CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H834_LEIBR

TriTrypDb:

LbrM.15.0650 , LBRM2903_150012400

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H834

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H834

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.383
CLV_C14_Caspase3-7	285	289	PF00656	0.369
CLV_C14_Caspase3-7	398	402	PF00656	0.631
CLV_NRD_NRD_1	114	116	PF00675	0.517
CLV_NRD_NRD_1	215	217	PF00675	0.291
CLV_NRD_NRD_1	254	256	PF00675	0.377
CLV_NRD_NRD_1	509	511	PF00675	0.652
CLV_NRD_NRD_1	65	67	PF00675	0.515
CLV_PCSK_KEX2_1	114	116	PF00082	0.592
CLV_PCSK_KEX2_1	195	197	PF00082	0.488
CLV_PCSK_KEX2_1	215	217	PF00082	0.366
CLV_PCSK_KEX2_1	254	256	PF00082	0.366
CLV_PCSK_KEX2_1	453	455	PF00082	0.725
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.488
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.725
CLV_PCSK_SKI1_1	179	183	PF00082	0.603
CLV_PCSK_SKI1_1	269	273	PF00082	0.358
CLV_PCSK_SKI1_1	313	317	PF00082	0.408
CLV_PCSK_SKI1_1	36	40	PF00082	0.479
CLV_PCSK_SKI1_1	364	368	PF00082	0.408
CLV_PCSK_SKI1_1	373	377	PF00082	0.408
CLV_PCSK_SKI1_1	414	418	PF00082	0.534
CLV_PCSK_SKI1_1	490	494	PF00082	0.622
CLV_PCSK_SKI1_1	87	91	PF00082	0.464
CLV_Separin_Metazoa	270	274	PF03568	0.262
DEG_APCC_DBOX_1	243	251	PF00400	0.408
DEG_SCF_FBW7_1	234	239	PF00400	0.408
DOC_CYCLIN_RxL_1	314	328	PF00134	0.509
DOC_CYCLIN_yClb5_NLxxxL_5	134	141	PF00134	0.386
DOC_MAPK_gen_1	114	120	PF00069	0.587
DOC_MAPK_gen_1	195	201	PF00069	0.509
DOC_MAPK_gen_1	313	324	PF00069	0.430
DOC_MAPK_gen_1	87	95	PF00069	0.497
DOC_PP2B_LxvP_1	93	96	PF13499	0.573
DOC_SPAK_OSR1_1	109	113	PF12202	0.447
DOC_USP7_MATH_1	386	390	PF00917	0.601
DOC_USP7_UBL2_3	28	32	PF12436	0.362
DOC_USP7_UBL2_3	313	317	PF12436	0.408
DOC_WW_Pin1_4	225	230	PF00397	0.418
DOC_WW_Pin1_4	232	237	PF00397	0.401
DOC_WW_Pin1_4	276	281	PF00397	0.262
DOC_WW_Pin1_4	384	389	PF00397	0.603
DOC_WW_Pin1_4	440	445	PF00397	0.582
DOC_WW_Pin1_4	470	475	PF00397	0.455
LIG_14-3-3_CanoR_1	320	325	PF00244	0.509
LIG_Actin_RPEL_3	107	126	PF02755	0.460
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BRCT_BRCA1_1	227	231	PF00533	0.262
LIG_BRCT_BRCA1_1	308	312	PF00533	0.262
LIG_BRCT_BRCA1_1	442	446	PF00533	0.639
LIG_BRCT_BRCA1_1	53	57	PF00533	0.465
LIG_BRCT_BRCA1_2	308	314	PF00533	0.262
LIG_CtBP_PxDLS_1	78	82	PF00389	0.563
LIG_deltaCOP1_diTrp_1	495	500	PF00928	0.596
LIG_FHA_1	120	126	PF00498	0.557
LIG_FHA_1	176	182	PF00498	0.687
LIG_FHA_1	292	298	PF00498	0.408
LIG_FHA_1	471	477	PF00498	0.530
LIG_FHA_2	279	285	PF00498	0.356
LIG_FHA_2	404	410	PF00498	0.616
LIG_FHA_2	491	497	PF00498	0.455
LIG_FHA_2	500	506	PF00498	0.412
LIG_FHA_2	80	86	PF00498	0.651
LIG_LIR_Gen_1	228	238	PF02991	0.434
LIG_LIR_Nem_3	105	111	PF02991	0.435
LIG_LIR_Nem_3	149	153	PF02991	0.558
LIG_LIR_Nem_3	214	220	PF02991	0.408
LIG_LIR_Nem_3	228	234	PF02991	0.408
LIG_LIR_Nem_3	235	241	PF02991	0.405
LIG_LIR_Nem_3	309	315	PF02991	0.262
LIG_LIR_Nem_3	495	500	PF02991	0.596
LIG_MYND_1	355	359	PF01753	0.408
LIG_NRBOX	317	323	PF00104	0.262
LIG_NRP_CendR_1	510	512	PF00754	0.524
LIG_PCNA_yPIPBox_3	258	272	PF02747	0.262
LIG_Pex14_1	186	190	PF04695	0.365
LIG_Pex14_2	312	316	PF04695	0.262
LIG_Pex14_2	346	350	PF04695	0.408
LIG_PTB_Apo_2	338	345	PF02174	0.408
LIG_PTB_Apo_2	455	462	PF02174	0.650
LIG_PTB_Phospho_1	455	461	PF10480	0.617
LIG_SH2_CRK	108	112	PF00017	0.421
LIG_SH2_CRK	202	206	PF00017	0.408
LIG_SH2_CRK	238	242	PF00017	0.509
LIG_SH2_GRB2like	238	241	PF00017	0.408
LIG_SH2_SRC	219	222	PF00017	0.509
LIG_SH2_STAP1	11	15	PF00017	0.586
LIG_SH2_STAP1	238	242	PF00017	0.408
LIG_SH2_STAT5	128	131	PF00017	0.438
LIG_SH2_STAT5	190	193	PF00017	0.364
LIG_SH2_STAT5	219	222	PF00017	0.408
LIG_SH2_STAT5	246	249	PF00017	0.408
LIG_SH2_STAT5	424	427	PF00017	0.509
LIG_SH3_3	231	237	PF00018	0.509
LIG_SH3_3	438	444	PF00018	0.601
LIG_SH3_3	456	462	PF00018	0.650
LIG_SH3_3	53	59	PF00018	0.548
LIG_SH3_3	72	78	PF00018	0.653
LIG_SUMO_SIM_par_1	294	301	PF11976	0.408
LIG_SUMO_SIM_par_1	364	369	PF11976	0.408
LIG_TRAF2_1	493	496	PF00917	0.498
LIG_TYR_ITIM	106	111	PF00017	0.520
LIG_UBA3_1	125	134	PF00899	0.444
LIG_UBA3_1	503	511	PF00899	0.479
LIG_UBA3_1	92	100	PF00899	0.574
LIG_WRC_WIRS_1	147	152	PF05994	0.405
MOD_CK1_1	119	125	PF00069	0.345
MOD_CK1_1	282	288	PF00069	0.390
MOD_CK1_1	377	383	PF00069	0.606
MOD_CK1_1	387	393	PF00069	0.644
MOD_CK1_1	395	401	PF00069	0.599
MOD_CK1_1	410	416	PF00069	0.518
MOD_CK1_1	68	74	PF00069	0.625
MOD_CK2_1	403	409	PF00069	0.608
MOD_CK2_1	490	496	PF00069	0.621
MOD_CK2_1	499	505	PF00069	0.688
MOD_Cter_Amidation	252	255	PF01082	0.408
MOD_GlcNHglycan	170	173	PF01048	0.514
MOD_GlcNHglycan	378	382	PF01048	0.585
MOD_GlcNHglycan	389	392	PF01048	0.569
MOD_GlcNHglycan	71	74	PF01048	0.785
MOD_GSK3_1	116	123	PF00069	0.469
MOD_GSK3_1	232	239	PF00069	0.374
MOD_GSK3_1	276	283	PF00069	0.355
MOD_GSK3_1	298	305	PF00069	0.408
MOD_GSK3_1	386	393	PF00069	0.680
MOD_GSK3_1	403	410	PF00069	0.714
MOD_GSK3_1	65	72	PF00069	0.681
MOD_N-GLC_1	16	21	PF02516	0.556
MOD_NEK2_1	116	121	PF00069	0.559
MOD_NEK2_1	166	171	PF00069	0.506
MOD_NEK2_1	325	330	PF00069	0.321
MOD_NEK2_1	368	373	PF00069	0.377
MOD_NEK2_1	446	451	PF00069	0.514
MOD_PIKK_1	358	364	PF00454	0.408
MOD_PIKK_1	429	435	PF00454	0.364
MOD_PIKK_1	490	496	PF00454	0.503
MOD_PKA_1	254	260	PF00069	0.408
MOD_PKA_2	254	260	PF00069	0.400
MOD_PKA_2	65	71	PF00069	0.560
MOD_Plk_1	116	122	PF00069	0.319
MOD_Plk_2-3	79	85	PF00069	0.655
MOD_Plk_4	136	142	PF00069	0.493
MOD_Plk_4	320	326	PF00069	0.391
MOD_Plk_4	499	505	PF00069	0.463
MOD_ProDKin_1	225	231	PF00069	0.418
MOD_ProDKin_1	232	238	PF00069	0.401
MOD_ProDKin_1	276	282	PF00069	0.262
MOD_ProDKin_1	384	390	PF00069	0.605
MOD_ProDKin_1	440	446	PF00069	0.588
MOD_ProDKin_1	470	476	PF00069	0.457
MOD_SUMO_for_1	27	30	PF00179	0.418
MOD_SUMO_rev_2	25	34	PF00179	0.475
MOD_SUMO_rev_2	495	500	PF00179	0.446
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.574
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.408
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.262
TRG_ENDOCYTIC_2	108	111	PF00928	0.418
TRG_ENDOCYTIC_2	128	131	PF00928	0.209
TRG_ENDOCYTIC_2	190	193	PF00928	0.365
TRG_ENDOCYTIC_2	238	241	PF00928	0.408
TRG_ER_diArg_1	114	116	PF00400	0.592
TRG_ER_diArg_1	215	217	PF00400	0.262
TRG_ER_diArg_1	254	256	PF00400	0.408
TRG_ER_diArg_1	468	471	PF00400	0.627
TRG_ER_diArg_1	509	512	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.759
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ3	Leptomonas seymouri	62%	99%
A0A3Q8IC92	Leishmania donovani	79%	99%
E9AQ59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QFC4	Leishmania major	78%	100%