%	100%
A0A3Q8IIP4	Leishmania donovani	62%	97%
A4HWG1	Leishmania infantum	61%	97%
E9AQ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QFC2	Leishmania major	63%	100%