Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal peptidase subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H830_LEIBR

TriTrypDb:

LbrM.15.0610 , LBRM2903_150011900

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005787	signal peptidase complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1905368	peptidase complex	3	7

Expansion

Sequence features

A4H830

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H830

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	7
GO:0006508	proteolysis	4	7
GO:0006518	peptide metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043603	amide metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0051604	protein maturation	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006605	protein targeting	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.541
CLV_C14_Caspase3-7	80	84	PF00656	0.625
CLV_NRD_NRD_1	111	113	PF00675	0.644
CLV_NRD_NRD_1	198	200	PF00675	0.636
CLV_NRD_NRD_1	60	62	PF00675	0.550
CLV_PCSK_KEX2_1	113	115	PF00082	0.599
CLV_PCSK_KEX2_1	198	200	PF00082	0.627
CLV_PCSK_KEX2_1	260	262	PF00082	0.660
CLV_PCSK_KEX2_1	60	62	PF00082	0.550
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.685
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.660
CLV_PCSK_SKI1_1	135	139	PF00082	0.534
CLV_PCSK_SKI1_1	261	265	PF00082	0.598
CLV_PCSK_SKI1_1	60	64	PF00082	0.538
DEG_COP1_1	63	72	PF00400	0.341
DEG_SPOP_SBC_1	50	54	PF00917	0.362
DOC_CYCLIN_RxL_1	57	68	PF00134	0.332
DOC_MAPK_HePTP_8	128	140	PF00069	0.419
DOC_MAPK_MEF2A_6	131	140	PF00069	0.346
DOC_USP7_MATH_1	105	109	PF00917	0.500
DOC_USP7_MATH_1	2	6	PF00917	0.559
DOC_USP7_MATH_1	43	47	PF00917	0.478
DOC_USP7_MATH_1	70	74	PF00917	0.521
DOC_WW_Pin1_4	144	149	PF00397	0.419
DOC_WW_Pin1_4	51	56	PF00397	0.446
DOC_WW_Pin1_4	63	68	PF00397	0.447
LIG_14-3-3_CanoR_1	183	188	PF00244	0.487
LIG_14-3-3_CanoR_1	49	55	PF00244	0.430
LIG_14-3-3_CanoR_1	60	65	PF00244	0.400
LIG_14-3-3_CanoR_1	86	93	PF00244	0.429
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_4	305	309	PF00653	0.348
LIG_BRCT_BRCA1_1	142	146	PF00533	0.419
LIG_BRCT_BRCA1_1	30	34	PF00533	0.261
LIG_CtBP_PxDLS_1	184	188	PF00389	0.307
LIG_FHA_1	13	19	PF00498	0.391
LIG_FHA_1	152	158	PF00498	0.346
LIG_FHA_1	22	28	PF00498	0.487
LIG_FHA_1	223	229	PF00498	0.457
LIG_FHA_1	282	288	PF00498	0.489
LIG_FHA_2	227	233	PF00498	0.436
LIG_LIR_Apic_2	73	78	PF02991	0.474
LIG_LIR_Gen_1	273	280	PF02991	0.390
LIG_LIR_Nem_3	266	271	PF02991	0.464
LIG_LIR_Nem_3	273	278	PF02991	0.453
LIG_LIR_Nem_3	297	302	PF02991	0.414
LIG_LIR_Nem_3	31	37	PF02991	0.359
LIG_Pex14_2	146	150	PF04695	0.346
LIG_Pex14_2	161	165	PF04695	0.346
LIG_PTB_Apo_2	262	269	PF02174	0.380
LIG_SH2_CRK	11	15	PF00017	0.438
LIG_SH2_SRC	271	274	PF00017	0.292
LIG_SH2_STAP1	158	162	PF00017	0.238
LIG_SH2_STAT5	139	142	PF00017	0.346
LIG_SH2_STAT5	271	274	PF00017	0.464
LIG_SH3_3	178	184	PF00018	0.355
LIG_SH3_3	310	316	PF00018	0.470
LIG_SH3_3	35	41	PF00018	0.502
LIG_SH3_3	64	70	PF00018	0.446
LIG_Sin3_3	23	30	PF02671	0.261
LIG_SUMO_SIM_anti_2	174	179	PF11976	0.419
LIG_SUMO_SIM_anti_2	284	289	PF11976	0.463
LIG_SUMO_SIM_anti_2	94	101	PF11976	0.444
LIG_SUMO_SIM_par_1	174	179	PF11976	0.419
LIG_SUMO_SIM_par_1	183	188	PF11976	0.381
LIG_SUMO_SIM_par_1	94	101	PF11976	0.373
LIG_TRAF2_1	238	241	PF00917	0.431
LIG_WRC_WIRS_1	158	163	PF05994	0.346
MOD_CK1_1	16	22	PF00069	0.411
MOD_CK1_1	166	172	PF00069	0.262
MOD_CK1_1	211	217	PF00069	0.503
MOD_CK2_1	206	212	PF00069	0.570
MOD_CK2_1	226	232	PF00069	0.420
MOD_GlcNHglycan	140	143	PF01048	0.546
MOD_GlcNHglycan	18	21	PF01048	0.513
MOD_GlcNHglycan	187	190	PF01048	0.525
MOD_GlcNHglycan	201	205	PF01048	0.700
MOD_GlcNHglycan	208	211	PF01048	0.722
MOD_GlcNHglycan	296	299	PF01048	0.637
MOD_GlcNHglycan	317	320	PF01048	0.585
MOD_GlcNHglycan	79	82	PF01048	0.685
MOD_GSK3_1	12	19	PF00069	0.531
MOD_GSK3_1	140	147	PF00069	0.398
MOD_GSK3_1	164	171	PF00069	0.330
MOD_GSK3_1	21	28	PF00069	0.487
MOD_GSK3_1	222	229	PF00069	0.509
MOD_LATS_1	58	64	PF00433	0.512
MOD_N-GLC_1	264	269	PF02516	0.593
MOD_NEK2_1	138	143	PF00069	0.309
MOD_NEK2_1	14	19	PF00069	0.500
MOD_NEK2_1	21	26	PF00069	0.411
MOD_NEK2_1	239	244	PF00069	0.431
MOD_NEK2_1	264	269	PF00069	0.393
MOD_NEK2_1	294	299	PF00069	0.345
MOD_NEK2_2	2	7	PF00069	0.557
MOD_NEK2_2	29	34	PF00069	0.261
MOD_PIKK_1	168	174	PF00454	0.330
MOD_PIKK_1	222	228	PF00454	0.491
MOD_PIKK_1	321	327	PF00454	0.405
MOD_PKA_1	60	66	PF00069	0.328
MOD_PKA_2	163	169	PF00069	0.238
MOD_PKA_2	48	54	PF00069	0.443
MOD_PKA_2	60	66	PF00069	0.436
MOD_PKA_2	85	91	PF00069	0.571
MOD_Plk_1	222	228	PF00069	0.522
MOD_Plk_1	239	245	PF00069	0.391
MOD_Plk_1	264	270	PF00069	0.390
MOD_Plk_1	276	282	PF00069	0.380
MOD_Plk_1	70	76	PF00069	0.388
MOD_Plk_4	157	163	PF00069	0.391
MOD_Plk_4	29	35	PF00069	0.478
MOD_Plk_4	60	66	PF00069	0.484
MOD_Plk_4	71	77	PF00069	0.402
MOD_ProDKin_1	144	150	PF00069	0.419
MOD_ProDKin_1	51	57	PF00069	0.443
MOD_ProDKin_1	63	69	PF00069	0.450
TRG_ENDOCYTIC_2	11	14	PF00928	0.519
TRG_ENDOCYTIC_2	158	161	PF00928	0.355
TRG_ENDOCYTIC_2	291	294	PF00928	0.391
TRG_ER_diArg_1	197	199	PF00400	0.416
TRG_ER_diArg_1	59	61	PF00400	0.334
TRG_ER_diArg_1	6	9	PF00400	0.654
TRG_NLS_MonoExtN_4	112	117	PF00514	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I7	Leptomonas seymouri	55%	100%
A0A3S5H6U6	Leishmania donovani	78%	100%
A4HWF6	Leishmania infantum	78%	100%
E9AQ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QFC7	Leishmania major	77%	100%