Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H826_LEIBR

TriTrypDb:

LbrM.15.0570 , LBRM2903_150011500

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005815	microtubule organizing center	2	1
GO:0035253	ciliary rootlet	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H826

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H826

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	10
GO:0007017	microtubule-based process	2	10
GO:0007018	microtubule-based movement	3	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.716
CLV_C14_Caspase3-7	531	535	PF00656	0.549
CLV_NRD_NRD_1	152	154	PF00675	0.378
CLV_NRD_NRD_1	222	224	PF00675	0.409
CLV_NRD_NRD_1	229	231	PF00675	0.435
CLV_NRD_NRD_1	275	277	PF00675	0.689
CLV_NRD_NRD_1	35	37	PF00675	0.434
CLV_NRD_NRD_1	45	47	PF00675	0.424
CLV_NRD_NRD_1	663	665	PF00675	0.521
CLV_NRD_NRD_1	671	673	PF00675	0.580
CLV_PCSK_KEX2_1	152	154	PF00082	0.378
CLV_PCSK_KEX2_1	229	231	PF00082	0.452
CLV_PCSK_KEX2_1	236	238	PF00082	0.483
CLV_PCSK_KEX2_1	274	276	PF00082	0.674
CLV_PCSK_KEX2_1	35	37	PF00082	0.428
CLV_PCSK_KEX2_1	45	47	PF00082	0.397
CLV_PCSK_KEX2_1	665	667	PF00082	0.602
CLV_PCSK_KEX2_1	671	673	PF00082	0.580
CLV_PCSK_KEX2_1	86	88	PF00082	0.437
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.420
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.535
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.390
CLV_PCSK_SKI1_1	229	233	PF00082	0.406
CLV_PCSK_SKI1_1	307	311	PF00082	0.401
CLV_PCSK_SKI1_1	350	354	PF00082	0.566
CLV_PCSK_SKI1_1	502	506	PF00082	0.490
CLV_PCSK_SKI1_1	52	56	PF00082	0.507
DEG_APCC_DBOX_1	23	31	PF00400	0.420
DEG_APCC_DBOX_1	644	652	PF00400	0.487
DOC_CYCLIN_RxL_1	425	435	PF00134	0.495
DOC_MAPK_gen_1	13	21	PF00069	0.447
DOC_MAPK_gen_1	242	249	PF00069	0.499
DOC_MAPK_gen_1	323	332	PF00069	0.548
DOC_MAPK_gen_1	45	55	PF00069	0.553
DOC_MAPK_MEF2A_6	242	251	PF00069	0.547
DOC_MAPK_MEF2A_6	46	55	PF00069	0.430
DOC_PP4_FxxP_1	545	548	PF00568	0.547
DOC_USP7_MATH_1	206	210	PF00917	0.461
DOC_USP7_MATH_1	352	356	PF00917	0.605
DOC_USP7_MATH_1	367	371	PF00917	0.545
DOC_USP7_MATH_1	629	633	PF00917	0.657
DOC_USP7_UBL2_3	140	144	PF12436	0.378
DOC_USP7_UBL2_3	195	199	PF12436	0.506
DOC_WW_Pin1_4	286	291	PF00397	0.655
DOC_WW_Pin1_4	526	531	PF00397	0.657
DOC_WW_Pin1_4	570	575	PF00397	0.689
DOC_WW_Pin1_4	597	602	PF00397	0.726
LIG_14-3-3_CanoR_1	105	113	PF00244	0.584
LIG_14-3-3_CanoR_1	15	19	PF00244	0.582
LIG_14-3-3_CanoR_1	152	156	PF00244	0.376
LIG_14-3-3_CanoR_1	260	268	PF00244	0.733
LIG_14-3-3_CanoR_1	281	290	PF00244	0.648
LIG_14-3-3_CanoR_1	502	509	PF00244	0.472
LIG_14-3-3_CanoR_1	538	548	PF00244	0.536
LIG_14-3-3_CanoR_1	565	574	PF00244	0.497
LIG_14-3-3_CanoR_1	63	68	PF00244	0.558
LIG_Actin_WH2_2	37	54	PF00022	0.540
LIG_Actin_WH2_2	85	103	PF00022	0.455
LIG_CaM_IQ_9	249	265	PF13499	0.397
LIG_CaM_IQ_9	27	42	PF13499	0.480
LIG_FHA_1	299	305	PF00498	0.556
LIG_FHA_1	508	514	PF00498	0.535
LIG_FHA_2	104	110	PF00498	0.322
LIG_FHA_2	155	161	PF00498	0.393
LIG_FHA_2	250	256	PF00498	0.460
LIG_FHA_2	333	339	PF00498	0.415
LIG_FHA_2	671	677	PF00498	0.527
LIG_GLEBS_BUB3_1	527	535	PF00400	0.543
LIG_IRF3_LxIS_1	471	478	PF10401	0.466
LIG_LIR_Apic_2	542	548	PF02991	0.437
LIG_LIR_Gen_1	154	162	PF02991	0.374
LIG_LIR_Gen_1	301	311	PF02991	0.409
LIG_LIR_Gen_1	355	364	PF02991	0.525
LIG_LIR_Nem_3	154	158	PF02991	0.374
LIG_LIR_Nem_3	301	306	PF02991	0.410
LIG_LIR_Nem_3	355	360	PF02991	0.457
LIG_LIR_Nem_3	418	422	PF02991	0.532
LIG_NRBOX	456	462	PF00104	0.480
LIG_PCNA_yPIPBox_3	184	195	PF02747	0.307
LIG_PDZ_Class_3	673	678	PF00595	0.589
LIG_SH2_CRK	419	423	PF00017	0.540
LIG_SH2_STAP1	155	159	PF00017	0.341
LIG_SH2_STAT5	303	306	PF00017	0.537
LIG_SH2_STAT5	470	473	PF00017	0.522
LIG_SH3_3	549	555	PF00018	0.672
LIG_TRAF2_1	106	109	PF00917	0.395
LIG_TRAF2_1	252	255	PF00917	0.493
LIG_TRAF2_1	529	532	PF00917	0.545
LIG_TRAF2_1	673	676	PF00917	0.558
LIG_TRAF2_1	72	75	PF00917	0.498
LIG_TYR_ITIM	417	422	PF00017	0.519
MOD_CDC14_SPxK_1	573	576	PF00782	0.525
MOD_CDK_SPxK_1	570	576	PF00069	0.521
MOD_CDK_SPxxK_3	597	604	PF00069	0.526
MOD_CK1_1	284	290	PF00069	0.686
MOD_CK1_1	539	545	PF00069	0.507
MOD_CK1_1	570	576	PF00069	0.749
MOD_CK1_1	588	594	PF00069	0.793
MOD_CK1_1	600	606	PF00069	0.621
MOD_CK1_1	608	614	PF00069	0.753
MOD_CK1_1	621	627	PF00069	0.669
MOD_CK2_1	103	109	PF00069	0.321
MOD_CK2_1	154	160	PF00069	0.392
MOD_CK2_1	171	177	PF00069	0.407
MOD_CK2_1	249	255	PF00069	0.598
MOD_CK2_1	286	292	PF00069	0.425
MOD_CK2_1	332	338	PF00069	0.414
MOD_CK2_1	352	358	PF00069	0.335
MOD_CK2_1	526	532	PF00069	0.526
MOD_CK2_1	670	676	PF00069	0.562
MOD_GlcNHglycan	195	198	PF01048	0.489
MOD_GlcNHglycan	263	266	PF01048	0.665
MOD_GlcNHglycan	271	274	PF01048	0.712
MOD_GlcNHglycan	283	286	PF01048	0.746
MOD_GlcNHglycan	324	328	PF01048	0.602
MOD_GlcNHglycan	349	353	PF01048	0.539
MOD_GlcNHglycan	369	372	PF01048	0.637
MOD_GlcNHglycan	477	480	PF01048	0.581
MOD_GlcNHglycan	490	494	PF01048	0.624
MOD_GlcNHglycan	570	573	PF01048	0.701
MOD_GlcNHglycan	620	623	PF01048	0.632
MOD_GSK3_1	147	154	PF00069	0.523
MOD_GSK3_1	168	175	PF00069	0.462
MOD_GSK3_1	277	284	PF00069	0.713
MOD_GSK3_1	348	355	PF00069	0.573
MOD_GSK3_1	566	573	PF00069	0.613
MOD_LATS_1	279	285	PF00433	0.496
MOD_N-GLC_1	123	128	PF02516	0.471
MOD_N-GLC_1	313	318	PF02516	0.361
MOD_N-GLC_1	401	406	PF02516	0.711
MOD_N-GLC_1	63	68	PF02516	0.598
MOD_NEK2_1	232	237	PF00069	0.414
MOD_NEK2_1	249	254	PF00069	0.562
MOD_NEK2_1	332	337	PF00069	0.424
MOD_NEK2_1	339	344	PF00069	0.432
MOD_NEK2_1	475	480	PF00069	0.514
MOD_NEK2_1	55	60	PF00069	0.557
MOD_NEK2_1	85	90	PF00069	0.382
MOD_PIKK_1	168	174	PF00454	0.401
MOD_PIKK_1	249	255	PF00454	0.589
MOD_PIKK_1	502	508	PF00454	0.479
MOD_PIKK_1	585	591	PF00454	0.519
MOD_PIKK_1	610	616	PF00454	0.519
MOD_PK_1	63	69	PF00069	0.594
MOD_PKA_2	104	110	PF00069	0.437
MOD_PKA_2	14	20	PF00069	0.580
MOD_PKA_2	151	157	PF00069	0.376
MOD_PKA_2	670	676	PF00069	0.582
MOD_PKB_1	305	313	PF00069	0.536
MOD_Plk_1	122	128	PF00069	0.537
MOD_Plk_1	307	313	PF00069	0.399
MOD_Plk_1	339	345	PF00069	0.523
MOD_Plk_1	348	354	PF00069	0.461
MOD_Plk_1	63	69	PF00069	0.594
MOD_Plk_2-3	104	110	PF00069	0.437
MOD_Plk_4	14	20	PF00069	0.448
MOD_Plk_4	154	160	PF00069	0.400
MOD_Plk_4	39	45	PF00069	0.344
MOD_Plk_4	629	635	PF00069	0.475
MOD_ProDKin_1	286	292	PF00069	0.647
MOD_ProDKin_1	526	532	PF00069	0.659
MOD_ProDKin_1	570	576	PF00069	0.690
MOD_ProDKin_1	597	603	PF00069	0.727
MOD_SUMO_for_1	204	207	PF00179	0.389
MOD_SUMO_for_1	72	75	PF00179	0.539
MOD_SUMO_rev_2	207	213	PF00179	0.489
MOD_SUMO_rev_2	641	651	PF00179	0.544
TRG_DiLeu_BaEn_1	186	191	PF01217	0.503
TRG_DiLeu_BaEn_2	107	113	PF01217	0.492
TRG_DiLeu_BaEn_2	227	233	PF01217	0.357
TRG_ENDOCYTIC_2	155	158	PF00928	0.374
TRG_ENDOCYTIC_2	303	306	PF00928	0.405
TRG_ENDOCYTIC_2	419	422	PF00928	0.545
TRG_ER_diArg_1	151	153	PF00400	0.392
TRG_ER_diArg_1	274	276	PF00400	0.682
TRG_ER_diArg_1	304	307	PF00400	0.539
TRG_ER_diArg_1	34	36	PF00400	0.435
TRG_ER_diArg_1	44	46	PF00400	0.433
TRG_NLS_MonoExtN_4	662	668	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF92	Leptomonas seymouri	66%	100%
A0A1X0NV64	Trypanosomatidae	39%	96%
A0A3Q8IA72	Leishmania donovani	81%	100%
A0A422NLI6	Trypanosoma rangeli	40%	100%
C9ZNZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AQ51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QFD1	Leishmania major	81%	100%
V5BBE7	Trypanosoma cruzi	41%	100%