GPI-anchored protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H829_LEIBR

TriTrypDb:

LbrM.15.0600 , LBRM2903_150011800

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H829

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H829

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.473
CLV_C14_Caspase3-7	271	275	PF00656	0.495
CLV_NRD_NRD_1	73	75	PF00675	0.673
CLV_PCSK_KEX2_1	75	77	PF00082	0.553
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.536
CLV_PCSK_SKI1_1	286	290	PF00082	0.654
CLV_PCSK_SKI1_1	44	48	PF00082	0.654
DEG_SPOP_SBC_1	136	140	PF00917	0.559
DOC_MAPK_MEF2A_6	14	22	PF00069	0.411
DOC_PP2B_LxvP_1	240	243	PF13499	0.436
DOC_USP7_MATH_1	148	152	PF00917	0.434
DOC_USP7_MATH_1	234	238	PF00917	0.423
DOC_USP7_MATH_1	309	313	PF00917	0.352
DOC_USP7_MATH_1	35	39	PF00917	0.452
DOC_USP7_UBL2_3	75	79	PF12436	0.456
DOC_WW_Pin1_4	305	310	PF00397	0.534
LIG_14-3-3_CanoR_1	112	122	PF00244	0.396
LIG_14-3-3_CanoR_1	286	291	PF00244	0.368
LIG_14-3-3_CanoR_1	316	320	PF00244	0.325
LIG_APCC_ABBA_1	196	201	PF00400	0.501
LIG_BRCT_BRCA1_1	284	288	PF00533	0.381
LIG_FHA_1	3	9	PF00498	0.507
LIG_FHA_1	312	318	PF00498	0.253
LIG_FHA_2	137	143	PF00498	0.481
LIG_FHA_2	59	65	PF00498	0.487
LIG_FHA_2	82	88	PF00498	0.364
LIG_Integrin_isoDGR_2	263	265	PF01839	0.641
LIG_LIR_Gen_1	245	254	PF02991	0.355
LIG_LIR_Gen_1	285	296	PF02991	0.562
LIG_LIR_Nem_3	181	186	PF02991	0.389
LIG_LIR_Nem_3	285	291	PF02991	0.563
LIG_LIR_Nem_3	50	55	PF02991	0.392
LIG_SH2_GRB2like	203	206	PF00017	0.436
LIG_SH2_NCK_1	199	203	PF00017	0.485
LIG_SH2_NCK_1	215	219	PF00017	0.385
LIG_SH2_STAP1	199	203	PF00017	0.436
LIG_SH2_STAP1	52	56	PF00017	0.507
LIG_SH2_STAT5	199	202	PF00017	0.455
LIG_SH2_STAT5	203	206	PF00017	0.447
LIG_SH2_STAT5	215	218	PF00017	0.383
LIG_SH2_STAT5	290	293	PF00017	0.433
LIG_SH2_STAT5	328	331	PF00017	0.450
LIG_SH2_STAT5	55	58	PF00017	0.417
LIG_SH3_3	141	147	PF00018	0.512
LIG_SH3_3	4	10	PF00018	0.489
LIG_SUMO_SIM_anti_2	318	323	PF11976	0.240
LIG_SUMO_SIM_par_1	317	323	PF11976	0.273
LIG_TRAF2_1	153	156	PF00917	0.506
LIG_UBA3_1	251	259	PF00899	0.356
LIG_WRC_WIRS_1	92	97	PF05994	0.417
MOD_CK1_1	107	113	PF00069	0.423
MOD_CK1_1	114	120	PF00069	0.372
MOD_CK1_1	158	164	PF00069	0.492
MOD_CK1_1	197	203	PF00069	0.385
MOD_CK1_1	224	230	PF00069	0.460
MOD_CK1_1	24	30	PF00069	0.434
MOD_CK1_1	273	279	PF00069	0.425
MOD_CK1_1	282	288	PF00069	0.389
MOD_CK1_1	3	9	PF00069	0.515
MOD_CK1_1	305	311	PF00069	0.491
MOD_CK1_1	38	44	PF00069	0.387
MOD_CK1_1	96	102	PF00069	0.498
MOD_CK2_1	136	142	PF00069	0.495
MOD_CK2_1	149	155	PF00069	0.478
MOD_GlcNHglycan	278	281	PF01048	0.645
MOD_GlcNHglycan	304	307	PF01048	0.649
MOD_GlcNHglycan	49	52	PF01048	0.716
MOD_GSK3_1	104	111	PF00069	0.511
MOD_GSK3_1	171	178	PF00069	0.483
MOD_GSK3_1	269	276	PF00069	0.460
MOD_GSK3_1	278	285	PF00069	0.607
MOD_GSK3_1	298	305	PF00069	0.413
MOD_GSK3_1	311	318	PF00069	0.307
MOD_N-GLC_1	104	109	PF02516	0.640
MOD_N-GLC_1	194	199	PF02516	0.589
MOD_N-GLC_1	224	229	PF02516	0.684
MOD_N-GLC_1	81	86	PF02516	0.671
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	149	154	PF00069	0.432
MOD_NEK2_1	311	316	PF00069	0.231
MOD_NEK2_1	47	52	PF00069	0.396
MOD_NEK2_1	70	75	PF00069	0.433
MOD_NEK2_1	90	95	PF00069	0.504
MOD_NEK2_2	194	199	PF00069	0.389
MOD_PIKK_1	121	127	PF00454	0.477
MOD_PIKK_1	155	161	PF00454	0.436
MOD_PIKK_1	311	317	PF00454	0.231
MOD_PKA_2	111	117	PF00069	0.390
MOD_PKA_2	315	321	PF00069	0.233
MOD_Plk_1	149	155	PF00069	0.435
MOD_Plk_1	194	200	PF00069	0.388
MOD_Plk_1	224	230	PF00069	0.408
MOD_Plk_1	35	41	PF00069	0.447
MOD_Plk_1	90	96	PF00069	0.432
MOD_Plk_2-3	150	156	PF00069	0.478
MOD_Plk_4	127	133	PF00069	0.580
MOD_Plk_4	175	181	PF00069	0.426
MOD_Plk_4	194	200	PF00069	0.468
MOD_Plk_4	3	9	PF00069	0.510
MOD_Plk_4	320	326	PF00069	0.307
MOD_ProDKin_1	305	311	PF00069	0.532
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.576
TRG_ENDOCYTIC_2	248	251	PF00928	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P748	Leptomonas seymouri	39%	100%
A0A3S7WTK4	Leishmania donovani	64%	100%
A4HWF5	Leishmania infantum	64%	100%
E9AQ54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QFC8	Leishmania major	62%	100%