DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H835_LEIBR

TriTrypDb:

LbrM.15.0660 , LBRM2903_150012500

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H835

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H835

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.535
CLV_NRD_NRD_1	261	263	PF00675	0.379
CLV_NRD_NRD_1	351	353	PF00675	0.555
CLV_NRD_NRD_1	398	400	PF00675	0.582
CLV_NRD_NRD_1	431	433	PF00675	0.500
CLV_NRD_NRD_1	77	79	PF00675	0.768
CLV_PCSK_KEX2_1	258	260	PF00082	0.492
CLV_PCSK_KEX2_1	333	335	PF00082	0.650
CLV_PCSK_KEX2_1	351	353	PF00082	0.569
CLV_PCSK_KEX2_1	398	400	PF00082	0.674
CLV_PCSK_KEX2_1	431	433	PF00082	0.540
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.592
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.650
CLV_PCSK_SKI1_1	115	119	PF00082	0.423
CLV_PCSK_SKI1_1	157	161	PF00082	0.466
CLV_PCSK_SKI1_1	237	241	PF00082	0.398
CLV_PCSK_SKI1_1	447	451	PF00082	0.556
DEG_APCC_DBOX_1	114	122	PF00400	0.501
DEG_APCC_DBOX_1	401	409	PF00400	0.465
DEG_SPOP_SBC_1	292	296	PF00917	0.679
DEG_SPOP_SBC_1	40	44	PF00917	0.724
DOC_ANK_TNKS_1	160	167	PF00023	0.598
DOC_CKS1_1	150	155	PF01111	0.409
DOC_CKS1_1	354	359	PF01111	0.506
DOC_CYCLIN_RxL_1	234	243	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.780
DOC_MAPK_gen_1	332	340	PF00069	0.656
DOC_MAPK_RevD_3	118	133	PF00069	0.306
DOC_PP4_FxxP_1	148	151	PF00568	0.377
DOC_PP4_FxxP_1	422	425	PF00568	0.524
DOC_USP7_MATH_1	281	285	PF00917	0.681
DOC_USP7_MATH_1	292	296	PF00917	0.666
DOC_USP7_MATH_1	40	44	PF00917	0.708
DOC_USP7_MATH_1	445	449	PF00917	0.614
DOC_WW_Pin1_4	149	154	PF00397	0.384
DOC_WW_Pin1_4	177	182	PF00397	0.732
DOC_WW_Pin1_4	265	270	PF00397	0.516
DOC_WW_Pin1_4	353	358	PF00397	0.481
DOC_WW_Pin1_4	41	46	PF00397	0.664
LIG_14-3-3_CanoR_1	262	272	PF00244	0.354
LIG_Actin_WH2_2	217	232	PF00022	0.411
LIG_APCC_ABBA_1	102	107	PF00400	0.651
LIG_APCC_ABBA_1	208	213	PF00400	0.648
LIG_BIR_II_1	1	5	PF00653	0.764
LIG_BRCT_BRCA1_1	102	106	PF00533	0.439
LIG_BRCT_BRCA1_1	360	364	PF00533	0.439
LIG_FHA_1	17	23	PF00498	0.741
LIG_FHA_1	405	411	PF00498	0.475
LIG_LIR_Apic_2	146	151	PF02991	0.397
LIG_LIR_Gen_1	103	114	PF02991	0.367
LIG_LIR_Gen_1	196	203	PF02991	0.623
LIG_LIR_Gen_1	222	231	PF02991	0.433
LIG_LIR_Gen_1	23	28	PF02991	0.642
LIG_LIR_Gen_1	268	278	PF02991	0.391
LIG_LIR_Gen_1	51	61	PF02991	0.483
LIG_LIR_Nem_3	103	109	PF02991	0.646
LIG_LIR_Nem_3	195	201	PF02991	0.625
LIG_LIR_Nem_3	222	226	PF02991	0.475
LIG_LIR_Nem_3	23	27	PF02991	0.674
LIG_LIR_Nem_3	268	273	PF02991	0.355
LIG_LIR_Nem_3	51	56	PF02991	0.446
LIG_Pex14_2	102	106	PF04695	0.439
LIG_Pex14_2	124	128	PF04695	0.397
LIG_Pex14_2	144	148	PF04695	0.219
LIG_SH2_CRK	355	359	PF00017	0.579
LIG_SH2_NCK_1	355	359	PF00017	0.579
LIG_SH2_NCK_1	63	67	PF00017	0.490
LIG_SH2_STAT5	143	146	PF00017	0.455
LIG_SH2_STAT5	198	201	PF00017	0.498
LIG_SH2_STAT5	223	226	PF00017	0.434
LIG_SH2_STAT5	355	358	PF00017	0.606
LIG_SH2_STAT5	404	407	PF00017	0.446
LIG_SH3_1	351	357	PF00018	0.579
LIG_SH3_3	150	156	PF00018	0.418
LIG_SH3_3	351	357	PF00018	0.480
LIG_SH3_3	369	375	PF00018	0.291
LIG_SH3_3	405	411	PF00018	0.419
LIG_SH3_3	6	12	PF00018	0.686
LIG_TRAF2_1	13	16	PF00917	0.773
LIG_TRAF2_1	328	331	PF00917	0.643
LIG_TRAF2_1	365	368	PF00917	0.476
LIG_TRFH_1	199	203	PF08558	0.665
LIG_TRFH_1	270	274	PF08558	0.474
LIG_UBA3_1	443	450	PF00899	0.582
LIG_WRC_WIRS_1	145	150	PF05994	0.397
MOD_CDK_SPK_2	149	154	PF00069	0.404
MOD_CDK_SPxxK_3	353	360	PF00069	0.503
MOD_CDK_SPxxK_3	41	48	PF00069	0.432
MOD_CK1_1	175	181	PF00069	0.793
MOD_CK1_1	284	290	PF00069	0.639
MOD_CK1_1	293	299	PF00069	0.631
MOD_CK1_1	43	49	PF00069	0.581
MOD_CK1_1	51	57	PF00069	0.458
MOD_CK2_1	159	165	PF00069	0.578
MOD_CK2_1	362	368	PF00069	0.443
MOD_Cter_Amidation	130	133	PF01082	0.343
MOD_GlcNHglycan	115	118	PF01048	0.376
MOD_GlcNHglycan	283	286	PF01048	0.659
MOD_GlcNHglycan	295	298	PF01048	0.638
MOD_GlcNHglycan	316	319	PF01048	0.733
MOD_GlcNHglycan	435	438	PF01048	0.529
MOD_GlcNHglycan	53	56	PF01048	0.401
MOD_GlcNHglycan	86	89	PF01048	0.754
MOD_GlcNHglycan	96	99	PF01048	0.670
MOD_GSK3_1	16	23	PF00069	0.770
MOD_GSK3_1	172	179	PF00069	0.693
MOD_GSK3_1	188	195	PF00069	0.683
MOD_GSK3_1	31	38	PF00069	0.638
MOD_GSK3_1	358	365	PF00069	0.435
MOD_GSK3_1	39	46	PF00069	0.508
MOD_N-GLC_1	193	198	PF02516	0.649
MOD_N-GLC_1	263	268	PF02516	0.425
MOD_N-GLC_1	94	99	PF02516	0.669
MOD_N-GLC_2	347	349	PF02516	0.348
MOD_NEK2_1	144	149	PF00069	0.442
MOD_NEK2_1	187	192	PF00069	0.692
MOD_NEK2_1	240	245	PF00069	0.534
MOD_NEK2_2	100	105	PF00069	0.464
MOD_NEK2_2	445	450	PF00069	0.589
MOD_PIKK_1	273	279	PF00454	0.551
MOD_PIKK_1	29	35	PF00454	0.532
MOD_PK_1	48	54	PF00069	0.311
MOD_PKA_2	77	83	PF00069	0.774
MOD_Plk_1	100	106	PF00069	0.707
MOD_Plk_1	193	199	PF00069	0.634
MOD_Plk_1	439	445	PF00069	0.552
MOD_Plk_4	439	445	PF00069	0.525
MOD_ProDKin_1	149	155	PF00069	0.386
MOD_ProDKin_1	177	183	PF00069	0.730
MOD_ProDKin_1	265	271	PF00069	0.512
MOD_ProDKin_1	353	359	PF00069	0.484
MOD_ProDKin_1	41	47	PF00069	0.650
MOD_SUMO_rev_2	238	246	PF00179	0.447
MOD_SUMO_rev_2	325	335	PF00179	0.600
MOD_SUMO_rev_2	80	86	PF00179	0.589
TRG_DiLeu_BaEn_1	380	385	PF01217	0.425
TRG_DiLeu_BaEn_4	213	219	PF01217	0.389
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.495
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.457
TRG_ENDOCYTIC_2	198	201	PF00928	0.606
TRG_ENDOCYTIC_2	223	226	PF00928	0.431
TRG_ENDOCYTIC_2	355	358	PF00928	0.550
TRG_ER_diArg_1	351	353	PF00400	0.569
TRG_NES_CRM1_1	216	227	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I615	Leptomonas seymouri	72%	100%
A0A1X0NTS1	Trypanosomatidae	39%	100%
A0A3S5H6U7	Leishmania donovani	76%	100%
A0A422NLQ5	Trypanosoma rangeli	39%	100%
A4HWG0	Leishmania infantum	76%	100%
C9ZP02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQ60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QFC3	Leishmania major	78%	99%