Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H828_LEIBR

TriTrypDb:

LbrM.15.0590 , LBRM2903_150011700

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H828

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H828

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.672
CLV_NRD_NRD_1	208	210	PF00675	0.611
CLV_NRD_NRD_1	313	315	PF00675	0.591
CLV_NRD_NRD_1	316	318	PF00675	0.522
CLV_NRD_NRD_1	412	414	PF00675	0.562
CLV_NRD_NRD_1	576	578	PF00675	0.396
CLV_NRD_NRD_1	73	75	PF00675	0.525
CLV_PCSK_FUR_1	314	318	PF00082	0.630
CLV_PCSK_KEX2_1	208	210	PF00082	0.530
CLV_PCSK_KEX2_1	313	315	PF00082	0.586
CLV_PCSK_KEX2_1	316	318	PF00082	0.527
CLV_PCSK_KEX2_1	412	414	PF00082	0.649
CLV_PCSK_KEX2_1	575	577	PF00082	0.489
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.489
CLV_PCSK_SKI1_1	119	123	PF00082	0.685
CLV_PCSK_SKI1_1	256	260	PF00082	0.418
CLV_PCSK_SKI1_1	288	292	PF00082	0.612
CLV_PCSK_SKI1_1	367	371	PF00082	0.448
CLV_PCSK_SKI1_1	459	463	PF00082	0.562
CLV_PCSK_SKI1_1	58	62	PF00082	0.458
CLV_PCSK_SKI1_1	68	72	PF00082	0.413
CLV_PCSK_SKI1_1	77	81	PF00082	0.502
DEG_APCC_DBOX_1	323	331	PF00400	0.462
DEG_SPOP_SBC_1	121	125	PF00917	0.515
DEG_SPOP_SBC_1	156	160	PF00917	0.414
DEG_SPOP_SBC_1	212	216	PF00917	0.651
DEG_SPOP_SBC_1	305	309	PF00917	0.683
DEG_SPOP_SBC_1	557	561	PF00917	0.459
DEG_SPOP_SBC_1	605	609	PF00917	0.588
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.567
DOC_MAPK_gen_1	103	113	PF00069	0.564
DOC_MAPK_gen_1	238	247	PF00069	0.474
DOC_MAPK_gen_1	74	83	PF00069	0.447
DOC_MAPK_HePTP_8	71	83	PF00069	0.363
DOC_MAPK_MEF2A_6	74	83	PF00069	0.447
DOC_PIKK_1	198	206	PF02985	0.430
DOC_PP1_RVXF_1	591	597	PF00149	0.471
DOC_PP2B_LxvP_1	281	284	PF13499	0.528
DOC_PP2B_LxvP_1	555	558	PF13499	0.466
DOC_USP7_MATH_1	155	159	PF00917	0.604
DOC_USP7_MATH_1	211	215	PF00917	0.688
DOC_USP7_MATH_1	603	607	PF00917	0.694
DOC_USP7_UBL2_3	122	126	PF12436	0.673
DOC_USP7_UBL2_3	248	252	PF12436	0.452
DOC_WW_Pin1_4	12	17	PF00397	0.496
DOC_WW_Pin1_4	217	222	PF00397	0.612
DOC_WW_Pin1_4	35	40	PF00397	0.564
DOC_WW_Pin1_4	487	492	PF00397	0.479
DOC_WW_Pin1_4	6	11	PF00397	0.598
DOC_WW_Pin1_4	601	606	PF00397	0.541
LIG_14-3-3_CanoR_1	106	113	PF00244	0.449
LIG_14-3-3_CanoR_1	119	128	PF00244	0.580
LIG_14-3-3_CanoR_1	302	312	PF00244	0.609
LIG_14-3-3_CanoR_1	356	366	PF00244	0.478
LIG_14-3-3_CanoR_1	454	459	PF00244	0.556
LIG_14-3-3_CanoR_1	545	549	PF00244	0.443
LIG_Actin_WH2_2	244	261	PF00022	0.388
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_2	294	298	PF00653	0.493
LIG_BIR_III_2	602	606	PF00653	0.470
LIG_BIR_III_4	233	237	PF00653	0.477
LIG_BRCT_BRCA1_1	432	436	PF00533	0.579
LIG_CaM_IQ_9	251	266	PF13499	0.424
LIG_DLG_GKlike_1	454	462	PF00625	0.475
LIG_eIF4E_1	537	543	PF01652	0.390
LIG_FHA_1	102	108	PF00498	0.522
LIG_FHA_1	116	122	PF00498	0.531
LIG_FHA_1	198	204	PF00498	0.515
LIG_FHA_1	307	313	PF00498	0.676
LIG_FHA_1	78	84	PF00498	0.491
LIG_FHA_2	130	136	PF00498	0.534
LIG_FHA_2	274	280	PF00498	0.509
LIG_FHA_2	36	42	PF00498	0.577
LIG_FHA_2	380	386	PF00498	0.507
LIG_FHA_2	387	393	PF00498	0.591
LIG_FHA_2	47	53	PF00498	0.531
LIG_FHA_2	559	565	PF00498	0.705
LIG_Integrin_RGD_1	50	52	PF01839	0.530
LIG_LIR_Gen_1	497	505	PF02991	0.582
LIG_LIR_Gen_1	66	73	PF02991	0.538
LIG_LIR_Nem_3	497	502	PF02991	0.582
LIG_LIR_Nem_3	66	72	PF02991	0.492
LIG_PCNA_yPIPBox_3	181	190	PF02747	0.474
LIG_SH2_CRK	166	170	PF00017	0.457
LIG_SH2_SRC	537	540	PF00017	0.395
LIG_SH2_STAT5	379	382	PF00017	0.440
LIG_SH2_STAT5	69	72	PF00017	0.388
LIG_SH3_3	309	315	PF00018	0.667
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.455
LIG_SUMO_SIM_par_1	539	544	PF11976	0.529
LIG_TRAF2_1	404	407	PF00917	0.447
LIG_TRAF2_1	414	417	PF00917	0.464
LIG_TRAF2_1	99	102	PF00917	0.539
LIG_UBA3_1	70	77	PF00899	0.362
MOD_CDK_SPK_2	487	492	PF00069	0.479
MOD_CK1_1	109	115	PF00069	0.447
MOD_CK1_1	139	145	PF00069	0.639
MOD_CK1_1	2	8	PF00069	0.584
MOD_CK1_1	216	222	PF00069	0.624
MOD_CK1_1	229	235	PF00069	0.528
MOD_CK1_1	303	309	PF00069	0.583
MOD_CK1_1	487	493	PF00069	0.474
MOD_CK1_1	562	568	PF00069	0.578
MOD_CK1_1	9	15	PF00069	0.574
MOD_CK2_1	37	43	PF00069	0.578
MOD_CK2_1	379	385	PF00069	0.439
MOD_CK2_1	386	392	PF00069	0.446
MOD_CK2_1	425	431	PF00069	0.493
MOD_CK2_1	494	500	PF00069	0.585
MOD_CK2_1	558	564	PF00069	0.526
MOD_GlcNHglycan	108	111	PF01048	0.467
MOD_GlcNHglycan	141	144	PF01048	0.578
MOD_GlcNHglycan	149	152	PF01048	0.572
MOD_GlcNHglycan	215	218	PF01048	0.653
MOD_GlcNHglycan	229	232	PF01048	0.655
MOD_GlcNHglycan	264	267	PF01048	0.490
MOD_GlcNHglycan	327	330	PF01048	0.556
MOD_GlcNHglycan	340	344	PF01048	0.421
MOD_GlcNHglycan	359	362	PF01048	0.530
MOD_GlcNHglycan	442	445	PF01048	0.705
MOD_GlcNHglycan	468	471	PF01048	0.544
MOD_GlcNHglycan	523	527	PF01048	0.597
MOD_GlcNHglycan	561	564	PF01048	0.604
MOD_GSK3_1	111	118	PF00069	0.506
MOD_GSK3_1	139	146	PF00069	0.711
MOD_GSK3_1	2	9	PF00069	0.615
MOD_GSK3_1	212	219	PF00069	0.618
MOD_GSK3_1	225	232	PF00069	0.598
MOD_GSK3_1	296	303	PF00069	0.555
MOD_GSK3_1	368	375	PF00069	0.467
MOD_GSK3_1	425	432	PF00069	0.588
MOD_GSK3_1	459	466	PF00069	0.542
MOD_GSK3_1	46	53	PF00069	0.614
MOD_GSK3_1	490	497	PF00069	0.601
MOD_GSK3_1	558	565	PF00069	0.685
MOD_GSK3_1	601	608	PF00069	0.649
MOD_N-GLC_1	143	148	PF02516	0.594
MOD_N-GLC_1	182	187	PF02516	0.388
MOD_NEK2_1	3	8	PF00069	0.563
MOD_NEK2_1	357	362	PF00069	0.552
MOD_NEK2_1	384	389	PF00069	0.438
MOD_NEK2_1	485	490	PF00069	0.565
MOD_NEK2_1	494	499	PF00069	0.556
MOD_NEK2_2	415	420	PF00069	0.404
MOD_PIKK_1	101	107	PF00454	0.550
MOD_PIKK_1	307	313	PF00454	0.573
MOD_PIKK_1	485	491	PF00454	0.495
MOD_PIKK_1	515	521	PF00454	0.501
MOD_PKA_2	325	331	PF00069	0.460
MOD_PKA_2	544	550	PF00069	0.444
MOD_Plk_1	182	188	PF00069	0.390
MOD_Plk_1	415	421	PF00069	0.408
MOD_Plk_1	463	469	PF00069	0.506
MOD_Plk_1	543	549	PF00069	0.412
MOD_Plk_1	569	575	PF00069	0.388
MOD_Plk_1	77	83	PF00069	0.456
MOD_Plk_4	273	279	PF00069	0.592
MOD_Plk_4	379	385	PF00069	0.457
MOD_Plk_4	463	469	PF00069	0.518
MOD_Plk_4	562	568	PF00069	0.600
MOD_ProDKin_1	217	223	PF00069	0.616
MOD_ProDKin_1	35	41	PF00069	0.565
MOD_ProDKin_1	487	493	PF00069	0.474
MOD_ProDKin_1	6	12	PF00069	0.594
MOD_ProDKin_1	601	607	PF00069	0.546
MOD_SUMO_for_1	369	372	PF00179	0.441
MOD_SUMO_rev_2	253	261	PF00179	0.408
MOD_SUMO_rev_2	457	467	PF00179	0.491
MOD_SUMO_rev_2	469	478	PF00179	0.507
MOD_SUMO_rev_2	508	518	PF00179	0.515
MOD_SUMO_rev_2	63	70	PF00179	0.416
TRG_DiLeu_BaEn_1	202	207	PF01217	0.502
TRG_DiLeu_BaEn_1	242	247	PF01217	0.454
TRG_DiLeu_BaEn_1	66	71	PF01217	0.373
TRG_DiLeu_BaEn_4	242	248	PF01217	0.535
TRG_ENDOCYTIC_2	166	169	PF00928	0.459
TRG_ENDOCYTIC_2	499	502	PF00928	0.502
TRG_ENDOCYTIC_2	537	540	PF00928	0.395
TRG_ENDOCYTIC_2	69	72	PF00928	0.406
TRG_ER_diArg_1	207	209	PF00400	0.711
TRG_ER_diArg_1	237	240	PF00400	0.516
TRG_ER_diArg_1	312	314	PF00400	0.597
TRG_ER_diArg_1	315	317	PF00400	0.547
TRG_ER_diArg_1	411	413	PF00400	0.667
TRG_ER_diArg_1	576	578	PF00400	0.396
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I948	Leptomonas seymouri	40%	98%
A0A3Q8IA19	Leishmania donovani	70%	100%
A4HWF4	Leishmania infantum	70%	100%
E9AQ53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QFC9	Leishmania major	70%	100%