Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H831_LEIBR

TriTrypDb:

LbrM.15.0620 , LBRM2903_150012000

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H831

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H831

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.627
CLV_NRD_NRD_1	215	217	PF00675	0.547
CLV_NRD_NRD_1	46	48	PF00675	0.445
CLV_PCSK_FUR_1	206	210	PF00082	0.502
CLV_PCSK_KEX2_1	102	104	PF00082	0.522
CLV_PCSK_KEX2_1	208	210	PF00082	0.674
CLV_PCSK_KEX2_1	46	48	PF00082	0.432
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.522
CLV_PCSK_SKI1_1	5	9	PF00082	0.614
CLV_PCSK_SKI1_1	67	71	PF00082	0.466
DEG_SCF_TRCP1_1	111	116	PF00400	0.508
DEG_SPOP_SBC_1	117	121	PF00917	0.601
DEG_SPOP_SBC_1	150	154	PF00917	0.451
DOC_USP7_MATH_1	117	121	PF00917	0.769
DOC_USP7_MATH_1	122	126	PF00917	0.705
DOC_WW_Pin1_4	118	123	PF00397	0.718
DOC_WW_Pin1_4	199	204	PF00397	0.673
LIG_14-3-3_CanoR_1	148	158	PF00244	0.569
LIG_14-3-3_CanoR_1	163	168	PF00244	0.481
LIG_FHA_2	132	138	PF00498	0.613
LIG_FHA_2	151	157	PF00498	0.453
LIG_LIR_Apic_2	214	218	PF02991	0.540
LIG_LIR_Apic_2	85	90	PF02991	0.653
LIG_LIR_Apic_2	98	104	PF02991	0.475
LIG_LIR_Gen_1	95	105	PF02991	0.531
LIG_LIR_Nem_3	145	149	PF02991	0.505
LIG_LIR_Nem_3	95	100	PF02991	0.584
LIG_Pex14_1	55	59	PF04695	0.535
LIG_SH2_CRK	97	101	PF00017	0.588
LIG_SH2_GRB2like	87	90	PF00017	0.663
LIG_SH2_PTP2	87	90	PF00017	0.645
LIG_SH2_SRC	229	232	PF00017	0.462
LIG_SH2_SRC	87	90	PF00017	0.645
LIG_SH2_STAP1	97	101	PF00017	0.531
LIG_SH2_STAT3	59	62	PF00017	0.543
LIG_SH2_STAT5	157	160	PF00017	0.581
LIG_SH2_STAT5	87	90	PF00017	0.663
LIG_SH3_3	169	175	PF00018	0.662
LIG_TRAF2_1	130	133	PF00917	0.524
MOD_CDK_SPxxK_3	199	206	PF00069	0.490
MOD_CK1_1	112	118	PF00069	0.660
MOD_CK1_1	125	131	PF00069	0.499
MOD_CK1_1	193	199	PF00069	0.675
MOD_CK1_1	34	40	PF00069	0.571
MOD_CK2_1	150	156	PF00069	0.451
MOD_CK2_1	192	198	PF00069	0.703
MOD_GlcNHglycan	111	114	PF01048	0.593
MOD_GlcNHglycan	140	143	PF01048	0.675
MOD_GlcNHglycan	172	175	PF01048	0.690
MOD_GlcNHglycan	55	58	PF01048	0.447
MOD_GSK3_1	105	112	PF00069	0.685
MOD_GSK3_1	113	120	PF00069	0.690
MOD_GSK3_1	131	138	PF00069	0.674
MOD_GSK3_1	170	177	PF00069	0.674
MOD_GSK3_1	186	193	PF00069	0.617
MOD_GSK3_1	30	37	PF00069	0.572
MOD_N-GLC_1	142	147	PF02516	0.762
MOD_N-GLC_1	163	168	PF02516	0.519
MOD_NEK2_1	31	36	PF00069	0.535
MOD_PIKK_1	31	37	PF00454	0.644
MOD_PKA_2	150	156	PF00069	0.465
MOD_PKB_1	161	169	PF00069	0.722
MOD_Plk_1	142	148	PF00069	0.496
MOD_Plk_1	163	169	PF00069	0.485
MOD_Plk_1	197	203	PF00069	0.487
MOD_Plk_4	95	101	PF00069	0.519
MOD_ProDKin_1	118	124	PF00069	0.720
MOD_ProDKin_1	199	205	PF00069	0.671
MOD_SUMO_rev_2	60	70	PF00179	0.462
TRG_ENDOCYTIC_2	97	100	PF00928	0.588
TRG_ER_diArg_1	205	208	PF00400	0.656
TRG_ER_diArg_1	45	47	PF00400	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F5	Leptomonas seymouri	47%	100%
A0A3Q8IDE0	Leishmania donovani	75%	100%
A0A3R7KEI8	Trypanosoma rangeli	33%	100%
A4HWF7	Leishmania infantum	75%	100%
C9ZNZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AQ56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QFC6	Leishmania major	73%	100%